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Identification of Disease-associated Genes for Cardiovascular Diseases

Research Project

Project/Area Number 12204004
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionMedical Research Institute, Tokyo Medical and Dental University

Principal Investigator

KIMURA Akinori  Tokyo Medical and Dental University, Medical Research Institute, Professor, 難治疾患研究所, 教授 (60161551)

Co-Investigator(Kenkyū-buntansha) IZUMI Toru  Kitasato University, Faculty of Medicine, Professor, 医学部, 教授 (80143775)
YASUAMI Michio  Tokyo Medical University, School of Biomedical Sciences, Associated Professor, 大学院疾患生命科学研究部, 助教授 (80244127)
赤井 潤  東京医科歯科大学, 難治疾患研究所, 助手 (70302891)
吉田 雅幸  東京医科歯科大学, 難治疾患研究所, 助教授 (80282771)
Project Period (FY) 2000 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥59,900,000 (Direct Cost: ¥59,900,000)
Fiscal Year 2004: ¥16,000,000 (Direct Cost: ¥16,000,000)
Fiscal Year 2003: ¥16,000,000 (Direct Cost: ¥16,000,000)
Fiscal Year 2002: ¥14,400,000 (Direct Cost: ¥14,400,000)
Fiscal Year 2001: ¥13,500,000 (Direct Cost: ¥13,500,000)
Keywordsgene mutation / hypertensive cardiomyopathy / arrhythmia / heart failure / myocardial infarction / microsatellite / Intractable arteritis / idiopathic cardiomyopathy / ゲノム多様性 / LTA / 高血圧 / 心筋症 / 高安病 / 動物モデル / HLA / 心肥大 / 循環器疾患 / 機能解析 / DSSラット
Research Abstract

Myocardial infarction: We found significant associations of myocardial infarction with polymorphisms in SELE, PECAM1 and CD14. It also was revealed that the disease-associated SELE allele lead higher binding between leukocytes and vascular endothelial cells. In contrast no association was found for the reported polymorphisms in LTA, LGALS2 and p22phox genes via the analysis of more than 500 patients and 500 controls. On the other hand, we could identify five novel disease-related loci for myocardial infarction via the analysis of 18,800 microsatellite markers.
Cardiomyopathy: Gene-Chip analysis of hypertrophied hearts and failing hearts from Dahl salt-sensitive hypertensive rats enabled us to identify 258 genes showing increased or decreased expression in association with hypertensive cardiomyopathy. By analyzing human orthologues of these genes we identified a BMP10 variant associated with hypertensive dilated cardiomyopathy. Biochemical and cell biological analyses revealed that BMP10 … More localized in Z-disc and bound Tcap. The BMP10 variant reduced the binding to Tcap and augmented extracellular secretion of BMP10. In addition, candidate gene approaches have revealed two novel disease genes for hypertrophic cardiomyopathy and four disease genes for dilated cardiomyopathy.
Arrhythmia: In this study, we have identified many disease-associated mutations in cardiac channel genes and revealed functional changes caused by the mutations. In addition, an HCN4 mutation was revealed to be a novel disease gene for ventricular arrhythmia since a disease-linked mutation showed dominant loss-of-function of HCN4 channel.
Vasculitis: We have investigated polymorphisms of microsatellite markers and SNPs in the HLA region in patients with Takayasu arteritis or Buerger disease. It was revealed that there were two disease-associated loci for Takayasu arteritis; one was HLA-B and the other was mapped in TNF-MICA region. In contrast, there were at least three disease-associated loci for Buerger disease; first was HLA-DPB1, second was HLA-DRB1, and third was mapped near the HLA-E gene. Less

Report

(6 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (113 results)

All 2005 2004 2003 2002 2001 2000 Other

All Journal Article (70 results) Book (3 results) Patent(Industrial Property Rights) (2 results) Publications (38 results)

  • [Journal Article] Association of clinical features with HLA in chronic pulmonary thromboembolism in Japan2005

    • Author(s)
      Tanabe N, Kimura A, Amano S, Okada O, Kasahara Y, Tatsumi K, Takahashi M, Shibata H, Yasunami M, Kuriyama T
    • Journal Title

      Eur Resp J 25

      Pages: 131-138

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association of clinical features with HLA in chronic pulmonary thromboembolism in Japan.2005

    • Author(s)
      Tanabe N, Kimura A, Amano S, Okada O, Kasahara Y, T atsumi K, Takahashi M, Shibata H, Yasunami M, Kuriyama T
    • Journal Title

      Eur Resp J 25

      Pages: 131-138

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association of clinical features with HLA in chronic pulmonary thromboembolism in Japan2005

    • Author(s)
      Tanabe N, Kimura A, Amano S, Okada O, Kasahara Y, Tatsumi K, Takahashi M, Shibata H, Yasunami M, Kuriyama T
    • Journal Title

