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Study on susceptibly genes for schizophrenia and tubercubsis

Research Project

Project/Area Number 12204009
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyushu University

Principal Investigator

FUKUMAKI Yasuyuki  Kyushu Universty, Medical Institute of Bioregulation, Professor, 生体防御医学研究所, 教授 (90128083)

Co-Investigator(Kenkyū-buntansha) KUSUHARA Koichi  Kyushu University, Graduate School of Medical Sciences, Associate Prof., 医学研究院, 助教授 (20243941)
田代 信維  九州大学, 医学研究院, 教授 (80037407)
Project Period (FY) 2000 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥71,300,000 (Direct Cost: ¥71,300,000)
Fiscal Year 2004: ¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2003: ¥18,400,000 (Direct Cost: ¥18,400,000)
Fiscal Year 2002: ¥18,400,000 (Direct Cost: ¥18,400,000)
Fiscal Year 2001: ¥19,500,000 (Direct Cost: ¥19,500,000)
Keywordsschizophrenia / affected sib-pair analysis / association study / polymorphism / qlutamate receptor / tuberculosis / host qenetic factor / susceptibility / 連鎖不平衡 / インターフェロン受容体 / DNAマイクロアレイ / 精神分裂病 / 連鎖不平衡解析 / メタンフェタミン / 相関解析 / 逆耐性現象
Research Abstract

1. Study on schizophrenia susceptibility
The first genome-wide scan using 417 STR markers in 130 families with affected sib-pairs revealed that ten chromosomes (1, 2, 3, 4, 5, 8, 9, 14, 17, and 20) had at least one region with a nominal p value < 0.05. The second genome-wide scan using 5,861 SNPs in 236 Japanese families including 122 ones used in the first scan revealed that significant evidence of linkage of schizophrenia to 1p21.1-1p13.1 and suggestive evidence of linkage to 14q11.2, 4q11.2-q13.2 and 20p12.1-p11.2.
Based on the glutamatergic dysfunction hypothesis for the pathogenesis of schizophrenia, we conducted a systematic study of associations between glutamate receptor genes and schizophrenia. We selected SNPs evenly distributed across the relevant gene region for typing and did single marker and haplotype association studies. We found significant associations of halotypes of GRIN2D, GRIA4, GRM3 and GRM8 with schizophrenia. Genome- wide association study using 27,000 STR markers is on the way. The second set of screening showed significant associations of 720 markers with schizophrenia. The third and fourth sets of screening followed by dense SNP typing will elucidate the susceptibility loci for schizophrenia.
2. Study on tuberculosis susceptibility
We performed a gene-based association analysis of 21 candidate genes on 87 TB patients and 265 controls using 118 marker single nucleotide polymorphisms (SNPs). Subsequently, we analyzed the association between TB and coding SNPs (cSNPs) adjacent to positive marker SNPs. Three cSNPs of 1L.12RB1 were significantly associated with the development of TB, suggesting that 1L_12RB1 confers genetic susceptibility to TB in Japanese. We also collected blood samples from 56 patients who showed susceptibility to mycobacterial infection, and identified partial dominant IFN-y receptor 1 deficiency in 3 unrelated patients with BCG osteomyelitis and in one of their fathers. This is the first report of this disorder in Japanese.

Report

(6 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (74 results)

All 2006 2005 2004 2003 2002 2001 Other

All Journal Article (44 results) Book (1 results) Patent(Industrial Property Rights) (2 results) Publications (27 results)

  • [Journal Article] Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia.2006

    • Author(s)
      Shibata, H. et al.
    • Journal Title

      Psychiatry Res. 141(1)

      Pages: 39-51

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5 ) with schizophrenia.2006

    • Author(s)
      Shibata, H. et al.
    • Journal Title

      Psychiatry Res. 141(1)

      Pages: 39-51

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification of single-nucleotide polymorphisms in the human N-methyl-Daspartate receptor subunit NR2D gene, GRIN2D, and association study with schizophrenia.2005

    • Author(s)
      Makino, C. et al.
    • Journal Title

      Psychiatr. Genet. 15(3)

