Evaluation of molecular and cellular mechanisms of helper T cell-mediated immunity during tumor-rejection

• Project/Area Number: 12213003
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Hokkaido University
• Principal Investigator: NISHIMURA Takashi Hokkaido. University, Institute for Genetic Medicine, Professor, 遺伝子病制御研究所, 教授 (30143001)
• Co-Investigator(Kenkyū-buntansha): 幸田 敏明 北海道大学, 大学院・理学研究科, 教授 (20170186)
• Project Period (FY): 2000 – 2004
• Project Status: Completed (Fiscal Year 2004)
• Budget Amount: ¥47,300,000 (Direct Cost: ¥47,300,000); Fiscal Year 2004: ¥8,800,000 (Direct Cost: ¥8,800,000); Fiscal Year 2003: ¥9,700,000 (Direct Cost: ¥9,700,000); Fiscal Year 2002: ¥10,000,000 (Direct Cost: ¥10,000,000); Fiscal Year 2001: ¥9,800,000 (Direct Cost: ¥9,800,000); Fiscal Year 2000: ¥9,000,000 (Direct Cost: ¥9,000,000)
• Keywords: Helper T cells / Cancer / Th1 / Cancer antigen / Dendritic cells / Gene Therapy / T cell receptor / サイトカイン / CTL / 癌ワクチン療法 / ヒト白血病 / IFN-β / 癌治療

Research Abstract

The purpose of this project is to evaluate the function of DC subsets and the mechanisms of Th1 /Th2 balance control, which are critical for development of tumor-specific CTL -mediated immunotherapy. We have demonstrated the following evidence. 1. Th1-dominant immunity is critical for activation of Th1 /Tc1 circuit important for tumor-specific immunotherapy. 2. BMDC1, which were induced from bone-marrow cells by culture with GM-CSF, IL-3 and Th1 cytokines, exhibited a potent stimulating activity for inducing allogeneic CTL. Moreover, combination therapy with BM DC1, inactivated tumor and tumor antigen protein caused a complete rejection of tumor tissue. 3. We established a culture method for inducing leukemia-specific CTL from PBMC of leukemia patients. 4. We established the method to prepare gene-modified tumor-specific Th1 cells using tumor-specific TCR genes or Iggene.Especially, it was demonstrated that transfer of class-I-restricted TCR genes into Th1 cells resulted in the generation of functional class-I-restricted Th1 cells. 5. CpG coencapsulated with tumor antigen protein induced tetramer-positive CTL in tumor-bearing mice and cured the mice from tumor. 6. We established a method to prepare Th1 cells, which specifically react to cancer-testis tumor antigen such as NY-ESO-1, MAGE-A4. These Th1 cells are useful to determine helper epitopes of tumor antigen.

Research Products

• [Journal Article] Natural killer cells play a role in MHC class I in vivo induction in tumor cells that are MHC negative in vitro. (2005)
  • Author(s): Kijima, M.
  • Journal Title: Int J Oncol 26 Pages: 679-684
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Natural killer cells play a role in MHC class I in vivo induction in tumor cells that are MHC negative in vitro. (2005)
  • Author(s): Kijima, M., Saio, M., Oyang, G.F., Suwa, T., Miyauchi, R., Kojima, Y., Imai, H., Nakagawa, J., Nonaka, K., Umemura, N., Nishimura, T., Takami, T.
  • Journal Title: Int J Oncol 26 Pages: 679-684
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Natural killer cells play a role in MHC class I in vivo induction in tumor cells that are MHC negative in vitro. (2005)
  • Author(s): Kijima, M.
  • Journal Title: Int J Oncol. 26・3 Pages: 679-684
• [Journal Article] Liposome-encapsulated CpG oligodeoxynucleotides as a potent adjuvant for inducing type 1 innate immunity. (2004)
  • Author(s): Suzuki, Y.
  • Journal Title: Cancer Res 64 Pages: 8754-8760
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Generation and targeting of human tumor-specific Tc1 and Th1 cells transduced with a lentivirus containing a chimeric immunoglobulin T-cell receptor. (2004)
  • Author(s): Gyobu, H.
