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Characterization of genetic alterations in human cancer and its application for diagnosis and treatment

Research Project

Project/Area Number 12213010
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTohoku University

Principal Investigator

HORIII Akira  Tbhoku University School of Medicine, Professor, 大学院医学系研究科, 教授 (40249983)

Co-Investigator(Kenkyū-buntansha) YAEGASHI Nobuo  Tohoku University, School of Medicine, Professor, 大学院医学系研究科, 教授 (00241597)
SUNAMURA Makoto  Tohoku University, Hospital, Lecturer, 病院・講師 (10201584)
Project Period (FY) 2000 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥64,100,000 (Direct Cost: ¥64,100,000)
Fiscal Year 2004: ¥12,400,000 (Direct Cost: ¥12,400,000)
Fiscal Year 2003: ¥13,600,000 (Direct Cost: ¥13,600,000)
Fiscal Year 2002: ¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 2001: ¥13,100,000 (Direct Cost: ¥13,100,000)
Fiscal Year 2000: ¥11,000,000 (Direct Cost: ¥11,000,000)
KeywordsPancreatic cancer / DUSP6 / AURKA / RNAi / Micro array / Malignant melanoma / BRAF / Wnt / 遺伝子治療 / アデノウイルス / MKP-3 / DNAミスマッチ修復異常 / 染色体12q / SMAD4 / 染色体18q / 酵母two-hybrid / 下垂体腺腫 / 18q / 1p36-p35 / BAI1 / RIZ / 膵がん / 遺伝子変異 / 神経芽細胞腫 / 1p / MSI
Research Abstract

In human pancreatic cancer, frequent loss of lp, 12q, and 18q, and gain of 20q are observed. We analyzed these regions in this study. RAW a candidate tumor suppressor gene that encodes a protein specifically binds to RB protein. This gene localizes in 1p36, and we found mutations of this gene in pancreatic cancer. This may be a target tumor suppressor gene in human pancreatic cancer.
In 12q, we previously detected frequent loss of expression of DUSP6 This gene encodes a protein that specifically inactivates ERK Overexpression of DUSP6 protein was frequently observed in precursor lesions of pancreatic cancer However, expression gradually decreases according to progression of carcinogenesis. The main mechanisms of loss of expression were epigenetic modification, and adeno-virus mediated expression caused apoptosis. On the other hand, chromosome 12 transfer induced growth suppression in vivo, but suppressed DUSP6expression did not recover. We further discovered that suppression of angiogen … More esis was one of the main mechanisms of growth suppression. Microarray analysis identified several candidate genes, and further analyses will lead to the responsible gene for angiogenesis inhibition.
Loss of 18q is also frequently observed early event in human pancreatic cancer, but SMAD4 does not mutate at the early stage. Moreover introduction of SMAD4 did not suppress cell growth in vitro. After chromosome transfer, however, growth suppression was prominent in vitro. Suppression of metastasis was also observed in our mice model Microarray analysis also suggested some candidate genes, and we are on the way of further characterization.
Frequent gain of 20q was observed in human pancreatic cancer. We analyzed AURKA on this arm and frequent overexpression was observed. We further performed siRNA-mediated knockdown and observed growth suppression and induction of apoptosis. Moreover, synergistic enhancement of knockdown of AURKA with taxane was observed.
Beta-catenin is one of the oncogenes in several human cancers. We found frequent abnormal accumulation of beta-catenin in human pituitary adenomas. However, mutation was not so frequent We also analyzed other genes that play in the Wnt pathway such as APC, AXINI, GSK3B, and ICAT, but mutations in these genes were not observed.
BRAF is a recently detected oncogene in human melanoma. We also performed mutation analysis in this gene in melanomas, but mutation frequency was not high when compared with that of Caucasians. However, distinct mutation frequencies were found by the histopathological subtypes. This may be the reason of difference in mutation frequency.
Frequent missense mutation of hMLH1 was observed and accurate evaluation is important We developed effective and quite accurate monitoring system using yeast two-hybrid system. We also analyzed MBD4 that was thought to work in the DNA repair system. We found that this protein works as one of the transcription repressors associated with methylation. Less

Report

(6 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (198 results)

All 2005 2004 2003 2002 2001 2000 Other

All Journal Article (130 results) Book (2 results) Publications (66 results)

  • [Journal Article] Comparative genomic hybridization and mutation analyses of sporadic schwannomas2005

    • Author(s)
      Ikeda T, Hashimoto S, Fukushige S, Ohmori H, Horii A
    • Journal Title

      J Neuro-Oncol (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Infrequent mutation of APC, AXIN1, and GSK3B in human pituitary adenomas with abnormal accumulation of CTNNB12005

    • Author(s)
      Sun C, Yamato T, Kondo E, Furukawa T, Ikeda H, Horii A
    • Journal Title

      J Neuro-Oncol (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas.2005

    • Author(s)
      Furukawa T, Fujisaki R, Yoshida Y, Kanai N, Sunamura M, Abe T, Takeda K, Matsuno S, Horii A
    • Journal Title

      Mod Pathol (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Computed tomographic images reflect the biological behavior of small lung adenocarcinoma; They correlate with cell proliferation, microvascularization, cell adhesion, degradation of extracellular matrix and K-ras mutation.2005

    • Author(s)
      Dong B, Sato M, Sakurada A, Sagawa M, Endo C, Wu S, Yamanaka S, Horii A, Kondo T
    • Journal Title

      J Thorac Cardiovasc Surg (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis.2005

    • Author(s)
      Okada T, Noji S, Goto Y, Iwata T, Fujita T, Okada T, Matsuzaki Y, Kuwana M, Hirakata M, Horii A, Matsuno S, Sunamura M, Kawakami Y
    • Journal Title

      Int J Cancer (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] RNA interference targeting aurora kinase A suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells2005

    • Author(s)
      Hata T, Furukawa T, Sunamura M, Egawa S, Motoi F, Ohmura N, Marumoto T, Saya H, Horii A
    • Journal Title

      Cancer Res 65

      Pages: 2899-2905

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Abrogation of DUSP6 by hypermethylation in human pancreatic cancer.2005

    • Author(s)
      Xu S, Furukawa T, Kanai N, Sunamura M, Horii A
    • Journal Title

      J Hum Genet 50

      Pages: 159-167

    • NAID

      10015696534

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16^<INK4a> and MLH1 genes.2005

    • Author(s)
      Kondo E, Gu Z, Horii A, Fukushige S
    • Journal Title

      Mol Cell Biol 25

      Pages: 4388-4396

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] In frequent mutation of APQ, AXIN1, and GSK3B In human pituitary adenomas with abnormal accumulation of CTNNBI.2005

    • Author(s)
      Sun C, Yamato T, Kondo E, Furukawa T, Ikeda H, Horii A.
    • Journal Title

      J Neuro-Oncol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas.2005

    • Author(s)
      Furukawa T, Fujisaki R, Yoshida Y, Kanai N, Sunamura M, Abe T, Takeda K, Matsuno S, Horii A.
    • Journal Title

      Mod Pathol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Comparative genomic hybridization and mutation analyses of sporadic schwannomas.2005

    • Author(s)
      Ikeda T, Hashimoto S, Fukushige S, Ohmori H, Horii A.
    • Journal Title

      J Neuro-Oncol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Computed tomographic images reflect the biological behavior of small lung adenocarcinoma; They correlate with cell proliferation, microvascularization, cell adhesion, degradation of extracellular matrix and K-ras mutation.2005

    • Author(s)
      Dong B, Sato M, Sakurada A, Sagawa M, Endo C, Wu S, Yamanaka S, Horii A, Kondo T.
    • Journal Title

      J Thorac Cardiovasc Surg (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis.2005

    • Author(s)
      Okada T, Noji S, Goto Y, Iwata T, Fujita T, Okada T, Matsuzaki Y,. Kuwana M, Hirakata M, Horii A, Matsuno S, Sunamura M, Kawakami Y.
    • Journal Title

