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Development of pathogenesis-analyzing methods-based on gene expression profiles

Research Project

Project/Area Number 12204006
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNational Institute of Genetics (2003-2004)
Kyushu University (2002)
Osaka University (2000-2001)

Principal Investigator

OKUBO Kousaku  National Institute of Genetics, Center for Information Biology and DDBJ, Professor, 生命情報・DDBJ研究センター, 教授 (40233069)

Co-Investigator(Kenkyū-buntansha) 日紫喜 光良  信州大学, 医学部・附属病院, 助手 (30324271)
Project Period (FY) 2000 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥82,700,000 (Direct Cost: ¥82,700,000)
Fiscal Year 2004: ¥17,900,000 (Direct Cost: ¥17,900,000)
Fiscal Year 2003: ¥22,400,000 (Direct Cost: ¥22,400,000)
Fiscal Year 2002: ¥22,400,000 (Direct Cost: ¥22,400,000)
Fiscal Year 2001: ¥20,000,000 (Direct Cost: ¥20,000,000)
KeywordsInformation retrieval / Automatic Indexing / BioNLP / Natural language processing / Gene Expression / Comparative genomics / Expresed Sequence Tags / 情報工学 / マイクロアレイ / 遺伝子 / 生体生命情報学 / 疾患遺伝子 / iAFLP法 / 発現プロファイル / 遺伝子発現プロフィール / 病理組織 / 乾癬 / アレルギー性皮膚炎 / 乳がん / 知識発見 / オントロジー / 塩基配列決定
Research Abstract

We report the development of an information system that utilizes vocabulary and topics extracted from textbooks to organize and visualize a wide variety of biomedical contents. The system, called biomedical omin-book (BOB), consists of two modules; module I uses index sections at the end of textbooks to represent global association patterns among terms and pages by vectors in a high-dimensional space; module II indexes a query text with textbook-derived terms and represent it as a pseudo-page vector in the same space so that it directs close to the pages with similar content. By treating records in databases on biomolecules as independent queries, module II incorporates characteristics of biomolecules in the space generated from textbooks. Under the visualization scheme of module III, a meaningful gathering in a long list of genes is easily notable. Moreover, if the list is binned into multiple clusters, the system rearranges the list within each bin to make best sense. The list may be a microarray results or a gene map along chromosomes. Man made structure of function of genes still contains unsolved problems inherent to the declarative method: how to keep the structure consistent as well as updated and how to represent complex aspects of relations. In BOB, the new addition of citations to the records in molecular database can be automatically reflected in the corresponding vectors by the module II. Major advance in a field is also incorporated by replacing old textbooks with revised ones in the module I. Any aspect of relation, such as anatomical or biochemical, can be emphasized by selective use of textbooks in module I or more conveniently, by focusing on a certain textbook in visualization in module III. In short, BOB is an expert-free system that makes the most of existing source of knowledge and BOB is a flexible system that accepts user's selection of viewpoints in organizing records.

Report

(6 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (97 results)

All 2005 2004 2003 2002 2001 2000 Other

All Journal Article (63 results) Book (10 results) Patent(Industrial Property Rights) (1 results) Publications (23 results)

  • [Journal Article] DDBJ in collaboration with mass-sequencing teams on annotation.2005

    • Author(s)
      Tateno, Y.
    • Journal Title

      Nucleic Acids Res. 33

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The Human Anatomic Gene Expression Liberary (H-ANGEL), theH-Invitegrativedisplay of human gene expression across disparate technologies and platforms.2005

    • Author(s)
      Tanino, M.
    • Journal Title

      Nucleic Acids Res. 33

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Identification and characterization of a novel component of the cornified envelope, cornifelin.2004

    • Author(s)
      Michibata, H.
    • Journal Title

      Biochem Biophys Res Commun. 318

      Pages: 803-813

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Integrative annotation of 21, 037 human genes validated by full-Length cDNA clones.2004

    • Author(s)
      Imanishi, T.
    • Journal Title

      PLoS Biol. 2

      Pages: 856-875

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Indexing anatomical concepts to OMIM Clinical Synopsis using the UMLS Metathesaurus.2004