      Pages: 215-221

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia.2005

    • Author(s)
      Lee, H.J.et al.
    • Journal Title

      Behav. Brain Funct. 1

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility Loci on chromosomes 1p, 14q, and 20p.2005

    • Author(s)
      Arinami, T. et al.
    • Journal Title

      Am. J. Hum Genet. 77(6)

      Pages: 937-944

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification of single-nucleotide polymorphisms in the human N-methyl-D-aspartate receptor subunit NR2D gene, GRIN2D, and association study with schizophrenia.2005

    • Author(s)
      Makino, C. et al.
    • Journal Title

      Psychiatr. Genet 15(3)

      Pages: 215-221

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia.2005

    • Author(s)
      Lee, H.et al.
    • Journal Title

      Behav. Brain Funct. 1

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p.2005

    • Author(s)
      Arinami, T. et al.
    • Journal Title

      Am. J. Hum. Genet 77(6)

      Pages: 937-944

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification of single-nucleotide polymorphisms in the human N-methyl-D-aspartate receptor subunit NR2D gene, GRIN2D, and association study with schizophrenia.2005

    • Author(s)
      Makino, C.
    • Journal Title

      Psychiatric Genetics (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Positive associations of polymorphisms in the metabotropic glutamate receptor type 8 gene (GRM8) with schizophrenia.2004

    • Author(s)
      Takaki, H. et al.
    • Journal Title

      Am. J. Med. Genet. 128B(1)

      Pages: 6-14

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2) with schizophrenia.2004

    • Author(s)
      Deng, X. et al.
    • Journal Title

      BMC Psychiatry 4

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Selective changes in the shapes of parasagittal bands of Aldoc (Zebrin) mRNA in the rat vermis of the cerebellum after repeated methamphetamine injections.2004

    • Author(s)
      Hamamura, M. et al.
    • Journal Title

      Cerebellum 3(4)

      Pages: 236-247

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Functional MxA promoter polymorphism associated with subacute sclerosing panencephalitis in Japan.2004

    • Author(s)
      Torisu, H. et al.
    • Journal Title

      Neurol. 62 (3)

      Pages: 457-460

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Tumour necrosis factor receptor-associated periodic syndrome with a novel mutation in the TNFRSF1A gene in a Japanese family.2004

    • Author(s)
      Kusuhara, K. et al.
    • Journal Title

      Eur. J. Pediatr. 163 (1)

      Pages: 30-32

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Positive associations of polymorphisms in the metabotropic glutamate receptor type 8 gene (GRM8 ) with schizophrenia.2004

    • Author(s)
      Takaki, H. et al.
    • Journal Title

      Am. J. Med. Genet 128(1)

      Pages: 6-14

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2 ) with schizophrenia.2004

    • Author(s)
      Deng, X. et al.
    • Journal Title

      BMC Psychiatry 4

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Functional MxA promoter polymorphism associated with subacute sclerosing panencephalitis in Japan.2004

    • Author(s)
      Torisu, H. et al.
    • Journal Title

      Neuroi 62(3)

      Pages: 457-460

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Tumour necrosis factor receptor-associated periodic syndrome with a novel mutation in the TNFRSF1 A gene in a Japanese family.2004

    • Author(s)
      Kusuhara, K. et al.
    • Journal Title

      Ear. J. Pediatr. 163(1)

      Pages: 30-32

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Positive associations of polymorphisms in the metabotropic glutamate receptor type 8 gene (GRM8) with schizophrenia.2004

    • Author(s)
      Takaki, H.
    • Journal Title

      American Journal of Medical Genetics 128B・1

      Pages: 6-14

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2) with schizophrenia.2004

    • Author(s)
      Deng, X.
    • Journal Title

      BMC Psychiatry 4・1

      Pages: 21-21

    • Related Report
      2004 Annual Research Report
  • [Journal Article] TGFB1 mutations in four new families with Camurati-Engelmann disease : confirmation of independently arising LAP-domain-specific mutations.2004