      Int J Cancer (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The Role of DUSP6/MKP-3 in Pancreatic Carcinoma. In : Hayat MA (ed.) Handbook of immunohistochemistry and in situ hybridization of human carcinomas, volume 3 : Molecular genetics, liver carcinoma, and pancreatic carcinoma2005

    • Author(s)
      Furukawa T, Horii A.
    • Journal Title

      Elsevier (USA), Philadelphia, PA (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] RNA interference targeting aurora kinase A suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells.2005

    • Author(s)
      Hata T, Furukawa T, Sunamura M, Egawa S, Motoi F, Ohmura N, Marumoto T, Saya H, Horii A.
    • Journal Title

      Cancer Res 65

      Pages: 2899-2905

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Abrogation of DUSP6by hypermethylation in human pancreatic cancer.2005

    • Author(s)
      Xu S, Furukawa T, Kanai N, Sunamura M, Horii A.
    • Journal Title

      J Hum Genet 50

      Pages: 159-167

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p167NK4a and MLHI genes.2005

    • Author(s)
      Kondo E, Gu Z, Horii A, Fukushige S.
    • Journal Title

      Mol Cell Biol 25

      Pages: 4388-4396

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Infrequent mutation of APC, AXIN1,and GSK3B in human pituitary adenomas with abnormal accumulation of CTNINB1.2005

    • Author(s)
      Sun C, Yamato T, Kondo E, Furukawa T, Ikeda H, Horii A.
    • Journal Title

      J Neuro-Oncol (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] RNA interference targeting aurora kinase A suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells.2005

    • Author(s)
      Hata T, Furukawa T, Sunamura M, Egawa S, Motoi F, Ohmura N, Marumoto T, Saya H, Horii A.
    • Journal Title

      Cancer Res (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Abrogation of DUSP6 by hypermethylation in human pancreatic cancer.2005

    • Author(s)
      Xu S, Furukawa T, Kanai N, Sunamura M, Horii A.
    • Journal Title

      J Hum Genet (in press)

    • NAID

      10015696534

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The thymine DNA glycosylase MBD4 represses transcription and associated with methylated p16^<INK4a> and MLH1 genes.2005

    • Author(s)
      Kondo E, Gu Z, Horii A, Fukushige S.
    • Journal Title

      Mol Cell Biol (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro.2004

    • Author(s)
      Hata T, Ogawa T, Yokoyama T, Fukushige S, Horii A, Furukawa T
    • Journal Title

      Int J Oncol 24

      Pages: 513-520

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A new assay using surface plasmon resonance (SPR) to determine binding of Lactobacillus acidophilus group to human colonic mucin2004

    • Author(s)
      Uchida H, Fujitani K, Kawai Y, Kitazawa H, Horii A, Shiiba K, Saito K, Saito T
    • Journal Title

      Biosci Biotecnnol Biochem 68

      Pages: 1004-1010

    • NAID

      10013144409

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Molecular pathology of pancreatic cancer : In quest of tumor suppressor genes.2004

    • Author(s)
      Furukawa T, Horii A
    • Journal Title

      Pancreas 28

      Pages: 253-256

    • NAID

      10016168077

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma.2004

    • Author(s)
      Sunamura M, Lefter LP, Duda DG, Morita R, Inoue H, Yokoyama T, Yatsuoka T, Abe T, Egawa S, Furukawa T, Fukushige S, Oshimura M, Horii A, Matsuno S
    • Journal Title

      Pancreas 28

      Pages: 311-316

    • NAID

      10016168472

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Screening for functional tumor suppressor activity in pancreatic cancer.2004

    • Author(s)
      Lefter L, Scripcaru V, Sunamura M, Furukawa T, Matsuno S, Oshimura M, Drug V, Dragomir C, Horii A
    • Journal Title

      Rom J Gastroenterol 13

      Pages: 195-201

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells.2004

    • Author(s)
      Yatsuoka T, Furukawa T, Sunamura M, Matsuno S, Horii A
    • Journal Title

      Oncol Rep 12

      Pages: 1263-1268

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Infrequent somatic mutations of the ICAT gene in various human cancers with frequent 1p-LOH and/or abnormal nuclear accumulation of β-catenin.2004

    • Author(s)
      Imai M, Nakamura T, Akiyama T, Horii
    • Journal Title

      Oncol Rep 12

      Pages: 1099-1103

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Chromosome 12, frequently deleted in human pancreatic cancer, may encode a tumor suppressor gene that suppresses angiogenesis.2004

    • Author(s)
      Yamanaka S, Sunamura M, Furukawa T, Sun L, Lefter LP, Abe T, Yatsuoka T, Fujimura H, Shibuya E, Kotobuki N, Oshimura M, Sakurada A, Sato M, Kondo T, Matsuno S, Horii A
    • Journal Title

      Lab Invest 84

      Pages: 1339-1351

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] BRAF point mutations in primary malignant melanoma show different prevalences by subtype.2004

    • Author(s)
      Sasaki Y, Niu C, Makino R, Kudo C, Sun C, Watanabe H, Matsunaga J, Takahashi K, Tagami H, Aiba S, Horii A
    • Journal Title

      J Invest Dermatol 123

      Pages: 177-183

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Functional Analysis of chromosome 18 in pancreatic cancer : strong evidence for new tumour suppressor genes.2004

    • Author(s)
      Lefter LP, Sunamura M, Furukawa T, Yastsuoka T, Abe H, Inoue H, Abe T, Egawa S, Miura K, Morita R, Horii A, Matsuno S
    • Journal Title

      Asian J Surg 27

      Pages: 85-92

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Molecular pathology of pancreatic cancer : In quest of tumor suppressor genes.2004

    • Author(s)
      Furukawa, T., Horii, A.
    • Journal Title

      Pancreas 28

      Pages: 253-256

    • NAID

      10016168077

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma.2004

    • Author(s)
      Sunamura M, Lefter LP, Duda DG, Morita R, Inoue H, Yokoyama T, Yatsuoka T, Abe T, Egawa S, Furukawa T, Fukushige S, Oshimura M, Horii A, Matsuno S.
    • Journal Title

      Pancreas 28

      Pages: 311-316

    • NAID

      10016168472

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro.2004

    • Author(s)
      Hata T, Ogawa T, Yokoyama T, Fukushige S, Horii A, Furukawa T.
    • Journal Title

      Int J Oncol 24

      Pages: 513-520

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A new assay using surface plasmon resonance (SPR) to determine binding of Lactobacillus acidophilus group to human colonic mucin"2004

    • Author(s)
      Uchida H, Fujitani K, Kawai Y, Kitazawa H, Horii A, Shiiba K, Saito K, Saito T.
    • Journal Title

      Biosci Biotecnnol Biochem 68

      Pages: 1004-1010

    • NAID

      10013144409

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] BRAF point mutations in primary malignant melanoma show different prevalences by subtype "2004

    • Author(s)
      Sasaki Y, Niu C, Makino R, Kudo C, Sun C, Watanabe H, Matsunaga J, Takahashi K, Tagami H, Aiba S, Horii A.
    • Journal Title

      J Invest Dermatol 123

      Pages: 177-183

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] FunctionalAnalysisofchromosome18inpancreaticcancer : strong evidence for new tumour suppressor genes.2004

    • Author(s)
      Lefter LP, Sunamura M, Furukawa T, Yastsuoka T, Abe H, Inoue H, Abe T, Egawa S, Miura K, Morita R, Horii A, Matsuno S.
    • Journal Title

      Asian J Surg 27

      Pages: 85-92

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Chromosome 12, frequently deleted in human pancreatic cancer, may encode a tumor suppressor gene that suppresses angiogenesis.2004

    • Author(s)
      Yamanaka S, Sunamura M, Furukawa T, Sun L, Lefter LP, Abe T, Yatsuoka T, Fujimura H, Shibuya E, Kotobuki N, Oshimura M, Sakurada A, Sato M, Kondo T, Matsuno S, Horii A.
    • Journal Title