  • Journal Title: Cancer Res 64 Pages: 1490-1495
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Potentiation of tumor eradication by adoptive immunotherapy with T-cell receptor gene-transduced T-helper type 1 cells. (2004)
  • Author(s): Chamoto, K.
  • Journal Title: Cancer Res 64 Pages: 386-390
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Generation of leukemia-specific T-helper type 1 cells applicable to human leukemia cell-therapy. (2004)
  • Author(s): Fujimura, T
  • Journal Title: Immunol Lett 93 Pages: 17-25
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The critical role of type-1 innate and acquired immunity in tumor immunotherapy. (2004)
  • Author(s): Ikeda, H.
  • Journal Title: Cancer Sci 95 Pages: 697-703
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Unexpected role of TNF-α in graft versus host reaction (GVHR) : donor-derived TNF-α suppresses GVHR via inhibition of IFN-γ -dependent donor type-1 immunity. (2004)
  • Author(s): Yamamoto, S.
  • Journal Title: Int Immunol, :, 2004 16 Pages: 811-817
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] IFN-γ-induced SOCS-1 regulates STAT6-dependent eotaxin production triggered by IL-4 and TNF-α. (2004)
  • Author(s): Sato, T.
  • Journal Title: Biochem Biophys Res Commun 314 Pages: 468-475
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] STAT6-mediated signaling in Th2-dependent allergic asthma : critical role for the development of eosinophilia, airway hyper-responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation. (2004)
  • Author(s): Hoshino, A.
  • Journal Title: Int Immunol 16 Pages: 1497-1505
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] NKT cells act as regulatory cells rather than killer cells during activation of NK cell-mediated cytotoxicity by α-galactosylceramide in vivo. (2004)
  • Author(s): Chamoto, K.
  • Journal Title: Immunol Lett 95 Pages: 5-11
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Liposome-encapsulated CpG oligodeoxynucleotides as a potent adjuvant for inducing type 1 innate immunity. (2004)
  • Author(s): Suzuki, Y., Wakita, D., Chamoto, K., Narita, Y., Tsuji, T., Takeshima, T., Gyobu, H., Kawarada, Y., Kondo, S., Akira, S., Katoh, H., Ikeda, H., Nishimura, T.
  • Journal Title: Cancer Res 64 Pages: 8754-8760
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Its possible role inautoimmune diseases (2004)
  • Author(s): Matsuzaki, J., Tsuji, T., Imazeki, I., Ikeda, H., Nishimura, T., Immunosteroid as a regulator for Th1/Th2 balance
  • Journal Title: Autoimmunity (In press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The critical role of type-1 innate and acquired immunity in tumor immunotherapy. (2004)
  • Author(s): Ikeda, H., Chamoto, K., Tsuji, T., Suzuki, Y., Wakita, D., Takeshima, T., Nishimura, T.
  • Journal Title: Cancer Sci 95 Pages: 697-703
  • NAID: 10014197100
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Unexpected role of TNF-a in graft versus host reaction (GVHR) : donor-derived TNF-a suppresses GVHR via inhibition of IFN-y-dependent donor type-1 immunity. (2004)
  • Author(s): Yamamoto, S., Tsuji, T., Matsuzaki, J., Zhange, Y., Chamoto, K., Kosaka, A., Togashi, Y., Sekikawa, K., Sawada, K.I., Takeshima, T., Koike, T., Nishimura, T.
  • Journal Title: Int Immunol 16 Pages: 811-817
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] IFN-y-induced SOCS-1 regulates STAT6-dependent eotaxin production triggered by IL-4 and TNF-a. (2004)
  • Author(s): Sato, T., Saito, R., Jinushi, T., Tsuji, T., Matsuzaki, J., Koda, T., Nishimura, S., Takeshima, H., Nishimura, T.
  • Journal Title: Biochem Biophys Res Commun 314 Pages: 468-475
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] STAT6-mediated signaling in Th2-dependent allergic asthma : critical role for the development of eosinophilia, airway hyper- responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation. (2004)
  • Author(s): Hoshino, A., Tsuji, T., Matsuzaki, J., Jinushi, T., Ashino, S., Teramura, T., Chamoto, K., Tanaka, Y., Asakura, Y., Sakurai, T., Mita, Y., Takaoka, A., Nakaike, S., Takeshima, T., Ikeda, H., Nishimura, T.