    • Author(s)
      Hishiki, T.
    • Journal Title

      In Silico Biol. 4

      Pages: 31-54

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Cloning of a Gene for a Novel Epithelium-specific Cytosolic Phospholipase A2, cPLA2{delta}, Induced in Psoriatic Skin.2004

    • Author(s)
      Chiba H.
    • Journal Title

      J Biol Chem. 279

      Pages: 12890-12897

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification and characterization of a novel component of the cornified envelope, cornifelin.2004

    • Author(s)
      Michibata, H., Chiba, H., Wakimoto, K., Seishima, M., Kawasaki, S., Okubo, K., Mitsui, H., Torii, H., Imai, Y.
    • Journal Title

      Biochem Biophys Res Commun. 318

      Pages: 803-13

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Integrative annotation of 21,037 human genes validated by full-Length cDNA clones.2004

    • Author(s)
      Imanishi, T., Itoh, T., Suzuki, Y., O'Donovan, C., Fukuchi, S., Koyanagi, KO., Barrero, RA., Tamura, T., Yamaguchi-Kabata, Y., Tanino, M., Yura, K., Miyazaki, S., Ikeo, K., Homma, K., Kasprzyk, A., Nishikawa, T., Hirakawa, M., Thierry-Mieg, J., Thierry-Mieg, D., Ashurst, J., Jia, L., Nakao, M., Thomas, MA., Mulder, N., Karavidopoulou, Y., Jin, L., Kim, S., Yasuda, T., Lenhard, B., Eveno, E., Suzuki, Y., Yamasaki, C., Takeda, JI., Gough, C., Hilton, P., Fujii, Y., Sakai, H., Tanaka, S., Amid, C., Bellgard, M., Bonaldo, Mde F., Bono, H., Bromberg, SK., Brookes, AJ., Bruford, E., Carninci, P., Chelala, C., Couillault, C., Souza, SJ., Debily, MA., Devignes, MD., Dubchak, I., Endo, T., Estreicher, A., Eyras, E., Fukami-Kobayashi, K., R Gopinath, G., Graudens, E., Hahn, Y., Han, M., Han, ZG., Hanada, K, Hanaoka, H., Harada, E., Hashimoto, K., Hinz, U., Hirai, M., Hishiki, T., Hopkinson, I., Imbeaud, S., Inoko, H., Kanapiri, A., Kaneko, Y., Kasukawa, T., Kelso, J., Kersey, P., Kikuno, R., Kimura, K., Korn, B., Kuryshev, V., Makalowska, I., Makino, T., Mano, S., Mariage-Samson, R., Mashima, J., Matsuda, H., Mewes, HW., Minoshima, S., Nagai, K., Nagasaki, H., Nagata, N., Nigam, R., Ogasawara, O., Ohara, O., Ohtsubo, M., Okada, N., Okido, T., Oota, S., Ota, M., Ota, T., Otsuki, T., Piatier-Tonneau, D., Poustka, A., Ren, SX., Saitou, N., Sakai, K, Sakamoto, S., Sakate, R., Schupp, I., Servant, F., Sherry, S., Shiba, R., Shimizu, N., Shimoyama, M., Simpson, AJ., Soares, B., Steward, C., Suwa, M., Suzuki, M., Takahashi, A., Tamiya, G., Tanaka, H., Taylor, T., Terwilliger, JD., Unneberg, P., Veeramachaneni, V., Watanabe, S., Wilming, L., Yasuda, N., Yoo, HS., Stodolsky, M., Makalowski, W., Go, M., Nakai, K, Takagi, T., Kanehisa, M., Sakaki, Y., Quackenbush, J., Okazaki, Y., Hayashizaki, Y., Hide, W., Chakraborty, R., Nishikawa, K., Sugawara, H., Tateno, Y., Chen, Z., Oishi, M., Tonellato, P., Apweiler, R., Okubo, K., Wagner, L., Wiemann, S., Strausberg, RL., Isogai, T., Auffray, C., Nomura, N., Gojobori, T., Sugano, S.
    • Journal Title