      Lab lnvest 84

      Pages: 1339-1351

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Infrequent somatic mutations of the ICAT gene in various human cancers with frequent 1p-LOH and/or abnormal nuclear accumulation of (3).catenin. "2004

    • Author(s)
      Imai M, Nakamura T, Akiyama T, Horii
    • Journal Title

      Oncol Rep 12

      Pages: 1099-1103

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells.2004

    • Author(s)
      Yatsuoka T, Furukawa T, Sunamura M, Matsuno S, Horii A.
    • Journal Title

      Oncol Rep 12

      Pages: 1263-1268

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] DSCP1,a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro.2004

    • Author(s)
      Hata T, Ogawa T, Yokoyama T, Fukushige S, Horii A, Furukawa T.
    • Journal Title

      Int J Oncol 24

      Pages: 513-520

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A new assay using surface plasmon resonance (SPR) to determine binding of Lactobacillus acidophilus group to human colonic mucin2004

    • Author(s)
      Uchida H, Fujitani K, Kawai Y, Kitazawa H, Horii A, Shiiba K, Saito K, Saito T.
    • Journal Title

      Biosci Biotecnnol Biochem 68

      Pages: 1004-1010

    • NAID

      10013144409

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Molecular pathology of pancreatic cancer : In quest of tumor suppressor genes.2004

    • Author(s)
      Furukawa T, Horii A.
    • Journal Title

      Pancreas 28

      Pages: 253-256

    • NAID

      10016168077

    • Related Report
      2004 Annual Research Report
  • [Journal Article] BRAF point mutations in primary malignant melanoma show different prevalences by subtype.2004

    • Author(s)
      Sasaki Y, Niu C, Makino R, Kudo C, Sun C, Watanabe H, Matsunaga J, Takahashi K, Tagami H, Aiba S, Horii A.
    • Journal Title

      J Invest Dermatol 123

      Pages: 177-183

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Functional Analysis of chromosome 18 in pancreatic cancer : strong evidence for new tumour suppressor genes.2004

    • Author(s)
      Lefter LP, Sunamura M, Furukawa T, Yatsuoka T, Abe H, Inoue H, Abe T, Egawa S, Miura K, Morita R, Horii A, Matsuno S.
    • Journal Title

      Asian J Surg 27

      Pages: 85-92

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Chromosome 12,frequently deleted in human pancreatic cancer, may encode a tumor suppressor gene that suppresses angiogenesis.2004

    • Author(s)
      Yamanaka S, Sunamura M, Furukawa T, Sun L, Lefter LP, Abe T, Yatsuoka T, Fujimura H, Shibuya E, Kotobuki N, Oshimura M, Sakurada A, Sato M, Kondo T, Matsuno S, Horii A.
    • Journal Title

      Lab Invest 84

      Pages: 1339-1351

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Infrequent somatic mutations of the ICAT gene in various human cancers with frequent 1p-LOH and/or abnormal nuclear accumulation of β-catenin.2004

    • Author(s)
      Imai M, Nakamura T, Akiyama T, Horii A.
    • Journal Title

      Oncol Rep 12

      Pages: 1099-1103

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Screening for functional tumor suppressor activity in pancreatic cancer.2004

    • Author(s)
      Lefter L, Scripcaru V, Sunamura M, Furukawa T, Matsuno S, Oshimura M, Drug V, Dragomir C, Horii A.
    • Journal Title

      Rom J Gastroenterol 13

      Pages: 195-201

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Loss of heterozygosity analyses of asynchronous lesions of ductal carcinoma in situ and invasive ductal carcinoma of the human breast.2003

    • Author(s)
      Aamari, M., Horiya, T., Ishida, T., Harada, Y., Ohnuki K., Takeda, M., Sasano, H., Horii, A., Ohuchi, N.
    • Journal Title

      Jpn J Clin Oncol 33

      Pages: 556-562

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Inserting chromosome 18 into pancreatic cancer cells switches them to a dormant metastatic phenotype.2003

    • Author(s)
      Lefter LP, Sunamura M, Furukawa T, Takeda K, Kotobuki N, Oshimura M, Matsuno S, Horii A
    • Journal Title

      Clin Cancer Res 9

      Pages: 5044-5052

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] APAF-l-ALT, a novel alternative splicing form of APAF-1, potentially causes impeded ability of undergoing DNA damage-induced apoptosis in the LNCaP human prostate cancer cell line.2003

    • Author(s)
      Ogawa T, Shiga K, Hashimoto S, Kobayashi T, Horii A, Furukawa T
    • Journal Title

      Biochem Biophys Res Commun 306

      Pages: 537-543

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells.2003

    • Author(s)
      Duda DG, Sunamura M, Lefter LP, Furukawa T, Yokoyama T, Yatsuoka T, Abe T, Inoue H, Motoi F, Egawa S, Matsuno S, Horii A
    • Journal Title

      Oncogene 22

      Pages: 6857-6864

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A yeast two-hybrid assay provides a simple way to evaluate the vast majority of hMLH1 germline mutations.2003

    • Author(s)
      Kondo E, Suzuki H, Horii A, Fukushige S
    • Journal Title

      Cancer Res 63

      Pages: 3302-3308

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer.2003

    • Author(s)
      Furukawa T, Sunamura M, Motoi F, Matsuno S, Horii A
    • Journal Title

      Am J Pathol 162

      Pages: 1807-1815

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Loss of heterozygosity on chromosome 16p and 18q in anaplastic thyroid carcinoma.2003

    • Author(s)
      Kadota M, Tamaki Y, Sekimoto M, Fujiwara Y, Aritake N, Hasegawa S, Kobayashi T, Ikeda T, Horii A, Monden M
    • Journal Title

      Oncol Rep 10

      Pages: 35-38

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Loss of heterozygosity analyses of asynchronous lesions of ductal carcinoma in situ and invasive ductal carcinoma of the human breast.2003

    • Author(s)
      Amari, M., Moriya, T., Ishida, T., Harada, Y., Ohnuki, K., Takeda, M., Sasano, H., Horii, A., Ohuchi, N.
    • Journal Title

      Jpn.J.Clin.Oncol. 33

      Pages: 556-562

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Inserting chromosome 18 into pancreatic cancer cells switches them to a dormant metastatic phenotype.2003

    • Author(s)
      Lefter, L.P., Sunamura, M., Furukawa, T., Takeda, K., Kotobuki, N., Oshimura, M., Matsuno, S., Horii, A.
    • Journal Title

      Clin.Cancer Res. 9

      Pages: 5044-5052

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] APAF-1-ALT, a novel alternative splicing form of APAF-1, potentially causes impeded ability of undergoing DNA damage-induced apoptosis in the LNCaP human prostate cancer cell line.2003

    • Author(s)
      Ogawa, T., Shiga, K., Hashimoto, S., Kobayashi, T., Horii, A., Furukawa, T.
    • Journal Title

      Biochem.Biophys.Res.Commun. 306

      Pages: 537-543

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells.2003

    • Author(s)
      Duda, D.G., Sunamura, M., Lefter, L.P., Furukawa, T., Yokoyama, T., Yatsuoka, T., Abe, T., Inoue, H., Motoi, F., Egawa, S., Matsuno, S., Horii, A.
    • Journal Title

      Oncogene 22

      Pages: 6857-6864

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A yeast two-hybrid assay provides a simple way to evaluate the vast majority of hMLH1 germline mutations.2003

    • Author(s)
      Kondo, E., Suzuki, H., Horii, A., Fukushige, S.
    • Journal Title

      Cancer Res. 63

      Pages: 3302-3308

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer.2003

    • Author(s)
      Furukawa, T., Sunamura, M., Motoi, F., Matsuno, S., Horii, A.
    • Journal Title

      Am.J.Pathol. 162

      Pages: 1807-1815

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Loss of heterozygosity on chromosome 16p and 18q in anaplastic thyroid carcinoma.2003

