| Project/Area Number |
12210015
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KIMURA Minoru Kyoto Prefectural University of Medicine, Graduate School of Medicine, Professor, 医学研究科, 教授 (40118451)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Minoru Kyoto Prefectural University of Medicine, Graduate School of Medicine, Instructor, 医学研究科, 助手 (00252726)
UEDA Yasumasa Kyoto Prefectural University of Medicine, Graduate School of Medicine, Instructor, 医学研究科, 助手 (60332954)
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| Project Period (FY) |
2000 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥106,500,000 (Direct Cost: ¥106,500,000)
Fiscal Year 2004: ¥25,600,000 (Direct Cost: ¥25,600,000)
Fiscal Year 2003: ¥25,600,000 (Direct Cost: ¥25,600,000)
Fiscal Year 2002: ¥25,600,000 (Direct Cost: ¥25,600,000)
Fiscal Year 2001: ¥29,700,000 (Direct Cost: ¥29,700,000)
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| Keywords | Basal ganglia / Striatum / Thalamus / Motivation / CM / Pf nucleus / Reward / Dopamine neuron / 注意 / 髄板内核 / 順序運動 / 企画 |
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| Research Abstract |
We conducted the following two core projects supported by the grant for the three-year term from 2002 to 2004.
Functional roles of the thalamo-striate projections originating from CM/Pf complex: We demonstrated that the neurons in the CM/Pf thalamus convey information about biologically significant, attention-drawing external events to the striatum (Matsumoto et al., 2001; Minamimoto et al., 2002). Based on our recent findings on the basal ganglia and thalamus, we proposed a network model that the cortico-basal ganglia loops work as reward-based decision and action selection, while the thalamo-striate projection plays complementary roles to the reward-based decision and action bias (Kimura et al. 2004). The proposed model was supported experimentally (Minamimoto et al., 2005).
Reward-dependent action selection and learning: We demonstrated that the striate projection neurons encode information about procedure of performing sequential movement task (Kimura et al., 2003; Ueda et al., 2003). Using functional MRI imaging study of human brain, we showed that the caudate nucleus play a critical roles in reward-based learning of decision strategy to select higher-valued action (Haruno et al. 2004). By recording striate neuron activity of macaque monkeys performing reward-based decision task, we recently found that the striate projection neurons encode action-specific reward value (Samejima et al., submitted).
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