  • Journal Title: Int Immunol 16 Pages: 1497-1505
  • NAID: 10013567497
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Generation and targeting of human tumor-specific Tc1 and Th1 cells transduced with a lentivirus containing a chimeric immunoglobulin T-cell receptor. (2004)
  • Author(s): Gyobu, H., Tsuji, T., Suzuki, Y., Ohkuri, T., Chamoto, K., Kuroki, M., Miyoshi, H., Kawarada, Y., Katoh, H., Takeshima, T., Nishimura, T.
  • Journal Title: Cancer Res 64 Pages: 1490-1495
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Generation of leukemia-specific T-helper type 1 cells applicable to human leukemia cell-therapy. (2004)
  • Author(s): Fujimura, T., Chamoto, K., Tsuji, T., Sato, T., Yokouchi, H., Aiba, S., Tagami, H., Tanaka, J., Imamura, M., Togashi, Y., Koda, T., Nishimura, T.
  • Journal Title: Immunol Lett 93 Pages: 17-25
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Potentiation of tumor eradication by adoptive immunotherapy with T-cell receptor gene-transduced T-helper type 1 cells. (2004)
  • Author(s): Chamoto, K., Tsuji, T., Funamoto, H., Kosaka, A., Matsuzaki, J., Sato, T., Abe, H., Fujio, K., Yamamoto, K., Kitamura, T., Takeshima, T., Togashi, Y., Nishimura, T.
  • Journal Title: Cancer Res 64 Pages: 386-390
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] NKT cells act as regulatory cells rather than killer cells during activation of NK cell-mediated cytotoxicity by α- galactosylceramide in vivo. (2004)
  • Author(s): Chamoto, K., Takeshima, T., Kosaka, A., Tsuji, T., Matsuzaki, J., Togashi, Y., Ikeda, H., Nishimura, T.
  • Journal Title: Immunol Lett 95 Pages: 5-11
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Liposome-encapsulated CpG oligodeoxynucleotides as a potent adjuvant for inducing type 1 innate immunity. (2004)
  • Author(s): Suzuki, Y.
  • Journal Title: Cancer Res 64・23 Pages: 8754-8760
• [Journal Article] Generation and targeting of human tumor-specific Tc1 and Th1 cells transduced with a lentivirus containing a chimeric immunoglobulin T-cell receptor. (2004)
  • Author(s): Gyobu, H.
  • Journal Title: Cancer Res 64・4 Pages: 1490-1495
• [Journal Article] Potentiation of tumor eradication by adoptive immunotherapy with T-cell receptor gene-transduced T-helper type 1 cells. (2004)
  • Author(s): Chamoto, K.
  • Journal Title: Cancer Res 64・1 Pages: 386-390
• [Journal Article] Generation of leukemia-specific T-helper type 1 cells applicable to human leukemia cell-therapy. (2004)
  • Author(s): Fujimura, T
  • Journal Title: Immunol Lett. 93・1 Pages: 17-25
• [Journal Article] The critical role of type-1 innate and acquired immunity in tumor immunotherapy. (2004)
  • Author(s): Ikeda, H.
  • Journal Title: Cancer Sci. 95・9 Pages: 697-703
• [Journal Article] Unexpected role of TNF-α in graft versus host reaction (GVHR) : donor-derived TNF-α suppresses GVHR via inhibition of IFN-γ -dependent donor type-1 immunity. (2004)
  • Author(s): Yamamoto, S.
  • Journal Title: Int Immunol 16・6 Pages: 811-817
• [Journal Article] IFN-γ-induced SOCS-1 regulates STAT6-dependent eotaxin production triggered by IL-4 and TNF-α. (2004)
  • Author(s): Sato, T.
  • Journal Title: Biochem Biophys Res Commun 314・2 Pages: 468-475
• [Journal Article] STAT6-mediated signaling in Th2-dependent allergic asthma : critical role for the development of eosinophilia, airway hyper-responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation. (2004)
  • Author(s): Hoshino, A.
  • Journal Title: Int Immunol 16・10 Pages: 1497-1505
• [Journal Article] NKT cells act as regulatory cells rather than killer cells during activation of NK cell-mediated cytotoxicity by α-galactosylceramide in vivo. (2004)
  • Author(s): Chamoto, K.