      PLoS Biol. 2

      Pages: 856-75

    • NAID

      120004667172

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Indexing anatomical concepts to OMIM Clinical Synopsis using the UMLS Metathesaurus.2004

    • Author(s)
      Hishiki, T., Ogasawara, O., Tsuruoka, Y., Okubo, K.
    • Journal Title

      In Silico Biol. 4

      Pages: 31-54

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cloning of a gene for a novel epithelium-specific Cytosolic Phospholipase A2,cPLA2delta, induced in Psoriatic Skin.2004

    • Author(s)
      Chiba, H., Michibata, H., Wakimoto, K, Seishima, M., Kawasaki, S., Okubo, K, Mitsui, H., Torii, H., Imai, Y.
    • Journal Title

      J Biol Chem. 279

      Pages: 12890-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Quantification of Gene Expression in Mouse, Human Renal Proximal Tubules., 「Laser Capture Microdissection Methods and Protocols」 (Grame I. Murray and Stephanie Curran ed.) Methods in Molecular Biology2004

    • Author(s)
      Kaimori, J., Takenaka, M., Okubo, K.
    • Journal Title

      Humana Press 293

      Pages: 209-220

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Integrative annotation of 21,037 human genes validated by full-Length cDNA clones.2004

    • Author(s)
      Imanishi, T.
    • Journal Title

      PloS Biol. 2

      Pages: 856-875

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Cloning of a gene for a novel epithelium-specific Cytosolic Phospholipase A2, cPLA2delta, induced in Psoriatic Skin.2004

    • Author(s)
      Chiba, H.
    • Journal Title

      J Biol Chem. 279

      Pages: 12890-12897

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Zipf's law and human transcriptomes : an explanation with an evolutionary model.2003

    • Author(s)
      Ogasawara O.
    • Journal Title

      C R Biol. 326

      Pages: 1097-1101

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A novel diacylglycerol acyltransferase(DGAT2) is decreased in human psoriatic skin and increased in diabetic mice.2003

    • Author(s)
      Wakimoto K.
    • Journal Title

      Biochemical and Biophysical Research Communication. 310

      Pages: 296-302

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Up-regulated gene expression in the conjunctival epithelium of patients with Sjogren's syndorome.2003

    • Author(s)
      Kawasaki S.
    • Journal Title

      Exp Eye Res. 77

      Pages: 17-26

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Induction of glia maturation factor-beta in proximal tubular cells leads to vulnerability to oxidative injury through the p38 pathway and changes in antioxidant enzyme activities.2003

    • Author(s)
      Kaimori JY.
    • Journal Title

      J. biol. chem. 278

      Pages: 33519-33527

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Zipfs law and human transcriptomes : an explanation with an evolutionary model.2003

    • Author(s)
      Ogasawara, O., Kawamoto, S., Okubo, K.
    • Journal Title

      C R Biol. 326

      Pages: 1097-1101

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A novel diacylglycerol acyltransferase(DGAT2)is decreased in human psoriatic skin and increased in diabetic mice.2003

    • Author(s)
      Wakimoto K, Chiba H, Michibata H, Seishima M, Kawasaki S, Okubo K, Mitsui H, Torii H, Imai Y.
    • Journal Title

      Biochem Biophys Res Commun. 310

      Pages: 296-302

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Up-regulated gene expression in the conjunctival epithelium of patients with Sjogren's syndorome.2003

    • Author(s)
      Kawasaki S, Kawamoto S, Yokoi N, Connon C, Minesaki Y, Kinoshita S, Okubo K.
    • Journal Title

      Exp Eye Res. 77

      Pages: 17-26

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Induction of glia maturation factor-beta in proximal tubular cells leads to vulnerability to oxidative injury through the p38 pathway and changes in antioxidant enzyme activities.2003

    • Author(s)
      Kaimori JY, Takenaka M, Nakajima H, Hamano T, Horio M, Sugaya T, Ito T, Hori M, Okubo K, Imai E.
    • Journal Title

      J. Biol Chem. 278

      Pages: 33519-33527

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Knowledge Discovery from the Human Transcriptome. Introduction to Bioinformatics 「A Theoretical And Practical Approach2003