      Eur.Resp.J. 25

      Pages: 131-138

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Functional analysis of titin/connectin N2-B mutations found in cardiomyopathy2005

    • Author(s)
      Matsumoto Y, Hayashi T, Inagaki N, Takahashi M, Hiroi S, Nakamura T, Arimura T, Nakamura K, Ashizawa N, Yasunami M, Ohe T, Yano A, Kimura A
    • Journal Title

      J.Muscle Res.Cell Motil (In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Identification and functional analysis of a caveolon-3 mutation associated with familial hypertrophic cardiomyopathy2004

    • Author(s)
      Hayashi T, Arimura T, Ueda, K, Shibata H, Hohda S, Takahashi M, Hori H, Koga Y, Oka N, Imaizumi T, Yasunami M, Kimura A
    • Journal Title

      Biochem Biophys Res Commun 313

      Pages: 178-184

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C2004

    • Author(s)
      Arimura T, Hayashi T, Terada H, Lee SY, Zhou Q, Takahashi M, Ueda K, Nouchi T, Hohda S, Sibutani M, Hirose M, Chen J, Park JE, Yasunami M, Hayashi H, Kimura A
    • Journal Title

      J Biol Chem 279

      Pages: 6746-6752

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 17-year follow-up study of a patient with obstructive hypertrophic cardiomyopathy with a deletion mutation in the cardiac myosin binding protein C gene2004

    • Author(s)
      Ogimoto A, Hamada M, Nakura J, Shigematsu Y, Hara Y, Ohtsuka T, Morishima A, Kimura A, Miki T, Hiwada K
    • Journal Title

      Circ J 68

      Pages: 174-177

    • NAID

      110002667503

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] IKBL promoter polymorphism is strongly associated with resistance to type 1 diabetes in Japanese2004

    • Author(s)
      Yamashita T, Hamaguchi K, Kusuda Y, Kimura A, Sakata T, Yoshimatsu H
    • Journal Title

      Tissue Antigens 63

      Pages: 223-230

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] The role of a common TNNT2 polymorphism in cardiac hypertrophy2004

    • Author(s)
      Komamura K, Iwai N, Kokame K, Yasumura Y, Kim J, Yamagishi M, Morisaki T, Kimura A, Tomoike H, Kitakaze M, Miyatake K
    • Journal Title

      J Hum Genet 49

      Pages: 129-133

    • NAID

      10012891095

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia2004

    • Author(s)
      Ueda K, Nakamura K, Hayashi T, Inagaki N, Takahashi M, Arimura T, Morita H, Higashiuesata Y, Hirano Y, Yasunami M, Takishita S, Yamashina A, Ohe T, Sunamori M, Hiraoka M, Kimura A
    • Journal Title

      J Biol Chem 279

      Pages: 27194-27198

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Unexpected mexiletine responses of a mutant cardiac Na^+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access2004

    • Author(s)
      Sasaki K, Makita N, Sunami A, Sakurada H, Shirai N, Yokoi H, Kimura A, Tohse N, Hiraoka M, Kitabatake A
    • Journal Title

      Mol Pharmacol 66

      Pages: 330-336

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking2004

    • Author(s)
      Aizawa Y, Ueda K, Wu LM, Inagaki N, Hayashi T, Takahashi M, Ohta M, Kawano S, Hirano Y, Yasunami M, Aizawa Y, Kimura A, Hiraoka M
    • Journal Title

      FEBS Lett 574

      Pages: 145-150

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation2004

    • Author(s)
      Sasano T, Ueda K, Orikabe M, Hirano Y, Kawano S, Yasunami M, Isobe M, Kimura A, Hiraoka M
    • Journal Title

      J Mol Cell Cardiol 37

      Pages: 1205-1211

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] TCAP mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy2004

    • Author(s)
      Hayashi T, Arimura T, Itoh-Satoh M, Ueda K, Hohda S, Inagaki, N, Takahashi M, Hori H, Yasunami M, Nishi H, Koga Y, Nakamura H, Matsuzaki M, Cho BY, Bae SW, You CW, Han KH, Park JE, Knoll R, Hoshijima M, Chien KR, Kimura A
    • Journal Title

      J Am. Col Cardiol 44

      Pages: 2192-2201

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification and functional analysis of a caveolon-3 mutation associated with familial hypertrophic cardiomyopathy.2004

    • Author(s)
      Hayashi T, Arimura T, Ueda, K, Shibata H, Hohda S, Takahashi M, Hori H, Koga Y, Oka N, Imaizumi T, Yasunami M, Kimura A
    • Journal Title