  • Journal Title: Immunol Lett. 95・1 Pages: 5-11
• [Journal Article] Identification of Th1- and Th2-specific Genes by Microarray Analysis. (2003)
  • Author(s): Li, J.
  • Journal Title: Biomedical Res 24 Pages: 299-307
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] An efficient method to prepare T cell receptor gene-transduced cytotoxic T lymphocytes type 1 applicable to tumor gene cell-therapy. (2003)
  • Author(s): Tsuji, T.
  • Journal Title: Cancer Sci 94 Pages: 389-393
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Functional expression of the TrkC gene, encoding a high affinity recept or for NT-3, in antigen-specific T helper type 2 (Th2) cells. (2003)
  • Author(s): Sekimoto, M.
  • Journal Title: Immunol Lett 88 Pages: 221-226
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A novel tumor-vaccine cell therapy using bone marrow-derived dendritic cell type 1 and antigen-specific Th1 cells. (2003)
  • Author(s): Sato, M.
  • Journal Title: Int Immunol 15 Pages: 837-843
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Differential regulation of VLA-2 expression on Th1 and Th2 cells : a novel marker for the classification of Th subsets. (2003)
  • Author(s): Sasaki, K
  • Journal Title: Int Immunol 15 Pages: 701-710
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo. (2003)
  • Author(s): Matsuzaki, J
  • Journal Title: Cell Immunol 224 Pages: 98-105
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Critical role of the Th1/Tc1 circuit for the generation of tumor-specific CTL during tumor eradication in vivo by Th1-cell therapy. (2003)
  • Author(s): Chamoto, K.
  • Journal Title: Cancer Sci 94 Pages: 924-928
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Identification of Th1-and Th2-specific Genes by Microarray Analysis. (2003)
  • Author(s): Li, J., Koda, T., Yamaguchi, A., Yamamoto, S., Sato, T., Togashi, Y., Nishimura, T.
  • Journal Title: Biomedical Res 24 Pages: 299-307
  • NAID: 130004705174
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] An efficient method to prepare T cell receptor gene-transduced cytotoxic T lymphocytes type 1 applicable to tumor gene cell-therapy. (2003)
  • Author(s): Tsuji, T., Chamoto, K., Funamoto, H., Kosaka, A., Matsuzaki, J., Abe, H., Fujio, K., Yamamoto, K., Kitamura, T., Togashi, Y., Koda, T., Nishimura, T.
  • Journal Title: Cancer Sci 94 Pages: 389-393
  • NAID: 50000825584
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Functional expression of the TrkC gene, encoding a high affinity receptor for NT-3, in antigen-specific T helper type 2 (Th2) cells. (2003)
  • Author(s): Sekimoto, M., Tsuji, T., Matsuzaki, J., Chamoto, K., Koda, T., Nemoto, K., Degawa, M., Nishimura, S., Nishimura, T.
  • Journal Title: Immunol Lett 88 Pages: 221-226
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A novel tumor-vaccine cell therapy using bone marrow-derived dendritic cell type 1 and antigen-specific Th1 cells. (2003)
  • Author(s): Sato, M., Chamoto, K., Nishimura, T.
  • Journal Title: Int Immunol 15 Pages: 837-843
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differential regulation of VLA-2 expression on Th1 and Th2 cells : a novel marker for the classification of Th subsets. (2003)
  • Author(s): Sasaki, K., Tsuji, T., Jinushi, T., Matsuzaki, J., Sato, T., Chamoto, K., Togashi, Y., Koda, T., Nishimura, T.
  • Journal Title: Int Immunol 15 Pages: 701-710
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Successful elimination of memory-type CD8+T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo. (2003)
  • Author(s): Matsuzaki, J., Tsuji, T., Chamoto, K., Takeshima, T., Sendo, F., Nishimura, T.
  • Journal Title: Cell Immunol 224 Pages: 98-105
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Critical role of the Th1/Tc1 circuit for the generation of tumor-specific CTL during tumor eradication in vivo by Th1-cell therapy. (2003)
  • Author(s): Chamoto, K., Kosaka, A., Tsuji, T., Matsuzaki, J., Sato, T., Takeshima, T., Iwakabe, K., Togashi, Y., Koda, T., Nishimura, T.