    • Author(s)
      Okubo K., Hishiki T.
    • Journal Title

      Humana Press

      Pages: 693-717

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression map of human genes : between genome and proteome2002

    • Author(s)
      Tamura T
    • Journal Title

      Tanpakushitsu Kakusan Koso. 47

      Pages: 906-913

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Construction of human corneal endothelial cDNA library and identification of novel active genes.2002

    • Author(s)
      Sakai R.
    • Journal Title

      Invest Ophthalmol Vis Sci. 43

      Pages: 1749-1756

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gene expression profile of renal proximal tubules regulated by proteinuria.2002

    • Author(s)
      Nakajima H
    • Journal Title

      Kidney Int. 61

      Pages: 1577-1587

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Non-overlapping expression of Olig3 and Olig2 in the embryonic neural tube.2002

    • Author(s)
      Takebayashi H
    • Journal Title

      Mech Dev. 113

      Pages: 169-174

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression profile of active genes in the human pituitary gland.2002

    • Author(s)
      Tanaka S
    • Journal Title

      J Mol Endocrinol. 28

      Pages: 33-44

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gene expression profiling of mucosal addressin cell adhesion molecule-1+ high endothelial venule cells(HEV) and identification of a leucine-rich HEV glycoprotein as a HEV marker.2002

    • Author(s)
      Saito K
    • Journal Title

      J Immunol. 168

      Pages: 1050-1059

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression map of human genes : between genome and proteome2002

    • Author(s)
      Tamura T, Okubo K.
    • Journal Title

      Tanpakushitsu Kakusan Koso. 47

      Pages: 906-13

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Construction of human corneal endothelial cDNA library and identification of novel active genes.2002

    • Author(s)
      Sakai R, Kinouchi T, Kawamoto S, Dana MR, Hamamoto T, Tsuru T, Okubo K, Yamagami S.
    • Journal Title

      Invest Ophthalmol Vis Sci. 43

      Pages: 1749-56

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gene expression profile of renal proximal tubules regulated by proteinuria.2002

    • Author(s)
      Nakajima H, Takenaka M, Kaimori JY, Nagasawa Y, Kosugi A, Kawamoto S, Imai E, Hori M, Okubo K.
    • Journal Title

      Kidney Int. 61

      Pages: 1577-87

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Non-overlapping expression of Olig3 and Olig2 in the embryonic neural tube.2002

    • Author(s)
      Takebayashi H, Ohtsuki T, Uchida T, Kawamoto S, Okubo K, Ikenaka K, Takeichi M, Chisaka O, Nabeshima Y.
    • Journal Title

      Mech Dev. 113

      Pages: 169-74

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression profile of active genes in the human pituitary gland.2002

    • Author(s)
      Tanaka S, Tatsumi K, Okubo K, Itoh K, Kawamoto S, Matsubara K, Amino N.
    • Journal Title

      J Mol Endocrinol. 28

      Pages: 33-44

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gene expression profiling of mucosal addressin cell adhesion molecule-1+ high endothelial venule cells(HEV) and identification of a leucine-rich HEV glycoprotein as a HEV marker.2002

    • Author(s)
      Saito K, Tanaka T, Kanda H, Ebisuno Y, Izawa D, Kawamoto S, Okubo K, Miyasaka M.
    • Journal Title

      J Immunol. 168

      Pages: 1050-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] iAFLP-introduced amplified length polymorphism [Analysing Gene Expression」2002

    • Author(s)
      Okubo K.
    • Journal Title

      Wiley (Lorkowski and Cullen ed.)

      Pages: 98-103

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Bodymap an anatomical gene expression database of human and mouse 「Analysing GeneExpression」2002

    • Author(s)
      Kawamoto S., Okubo K.
    • Journal Title

      Wiley (Lorkowski and Cullen ed.)