      Biochem Biophys Res Commun 313

      Pages: 178-184

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C.2004

    • Author(s)
      Arimura T, Hayashi T, Terada H, Lee SY, Zhou Q, Takahashi M, Ueda K, Nouchi T, Hohda S, Sibutani M, Hirose M, Chen J, Park JE, Yasunami M, Hayashi H, Kimura A
    • Journal Title

      J Biol Chem 279

      Pages: 6746-6752

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 17-year follow-up study of a patient with obstructive hypertrophic cardiomyopathy with a deletion mutation in the cardiac myosin binding protein C gene.2004

    • Author(s)
      Ogimoto A, Hamada M, Nakura J, Shigematsu Y, Hara Y, Ohtsuka T, Morishima A, Kimura A, Miki T, Hiwada K
    • Journal Title

      Circ J 68

      Pages: 174-177

    • NAID

      110002667503

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] IKBL promoter polymorphism is strongly associated with resistance to type 1 diabetes in Japanese.2004

    • Author(s)
      Yamashita T, Hamaguchi K, Kusuda Y, Kimura A, Sakata T, Yoshimatsu H
    • Journal Title

      Tissue Antigens 63

      Pages: 223-230

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The role of a common TNNT2 polymorphism in cardiac hypertrophy.2004

    • Author(s)
      Komamura K, Iwai N, Kokame K, Yasumura Y, Kim J, Yamagishi M, Morisaki T, Kimura A, Tomoike H, Kitakaze M, Miyatake K
    • Journal Title

      J Hum Genet 49

      Pages: 129-133

    • NAID

      10012891095

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia.2004

    • Author(s)
      Ueda K, Nakamura K, Hayashi T, Inagaki N, Takahashi M, Arimura T, Morita H, Higashiuesata Y, Hirano Y, YasunamiM, Takishita S, Yamashina A, Ohe T, Sunamori M, Hiraoka M, Kimura A
    • Journal Title

      J Biol Chem 279

      Pages: 27194-27198

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Clinical and genetic characteristics of GAD-antibody positive patients initially diagnosed as having type 2 diabetes.2004

    • Author(s)
      Hamaguchi K, Kimura A, Kusuda Y, Yamashita T, Yasunami M, Takahashi M, Abe N, Yoshimatsu H
    • Journal Title

      Diabet. Res. Clin. Pract. 66

      Pages: 163-171

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access.2004

    • Author(s)
      Sasaki K, Makita N, Sunami A, Sakurada H, Shirai N, Yokoi H, Kimura A, Tohse N, Hiraoka M, Kitabatake A
    • Journal Title

      Mol Pharmacol 66

      Pages: 330-336

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Truncated KCNQ1 mutant, A178fs/105,forms hetero-multimer channel with wild-type causing adominant-negative suppression due to trafficking.2004

    • Author(s)
      Aizawa Y, Ueda K, Wu LM, Inagaki N, Hayashi T, Takahashi M, Ohta M, Kawano S, Hirano Y, Yasunami M, Aizawa Y, Kimura A, Hiraoka M
    • Journal Title

      FEBS Lett 574

      Pages: 145-150

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation.2004

    • Author(s)
      Sasano T, Ueda K, Orikabe M, Hirano Y, Kawano S, YasunamiM Isobe M, Kimura A, Hiraoka M
    • Journal Title

      J Mol Cell Cardiol 37

      Pages: 1205-1211

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] TCAP mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy.2004

    • Author(s)
      Hayashi T, Arimura T, Itoh-Satoh M, Ueda K, Hohda S, Inagaki, N, Takahashi M, Hori H, Yasunami M, Nishi H, Koga Y, Nakamura H, Matsuzaki M, Cho BY, Bae SW, You CW, Han KH, Park JE, Knoll R, Hoshijima M, Chien KR, Kimura A
    • Journal Title

      J Am. Col Cardiol 44

      Pages: 2192-2201

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C2004

    • Author(s)
      Arimura T, Hayashi T, Terada H, Lee SY, Zhou Q, Takahashi M, Ueda K, Nouchi T, Hohda S, Sibutani M, Hirose M, Chen J, Park JE, Yasunami M, Hayashi H, Kimura A
    • Journal Title

      J.Biol.Chem. 279

      Pages: 6746-6752

    • Related Report
      2004 Annual Research Report
  • [Journal Article] TCAP mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy2004

    • Author(s)
      Hayashi T, Arimura T, Itoh-Satoh M, Ueda K, Hohda S, Inagaki N, Takahashi M, Hori H, Yasunami M, Nishi H, Koga Y, Nakamura H, Matsuzaki M, Choi BY, Bae SW, You CW, Han KH, Park JE, Knoll R, Hoshijima M, Chien KR, Kimura A.
    • Journal Title

      J.Am.Col.Cardiol 44

      Pages: 2192-2201

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The role of a common TNNT2 polymorphism in cardiac hypertrophy2004