    • Author(s)
      Kinoshita, A.
    • Journal Title

      American Journal of Medical Genetics 127A・1

      Pages: 104-107

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Tumour necrosis factor receptor-associated periodic syndrome with a novel mutation in the TNFRSF1A gene in a Japanese family.2004

    • Author(s)
      Kusuhara, K.
    • Journal Title

      European Journal of Pediatrics 163・1

      Pages: 30-32

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Functional MxA promoter polymorphism associated with subacute sclerosing panencephalitis in Japan.2004

    • Author(s)
      Torisu, H.
    • Journal Title

      Neurology 62・3

      Pages: 457-460

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Positive association of the AMPA receptor subunit GluR4 (GRIA4) haplotype with schizophrenia : linkage disequilibrium mapping using SNPs evenly distributed across the gene region.2003

    • Author(s)
      Makino, C. et al.
    • Journal Title

      Am. J. Med. Genet. 116B(1)

      Pages: 17-22

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophren.2003

    • Author(s)
      Fujii, Y. et al.
    • Journal Title

      Psychiatr. Genet. 13(2)

      Pages: 71-78

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Glutamate receptor genes as candidates for schizophrenia susceptibility.2003

    • Author(s)
      Fukumaki, Y., Shibata, H.
    • Journal Title

      Drug Develop. Res. 60

      Pages: 137-151

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Initial genome-wide scan for linkage with schizophrenia in Japanese Schizophrenia Sib-pair Linkage Group (JSSLG) families.2003

    • Author(s)
      JSSLG
    • Journal Title

      Am. J. Med. Genet. 120B(1)

      Pages: 22-28

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Positive association of the AMPA receptor subunit GluR4 (GRIA4 ) haplotype with schizophrenia : linkage disequilibrium mapping using SNPs evenly distributed across the gene region.2003

    • Author(s)
      Makino, C. et al.
    • Journal Title

      Am. J. Med. Genet 116B(1)

      Pages: 17-22

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3 ) with schizophrenia.2003

    • Author(s)
      Fujii, Y. et al.
    • Journal Title

      Psychiatr. Genet 13(2)

      Pages: 71-78

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Initial genome-wide scan for linkage with schizophrenia in Japanese Schizophrenia Sib-pair Linkage Group (JSSLG) families.2003

    • Author(s)
      JSSLG
    • Journal Title

      Am. J. Med. Genet 120B(1)

      Pages: 22-28

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Polymorphism analysis of the upstream region of the human N-methyl-Daspartate receptor subunit NR1 gene (GRIN1) : implications for schizophrenia.2002

    • Author(s)
      Tani, A. et al.
    • Journal Title

      Schizophr. Res. 58(1)

      Pages: 83-86

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association study of polymorphisms in the GluR6 kainate receptor gene (GRIK2) with schizophrenia.2002

    • Author(s)
      Shibata, H. et al.
    • Journal Title

      Psychiatry Res. 113(1-2)

      Pages: 59-67

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Genetic basis of patients with Bacille Calmette-Guerin osteomyelitis in Japan : identification of dominant partial interferon-γ receptor 1 deficienc as a predominant type.2002

    • Author(s)
      Sasaki, Y. et al.
    • Journal Title

      J. Infect. Dis. 185 (5)

      Pages: 706-709

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Contribution of the interleukin 4 gene to susceptibility to subacute sclerosing panencephalitis.2002

    • Author(s)
      Inoue, T. et al.
    • Journal Title

      Arch. Neurol. 59 (5)

      Pages: 822-827

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Polymorphism analysis of the upstream region of the human N-methyl-D-aspartate receptor subunit NR1 gene (GRIN1 ) : implications for schizophrenia.2002

    • Author(s)
      Tani, A. et al.
    • Journal Title

      Schizophr. Res. 58(1)

      Pages: 83-86

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association study of polymorphisms in the GluR6 kainate receptor gene (GRIK2 ) with schizophrenia.2002

    • Author(s)
      Shibata, H. et al.
    • Journal Title

      Psychiatry Res. 113(1-2)