      Pages: 57-58

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Knowledge Discovery from the Human Transcriptome 「Introduction to Bioinformatics A Theoretical And Practical Approach」2002

    • Author(s)
      Okubo K., Hishiki T.
    • Journal Title

      (Krawetz, SA., Womble, DD. ed.) Human Press

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gene expression analysis on several human tissues.2001

    • Author(s)
      Kawasaki S
    • Journal Title

      Tanpakushitsu Kakusan Koso. 46

      Pages: 2351-2356

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cloning and characterization of a novel subunit of protein serine/threonine phosphatase 4 from mesangial cells.2001

    • Author(s)
      Wada T
    • Journal Title

      J Am Soc Nephrol. 12

      Pages: 2601-2608

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Characteristics of the human ocular surface epithelium.2001

    • Author(s)
      Kinoshita S
    • Journal Title

      Prog Retin Eye Res. 20

      Pages: 639-673

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Isolation of novel heart-specific genes using the BodyMap database.2001

    • Author(s)
      Soejima H
    • Journal Title

      Genomics. 74

      Pages: 115-120

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification and characterization of the potential promoter regions of 1031 kinds of human genes.2001

    • Author(s)
      Suzuki Y
    • Journal Title

      Genome Res. 11

      Pages: 677-684

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] An expression profile of active genes in human conjunctival epithelium.2001

    • Author(s)
      Dota A
    • Journal Title

      Exp Eye Res. 72

      Pages: 235-241

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] BodyMap incorporated PCR-based expression profiling data and a gene ranking system.2001

    • Author(s)
      Sese J
    • Journal Title

      Nucleic Acids Res. 29

      Pages: 156-158

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gene expression analysis on several human tissues.2001

    • Author(s)
      Kawasaki S, Okubo K.
    • Journal Title

      Tanpakushitsu Kakusan Koso. 46

      Pages: 2351-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cloning and characterization of a novel subunit of protein serine/threonine phosphatase 4 from mesangial cells.2001

    • Author(s)
      Wada T, Miyata T, Inagi R, Nangaku M, Wagatsuma M, Suzuki D, Wadzinski BE, Okubo K, Kurokawa K.
    • Journal Title

      J Am Soc Nephrol. 12

      Pages: 2601-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Characteristics of the human ocular surface epithelium.2001

    • Author(s)
      Kinoshita S, Adachi W, Sotozono C, Nishida K, Yokoi N, Quantock AJ, Okubo K.
    • Journal Title

      Prog Retin Eye Res. 20

      Pages: 639-73

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Isolation of novel heart-specific genes using the BodyMap database.2001

    • Author(s)
      Soejima H, Kawamoto S, Akai J, Miyoshi O, Arai Y, Morohka T, Matsuo S, Niikawa N, Kimura A, Okubo K, Mukai T.
    • Journal Title

      Genomics. 74

      Pages: 115-20

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification and characterization of the potential promoter regions of 1031 kinds of human genes.2001

    • Author(s)
      Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S.
    • Journal Title

      Genome Res. 11

      Pages: 677-84

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] An expression profile of active genes in human conjunctival epithelium.2001

    • Author(s)
      Dota A, Nishida K, Adachi W, Nakamura T, Koizumi N, Kawamoto S, Okubo K, Kinoshita S.
    • Journal Title

      Exp Eye Res. 72

      Pages: 235-41

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] BodyMap incorporated PCR-based expression profiling data and a gene ranking system.2001

    • Author(s)
      Sese J, Nikaidou H, Kawamoto S, Minesaki Y, Morishita S, Okubo K.
    • Journal Title

      Nucleic Acids Res. 29

      Pages: 156-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Knowledge Dicovery from transcriptome In Introduction to Bioinformatics.2001

    • Author(s)
      Okubo K.Hishiki T.
    • Journal Title

      (S.A.Krawetzed.)Humana Press (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Characteristics of the human ocular surface epithelium.2001

    • Author(s)
      Kinoshita S, Adachi W, Sotozono C, Nishida K, Yokoi N, Quantock A, Okubo K.
    • Journal Title

      Prog Retin Eye Res. 20

      Pages: 639-673

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gene expression profiles of the collecting duct in the mouse renal inner medulla.2000

    • Author(s)
      Takenaka M
    • Journal Title

      Kidney Int. 57

      Pages: 19-24

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Isolation and characterization of a Ca(2+)-activated chloride channel from human corneal epithelium.2000