    • Author(s)
      Komamura K, Iwai N, Kokame K, Yasumura Y, Kim J, Yamagishi M, Morisaki T, Kimura A, Tomoike H, Kitakaze M, Miyatake K
    • Journal Title

      J.Hum.Genet 49

      Pages: 129-133

    • NAID

      10012891095

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia2004

    • Author(s)
      Ueda K, Nakamura K, Hayashi T, Inagaki N, Takahashi M, Arimura T, Morita H, Higashiuesata Y, Hirano Y, Yasunami M, Takishita S, Yamashina A, Ohe T, Sunamori M, Hiraoka M, Kimura A
    • Journal Title

      J.Biol.Chem. 279

      Pages: 27194-27198

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking.2004

    • Author(s)
      Aizawa Y, Ueda K, Wu LM, Inagaki N, Hayashi T, Takahashi M, Ohta M, Kawano S, Hirano Y, Yasunami M, Aizawa Y, Kimura A, Hiraoka M
    • Journal Title

      FEBS Lett 574

      Pages: 145-150

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2: additional amino acids generated by frameshift cause accelerated inactivation2004

    • Author(s)
      Sasano T, Ueda K, Orikabe M, Hirano Y, Kawano S, Yasunami M, Isobe M, Kimura A, Hiraoka M
    • Journal Title

      J.Mol.Cell.Cardiol. 37

      Pages: 1205-1211

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Clinical and genetic characteristics of GAD-antibody positive patients initially diagnosed as having type 2 diabetes2004

    • Author(s)
      Hamaguchi K, Kimura A, Kusuda Y, Yamashita T, Yasunami M, Takahashi M, Abe N, Yoshimatsu H
    • Journal Title

      Diabet.Res.Clin.Pract. 66

      Pages: 163-171

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access.2004

    • Author(s)
      Sasaki K, Makita N, Sunami A, Sakurada H, Shirai N, Yokoi H, Kimura A, Tohse N, Hiraoka M, Kitabatake A
    • Journal Title

      Mol.Pharmacol. 66

      Pages: 330-336

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Identification of IkBL as the second MHC-linked susceptibility locus for Rheumatoid Arthritis2003

    • Author(s)
      Okamoto K, Makino S, Yoshikawa Y, Takaki A, Nagatsuka Y, Ota M, Tamiya G, Kimura A, Bahram S, Inoko H
    • Journal Title

      Am J Hum Genet 72

      Pages: 303-312

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association study of the CD 14 polymorphism with myocardial infarction in Japanese populations2003

    • Author(s)
      Hohda S, Kimura A, Sasaoka T, Hayashi T, Ueda K, Yasunami M, Okabe M, Fukuda N, Kurosawa T, Izumi T
    • Journal Title

      Jpn Heart J 44

      Pages: 613-622

    • NAID

      130000067313

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under physiological flow conditions2003

    • Author(s)
      Yoshida M, Takano Y, Sasaoka T, Izumi T, Kimura A
    • Journal Title

      Arter Thrombo Vasc Biol 23

      Pages: 783-788

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Analysis of HLA-B polymorphism in insulin dependent diabetes mellitus in Japanese.2003

    • Author(s)
      Shao W, Yasunami M, Takahashi M, Shibata H, Hamaguchi K, Sakata T, Ota M, Katsuyama Y, Inoko H, Kimura A
    • Journal Title

      MHC 9

      Pages: 163-169

    • NAID

      130005509796

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification of IkBL as the second MHC-linked susceptibility locus for Rheumatoid Arthritis.2003

    • Author(s)
      Okamoto K, Makino S, Yoshikawa Y, Takaki A, Nagatsuka Y, Ota M, Tamiya G, Kimura A, Bahram S, Inoko H
    • Journal Title

      Am J Hum Genet 72

      Pages: 303-312

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association study of the CD14 polymorphism with myocardial infarction in Japanese populations.2003

    • Author(s)
      Hohda S, Kimura A, Sasaoka T, Hayashi T, Ueda K, Yasunami M, Okabe M, Fukuda N, Kurosawa T, Izumi T
    • Journal Title

      Jpn Heart J 44

      Pages: 613-622

    • NAID

      130000067313

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under physiological flow conditions.2003

    • Author(s)
      Yoshida M, Takano Y, Sasaoka T, Izumi T, Kimura A
    • Journal Title

      Arter Thrombo Vasc Biol 23

      Pages: 783-788

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Titin mutations as the molecular basis for dilated cardiomyopathy2002

    • Author(s)
      Itoh-Satoh M, Hayashi T, Nishi H, Koga Y, Arimura T, Ueda K, Hohta S, Nouchi T, Takahashi M, Hiroe M, Marumo F, Imaizumi T, Yasunami M, Kimura A
    • Journal Title

