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Human cancer vaccines

Research Project

Project/Area Number 12213116
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionSapporo Medical University

Principal Investigator

SATO Noriyuki  Sapporo Medical University School of Medicine, Professor, 医学部, 教授 (50158937)

Co-Investigator(Kenkyū-buntansha) 田村 保明  札幌医科大学, 医学部, 助手 (80322329)
佐原 弘益  札幌医科大学, 臨海研究所, 助手 (10260762)
Project Period (FY) 2000 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥50,300,000 (Direct Cost: ¥50,300,000)
Fiscal Year 2004: ¥10,500,000 (Direct Cost: ¥10,500,000)
Fiscal Year 2003: ¥10,700,000 (Direct Cost: ¥10,700,000)
Fiscal Year 2002: ¥11,000,000 (Direct Cost: ¥11,000,000)
Fiscal Year 2001: ¥10,100,000 (Direct Cost: ¥10,100,000)
Fiscal Year 2000: ¥8,000,000 (Direct Cost: ¥8,000,000)
Keywordstumor antigens / peptide vaccines / CTL / clinical trials / autologous tumor / Bioinformatics / survivin / SYT-SSX / 癌ワクチン / 癌抗原ペプチド / 胃癌抗原遺伝子 / 骨肉腫抗原遺伝子 / HLA-A24 / PBF / 肉腫 / 臨床試験 / 癌免疫 / 癌抗原処理提示 / 抗原ペプチド / hsc 70 / 分子シャペロン / ヒト癌抗原 / リカバリン / HLA-DR8
Research Abstract

Three research projects were successfully studied. 1) We identified human osteosarcoma antigen PBF, papilloma-binding factor, from autologous CTL and osteosarcoma OS2000 line. PBF was expressed in a large part of soft part tumors as well as approximately 50 % tumors of epithelial origins, whereas it was not detected in normal part of tissues particularly in the protein level. These observations suggest that PBF could be utilized in the immunotherapy of cancers. 2) Reverse-immunological approaches of tumor antigens indicated that survivin could work as the tumor antigens. Particularly, survivin-derived 2Bpeptide induced CTL in many cancer patients in the HLA-A24 restricted manner. We are now underway the phase I clinical trials of this peptide in colon, breast, lung cancers, indicating that there are no adverse effects. Some of these patients demonstrated certain clinical responses such as reduction in tumor size in CT as well as in tumor marker levels. We are also underway the phase I clinical trials of HLA-A24-restricted B peptide derived from the SYT-SSX chromosomal translocation fusion product in synovial sarcoma patients. In this trial, there are no adverse effects, and two out of six patients indicated an increasing number of tetramer-positive CTL precursors. 3) We identified 35 novel tumor antigens by bioinformatics in silico approaches. Wet studies by using RT-PCR analysis confirmed that 7 out of 35 antigens have strict expression profiles as the tumor antigens.

Report

(6 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (51 results)

All 2005 2004 2003 2002 Other

All Journal Article (17 results) Book (2 results) Patent(Industrial Property Rights) (3 results) Publications (29 results)

  • [Journal Article] Aberrant expression and potency as a cancer immunotherapy target of IAP family, Livin/ML-IAP in Lung Cancer.2005

    • Author(s)
      Hariu, H.
    • Journal Title

      Clin.Cancer Res. 11

      Pages: 1000-1009

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Aberrant expression and potency as a cancer immunotherapy target of IAP family, Livin/ML-IAP in Lung Cancer.2005

    • Author(s)
      Hariu, H., Hirohashi, Y., Torigoe, T., Tamura, Y., Aketa, K., Kitamura, H., Idenoue, S., Hariu, M., Kamiguchi, K., Mano, Y., Kanaseki, T., Tsukahara, T., Shijubo, N., Sato, N.
    • Journal Title

      Clin.Cancer Res. 11

      Pages: 1000-1009

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A potent immunogenic general cancer vaccine that targets survivin, an inhibitor of apoptosis proteins.2005

    • Author(s)
      Idenoue, S., Hirohashi, Y., Torigoe, T., Sato, Y., Tamura, Y., Hariu, H., Yamamoto, M., Kurotaki, T., Tsuruma, T., Asanuma, H., Kanaseki, T., Ikeda, H., Kashiwagi, K., Okazaki, M., Sasaki, K., Sato, T., Ohmura, T., Hata, F., Yamaguchi, K., Hirata, K., Sato, N.
    • Journal Title