    • Author(s)
      Itoh R
    • Journal Title

      Curr Eye Res. 21

      Pages: 918-925

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Clinical significance of micrometastases in axillary lymph nodes assessed by reverse transcription-polymerase chain reaction in breast cancer patients.2000

    • Author(s)
      Masuda N
    • Journal Title

      Clin Cancer Res. 6

      Pages: 4176-4185

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Human uroplakin Ib in ocular surface epithelium.2000

    • Author(s)
      Adachi W
    • Journal Title

      Invest Ophthalmol Vis Sci. 41

      Pages: 2900-2905

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] BodyMap : a human and mouse gene expression database.2000

    • Author(s)
      Hishiki T
    • Journal Title

      Nucleic Acids Res. 28

      Pages: 136-138

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gene expression profiles of the collecting duct in the mouse renal inner medulla.2000

    • Author(s)
      Takenaka M, Imai E, Nagasawa Y, Matsuoka Y, Moriyama T, Kaneko T, Hori M, Kawamoto S, Okubo K.
    • Journal Title

      Kidney Int. 57

      Pages: 19-24

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Isolation and characterization of a Ca(2+)-activated chloride channel from human corneal epithelium.2000

    • Author(s)
      Itoh R, Kawamoto S, Miyamoto Y, Kinoshita S, Okubo K.
    • Journal Title

      Curr Eye Res. 21

      Pages: 918-25

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Clinical significance of micrometastases in axillary lymph nodes assessed by reverse transcription-polymerase chain reaction in breast cancer patients.2000

    • Author(s)
      Masuda N, Tamaki Y, Sakita I, Ooka M, Ohnishi T, Kadota M, Aritake N, Okubo K, Monden M.
    • Journal Title

      Clin Cancer Res. 6

      Pages: 4176-85

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Human uroplakin Ib in ocular surface epithelium.2000

    • Author(s)
      Adachi W, Okubo K, Kinoshita S.
    • Journal Title

      Invest Ophthalmol Vis Sci. 41

      Pages: 2900-5

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] BodyMap a human and mouse gene expression database.2000

    • Author(s)
      Hishiki T, Kawamoto S, Morishita S, Okubo K.
    • Journal Title

      Nucleic Acids Res. 28

      Pages: 136-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Analysing Gene Expression2004

    • Author(s)
      Kaimori, J.
    • Total Pages
      11
    • Publisher
      John Wiley&Sons, Inc.
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] ゲノム語とオントロジーという名の形而上学-進化と医学(科学)2004

    • Author(s)
      大久保公策
    • Total Pages
      3
    • Publisher
      岩波書店
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Quantification of Gene Expression in Mouse and Human Renal Proximal Tubules., 「Laser Capture Microdissection Methods and Protocols」2004

    • Author(s)
      Kaimori, J.
    • Publisher
      Humana Press
    • Related Report
      2004 Annual Research Report
  • [Book] Introduction to Bioinformatics A Theoretical And Practical Approach2003

    • Author(s)
      Okubo K.
    • Total Pages
      24
    • Publisher
      Humana Press
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Analysing Gene Expression2002

    • Author(s)
      Okubo K.
    • Total Pages
      5
    • Publisher
      John Wiley&Sons,Inc.
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Analysing Gene Expression2002

    • Author(s)
      Kawamoto S.
    • Total Pages
      1
    • Publisher
      John Wiley&Sons, Inc.
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 遺伝子の発現地図-ゲノムとプロテオームの間(蛋白質核酸酵素)2002

    • Author(s)
      田村卓郎
    • Total Pages
      7
    • Publisher
      共立出版株式会社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Characteristics of the human ocular surface epithelium.2001

    • Author(s)
      Kinoshita S
    • Total Pages
      34
    • Publisher
      Prog Retin Eye Res.
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] リアルタイム絶対および相対定量PCR,ゲノム機能研究プロトコール(実験医学別冊)2000

    • Author(s)
      伊藤玲子
    • Total Pages
      4
    • Publisher
      羊土社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] CRに基づくゲノムワイドな遺伝子発現解析(実験医学別冊)2000