      Biochem Biophys Res Commun 291

      Pages: 385-393

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A mutant cardiac sodium channel with multiple biophysical defects associated with overlapping clinical features of Brugada syndrome and cardiac conduction disease2002

    • Author(s)
      Shirai N, Makita N, Sasaki K, Yokoi H, Sakuma I, Sakurada H, Akai J, Kimura A, Hiraoka M, Kitabatake A
    • Journal Title

      Cardiovasc Res 53

      Pages: 348-354

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Analysis of HLA in children with gelatin allergy2002

    • Author(s)
      Sakaguchi M, Nakayama T, Kaku H, Taniguchi K, Saito S, Kimura A, Inoue S
    • Journal Title

      Tissue Antigens 59

      Pages: 412-416

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Genomic structure and eight novel exonic polymorphisms of the human N-cadherin gene2002

    • Author(s)
      Harada H, Kimura A, Fukino K, Yasunaga S, Nishi H, Emi M
    • Journal Title

      J Hum Genet 47

      Pages: 330-332

    • NAID

      10011575172

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy2002

    • Author(s)
      Knoll R, Hoshijima M, Hoffmann HM, Person V, Lorenzen-Schmidt I, Bang M-L, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork J, Jeffrey H, Omens J, Andrew D, McCulloch A, Kimura A, Gregorio CC, Poller W, Schaper J, Schulthelss HP, Chien KR
    • Journal Title

      Cell 111

      Pages: 943-955

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Analysis of the major epitope of the alpha 2 chain of bovine type I collagen in children with bovine gelatin allergy2002

    • Author(s)
      Hori H, Hattori S, Inouye S, Kimura A, Irie S, Miyazawa H, Sakaguchi M
    • Journal Title

      J Allergy Clin Immunol 110

      Pages: 652-658

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Analysis of HLA-B polymorphism in insulin dependent diabetes mellitus in Japanese2002

    • Author(s)
      Shao W, Yasunami M, Takahashi M, Shibata H, Hamaguchi K, Sakata T, Ota M, Katsuyama Y, Inoko H, Kimura A
    • Journal Title

      MHC 9

      Pages: 163-169

    • NAID

      130005509796

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Titin mutations as the molecular basis for dilated cardiomyopathy.2002

    • Author(s)
      Itoh-Satoh M, Hayashi T, Nishi H, Koga Y, Arimura T, Ueda K, Hohta S, Nouchi T, Takahashi M, Hiroe M, Marumo F, Imaizumi T, Yasunami M, Kimura A
    • Journal Title

      Biochem Biophys Res Commun 291

      Pages: 385-393

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A mutant cardiac sodium channel with multiple biophysical defects associated with overlapping clinical features of Brugada syndrome and cardiac conduction disease.2002

    • Author(s)
      Shirai N, Makita N, Sasaki K, Yokoi H, Sakuma I, Sakurada H, Akai J, Kimura A, Hiraoka M, Kitabatake A
    • Journal Title

      Cardiovasc Res 53

      Pages: 348-354

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Analysis of HLA in children with gelatine allergy.2002

    • Author(s)
      Sakaguchi M, Nakayama T, Kaku H, Taniguchi K, Saito S, Kimura A, Inoue S
    • Journal Title

      Tissue Antigens 59

      Pages: 412-416

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Genomic structure and eight novel exonic polymorphisms of the human N-cadherin gene.2002

    • Author(s)
      Harada H, Kimura A, Fukino K, Yasunaga S, Nishi H, Emi M
    • Journal Title

      J Hum Genet 47

      Pages: 330-332

    • NAID

      10011575172

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Clinical significance of T-wave alternans in hypertrophic cardiomyopathy.2002

    • Author(s)
      Kuroda N, Ohnishi Y, Kimura A, Yokoyama M
    • Journal Title

      Circ J 66

      Pages: 457-462

    • NAID

      110002682850

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy.2002

    • Author(s)
      Knoll R, Hoshijima M, Hoffmann HM, Person V, Lorenzen-Schmidt I, Bang M-L, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork J, Jeffrey H, Omens J, Andrew D, McCulloch A, Kimura A, Gregorio CC, Poller W, Schaper J, Schulthelss HP, Chien KR
    • Journal Title

      Cell 111

      Pages: 943-955

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Analysis of the major epitope of the alpha 2 chain of bovine type I collagen in children with bovine gelatine allergy.2002

    • Author(s)
      Hori H, Hattori S, Inouye S, Kimura A, Irie S, Miyazawa H, Sakaguchi M
    • Journal Title

      J Allergy Clin Immunol 110

      Pages: 652-658

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification, characterization and functional analysis of heart-specific myosin light chain phosphatase small subunit2001

    • Author(s)
      Arimura T, Suematsu N, Zhou YB, Nishimura J, Satoh S, Takeshita A, Kanaide H, Kimura A
    • Journal Title