  • Journal Title: Cancer Sci 94 Pages: 924-928
  • NAID: 10012438724
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Generation of human tumor-specific, HLA class l-restricted Th1 and Tc1 cells by cell engineering with tumor peptide-specific T cell receptor genes.
  • Author(s): Tsuji.T.
  • Journal Title: Blood (In press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Application of genetically engineered tumor-specific Th1 cells to adoptive tumor immunotherapy.
  • Author(s): Tsuji, T.
  • Journal Title: Annals of Cancer Research and Therapy (In press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Immunosteroid as a regulator for Th1/Th2 balance : Its possible role inautoimmune diseases
  • Author(s): Matsuzaki, J.
  • Journal Title: Autoimmunity (In press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Generation of human tumor-specific, HLA class I-restricted Th1 and Tc1 cells by cell engineering with tumor peptide-specific T cell receptor genes.
  • Author(s): Tsuji, T., Yasukawa, M., Matsuzaki, J., Ohkuri, T., Chamoto, K., Wakita, D., Azuma, T., Niiya, H., Miyoshi, H., Kuzushima, K., Oka, Y., Sugiyama, H., Ikeda, H., Nishimura, T.
  • Journal Title: Blood (In press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Application of genetically engineered tumor- specificTh1 cells to adoptive tumor immunotherapy Annals of Cancer Research and Therapy
  • Author(s): Tsuji, T., Chamoto, K., Gyobu, H., Ikeda.H., Nishimura, T.
  • Journal Title: (In press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Application of genetically engineered tumor-specific Th1 cells to adoptive tumor immunotherapy.
  • Author(s): Tsuji, T.
  • Journal Title: Annals of Cancer Research and Therapy (印刷中)
• [Journal Article] Immunosteroid as a regulator for Th1/Th2 balance : Its possible role inautoimmune diseases
  • Author(s): Matsuzaki, J.
  • Journal Title: Autoimmunity (印刷中)
• [Book] 分子生物学・免疫学キーワード事典(第2版) (2003)
  • Author(s): 永田和宏
  • Total Pages: 1056
  • Publisher: 医学書院
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 医学大辞典(第1版) (2003)
  • Author(s): 伊藤正男
  • Total Pages: 3088
  • Publisher: 医学書院
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 別冊・医学のあゆみ 細胞免疫療法の現状 (2003)
  • Author(s): 若杉尋
  • Total Pages: 120
  • Publisher: 医歯薬出版株式会社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 内科学 二分冊版(第2版) (2003)
  • Author(s): 黒川清
  • Publisher: 文光堂
  • Description: 「研究成果報告書概要(和文)」より
• [Book] アレルギー病学 (2002)
  • Author(s): 山本一彦
  • Total Pages: 404
  • Publisher: 朝倉書店
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 免疫学辞典(第2版) (2001)
  • Author(s): 大沢利昭
  • Total Pages: 848
  • Publisher: 東京化学同人
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Bio Science新用語ライブラリー免疫第2版 (2000)
  • Author(s): 斉藤隆
  • Publisher: 羊土社
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 改変標的化T細胞の製造方法及び医薬 (2004)
  • Inventor(s): 西村 孝司, 安川 正貴
  • Industrial Property Rights Holder: 北海道ティー・エル・オー株式会
  • Filing Date: 2004-12-22
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 癌抗原非特異的な標準化T細胞の製造方法及び医薬 (2004)
  • Inventor(s): 西村 孝司
  • Industrial Property Rights Holder: 北海道ティー・エル・オー株式会
  • Industrial Property Number: 2004-017740
  • Filing Date: 2004-01-27
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 標的化T細胞の製造方法及び医薬 (2004)
  • Inventor(s): 西村 孝司, 黒木 政秀
  • Industrial Property Rights Holder: 北海道ティー・エル・オー株式会
  • Industrial Property Number: 2004-017747
  • Filing Date: 2004-01-27
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] ヒトTh1免疫とTh2免疫のバランスを調べるための検査キット (2004)
  • Inventor(s): 西村 孝司
  • Industrial Property Rights Holder: 西村孝司, 東レ株式会社
  • Industrial Property Number: 2004-294522
  • Filing Date: 2004-10-07
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 改変標的化T細胞の製造方法及び医薬 (2003)
  • Inventor(s): 西村 孝司, 安川 正貴
  • Industrial Property Rights Holder: 北海道ティー・ェル・ォー株式会社