      Pages: 59-67

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Genetic basis of patients with Bacille Calmette-Guerin osteomyelitis in Japan : identification of dominant partial interferon-γ receptor 1 deficiency as a predominant type.2002

    • Author(s)
      Sasaki, Y. et al.
    • Journal Title

      J. Infect Dis. 185(5)

      Pages: 706-709

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Contribution of the interleukin 4 gene to susceptibility to subacute sclerosing panencephalitis.2002

    • Author(s)
      Inoue, T. et al.
    • Journal Title

      Arch. Neurol. 59(5)

      Pages: 822-827

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Structure and polymorphisms of the human metabotropic glutamate receptor type 2 gene (GRM2) : analysis of association with schizophrenia.2001

    • Author(s)
      Joo, A.et al.
    • Journal Title

      Mol. Psychiatry 6(2)

      Pages: 186-192

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia.2001

    • Author(s)
      Shibata, H. et al.
    • Journal Title

      Psychiatr. Genet. 11(3)

      Pages: 139-144

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene (DRD4) with schizophrenia and personality traits.2001

    • Author(s)
      Mitsuyasu, H., et al.
    • Journal Title

      J. Hum Genet. 46(1)

      Pages: 26-31

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Structure, polymorphisms of the human metabotropic glutamate receptor type 2 gene (GRM2 ): analysis of association with schizophrenia.2001

    • Author(s)
      Joo, A.et al.
    • Journal Title

      Mol. Psychiatry 6(2)

      Pages: 186-192

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1 ) with schizophrenia.2001

    • Author(s)
      Shibata, H. et al.
    • Journal Title

      Psychiatr. Genet. 11 (3)

      Pages: 139-144

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene (DRD4 ) with schizophrenia and personality traits.2001

    • Author(s)
      Mitsuyasu, H. et al.
    • Journal Title

      J. Hum. Genet. 46(1)

      Pages: 26-31

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 薬物動態・作用と遺伝子多型担当分 未知遺伝子多型の検索法2001

    • Author(s)
      澤田 康文編 担当分 柴田 弘紀, 服巻 保幸
    • Publisher
      医薬ジャーナル社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 疾患感受性遺伝子座の同定法および精神分裂病疾患感受性遺伝子としてのグルタミン酸受容体遺伝子2002

    • Inventor(s)
      服巻 保幸他5名
    • Industrial Property Rights Holder
      服巻 保幸他5名
    • Industrial Property Number
      2002-000964
    • Filing Date
      2002-01-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 統合失調症関連代謝型グルタミン酸受容体遺伝子内一塩基多型およびその同定方法2002

    • Inventor(s)
      服巻 保幸, 柴田 弘紀, 築原 智之
    • Industrial Property Rights Holder
      服巻 保幸, 柴田 弘紀, 築原 智之
    • Industrial Property Number
      2002-337434
    • Filing Date
      2002-11-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Takaki, H.: "Positive associations of polymorphisms in the metabotropic glutamate receptor type 8 gene (GRM8) with schizophrenia."American Journal of Medical Genetics. 印刷中.