      J Biol Chem. 276

      Pages: 6073-6082

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A second susceptibility gene for developing rheumatoid arthritis in the human MHC is located within a 70 kb interval telomeric of the TNF genes in the HLA class III region2001

    • Author(s)
      Ota M, Katsuyama Y, Kimura A, Tsuchiya K, Kondo M, Naruse T, Itoh K, Sasazuki T, Inoko H
    • Journal Title

      Genomics 71

      Pages: 263-270

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification of MICA alleles with a long Leu-repeat in the transmembrane region and no cytoplasmic tail due to a frameshift deletion in exon 42001

    • Author(s)
      Obuchi N, Takahashi M, Nouchi T, Satoh M, Arimura T, Ueda K, Akai J, Ota M, Naruse T, Inoko H, Numano F, Kimura A
    • Journal Title

      Tissue Antigens 57

      Pages: 520-535

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Polymorphisms in the platelet-endothelial cell adhesion molecule-1 (PECAM-1) gene, Asn563Ser and Gly670Arg, are associated with myocardial infarction in Japanese2001

    • Author(s)
      Sasaoka T, Kimura A, Hohta S, Fukuda N, Kurosawa T, Izumi T
    • Journal Title

      Ann NY Acad Sci 947

      Pages: 259-269

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese.2001

    • Author(s)
      Takahashi M, Hashimoto H, Akizuki M, Sasazuki T, Nishikimi N, Ouchi H, Kobayashi Y, Numano F, Kimura A
    • Journal Title

      Tissue Antigens 57

      Pages: 66-69

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification, characterization and functional analysis of heart-specific myosin light chain phosphatase small subunit.2001

    • Author(s)
      Arimura T, Suematsu N, Zhou YB, Nishimura J, Satoh S, Takeshita A, Kanaide H, Kimura A
    • Journal Title

      J Biol Chem. 276

      Pages: 6073-6082

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A second susceptibility gene for developing rheumatoid arthritis in the human MHC is located within a 70 kb interval telomeric of the TNF genes in the HLA class III region.2001

    • Author(s)
      Ota M, Katsuyama Y, Kimura A, Tsuchiya K, Kondo M, Naruse T, Itoh K, Sasazuki T, Inoko H
    • Journal Title

      Genomics 71

      Pages: 263-270

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification of MICA alleles with a long Leu-repeat in the transmembrane region and no cytoplasmic tail due to a frameshift deletion in exon 4.2001

    • Author(s)
      Obuchi N, Takahashi M, Nouchi T, Satoh M, Arimura T, Ueda K, Akai J, Ota M, Naruse T, Inoko H, Numano F, Kimura A
    • Journal Title

      Tissue Antigens 57

      Pages: 520-535

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Polymorphisms in the platelet-endothelial cell adhesion molecule-1 (PECAM-1) gene, Asn563Ser and Gly670Arg, are associated with myocardial infarction in Japanese.2001

    • Author(s)
      Sasaoka T, Kimura A, Hohta S, Fukuda N, Kurosawa T, Izumi T
    • Journal Title

      Ann NY Acad Sci 947

      Pages: 259-269

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mapping of the HLA-linked genes controlling the susceptibility to Takayasu's arteritis2000

    • Author(s)
      Kimura A, Ota M, Katsuyama Y, Ohbuchi N, Takahashi M, Kobayashi Y, Inoko H, Numano F
    • Journal Title

      Int J Cardiol 75

      Pages: 105-110

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Analysis of the topological properties of the two dinucleotide repeat regions that enhance the transcriptional activity of the human type 1 collagen alpha2 chain (COL1A2) gene promoter2000

    • Author(s)
      Akai J, Kimura A, Hata R
    • Journal Title

      Connective Tissue 32

      Pages: 259-265

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Characterization of human nebulette gene : A polymorphism in an actin-binding motif is associated with non-familial idiopathic dilated cardiomyopathy2000

    • Author(s)
      Arimura T, Nakamura T, Hiroi S, Satoh M, Takahashi M, Ohbuchi N, Ueda K, Nouchi T, Yamaguchi N, Akai J, Matsumori A, Sasayama S, Kimura A
    • Journal Title

      Hum Genet 107

      Pages: 440-451

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese2000

    • Author(s)
      Takahashi M, Hashimoto H, Akizuki M, Sasazuki T, Nishikimi N, Ouchi H, Kobayashi Y, Numano F, Kimura A
    • Journal Title

      Tissue Antigens 57

      Pages: 66-69

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mapping of the HLA-linked genes controlling the susceptibility to Takayasu's arteritis.2000

    • Author(s)
      Kimura A, Ota M, Katsuyama Y, Ohbuchi N, Takahashi M, Kobayashi Y, Inoko H, Numano F
    • Journal Title