      Clin.Cancer Res. 11

      Pages: 1474-82

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A calcium binding protein, S100A4, mediates T cell dependent cytotoxicity as a transformation-associated antigen.2005

    • Author(s)
      Kondo, N., Ichimiya, S., Tamura, Y., Tonooka, A., Koshiba, S., Torigoe, T., Kamiguchi, K., Takenaga, K., Sato, N.
    • Journal Title

      Microbiol.Immunol. 49

      Pages: 49-56

    • NAID

      10014377175

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Identification of human autologous cytotoxic T-lymphocyte-defined osteosarcoma gene that encodes a transcriptional regulator, papillomavirus binding factor.2004

    • Author(s)
      Tsukahara, T.
    • Journal Title

      Cancer Res. 64

      Pages: 5442-5448

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Tumor-derived heat shock protein70-pulsed dendritic cells elicit tumor-specific cytotoxic T lymphocytes (CTLs) and tumor immunity.2004

    • Author(s)
      Ueda, G.
    • Journal Title

      Cancer Science 95

      Pages: 248-253

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Phase I clinical study of anti-apoptosis protein, survivin-derived peptide vaccine therapy for patients with advanced or recurrent colorectal cancer.2004

    • Author(s)
      Tsuruma, T.
    • Journal Title

      J.Translational Med. 2

      Pages: 19-29

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Crisscross CTL induction by SYT-SSX junction peptide and its HLA-A^*2402 anchor substitute.2004

    • Author(s)
      Ida, K.
    • Journal Title

      J.Immunol. 173

      Pages: 1436-1443

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Regulation of MHC class II expression in glioma cells by class II transactivator (C IITA).2004

    • Author(s)
      Takamura, Y.
    • Journal Title

      Glia 45

      Pages: 392-405

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Identification of human autologous cytotoxic T-lymphocyte-defined osteosarcoma gene that encodes a transcriptional regulator, papillomavirus binding factor.2004

    • Author(s)
      Tsukahara, T., Nabeta, Y., Kawaguchi, S., Ikeda, H., Sato, Y., Shimozawa, K., Ida, K., Asanuma, H., Hirohashi, Y., Torigoe, T., Hiraga, H., Nagoya, S., Wada, T., Yamashita, T., Sato, N.
    • Journal Title

      Cancer Res. 64

      Pages: 5442-5448

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Tumor- derived heat shock protein70-pulsed dendritic cells elicit tumor- specific cytotoxic T lymphocytes (CTLs) and tumor immunity.2004

    • Author(s)
      Ueda, G., Tamura, Y., Hirai, I., Kamigichi, K., Ichimiya, S., Torigoe, T., Hiratsuka, H., Sunakawa, H., Sato, N.
    • Journal Title

      Cancer Science 95

      Pages: 248-253

    • NAID

      10013721926

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Phase I clinical study of anti-apoptosis protein, survivin-derived peptide vaccine therapy for patients with advanced or recurrent colorectal cancer.2004

    • Author(s)
      Tsuruma, T., Hata, F., Torigoe, T., Furuhata, T., Idenoue, S., Kurotaki, T., Yamamoto, M., Yagihashi, A., Ohmura, T., Yamaguchi, K., Katsuramaki, T., Yasoshima, T., Sasaki, K., Mizushima, Y., Minamida, H., Kimura, H., Akiyama, M., Hirohashi, Y., Asanuma, H., Tamura, Y., Shimozawa, K., Sato, N., Hirata, K.
    • Journal Title

      J.Translational Med. 2

      Pages: 19-29

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Crisscross CTL induction by SYT-SSX junction peptide and its HLA-A^*2402 anchor substitute.2004

    • Author(s)
      Ida, K., Kawaguchi, S., Sato, Y., Tsukahara, T., Nabeta, Y., Sahara, H., Ikeda, H., Torigoe, T., Ichimiya, S., Kamiguchi, K., Wada, T., Nagoya, S., Hiraga, H., Kawai, A., Ishii, T., Araki, N., Myoui, A., Matsumoto, S., Ozaki, T., Yoshikawa, H., Yamashita, T., Sato, N.
    • Journal Title

      J.Immunol. 173

      Pages: 1436-1443

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Regulation of MHC class II expression in glioma cells by class II transactivator (C II TA).2004

    • Author(s)
      Takamura, Y., Ikeda, H., Kanaseki, T., Toyota, M., Tokino, T., Imai, K., Hokin, K., Sato, N.
    • Journal Title