  • Industrial Property Number: 2003-425009
  • Filing Date: 2003-12-22
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] ヒトT細胞による肝疾患治療剤 (2002)
  • Inventor(s): 内海 潤, 西村孝司, 富樫 裕二
  • Industrial Property Rights Holder: 東レ株式会社
  • Industrial Property Number: 2002-130032
  • Filing Date: 2002-05-01
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 免疫調節作用関連の新規遺伝子及びTh1ヘルパーT細胞とTh2ヘルパーT細胞のバランスを調べる検査方法 (2002)
  • Inventor(s): 西村 孝司
  • Industrial Property Rights Holder: 西村 孝司, 東レ株式会社
  • Industrial Property Number: 2002-314957
  • Filing Date: 2002-10-29
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 抗原特異的ヒトT細胞の製造方法及び医薬 (2001)
  • Inventor(s): 西村 孝司, 内海 潤
  • Industrial Property Rights Holder: 東レ株式会社, 西村 孝司
  • Industrial Property Number: 2001-255095
  • Filing Date: 2001-08-28
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 免疫賦活剤 (2000)
  • Inventor(s): 田中 善孝, 渡辺 一仁, 西村 孝司
  • Industrial Property Rights Holder: 大正製薬株式会社, 学校法人東海大学
  • Patent Publication Number: 2000-281571
  • Acquisition Date: 2000-10-10
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] ガン免疫賦活剤およびアレルギー免疫抑制剤 (2000)
  • Inventor(s): 西村 孝司, 佐藤 まりも, 水谷 武雄, 古家 健二
  • Industrial Property Rights Holder: 三井製糖株式会社
  • Patent Publication Number: 2000-297045
  • Acquisition Date: 2000-10-24
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Yamamoto, S.: "Unexpected Role of TNF-α in Graft Versus Host Reaction (GVHR) : Donor-Derived TNF-α Suppresses GVHR via Inhibition of IFN-γ-dependent Donor Type 1 Immunity."Int.Immunol.. (In press). (2004)
• [Publications] Fujimura, T.: "Generation of Leukemia-Specific T-Helper Type 1 Cells Applicable To Human Leukemia Cell-Therapy."Immunol.Letters. (in press). (2004)
• [Publications] Chamoto, K: "Identification of Th1- and Th2-specific Genes by Microarray Analysis."Cancer Res.. 64・1. 386-390 (2004)
• [Publications] Sato, T.: "IFN-gamma-induced SOCS-1 regulates STAT6-dependent eotaxin production triggered by IL-4 and TNF-alpha."Biochem Biophys Res Commun. 314・2. 468-475 (2004)
• [Publications] Gyobu, H.: "Generation and targeting of human tumor-specific Tc1 and Th1 cells transduced with a lentivirus containing a chimeric immunoglobulin T cell receptor"1.Cancer Res.. 64・2. 1490-1495 (2004)
• [Publications] Li, J: "Potentiation of Tumor Eradication by Adoptive Immunotherapy with T-cell Receptor Gene-Transduced T-Helper Type 1 Cells."Biomedical Res.. 24・6. 299-307 (2003)
• [Publications] Chamoto, K.: "Critical Role of Th1/Tc1 Circuit for the Generation of Tumor-specific CTL during Tumor Eradication in vivo by Th1-cell Therapy."Cancer Science. 94・10. 924-928 (2003)
• [Publications] Matsuzaki, J: "Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo."Cellular Immunol. 224. 98-105 (2003)
• [Publications] Sato, M.: "A novel tumorvaccine cell therapy using bone marrow-derived dendritic cell type 1 and antigen-specific T helper type 1 cells."Int.Immunol.. 15・7. 837-843 (2003)
• [Publications] Sasaki, K.: "Differential regulation of VLA-2 expression on Th1 and Th2 cells : novel marker for classification of T-helper subset."Int.Immunol.. 15・6, Jun.. 701-710 (2003)
• [Publications] Tsuji, T.: "An efficient methods to prepare T cell receptor genetransduced cytotoxic T lymphocytes type 1 applicable to tumor gene cell-therapy."Cancer Science. 94・4. 389-393 (2003)
• [Publications] Sekimoto, M: "Functional expression of TrkC gene encoding a high affinity receptor for NT-3 in antigen-specific T helper-type 2(Th2) cells."Immunology letters. 88. 221-226 (2003)
• [Publications] 伊藤正男: "別冊・医学のあゆみ"医歯薬出版株式会社. 3088 (2003)
• [Publications] 若杉尋編: "医学大辞典(第1版)"医学書院. 110 (2003)
• [Publications] Tsuji, T.: "An efficient methods to prepare T cell receptor gene-transduced cytotoxic T lymphocytes type 1 applicable to tumor gene cell-therapy"Cancer Science. (in press).