      Int J Cardiol 75

      Pages: 105-110

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Analysis of the topological properties of the two dinucleotide repeat regions that enhance the transcriptional activity of the human type 1 collagen alpha 2 chain (COL1A2) gene promoter.2000

    • Author(s)
      Akai J, Kimura A, Hata R
    • Journal Title

      Connective Tissue 32

      Pages: 259-265

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Characterization of human nebulette gene : A polymorphism in an actin-binding motif is associated with non-familial idiopathic dilated cardiomyopathy.2000

    • Author(s)
      Arimura T, Nakamura T, Hiroi S, Satoh M, Takahashi M, Ohbuchi N, Ueda K, Nouchi T, Yamaguchi N, Akai J, Matsumori A, Sasayama S, Kimura A
    • Journal Title

      Hum Genet 107

      Pages: 440-451

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] HLA2004 Immunobiology of the Human MHC2005

    • Author(s)
      Kimura A, Takahashi M, Shibata H, Kobayashi Y, Obuchi N, Ota M, Inoko H, Numano F, Yasunami M
    • Publisher
      (in press)
    • Related Report
      2004 Annual Research Report
  • [Book] HLA2004 Immunobiology of the Human MHC2005

    • Author(s)
      Yasunami M, Shibata H, Shao WS, Takahashi M, Hamaguchi K, Sakata T, Ota M, Inoko H, Kimura A
    • Publisher
      (in press)
    • Related Report
      2004 Annual Research Report
  • [Book] HLA2004 Immunobiology of the Human MHC2005

    • Author(s)
      Takahashi M, Yasunami M, Tamai H, Kimura A
    • Publisher
      (in press)
    • Related Report
      2004 Annual Research Report
  • [Patent(Industrial Property Rights)] 変異型HCN4遺伝子2003

    • Inventor(s)
      木村彰方, 上田和雄
    • Industrial Property Number
      2003-050469
    • Filing Date
      2003-02-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Patent(Industrial Property Rights)] I型糖尿病の検査方法2001

    • Inventor(s)
      木村彰方, 柴田宏樹, 安波道郎
    • Industrial Property Number
      2001-306868
    • Filing Date
      2001-10-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Okamoto K, et al.: "Identification of IkBL as the second MHC-linked susceptibility locus for Rheumatoid Arthritis."Am.J.Hum.Genet.. 72. 303-312 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Shao W, et al.: "Analysis of HLA-B polymorphism in insulin dependent diabetes mellitus in Japanese."MHC. 9. 163-169 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hohda S, et al.: "Association study of the CD14 polymorphism with myocardial infarction in Japanese populations."Jpn.Heart J.. 44. 613-622 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshida M, et al.: "E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under physiological flow conditions."Arter.Thrombo.Vasc.Biol.. 23. 783-788 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yamashita T, et al.: "IKBL promoter polymorphism is strongly associated with resistance to type 1 diabetes in Japanese."Tissue Antigens. (in pres).

    • Related Report
      2003 Annual Research Report
  • [Publications] Hayashi T, et al.: "Identification and functional analysis of a caveolon-3 mutation associated with familial hypertrophic cardiomyopathy."Biochem.Biophys.Res.Commun. 313. 178-184 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Arimura T, et al.: "A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C."J.Biol.Chem.. 279. 6746-6752 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ogimoto A, et al.: "17-year follow-up study of apatient with obstructive hypertrophic cardiorayopathy with a deletion mutation in the cardiac myosin binding protein C gene."Circ J.. 68. 174-177 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kimura A, et al.: "In HLA2002 Immunobiology of the Human MHC vol.1 (Hansen HA, Dupont B, eds.)"IHWG Press, Seattle(in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] Yasunami M, et al.: "In HLA2002 Immunobiology of the Human MHC vol.1 (Hansen HA, Dupont B, eds.)"IHWG Press, Seattle(in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] Takahashi M, et al.: "In HLA2002 Immunobiology of the Human MHC vol.1 (Hansen HA, Dupont B, eds.)"IHWG Press, Seattle(in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] Kimura A, et al.: "In Cardiomyopathies and Heart Failure ; Biomolecular, Infectious and Immune Mechanisms (ed.Matsumori A)"Klumer Academic Publishers, Boston. 415-428 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kimura A, et al.: "In Frontiers in Cardiovascular Health (eds.Dhalla NS, Chockalingam A, Berkovitz HI, Singal PK)"Klumer Academic Publishers, Boston. 195-206 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sakaguchi M, et al.: "Analysis of HLA in children with gelatin allergy"Tissue Antigens. 59. 412-416 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Harada H, et al.: "Genomic structure and eight novel exonic polymorphisms of the human N-cadherin gene"J Hum. Genet. 47. 330-332 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kuroda N, et al.: "Clinical significance of T-wave alternans in hypertrophic cardiomyopathy"Circ. J.. 66. 457-462 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hori H, et al.: "Analysis of the major epitope of the alpha 2 chain of bovine type I collagen in children with bovine gelatin allergy"J. Clin. Allergy Clin Immunol.. 110. 652-658 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Knoell R, et al.: "The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy"Cell. 111. 943-955 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Okamoto K, et al.: "Identification of IkBL as the second MHC-linked susceptibility locus for Rheumatoid Arthritis"Am. J. Hum. Genet.. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Shao W, et al.: "Analysis of HLA-B polymorphism in insulin dependent diabetes mellitus in Japanese"MHC. (印刷中).