    • Author(s)
      Kadota, M., Tamaki, Y., Sekimoto, M., Fujiwara, Y., Aritake, N., Hasegawa, S., Kobayashi, T., Ikeda, T., Horii, A., Monden, M.
    • Journal Title

      Oncol.Rep. 10

      Pages: 35-38

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gene therapy for pancreatic cancer targeting the genomic alterations of tumor suppressor genes using replication-selective oncolytic adenovirus.2002

    • Author(s)
      Sunamura M, Oonuma M, Motoi F, Abe H, Saito U, Hoshida T, Ottomo S, Horii A, Matsuno S
    • Journal Title

      Hum Cell 15

      Pages: 138-150

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers2002

    • Author(s)
      Yokoi S, Yasui K, Saito-Ohara F, Koshikawa K, Iizasa T, Fujisawa T, Terasaki T, Horii A, Takahashi T, Hirohashi S, Inazawa J
    • Journal Title

      Am J Pathol 161

      Pages: 207-216

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A microarray-based method for detecting methylated loci.2002

    • Author(s)
      Hatada I, Kato A, Morita S, Obata Y, Nagaoka K, Sakurada A, Sato M, Horii A, Tsujimoto A, Matsubara K
    • Journal Title

      J Hum Genet 47

      Pages: 448-451

    • NAID

      50000580513

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis.2002

    • Author(s)
      Duda DG, Sunamura M, Lozonschi L, Yokoyama T, Yatsuoka T, Motoi F, Horii A, Tani K, Asano S, Nakamura Y, Matsuno S
    • Journal Title

      Br J Cancer 86

      Pages: 490-496

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines.2002

    • Author(s)
      Lefter LP, Furukawa T, Sunamura M, Duda D, Takeda K, Kotobuki N, Oshimura M, Matsuno S, Horii A
    • Journal Title

      Genes Chromosomes Cancer 27

      Pages: 234-242

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gene therapy for pancreatic cancer targeting the genomic alterations of tumor suppressor genes using replication-selective oncolytic adenovirus.2002

    • Author(s)
      Sunamura, M., Oonuma, M., Motoi, F., Abe, H., Saito, U., Hoshida, T., Ottomo, S., Horii, A., Matsuno, S.
    • Journal Title

      Hum.Cell 15

      Pages: 138-150

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.2002

    • Author(s)
      Yokoi, S., Yasui, K., Saito-Ohara, F., Koshikawa, K., Iizasa, T., Fujisawa, T., Terasaki, T., Horii, A., Takahashi, T., Hirohashi, S., Inazawa, J.
    • Journal Title

      Am.J.Pathol. 161

      Pages: 207-216

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A microarray-based method for detecting methylated loci.2002

    • Author(s)
      Hatada, I., Kato, A., Morita, S., Obata, Y., Nagaoka, K., Sakurada, A., Sato, M., Horii, A., Tsujimoto, A., Matsubara, K.
    • Journal Title

      J.Hum.Genet. 47

      Pages: 448-451

    • NAID

      50000580513

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Overexpression of the p53-inducible brain-specific angiogenesis inhibitor l suppresses efficiently tumour angiogenesis.2002

    • Author(s)
      Duda, D.G., Sunamura, M., Lozonschi, L., Yokoyama, T., Yatsuoka, T., Motoi, F., Horii, A., Tani, K., Asano, S., Nakamura, Y., Matsuno, S.
    • Journal Title

      Br.J.Cancer 86

      Pages: 490-496

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines.2002

    • Author(s)
      Lefter, L.P., Furukawa, T., Sunamura, M., Duda, D.G., Takeda, K., Kotobuki, N., Oshimura, M., Matsuno, S., Horii, A.
    • Journal Title

      Genes Chromosomes Cancer 27

      Pages: 234-242

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Allelic loss of the NF1 gene in anal malignant melanoma in a patient with neurofibromatosis type 12001

    • Author(s)
      Ishii S, Han S, Shiiba K, Mizoi T, Okabe M, Horii A, Nagura H, Matsuno S, Sasaki I
    • Journal Title

      Int J Clin Oncol 6

      Pages: 201-204

    • NAID

      10009601119

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Homozygous deletion in a neuroblastoma cell line defined by a high-density STS map spanning human chromosome band 1p36.2001

    • Author(s)
      Chen YZ, Soeda E, Yang HW, Takita J, Chai L, Horii A, Inazawa J, Ohki M, Hayashi Y
    • Journal Title

      Genes Chromosomes Cancer 31

      Pages: 326-332

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Germline mutation of the PTEN gene in a Japanese patient with Cowden's disease.2001

    • Author(s)
      Kato N, Kimura K, Sugawara H, Aoyagi S, Ikeda T, Horii A
    • Journal Title

      Int J Oncol 18

      Pages: 1017-1022

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The interacting domains of three MutL heterodimers in man : hMLH1 interacts with 36 homologous amino-acid residues within hMLH3, hPMS1 and hPMS2.2001

    • Author(s)
      Kondo E, Horii A, Fukushige S
    • Journal Title

      Nucl Acids Res 29

      Pages: 1695-1702

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene mutations in Japanese patients with chronic pancreatitis.2001

    • Author(s)
      Kaneko K, Nagasaki Y, Furukawa T, Mizutamari H, Sato A, Masamune A, Shimosegawa T, Horii A
    • Journal Title

      J Hum Genet 46

      Pages: 293-297

    • NAID

      50000889156

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A BAC-based STS-content map spanning a 35-megabase region of human chromosome 1p35-p36.2001

    • Author(s)
      Chen YZ, Hayashi Y, Wu JG, Takaoka E, Haekawa K, Watanabe N, Inazawa J, Hosoda F, Arai Y, Ohki M, Mizushima H, Morohoshi A, Ohira H, Nakagawara A, Liu S-Y, Hoshi M, Horii A, Soeda, E
    • Journal Title

      Genomics 74

      Pages: 55-70

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Exclusion of SMAD4 mutation as an early genetic change in human pancreatic ductal adenocarcinoma.2001

    • Author(s)
      Inoue H, Furukawa T, Sunamura M, Takeda K, Matsuno S, Horii A
    • Journal Title

      Genes Chromosomes Cancer 31

      Pages: 295-299

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Isolation and characterization of the human gene homologous to the Drosophila Headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer.2001

    • Author(s)
      Makino N, Yamato T, Inoue H, Furukawa T, Abe T, Yokoyama T, Yatsuoka T, Fukushige S, Orikasa S, Takahashi T, Horii A
    • Journal Title

      DNA Seq 11

      Pages: 547-553

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Human BAC contig covering the deleted region in pancreatic cancer at 12q21.2001

    • Author(s)
      Youssef EM, Kaneko K, Yatsuoka T, Hayashi Y, Hoshi M, Horii A, Furukawa T
    • Journal Title

      DNA Seq 11

      Pages: 541-546

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] RIZ, the retinoblastoma protein interacting zinc finger gene, is mutated in genetically unstable cancers of the pancreas, stomach, and colorectum.2001

    • Author(s)
      Sakurada K, Furukawa T, Kato Y, Kayama T, Huang S, Horii A
    • Journal Title

      Genes Chromosomes Cancer 30

      Pages: 207-211

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines.2001

    • Author(s)
      Sun C, Yamato T, Furukawa T, Ohnishi Y, Kijima H, Horii A
    • Journal Title

      Oncol Rep 8

      Pages: 89-92

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] requent nuclear accumulation of β-catenin (CTNNB1) in human pituitary adenoma.2001

    • Author(s)
      Semba S, Han S-Y, Ikeda H, Horii A
    • Journal Title

      Cancer 91

      Pages: 42-48

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Report of the sixth international workshop on human chromosome 1 mapping 2000.2001

    • Author(s)
      Schutte BC, Carpten JD, Forus A, Gregory SG, Horii A, White PS
    • Journal Title