    • Author(s)
      川崎 諭
    • Total Pages
      16
    • Publisher
      羊土社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 注目する情報を知識集積物との関係で可視的に処理するた2002

    • Inventor(s)
      大久保公策
    • Industrial Property Rights Holder
      大久保公策
    • Industrial Property Number
      2004-073614
    • Filing Date
      2002
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Chiba H.: "Cloning of a Gene for a Novel Epithelium-specific Cytosolic Phospholipase A2, cPLA2{delta}, Induced in Psoriatic Skin."J Biol Chem.. 279. 12890-12897 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ogasawara O.: "Zipf's law and human transcriptomes : an explanation with an evolutionary model."C R Biol.. 326. 1097-1101 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Wakimoto K.: "A novel diacylglycerol acyltransferase(DGAT2) is decreased in human psoriatic skin and increased in diabetic mice."Biochemical and Biophysical Research Communication.. 310. 296-302 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kawasaki S.: "Up-regulated gene expression in the conjunctival epithelium of patients with Sjogren's syndorome."Exp Eye Res.. 77. 17-26 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kaimori J.: "Induction of glia maturation factor-beta in proximal tubular cells leads to vulnerability to oxidative injury through the p38 pathway and changes in antioxidant enzyme activities."J.biol.chem.. 278. 33519-33527 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sakai R.: "Construction of human corneal endothelial cDNA library and identification of novel active genes."Invest Ophthalmol Vis Sci.. 43. 1749-1756 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Okubo K.: "iAFLP-introduced amplified length polymorphism, 「Analysing Gene Expression」(Lorkowski and Cullen ed.)"Wiley. 5 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sakai R et al.: "Construction of human corneal endothelial cDNA library and identification of novel active genes"Invest Ophthalmol Vis Sci. 43(6). 1749-1756 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nakajima H et al.: "Gene expression profile of renal proximal tubules regulated by proteinuria"Kidney Int. 61(5). 1577-1587 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tanaka S et al.: "Expression profile of active genes in the human pituitary gland"J Mol Endocrinol. 28(1). 33-34 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Saito K et al.: "Gene expression profiling of mucosal addressin cell adhesion molecule-1+ high endothelial venule cells (HEV) and identification of a leucine-rich HEV glycoprotein as a HEV marker"J Immunol. 168(3). 1050-1059 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Doa A.: "An expression profile of active genes in human conjunctival epithelium"Exp.Eye Res.. 72. 235-241 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sese J.: "BodyMap Incorporated PCR-based expression profiling data and a gene ranking system"Nucleic Acids Research. 29(1). 156-158 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Suzuki Y.: "Identification and characterization of the potential promoter regions of 1031 kinds of human genes"Genome Res.. 11. 677-684 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Okubo K.: "Knowledge discovery from transcriptome. In introduction to Bioinformatics"Humana Press. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Okubo K.: "Gene expression analysis by iAFLP. In Analysis of Gene Expression"Wiley-VCH. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Okubo K.: "Gene Expression Database ; BodyMap. In Analysis of Gene Expression"Wiley-VCH. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Kawamoto S.: "Body Map : a collection of 3'ESTs for analysis of human gene expression information."Genome Research. 10(11). 1817-1827 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hishiki M.: "Body Map : a human and mouse gene expression database."Nucleic Acids Research. 28(1). 136-138 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Masuda S.: "Clinical significance of micrometastases in axillary lymph nodes assessed by reverse transcription-polymerase chain reaction in breast cancer patients."Clin Cancer Research. 6(11). 4176-4185 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Takenaka M.: "Gene expression profiles of the collecting duct in the mouse renal inner medulla."Kidney Int.. 57(1). 19-24 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sese J.: "Body Map incorporated PCR-based expression profiling data and a gene ranking system."Nucleic Acids Research. 29(1). 156-158 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Dota A.: "An Expression Profile of Active Genes in Human Conjunctival Epithelium."Exp.Eye Research. 72(3). 235-241 (2001)

    • Related Report
      2000 Annual Research Report

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Published: 2001-04-01   Modified: 2018-03-28  

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