      Glia 45

      Pages: 392-405

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Tumor-derived heat shock protein70-pulsed dendritic cells elicit tumor-specific cytotoxic T lymohocytes (CTLs) and tumor immunity.2004

    • Author(s)
      Ueda, G.
    • Journal Title

      Cancer Science 95

      Pages: 248-253

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Heat shock proteins; Chaperoning of innate and adaptive immunities.2003

    • Author(s)
      Tamura, Y., Sato, N.
    • Journal Title

      Jpn.J.Hyperthermic Oncology 19

      Pages: 131-139

    • NAID

      10029675612

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Histone deacetylation, but not hypermethylation, modifies CIITA and MHC calss II gene expression in squamous cell carcinomas.2003

    • Author(s)
      Kanaseki, T., Ikeda, H., Takamura, Y., Toyota, M., Hirohashi, Y., Tokino, T., Himi, T., Sato, N.
    • Journal Title

      J.Immunol. 170

      Pages: 4980-4985

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Annual Review免疫2005;熱ショック蛋白質(HSP)-ペプチド複合体による新しいMHCクラスI抗原提示経路(佐藤昇志, 他編集)2005

    • Author(s)
      田村保明, 佐藤昇志
    • Total Pages
      8
    • Publisher
      中外医学社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Annual Review免疫2005;熱ショック蛋白質(HSP)-ペプチド複合体による新しいMHCクラスI抗原提示経路(佐藤昇志、他編集)2005

    • Author(s)
      田村保明, 佐藤昇志
    • Total Pages
      8
    • Publisher
      中外医学社
    • Related Report
      2004 Annual Research Report
  • [Patent(Industrial Property Rights)] サバイビン由来HLA-A24結合性癌抗原ペプチド2004

    • Inventor(s)
      佐藤 昇志 他 4名
    • Industrial Property Number
      2004-191478
    • Filing Date
      2004-01-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Patent(Industrial Property Rights)] サバイビン由来HLA-A24結合性癌抗原ペプチド2004

    • Inventor(s)
      佐藤 昇志 他4名
    • Industrial Property Rights Holder
      佐藤 昇志 他4名
    • Industrial Property Number
      2004-191478
    • Filing Date
      2004-01-30
    • Related Report
      2004 Annual Research Report
  • [Patent(Industrial Property Rights)] SYT-SSX改変ペプチド2002

    • Inventor(s)
      佐藤 昇志 他 7名
    • Industrial Property Number
      2002-350633
    • Filing Date
      2002-12-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Ida, K., Sato, N., et al.: "Improved induction of synovial sarcoma-reactive CTLs by SYT-SSX junction peptide/HLA-A*2402 complex anchor substitution."J.Immunol.. in press.

    • Related Report
      2003 Annual Research Report
  • [Publications] Idenoue, S., Sato, N., et al.: "A potent immunogenic general cancer vaccine that targets survivin, an inhibitor of apoptosis proteins."Clin.Cancer Res.. in press.