      Cytogenet Cell Genet 92

      Pages: 23-41

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Allelic loss of the NFI gene in anal malignant melanoma in a patient with neurofibromatosis type 1.2001

    • Author(s)
      Ishii, S., Han, S., Shiiba, K., Mizoi, T., Okabe, M., Horii, A., Nagura, H., Matsuno, S., Sasaki, I.
    • Journal Title

      Int.J.Clin.Oncol. 6

      Pages: 201-204

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Homozygous deletion in a neuroblastoma cell line defined by a high-density STS map spanning human chromosome band Ip36.2001

    • Author(s)
      Chen, Y.Z., Soeda, E., Yang, H.W., Takita, J., Chai, L., Horii, A., Inazawa, J., Ohki, M., Hayashi, Y.
    • Journal Title

      Genes Chromosomes Cancer 31

      Pages: 326-332

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Germline mutation of the PTEN gene in a Japanese patient with Cowden's disease.2001

    • Author(s)
      Kato, N., Kimura, K., Sugawara, H., Aoyagi, S., Ikeda, T., Horii, A.
    • Journal Title

      Int.J.Oncol. 18

      Pages: 1017-1022

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The interacting domains of three MutL heterodimers in man : hMLH1 interacts with 36 homologous amino-acid residues within hMLH3, hPMS1, and hPMS2.2001

    • Author(s)
      Kondo, E., Horii, A., Fukushige, S.
    • Journal Title

      Nucl.Acids Res. 29

      Pages: 1695-1702

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Analysis of the human pancreatic secretory trypsin inhibitor (PST1) gene mutations in Japanese patients with chronic pancreatitis.2001

    • Author(s)
      Kaneko, K., Nagasaki, Y., Furukawa, T., Mizutamari, H., Sato, A., Masamune, A., Shimosegawa, T., Horii, A.
    • Journal Title

      J.Hum.Genet. 46

      Pages: 293-297

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] ABAC-basedSTS-contentmapspanninga35-megabase region of human chromosome 1p35-p36.2001

    • Author(s)
      Chen, Y.Z., Hayashi, Y., Wu, J.G., Takaoka, E., Maekawa, K., Watanabe, N., Inazawa, J., Hosoda, F., Arai, Y., Ohki, M., Mizushima, H., Morohoshi, A., Ohira, M., Nakagawara, A., Liu, S.-Y., Hoshi, M., Horii, A., Soeda, E.
    • Journal Title

      Genomics 74

      Pages: 55-70

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Exclusion of SMAD4 mutation as an early genetic change in human pancreatic ductal adenocarcinoma.2001

    • Author(s)
      Inoue, H., Furukawa, T., Sunamura, M., Takeda, K., Matsuno, S., Horii, A.
    • Journal Title

      Genes Chromosomes Cancer 31

      Pages: 295-299

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Isolation and characterization of the human gene homologous to the Drosophila Headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer.2001

    • Author(s)
      Makino, N., Yamato, T, Inoue, H., Furukawa, T., Abe, T., Yokoyama, T., Yatsuoka, T., Fukushige, S., Orikasa, S., Takahashi, T., Horii, A.
    • Journal Title

      DNA Seq. 11

      Pages: 547-553

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Human BAC contig covering the deleted region in pancreatic cancer at 12q21.2001

    • Author(s)
      Youssef, E.M., Kaneko, K, Yatsuoka, T., Hayashi, Y, Hoshi, M., Horii, A., Furukawa, T.
    • Journal Title

      DNA Seq. 11

      Pages: 541-546

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] RIZ, the retinoblastoma protein interacting zinc finger gene, is mutated in genetically unstable cancers of the pancreas, stomach, and colorectum.2001

    • Author(s)
      Sakurada, K., Furukawa, T., Kato, Y., Kayama, T., Huang, S., Horii, A.
    • Journal Title

      Genes Chromosomes Cancer 30

      Pages: 207-211

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines.2001

    • Author(s)
      Sun, C., Yamato, T., Furukawa, T., Ohnishi, Y., Kijima, H., Horii, A.
    • Journal Title

      Oncol.Rep. 8

      Pages: 89-92

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Frequent nuclear accumulation of (3)-catenin (CTNNBI) in human pituitary adenoma.2001

    • Author(s)
      Semba, S., Han, S.-Y., Ikeda, H., Horii, A.
    • Journal Title

      Cancer 91

      Pages: 42-48

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Report of the sixth international workshop on human chromosome l mapping 2000.2001

    • Author(s)
      Schutte, B.C., Carpten, J.D., Forus, A., Gregory, S.G., Horii, A., White, P.S.
    • Journal Title

      Cytogenet.Cell Genet. 92

      Pages: 23-41

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1.2000

    • Author(s)
      Saito A, Furukawa T, Fukushige S, Koyama S, Hoshi M, Hayashi Y, Horii A
    • Journal Title

      J Hum Genet 45

      Pages: 177-181

    • NAID

      10011570238

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification of a 7-cM region of frequent allelic loss on chromosome band 16p13.3 that is specifically associated with anaplastic thyroid carcinoma2000

    • Author(s)
      Kadota M, Tamaki Y, Sakita I, Komoike Y, Miyazaki M, Ooka M, Hasuda N, Fujiwara Y, Ohnishi T, Tomita N, Sekimoto M, Ohue M, Ikeda T, Kobayashi T, Horii A, Monden M
    • Journal Title

      Oncol Rep 7

      Pages: 529-533

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mutational analysis of the CTNNB1 (β-catenin) gene in human endometrial cancer : Frequent mutations at codon 34 that cause nuclear accumulation2000

    • Author(s)
      Ikeda T, Yoshinaga K, Semba S, Kondo E, Ohmori H, Horii A
    • Journal Title

      Oncol Rep 7

      Pages: 323-326

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Detailed deletion mapping of chromosome band 14q32 in human neuroblastoma defines a 1.1-Mb region of common allelic loss.2000

    • Author(s)
      Hoshi M, Otagiri N, Shiwaku HO, Asakawa S, Shimizu N, Kaneko Y, Ohi R, Hayashi Y, Horii A
    • Journal Title

      Br J Cancer 82

      Pages: 1801-1807

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Anticorresponding mutations of the KRAS and PTEN genes in human endometrial cancer.2000

    • Author(s)
      Ikeda T, Yoshinaga K, Suzuki A, Sakurada A, Ohmori H, Horii A
    • Journal Title

      Oncol Rep 7

      Pages: 567-570

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Degree of apoptosis induced by adenovirus-mediated transduction of p53 or p73alpha depends on the p53 status of glioma cells.2000

    • Author(s)
      Shinoura N, Muramatsu Y, Asai A, Han S, Horii A, Kirino T, Hamada H
    • Journal Title

      Cancer Lett 160

      Pages: 67-73

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Molecular cloning and expression of cDNA encoding chicken UDP-GlcNAc : GlcNAcβ1-6(GlcNAcβ1-2) Manα1-R[GlcNAc to Man]β1, 4N-acetylglucosaminyltransferase VI.2000

    • Author(s)
      Sakamoto Y, Taguchi T, Honke K, Korekane H, Watanabe H, Tano Y, Dohmae N, Takio K, Horii A, Taniguchi N
    • Journal Title

      J Biol Chem 275

      Pages: 36029-36034

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer.2000

    • Author(s)
      Yuki M, Yoshinaga K, Yamakawa H, Sakurada K, Sato S, Yajima A, Horii A
    • Journal Title

      Oncol Rep 7

      Pages: 1339-1342

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Frequent frameshift mutations of RIZ in sporadic gastrointestinal and endometrial carcinomas with microsatellite instability.2000

    • Author(s)
      Piao Z, Fang W, Malkhosyan S, Kim H, Horii A, Perucho M, Huang S
    • Journal Title

      Cancer Res 60

      Pages: 4701-4704

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Not hMSH2 but hMLH1 is frequently silenced by hypermethylation in endometrial cancer but rarely silenced in pancreatic cancer with microsatellite instability2000