    • Related Report
      2003 Annual Research Report
  • [Publications] Makino, C.: "Positive association of the AMPA receptor subunit GluR4 (GRIA4) haplotype with schizophrenia : linkage disequilibrium mapping using SNPs evenly distributed across the gene region."American Journal of Medical Genetics. 116B・1. 17-22 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Arinami, T.: "Initial genome-wide scan for linkage with schizophrenia in Japanese Schizophrenia Sib-pair Linkage Group (JSSLG) families."American Journal of Medical Genetics. 120B・1. 22-28 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Fujii, Y.: "Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia."Psychiatric Genetics. 13・2. 71-76 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Torisu.H.: "Functional MxA promoter polymorphism associated with subacute sclerosing panencephalitis in Japan."Neurology. 62・3. 457-460 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kusuhara, K.: "Tumour necrosis factor receptor-associated periodic syndrome with a novel mutation in the TNFRSF1A gene in a Japanese family."European Journal of Pediatrics. 163・1. 30-32 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 服巻 保幸(共著): "図説 分子病態学"中外医学社. 501 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tani, A. et al.: "Polymorphism analysis of the upstream region of the human N-methyl-D-aspartate receptor subunit NR1 gene (GRIN1) : implications for schizophrenia"Schizophrenia Research. 58. 83-86 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shibata, H. et al.: "Association study of polymorphisms in the GluR6 kainate receptor gene (GRIK2) with schizophrenia"Psychiatry Research. 113. 59-67 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Makino, C. et al.: "Positive association of the AMPA receptor subunit GluR4 gene (GRIA4) haplotype with schizophrenia : linkage disequilibrium mapping using SNPs evenly distributed across the gene region"American Journal of Medical Genetics. 116B. 17-22 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Fujii, Y. et al.: "Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia"Psychiatry Genetics. (印刷中). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sasaki, Y. et al.: "Genetic basis of patients with Bacille Calmette-Guerin osteomyelitis in Japan : identification of dominant partial interferon-γreceptor 1 deficiency as a predominant type"Infectious Diseases. 185. 706-709 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Inoue, T. et al.: "Contribution of the interleukin 4 gene to susceptibility to subacute sclerosing panencephalitis"Archives of Neurology. 59. 822-827 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Joo, A.et al.: "Structure and polymorphisms of the human metabotropic glutamate receptor type 2 gene (GRM2) : analysis of association with schizophrenia"Molecular Psychiatry. 6. 186-192 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Mitsuyasu, H. et al.: "Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene (DRD4) with schizophrenia and personality traits"Journal of Human Genetics. 46. 26-31 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Shibata, H. et al.: "Association study of polymorphisms in the coding region of the GluR5 kainate receptor gene (GRIK1) with schizophrenia"Psychiatric Genetics. 11. 139-144 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nakagawa, M. et al.: "Association of HSPB2, a member of the small heat shock protein family, with mitochondria"Experimental Cell Research. 271. 161-168 (2001)

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  • [Publications] Tani, A. et al.: "Polymorphism analysis of upstream regions of the human N-methyl-D-aspartate receptor subunit NR1 gene (GRIN1) : implications for schizophrenia"Schizophrenia Research. (印刷中).

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  • [Publications] Sasaki, Y. et al.: "Genetic basis of patients with Bacille Calmette-Guerin osteomyelitis in Japan : identification of dominant partial interferon-γ receptor 1 deficiency as a predominant type"Journal of Infectious Diseases. (印刷中).

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  • [Publications] 澤田 康文編 担当分 柴田 弘紀, 服巻 保幸: "薬物動態・作用と遺伝子多型 担当分 未知遺伝子多型の検索法"医薬ジャーナル社. 457(13) (2001)

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  • [Publications] Imai,J. et al.: "Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients : genetic analysis of the CYP2C9 locus."Pharmacogenetics. 10. 85-89 (2000)

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  • [Publications] Sakai,Y. et al.: "Molecular analysis of α-thalassemia in Nepal : correlation with malaria endemicity."J.Hum.GeneL.. 45. 127-132 (2000)

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  • [Publications] Shirohzu,H. et al.: "Repression of aberrant splicing in human β-globin pre-mRNA with HbE mutation by zntisense oligoribonucleotide or splicing factor SF2/ASF."Int.J.HemaioL.. 72. 28-33 (2000)

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  • [Publications] Chijiwa,T. et al.: "Regional evolution of venom-gland phospholipase A2 isoenzymes of Trimeresurus flavoviridis snakes in the southwestern islands of Japan."Biochem.J.. 347. 441-491 (2000)

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  • [Publications] Chuman,Y. et al.: "Regional and accelerated molecular evolution in group I snake venom gland phospholipase A2 isozymes."Toxicon. 38. 449-462 (2000)

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  • [Publications] Mitsuyasu,H. et al.: "Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene (DRD4) with schizophrenia and personality trants."J.Hum.Genet.. 46. 26-31 (2001)

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  • [Publications] 春日雅人,平井久丸 編: "病気の分子医学"共立出版. 215 (2000)

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Published: 2001-04-01   Modified: 2018-03-28  

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