    • Related Report
      2003 Annual Research Report
  • [Publications] Ueda, G., Tamura, Y., Sato, N., et al.: "Tumor-derived Heat Shock Protein70-pulsed Dendritic Cells Elicit Tumor-specific Cytotoxic T Lymphocytes (CTLs) and Tumor Immunity."Cancer Science. 95・3. 248-253 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takamura, Y., Ikeda, H., Sato, N., et al.: "Regulation of MHC class II expression in glioma cells by class II transactivator (C II TA)."Glia. 45. 392-405 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tamura, Y., Sato, N.: "Heat shock proteins ; Chaperoning of innate and adaptive immunities."Jpn.J.Hyperthermic Oncology. 19. 131-139 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kanaseki, T., Sato, N., et al.: "Histone deacetylation, but not hypermethylation, modifies CIITA and MHC calss II gene expression in squamous cell carcinomas."J.Immunol.. 170. 4980-4985 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 佐藤百合子, 井田和功, 川口 哲, 佐藤昇志: "Annual Review 2003 染色体転座融合蛋白を標的とした癌治療"中外医学社. 6 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sato, Y., et al.: "Detection and induction of cytotoxic T lymphocytes specific for STY-SSX-derived peptides in HLA-A24+ patients with synovial sarcoma"J. Immunol.. 169. 1611-1618 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Maeda, A., et al.: "Vaccination with recoverin, a cancer-associated retinopathy antigen, induces autoimmune retinal dysfunction and tumor cell regression in mice"Eur. J. Immunol.. 32. 2300-2307 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hirohashi, Y., et al.: "An HLA-A24-restricted CTL epitope of a tumor asscoated protein, survivin"Clin. Cancer Res.. 8. 1731-1739 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Rong, S., et al.: "Frequent detection of anti-recoverin cytotoxic T-lymphocytes precursor in peripheral blood of cancer patients by using an HLA-A24-recoverin-tetramer"Cancer Immunol. Immunother.. 51. 282-290 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kondo, H., et al.: "Natural antigenic peptides from squamous cell carcinoma recognized by autologous HLA-DR8-restricted CD4+ T cells"Jap. J. Cancer Res.. 93. 917-924 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sahara, H., et al.: "A gene encoding human gastric signet ring cell carcinoma antigen recognized by HLA-A31-restricted cytotoxic T lymphocytes"J. Immunother.. 25. 235-242 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 佐藤 昇志他: "Annual Review 2002 免疫"中外医学社. 350 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shigehara, K.et al.: "IL-12 and IL-18 are increased and stimulate IFN-g production in sarcoid lungs"J.Immunol.. 166. 642-649 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kishi, A.et al: "The cell surface-expressed HSC70-like molecule preferentially reacts with rat T cell receptor d6 family"Immunogenetics. 53. 401-409 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Maeda, A.et al.: "Identification of human antitumor cytotoxic T lymphocytes epitopes of recoverin,cancer associated retinopathy antige,to achieve a clinical better prognosis in a paraneoplastic syndrome"Eur.J.Immunol.. 31. 563-572 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sahara, H.et al.: "A gene encoding human gastric signete ring cell carcinoma antigen recognized by HLA-A-A31-restricted cytotoxic T lymphocytes"J.Immunother. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Rong, S.et al.: "Frequent detection of anti-recoverin cytotoxic T-lymphocytes precursor in peripheral blood of cancer patients by using an HLA-A24-recoverin-tetramer"Cancer Immunol.Immunother.. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Sato, Y.et al.: "Detection and induction of cytotoxic T lymphocytes specific for SYT-SSX-derived peptides in HLA-A24+patients with synovial sarcoma"J.Immunol.. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] 分担執筆;佐藤昇志: "Annual Review免疫2002"中外医学社. 310 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Maeda,A.,Ohguro,H.,Maeda,T.,Wada.T.,Sato,N.,Kuroki,Y. and Nakagawa,T.: "Aberrant expression of photoreceptor specific calcium binding protein (recoverin) in cancer cell lines."Cancer Res.. 60. 1914-1920 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Maeda,A.,Ohguro,H.,Nabeta,Y.,Nishimura,Y.,Kuroki,Y.,Sato,N. et al.: "Identification of human antitumor cytotoxic T lymphocytes epitopes of recoverin, cancer associated retinopathy antige, to achieve a clinical better prognosis in a paraneoplastic syndrome."Eur.J.Immunol.. 31. 563-572 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Matsuura,A.,Kinebuchi,M.,Chen,H.Z,Kikuchi,K,Sato,N. et al.: "NK T cells in the rat : organ-specific distribution on NK T cells expressing distinct Va14 chains."J.Immunol.. 164. 3140-3148 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nabeta,Y.,Sahara,H.,Suzuki,K.,WadaT.,Kikuchi,K.,Sato,N. et al.: "Induction of CTL from peripheralblood of HLA-A31(+) gastric cancer patients by in vitro stimulation with antigenic peptide of signet ring cell carcinoma."Jap.J.Cancer. 91. 616-621 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shigehara,K.,Shujubo,N.,Ohmichi,M.,Abe,S.,Sato,N. et al.: "IL-12 and IL-18 are increased and stimulate IFN-γ production in sarcoid lungs."J.Immunol.. 166. 642-649 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kamiguchi,K.,Torigoe,T.,Fujiwara,O.,Hirohashi,Y.,Sahara,H.,Hiraii,I.,Sato.N.: "73kD heat shock cognate protein in associated with transporters associated with antigen processing (TAP) and involved in feeding of MHC class I-presentable antigenic peptides to TAP."J.Immunol.. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Sato,N.,Nabeta,Y.,Kondo,H.,Sahara,H.,Takahashi,S.,Torigoe,T. et al.: "Cancer Chemother.Pharmacol."Human CD8 and CD4T cell epitope of epithelial cancer antigens.. 4 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 佐藤昇志,矢田純一,奥村康: "中外医学社"Annual Review免疫2000. 354 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2018-03-28  

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