    • Author(s)
      Kondo E, Furukawa T, Yoshinaga K, Kijima H, Semba S, Yatsuoka T, Yokoyama T, Fukushige S, Horii A
    • Journal Title

      Int J Oncol 17

      Pages: 535-541

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line.2000

    • Author(s)
      Ohira M, Kageyama H, Mihara M, Furuta S, Machida T, Shishikura T, Takayasu H, Islam A, Nakamura Y, Takahashi M, Tomioka N, Sakiyama S, Kaneko Y, Toyoda A, Hattori M, Sakaki Y, Ohki M, Horii A, Soeda E, Inazawa J, Seki N, Kuma H, Nozawa I, Nakagawara A
    • Journal Title

      Oncogene 19

      Pages: 4302-4307

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification of the homozygously deleted region at chromosome 1p36.2 in human neuroblastoma.2000

    • Author(s)
      Nakagawara A, Ohira M, Kageyama H, Mihara M, Furuta S, Machida T, Takayasu H, Islam A, Nakamura Y, Takahashi M, Shishikura T, Kaneko Y, Toyoda A, Hattori M, Sakaki Y, Ohki M, Horii A, Soeda E, Inazawa J, Seki N, Kuma H, Nozawa, I, Sakiyama, S
    • Journal Title

      Med Pediat Oncol 35

      Pages: 516-521

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Deletion mapping of 14q32 in human neuroblastoma defines an 1100-kb region of common allelic loss.2000

    • Author(s)
      Hoshi M, Shiwaku HO, Hayashi Y, Kaneko Y, Horii A
    • Journal Title

      Med Pediat Oncol 35

      Pages: 522-525

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Frequent loss of copy number on the long arm of chromosome 21 in human esophageal squamous cell carcinoma.2000

    • Author(s)
      Mayama T, Fukushige S, Shineha R, Nishihira T, Satomi S, Horii A
    • Journal Title

      Int J Oncol 17

      Pages: 245-252

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Analysis of the candidate target genes for mutation in microsatellite instability-positive cancers of the colorectum, stomach, and endometrium.2000

    • Author(s)
      Semba S, Ouyang H, Han S-Y, Kato Y, Horii A
    • Journal Title

      Int J Oncol 16

      Pages: 731-737

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma.2000

    • Author(s)
      Yatsuoka T, Sunamura M, Furukawa T, Fukushige S, Yokoyama T, Inoue H, Shibuya K, Takeda K, Hatsuno S, Horii A
    • Journal Title

      Am J Gastroent 95

      Pages: 2080-2085

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Degree of apoptosis induced by adenovirus-mediated transduction of p53 or p73alpha depends on the p53 status of glioma cells.2000

    • Author(s)
      Shinoura, N., Muramatsu, Y., Asai, A., Han, S., Horii, A., Kirino, T., Hamada, H.
    • Journal Title

      Cancer Lett. 160

      Pages: 67-73

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Molecular cloning and expression of cDNA encoding chicken UDP-GlcNAc : GlcNAcβ1-6(GlcNAcβ1-2)Mana1-R[GlcNActoMan]pi,4 N-acetylglucosaminyltransferase VI.2000

    • Author(s)
      Sakamoto, Y., Taguchi, T., Honke, K., Korekane, H., Watanabe, H., Tano, Y., Dohmae, N., Takio, K, Horii, A., Taniguchi, N.
    • Journal Title

      J.Biol.Chem. 275

      Pages: 36029-36034

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer.2000

    • Author(s)
      Yuki, M., Yoshinaga, K., Yamakawa, H., Sakurada, K., Sato, S., Yajima, A., Horii, A.
    • Journal Title

      Oncol.Rep. 7

      Pages: 1339-1342

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Frequent frameshift mutations of RIZ in sporadic gastrointestinal and endometrial carcinomas with microsatellite instability.2000

    • Author(s)
      Piao, Z., Fang, W., Malkhosyan, S., Kim, H., Horii, A., Perucho, M., Huang, S.
    • Journal Title

      Cancer Res. 60

      Pages: 4701-4704

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Not hMSH2but hMLH1 is frequently silenced by hypermethylation in endometrial cancer but rarely silenced in pancreatic cancer with microsatellite instability.2000

    • Author(s)
      Kondo, E., Furukawa, T., Yoshinaga, K., Kijima, H., Semba, S., Yatsuoka, T., Yokoyama, T., Fukushige, S., Horii, A.
    • Journal Title

      Int.J.Oncol. 17

      Pages: 535-541

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Deletion mapping of 14q32 in human neuroblastoma defines an 1100-kb region of common allelic loss.2000

    • Author(s)
      Hoshi, M., Shiwaku, H.O., Hayashi, Y., Kaneko, Y., Horii, A.
    • Journal Title

      Med.Pediat.Onco1. 35

      Pages: 522-525

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification of the homozygously deleted region at chromosome Ip36.2 in human neuroblastoma.2000

    • Author(s)
      Nakagawara, A., Ohira, M., Kageyama, H., Mihara, M., Furuta, S., Machida, T., Takayasu, H., Islam, A., Nakamura, Y., Takahashi, M., Shishikura, T., Kaneko, Y., Toyoda, A., Hattori, M., Sakaki, Y., Ohki, M., Horii, A., Soeda, E., Inazawa, J., Seki, N., Kuma, H., Nozawa, 1., Sakiyama, S.
    • Journal Title

      Med. Pediat. Onco1. 35

      Pages: 516-521

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification and characterization of a 500-kb homozygously deleted region at Ip36.2-p36.3 in a neuroblastoma cell line.2000

    • Author(s)
      Ohira, M., Kageyama, H., Mihara, M., Furuta, S., Machida, T., Shishikura, T., Takayasu, H., Islam, A., Nakamura, Y., Takahashi, M., Tomioka, N., Sakiyama, S., Kaneko, Y., Toyoda, A., Hattori, M., Sakaki, Y., Ohki, M., Horii, A., Soeda, E., Inazawa, J., Seki, N., Kuma, H., Nozawa, I., Nakagawara, A.
    • Journal Title

      0ncogene 19

      Pages: 4302-4307

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Frequent loss of copy number on the long arm of chromosome 21 in human esophageal squamous cell carcinoma.2000

    • Author(s)
      Mayama, T., Fukushige, S., Shineha, R., Nishihira, T., Satomi, S., Horii, A.
    • Journal Title

      Int.J.Oncol. 17

      Pages: 245-252

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Analysis of the candidate target genes for mutation in microsatellite instability-positive cancers of the colorectum, stomach, and endometrium.2000

    • Author(s)
      Semba, S., Ouyang, H., Han, S.-Y., Kato, Y., Horii, A.
    • Journal Title

      Int.J.Oncol. 16

      Pages: 731-737

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma.2000

    • Author(s)
      Yatsuoka, T., Sunamura, M., Furukawa, T., Fukushige, S., Yokoyama, T., Inoue, H., Shibuya, K., Takeda, K., Matsuno, S., Horii, A.
    • Journal Title

      Am.J.Gastroent. 95

      Pages: 2080-2085

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Anticorresponding mutations of the KRAS and PTEN genes in human endometrial cancer.2000

    • Author(s)
      Ikeda, T., Yoshinaga, K., Suzuki, A., Sakurada, A., Ohmori, H., Horii, A.
    • Journal Title

      Oncol.Rep. 7

      Pages: 567-570

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] p24/INGI ALTI and p47/ING1 ALTZ, distinct alternative transcripts of p33/INGI.2000

    • Author(s)
      Saito, A., Furukawa, T., Fukushige, S., Koyama, S., Hoshi, M., Hayashi, Y., Horii, A.
    • Journal Title

      J.Hum.Genet. 45

      Pages: 177-181

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification of a 7-cM region of frequent allelic loss on chromosome band 16p13.3 that is specifically associated with anaplastic thyroid carcinoma.2000