• [Publications] Nishimura, T.: "The critical role of DC for NKT cell response to α-Galcer"Clinical Immunology. 37・1. 1-9 (2002)
• [Publications] Niishimura, T.: "Tumour-vaccine therapy combined with DC1 and Th1 cells"Journal of Clinical and Experimental Medicine. 200・6. 481-486 (2002)
• [Publications] 山本一彦: "アレルギー病学"朝倉書店. 404 (2002)
• [Publications] Sato, M.: "Th1 cytokine-conditioned bone marrow-derived dendritic cells can bypass the requirement for Th functions during the generation of CD8+ CTL"J.Immunol.. 167. 3687-3691 (2001)
• [Publications] Takaoka, A.: "A critical role for mouse CXC chemokine(s) in pulmonary neutrophilia during Th type1-dependent airway inflammation"J.Immunol.. 167. 2349-2353 (2001)
• [Publications] Matsuda, M.: "Heterobifunctional ligands : Practical chemoenzymatic synthesis of a cell adhesive glycopeptide thet interacts with both selectin and integrins"J.Med.Chem.. 44. 715-724 (2001)
• [Publications] 大沢利昭: "免疫学辞典(第2版)"東京化学同人. 848 (2001)
• [Publications] "南山堂医学大辞典(第18版・限定版)"南山堂. 2663 (2001)
• [Publications] Ohta,A.: "Indispensable Role for TNF-α and IFN-γ at the Effector Phase of Liver Injury Mediated by Th1 Cells Specific to Hepatitis B Virus Surface Antigen."J.Immunol.. 165. 956-961 (2000)
• [Publications] Nishimura,T.: "The interface between innate and acquired immunity : Glycolipid antigen presentation by CD1d-expressing dendritic cells to natural killer T cells induces the differentiation of antigen-specific cytotoxic T lymphocytes."Int.Immunol.. 12. 987-994 (2000)
• [Publications] Sato,M.: "Functional heterogeneity among bone marrow-derived dendritic cells conditioned by Th1-and Th2-biasing cytokines for the generation of allogeneic cytotoxic T lymphocytes."Int. Immunol.. 12. 335-342 (2000)
• [Publications] Kitamura,H.: "α-galactosylceramide induces early B-cell activation through IL-4 production by NKT cells."Cell Immunol.. 199. 37-42 (2000)
• [Publications] Nishimura,T.: "The critical role of Th1-dominant immunity in tumor immunology."Cancer Chemother.Pharmacol.. 46. S52-S61 (2000)
• [Publications] Fujio,K: "Molecular cloning of novel type I cytokine receptor."Blood.. 95. 2204-2211 (2000)
• [Publications] Yahata,T.: "Interleukin-4-dependent induction of preproenkephalin in antigen-specific T helper-type 2 (Th2) cells."J.Neuroimmunol.. 105. 103-108 (2000)
• [Publications] Sato,M: "Establishment of self priming cell culture system for monitoring genetically-controlled spontaneous cytokine-producing ability in mice."Immunol.Lett.. 70. 173-178 (2000)
• [Publications] Nakui,M.: "Potentiation of antitumor effect of NKT cell ligands,α-galctosylceramide by combination with IL-12 on lung metastasis of malignant melanoma cells."Clinic.Exp.Metastasis.. (2000)