    • Related Report
      2002 Annual Research Report
  • [Publications] Hohda S, et al.: "Association study of the CD14 polymorphism with myocardial infarction in Japanese populations"Jpn. Heart J. (印刷中).

    • Related Report
      2002 Annual Research Report
  • [Publications] Kimura A, et al.: "HLA2002 Immunobiology of the Human MHC vol.1 (Hansen HA, Dupont B, eds.)"IHWG Press, Seattle(印刷中).

    • Related Report
      2002 Annual Research Report
  • [Publications] Yasunami M, et al.: "HLA2002 Immunobiology of the Human MHC vol.1 (Hansen HA, Dupont B, eds.)"IHWG Press, Seattle(印刷中).

    • Related Report
      2002 Annual Research Report
  • [Publications] Takahashi M, et al.: "HLA2002 Immunobiology of the Human MHC vol.1 (Hansen HA, Dupont B, eds.)"IHWG Press, Seattle(印刷中).

    • Related Report
      2002 Annual Research Report
  • [Publications] Kimura A, et al.: "Proceedings of ICCHF (eds. Matsumori A, et al.)"Klumer Academic Publishers, Boston(印刷中).

    • Related Report
      2002 Annual Research Report
  • [Publications] Kimura A, et al.: "Frontiers in Cardiovascular Health (eds. Dhalla NS, et al.)"Klumer Academic Publishers, Boston(印刷中).

    • Related Report
      2002 Annual Research Report
  • [Publications] Obuchi N, Takahashi M, Nouchi T, et al.: "Identification of MICA alleles with a long Leu-repeat in the transmembrane region and no cytoplasmic tail due to a frameshift deletion in exon 4"Tissue Antigens. 57. 520-535 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kikuchi M, Looareesuwan S, Ubalee R, et al.: "Association of adhesion molecule PECAM-1/CD31 polymorphism with susceptibility to cerebral malaria in Thais"Parasitol.Int.. 50. 235-239 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sasaoka T, Kimura A, Hohta S, et al.: "Polymorphisms in the platelet-endothelial cell adhesion molecule-1 (PECAM-1) gene, Asn563Ser and Gly67OArg, are associated with myocardial infarction in Japanese"Ann NY Acad.Sci.. 947. 259-269 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ubalee R, Suzuki F, Kikuchi M, et al.: "Strong association of a tumor necrosis factor-α promoter allele with cerebral malaria in Myanmar"Tissue Antigens. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Tsuchiya K, Kimura A, Kondo M, et al.: "Combination of HLA-A and HLA class II alleles controls the susceptibility to rheumatoid arthritis"Tissue Antigens. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Itoh-Satoh M, Hayashi T, Nishi H, et al.: "Titin mutations as the molecular basis for dilated cardiomyopathy"Biochem.Biophys.Res.Commun.. 291. 385-393 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kimura A,Ota M,Katsuyama Y, et al.: "Mapping of the HLA-linked genes controlling the susceptibility to Takayasu's arteritis."Int.J.Cardiol.. 75. S105-S110 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Takahashi M,Hashimoto H,Akizuki M, et al.: "Lack of associatin between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese."Tissue Antigens. 57. 66-69 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Arimura T,Suematsu N,Zhou YB, et al.: "Identification, characterization and functional analysis of heart-specific myosin light chain phosphatase small subunit."J.Biol.Chem.. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Kimura A,Itoh-Satoh M,Hayashi T, et al.: "Molecular etiology of idiopathic cardiomyopathy in Asian populations."J Cardiol.. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] M.Yoshida,L-J Chen,Y.Yasukochi, et al.: "Differenfiation-induced transmigration of HL60 cells across activated HUVEC monolayer involves E-selectin-dependent mechanism."Ann.N.Y.Acad.. 902. 307-310 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] H.Ishii,M.Yoshida,A.Rosenzweig, et al.: "Adenoviral transduction of human E-selectin into isolated, perfused rat aortic segments : and ex vivo model for studying leukocyte-endothelial interactions."J.Leukocyte Biol.. 68. 687-692 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2001-04-01   Modified: 2018-03-28  

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