    • Author(s)
      Kadota, M., Tamaki, Y., Sakita, 1., Komoike, Y., Miyazaki, M., Ooka, M., Masuda, N., Fujiwara, Y., Ohnishi, T., Tomita, N., Sekimoto, M., Ohue, M., Ikeda, T., Kobayashi, T., Horii, A., Monden, M.
    • Journal Title

      Oncol.Rep. 7

      Pages: 529-533

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mutational analysis of the CTNNB1 (β-catenin) gene in human endometrial cancer : Frequent mutations at codon 34 that cause nuclear accumulation.2000

    • Author(s)
      Ikeda, T., Yoshinaga, K., Semba, S., Kondo, E., Ohmori, H., Horii, A.
    • Journal Title

      Oncol.Rep. 7

      Pages: 323-326

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Detailed deletion mapping of chromosome band 14q32 in human neuroblastoma defines a 1.1-Mb region of common allelic loss.2000

    • Author(s)
      Hoshi, M., Otagiri, N., Shiwaku, H.O., Asakawa, S., Shimizu, N., Kaneko, Y., Ohi, R., Hayashi, Y., Horii, A.
    • Journal Title

      Br.J.Cancer 82

      Pages: 1801-1807

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] The Role of DUSP6/HKP-3 in Pancreatic Carcinoma. In : Hayat MA (ed.) Handbook of immunohistochemistry and in situ hybridization of human carcinomas, volume 3 : Molecular genetics, liver carcinoma, and pancreatic carcinoma2005

    • Author(s)
      Furukawa T, Horii A
    • Publisher
      Elsevier (USA), Philadelphia, PA(in press)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] The Role of DUSP6/MKP-3 in Pancreatic Carcinoma In : Hayat MA (ed.) Handbook of immunohistochemistry and in situ hybridization of human carcinomas, volume 3: Molecular genetics, liver carcinoma, and pancreatic carcinoma.2005

    • Author(s)
      Furukawa T, Horii A.
    • Publisher
      Elsevier (USA), Philadelphia, PA (in press)
    • Related Report
      2004 Annual Research Report
  • [Publications] Sasaki Y, Niu C, Makino R, Kudo C, Sun C, Watanabe H, Matsunaga J, Takahashi K, Tagami H, Aiba S, Horii A.: "BRAF point mutations in primary malignant melanoma show different prevalences by subtype."J.Invest.Dermatol.. in press. (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Furukawa T, Horii A.: "Molecular pathology of pancreatic cancer : In quest of tumor suppressor genes."Pancreas. in press. (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sunamura M, Lefter LP, Duda DG, Morita R, Inoue H, Yokoyama T, Yatsuoka T, Abe T, Egawa S, Furukawa T, Fukushige S, Oshimura M, Horii A, Matsuno S: "The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma."Pancreas. in press. (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Lefter LP, Sunamura M, Furukawa T, Yastsuoka T, Abe H, Inoue H, Abe T, Egawa S, Miura K, Morita R, Horii A, Matsuno S: "Analysis of chromosome 18 in pancreatic cancer : strong evidence for new tumour suppressor genes."Asian J.Surg.. in press. (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Uchida H, Fujitani K, Kawai Y, Kitazawa H, Horii A, Shiiba K, Saito K, Saito T: "A new assay using surface plasmon resonance (SPR) to determine binding of Lactobacillus acidophilus group to human colonic mucin."Biosci.Biotecnnol.Biochem.. in press. (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hata T, Ogawa T, Yokoyama T, Fukushige S, Horii A, Furukawa T: "DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro."Int J Oncol.. 24. 513-520 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Amari M, Moriya T, Ishida T, Harada Y, Ohnuki K, Takeda M, Sasano H, Horii A, Ohuchi N: "Loss of heterozygosity analyses of asynchronous lesions of ductal carcinoma in situ and invasive ductal carcinoma of the human breast."Jpn.J.Clin.Oncol.. 33. 556-562 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Lefter LP, Sunamura M, Furukawa T, Takeda K, Kotobuki N, Oshimura M, Matsuno S, Horii A: "Inserting chromosome 18 into pancreatic cancer cells switches them to a dormant metastatic phenotype."Clin Cancer Res.. 9. 5044-5052 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kondo E, Suzuki H, Horii A, Fukushige S: "A yeast two-hybrid assay provides a simple way to evaluate the vast majority of hMLH1 germline mutations."Cancer Res. 63. 3302-3308 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Furukawa T, Sunamura M, Motoi F, Matsuno S, Horii A: "Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer."Am.J.Pathol. 162. 1807-1815 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kadota M, Tamaki Y, Sekimoto M, Fujiwara Y, Aritake N, Hasegawa S, Kobayashi T, Ikeda T, Horii A, Monden M: "Loss of heterozygosity on chromosome 16p and 18q in anaplastic thyroid carcinoma."Oncol.Rep. 10. 35-38 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Duda DG, Sunamura M, Lefter LP, Furukawa T, Yokoyama T, Yatsuoka T, Abe T, Inoue H, Motoi F, Egawa S, Matsuno S, Horii A: "Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatric adenocarcinoma cells."Oncogene. 22. 6857-6864 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ogawa T, Shiga K, Hashimoto S, Kobayashi T, Horii A, Furukawa T: "APAF-1-ALT, A Novel Alternative splicing form of APAF-1, potentially causes impeded ability of undergoing DNA damage-induced apoptosis in the LNCaP human prostate cancer cell line."Biochem.Biophys.Res.Commun.. 306. 537-543 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Furukawa, T., Sunamura, M., Horii, A., et al.: "Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer"Am.J.Pathol.. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Kondo, E., Horii, A., et al.: "Yeast two-hybrid assay provides a simple way to evaluate a vast majority of hMLH1 germline mutations"Cancer Res.. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Kadota, M., Horii, A.et al.: "Loss of heterozygosity on chromosome 16p and 18q in anaplastic thyroid carcinoma"Oncol.Rep.. 10. 35-38 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hatada, I., Horii, A.et al.: "A microarray-based method for detecting methylated loci"J.Hum.Genet.. 47. 448-451 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Lefter, L.P., Sunamura, M., Horii, A.et al.: "Suppression of the tumorigenic phenotype by chromosome 18transfer into pancreatic cancer cell lines"Genes Chromosomes Cancer. 27. 234-242 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yokoi, S., Horii, A.et al.: "A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers"Am.J.Pathol.. 161. 207-216 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Duda, D.G., Sunamura, M., Horii, A.et al.: "Brain specific angiogenesis inhibitor 1 mediates the p53 inhibitory effect on tumor angiogenesis by the downregulation of collagenase expression"Br.J.Cancer. 86. 490-496 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sunamura, M., et al.: "Gene therapy for pancreatic cancer based on its genetic characterization"J.Hep.Bil.Pancreat.Surg.. 9. 32-38 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Mikami, Y., Sunamura, M., et al.: "Peritoneal inflammatory cells in acute pancreatitis : Relationship of infiltration dynamics and cytokine production with severity of illness"Surgery. 132. 86-92 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hoshida, T., Sunamura, M., et al.: "Gene Therapy for pancreatic cancer using an adenovirus vector encoding soluble flt-1 vascular endothelial growth factor receptor"Pancreas. 25. 111-121 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Oonuma, M., Sunamura, M.et al.: "Gene therapy for intraperitoneally disseminated pancreatic cancers by Escherichia coli Uracil Phosphoribosiltransferase (UPRT) gene mediated by restricted replication-competent adenoviral vectors"Int.J.Cancer. 102. 51-59 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kadowaki, M., Yaegashi, N.et al.: "Prediction of the effects of gonadotropin-releasing hormone agonist therapy in uterine leiomyoma by contrast-enhanced magnetic resonance imaging sequences"Fertil.Steril.. 5. 1081-1082 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yokomizo, R., Yaegashi, N.et al.: "Erythropoietin and erythropoietin receptor expresiion in human endometrium throughout the menstrual cyst"Mol.Hum.Reproduct.. 8. 441-446 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Semba, S: "Frequent nuclear accumulation of b-catenin (CTNNB1) in human pituitary adenoma"Cancer. 91. 42-48 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sun, C.: "Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines"Oncol. Rep.. 8. 89-92 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sakurada, K.: "RIZ, the retinoblastoma protein interacting zinc finger gene, is mutated in genetically unstable cancers of the pancreas, stomach, and colorectum"Genes Chromosomes Cancer. 30. 207-211 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Youssef, E.M.: "Human BAC contig covering the deleted region in pancreatic cancer at 12q21"DNA Seq.. 11. 541-546 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Makino, N.: "Isolation and characterization of the human gene homologous to the Drosophila Headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer"DNA Seq.. 11. 547-553 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Inoue, H.: "Exclusion of SMAD4 mutation as an early genetic change in human pancreatic ductal adenocarcinoma"Genes Chromosomes Cancer. 31. 295-299 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Chen, Y.Z.: "A BAC-based STS-content map spanning a 35-megabase region of human chromosome 1p35-36"Genomics. 74. 55-70 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kaneko, K.: "Analysis of the human pancreatic secretory trypsin inhibitor (PST1) gene mutations in Japanese patients with chronic pancreatitis"J. Hum. Genet.. 46. 293-297 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kondo, E.: "The interacting domains of three MutL heterodimers in man : hMLH1 interacts with 36 homologous amino-acid residues within hMLH3, hPMS1, and hPMS2"Nucl. Acids Res.. 29. 1695-1702 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kato, N.: "Germline mutation of the PTEN gene in a Japanese patient with Cowden's disease"Int. J. Oncol.. 18. 1017-1022 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Chen, Y.Z.: "Homozygous deletion in a neuroblastoma cell line defined by a high-density STS map spanning human chromosome band 1p36"Genes Chromosomes Cancer. 31. 326-332 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ishii, S.: "Allelic loss of the NF1 gene in anal malignant melanoma in a patient with neurofibromatosis type 1"Int. J. Clin. Oncol.. 6. 201-204 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Lefter, L.P.: "Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines"Genes Chromosomes Cancer. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Duda, D.G.: "Overexpression of the p53-inducibIe brain-specific angiogenesis inhibitor 1 suppresses efficiently tumor angiogenesis"Br. J. Cancer. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Hoshi,M. et al.: "Detailed deletion mapping of chromosome band 14q32 in human neuroblastoma defines a 1.1-Mb region of common allelic loss."Br.J.Cancer. 82. 1801-1807 (2000)

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      2000 Annual Research Report
  • [Publications] Ikeda,T. et al.: "Mutational analysis of the CTNNB1 (β-catenin) gene in human endometrial cancer : Frequent mutations at codon 34 that cause nuclear accumulation."Oncol.Rep.. 7. 323-326 (2000)

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      2000 Annual Research Report
  • [Publications] Kadota,M. et al.: "Identification of a 7-cM region of frequent allelic loss on chromosome band 16p13.3 that is specifically associated with anaplastic thyroid carcinoma."Oncol.Rep.. 7. 529-533 (2000)

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      2000 Annual Research Report
  • [Publications] Saito,A. et al.: "p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1."J.Hum.Genet.. 45. 177-181 (2000)

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      2000 Annual Research Report
  • [Publications] Ikeda,T. et al.: "Anticorresponding mutations of the KRAS and PTEN genes in human endometrial cancer."Oncol.Rep.. 7. 567-570 (2000)

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      2000 Annual Research Report
  • [Publications] Yatsuoka,T. et al.: "Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma."Am.J.Gastroent.. 95. 2080-2085 (2000)

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      2000 Annual Research Report
  • [Publications] Semba,S. et al.: "Analysis of the candidate target genes for mutation in microsatellite instability-positive cancers of the colorectum, stomach, and endometrium."Int.J.Oncol.. 16. 731-737 (2000)

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  • [Publications] Mayama,T, et al.: "Frequent loss of copy number on the long arm of chromosome 21 in human esophageal squamous cell carcinoma."Int.J.Oncol.. 17. 245-252 (2000)

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      2000 Annual Research Report
  • [Publications] Ohira,M. et al.: "Identification and characterization of a 500-kb homozygously deleted-region at 1p36.2-p36.3 in a neuroblastoma cell line."Oncogene,, 2000s. 19. 4302-4307 (2000)

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  • [Publications] Nakagawara,A. et al.: "Identification of the homozygously deleted region at chromosome 1p36.2 in human neuroblastoma."Med Pediatr Oncol.. 35. 516-521 (2000)

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  • [Publications] Hoshi,M. et al.: "Deletion mapping of 14q32 in human neuroblastoma defines an 1100-kb region of common allelic loss."Med.Pediat.Oncol.. 35. 522-525 (2000)

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  • [Publications] Kondo,E. et al.: "Not hMSH2 but hMLH1 is frequently silenced by hypermethylation in endometrial cancer but rarely silenced in pancreatic cancer with microsatellite instability."Int.J.Oncol.,. 17. 535-541 (2000)

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  • [Publications] Piao,Z. et al.: "Frequent frameshift mutations of RIZ in sporadic gastrointestinal and endometrial carcinomas with microsatellite instability."Cancer Res.. 60. 4701-4704 (2000)

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  • [Publications] Yuki,M. et al.: "Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted retion in human endometrial cancer."Oncol.Rep.. 7. 1339-1342 (2000)

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  • [Publications] Sakamoto,Y. et al.: "Molecular cloning and expression of cDNA encoding chicken UDP-GlcNAc : GlcNAcβ1-6 (GlcNAcβ1-2) Manα1-R [GlcNAc to Man]β1,4N-acetylglucosaminyltransferase VI."J.Biol.Chem.. 275. 36029-36034 (2000)

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  • [Publications] Shinoura,N. et al.: "Degree of apoptosis induced by adenovirus -mediated transduction of p53 or p73 alpha depens on the p53 status of glioma cells."Cancer Lett.,. 160. 67-73 (2000)

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  • [Publications] Semba,S. et al.: "Frequent nuclear accumulation of β-catenin (CTNNB1) in human pituitary adenoma."Cancer. 91. 42-48 (2001)

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  • [Publications] Sun,C., et al.: "Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines."Oncol.Rep.. 8. 89-92 (2001)

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  • [Publications] Sakurada,K. et al.: "RIZ, the retinoblastoma protein interacting zinc finger gene, is mutated in genetically unstable cancers of the pancreas, stomach, and colorectum."Genes Chromosomes Cancer. 30. 207-211 (2001)

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  • [Publications] Schutte,B.C. et al.: "Report of the sixth international workshop on human chromosome 1 mapping 2000."Cytogenet.Cell Genet.. (in press).

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  • [Publications] Youssef,E.M. et al.: "Human BAC contig covering the deleted region in pancreatic cancer at 12q21."DNA Seq.. (in press).

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  • [Publications] Makino,N. et al.: "Isolation and characterization of the human gene homologous to the Drosophila Headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer."DNA Seq.. (in press).

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      2000 Annual Research Report
  • [Publications] Inoue,H. et al.: "Exclusion of SMAD4 mutation as an early genetic change in human pancreatic ductal tumorigenesis."Genes Chromosomes Cancer. (in press).

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      2000 Annual Research Report
  • [Publications] Chen,Y.Z. et al.: "A BAC-based STS-content map spanning a 35-megabase region of human chromosome 1p35-36."Genomics. (in press).

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      2000 Annual Research Report
  • [Publications] Kaneko,K. et al.: "Analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene mutations in Japanese patients with chronic pancreatitis."J.Hum Genet.. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Kondo,E. et al.: "The interacting domains of three MutL heterodimers in man : hMLH1 interacts with 36 homologous amino-acid residues within hMLH3,hPMS1, and hPMS2."Nucl.Acids Res.. (in press).

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Published: 2000-04-01   Modified: 2018-03-28  

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