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生活習慣要因と大腸がんに関する患者対照研究

Research Project

Project/Area Number 12218226
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyushu University

Principal Investigator

古野 純典  九州大学, 大学院・医学研究院, 教授 (70128015)

Co-Investigator(Kenkyū-buntansha) 掛地 吉弘  九州大学, 大学病院, 助教授 (80284488)
壬生 隆一  九州大学, 大学院・医学研究院, 教授 (20200107)
和田 守正  九州大学, 大学院・医学研究院, 助教授 (20220965)
安波 洋一  福岡大学, 医学部, 助教授 (00166521)
池田 典昭  九州大学, 大学院・医学研究院, 教授 (60176097)
池田 陽一  九州大学, 医学部・附属病院, 助手 (50311840)
佐々木 淳  福岡大学, 医学部, 助教授 (90122697)
Project Period (FY) 2000 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥143,800,000 (Direct Cost: ¥143,800,000)
Fiscal Year 2004: ¥28,200,000 (Direct Cost: ¥28,200,000)
Fiscal Year 2003: ¥28,600,000 (Direct Cost: ¥28,600,000)
Fiscal Year 2002: ¥30,000,000 (Direct Cost: ¥30,000,000)
Fiscal Year 2001: ¥29,000,000 (Direct Cost: ¥29,000,000)
Fiscal Year 2000: ¥28,000,000 (Direct Cost: ¥28,000,000)
Keywords大腸がん / 遺伝子多型 / 食物栄養 / 症例対照研究 / 生活習慣 / 食物 / 患者対照研究 / 生活習慣要因 / 大腸線種 / ライフスタイル / 栄養 / 遺伝子
Research Abstract

生活習慣要因および遺伝的要因(遺伝子多型)と大腸がんとの関連を検討する目的で大腸がんの患者対照研究をおこなった。対象は福岡市と近郊3地域に居住する者である。患者群は手術目的で調査地域の8つの病院に入院した大腸がん患者である。対照は調査地域で無作為に選ばれた住民である。面接調査により食物摂取を含む生活習慣を調査し、遺伝子解析のために血液提供を受けた。患者の調査は2000〜2003年の期間に、対照の調査は2001〜2002年の期間におこなった。合計で840名の患者と833名の対照から調査協力を受けた。患者および対照の協力率はそれぞれ80%と60%であった。遺伝子解析の同意は患者685名と対照778名から受けることができた。遺伝子多型解析の結果、葉酸が大腸がんに予防的であること、胆汁酸生合成酵素の遺伝子多型の解析では右側結腸がんに胆汁酸が関与していることが明らかになった。また、運動不足と肥満が特に結腸がんの危険因子であること、飲酒が大腸がんの危険度を高めること、喫煙が大腸発がんの早い時期に関与していること、大腸ポリープ切除が直腸がんおよび左側結腸がんに予防的であることが判明した。5訂食品成分表を使用するために食事調査の解析が若干遅れていたが、食事調査の妥当性検討が済み、食物・栄養素と大腸がんとの関連について結果をとりまとめた。また、そのほかの働きが知られている遺伝子多型についても解析を進めた。

Report

(5 results)
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (29 results)

All 2005 2004 Other

All Journal Article (6 results) Publications (23 results)

  • [Journal Article] Dietary patterns and colorectal adenomas in Japanese men : The Self-Defense Forces Health Study.2005

    • Author(s)
      Mizoue T
    • Journal Title

      Am J Epidemiol 161(4)

      Pages: 338-345

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Genetic polymorphism in cytochrome P450 (GYP) 7A1 and risk of colorectal cancer : The Fukuoka Colorectal Cancer Study.2005

    • Author(s)
      Hagiwara T
    • Journal Title

      Cancer Res (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Secular trend of colon cancer incidence and mortality in relation to fat and meat intake in Japan.2004

    • Author(s)
      Kono S
    • Journal Title

      Eur J Cancer Prev 13(2)

      Pages: 127-132

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A case-control study of colorectal cancer in relation to lifestyle factors and genetic polymorphisms : Design and conduct of the Fukuoka Colorectal Cancer Study.2004

    • Author(s)
      Kono S
    • Journal Title

      Asian Pacific J Cancer Prev 5(4)

      Pages: 393-400

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Methylenetetrahydrofolate reductase polymorphism, alcohol intake, and risks of colon and rectal cancers in Korea.2004

    • Author(s)
      Kim DH
    • Journal Title

      Cancer Lett 216(2)

      Pages: 199-205

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and colorectal cancer : The Fukuoka Colorectal Cancer Study.2004

    • Author(s)
      Yin G
    • Journal Title

      Cancer Sci 95(11)

      Pages: 908-913

    • Related Report
      2004 Annual Research Report
  • [Publications] Toyomura K, Kono S 他: "Relation of cigarette smoking and alcohol use to colorectal adenomas by subsite : The Self-Defense Forces Health Study."Cancer Sci. 95(1). 72-76 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Taniguchi S, Kono S 他: "Genetic polymorphisms at the 5' regulatory region of multidrug resistance 1 (MDR1) and its association with interindividual variation..."Mol Cancer Ther. 2(12). 1351-1359 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kono S: "Secular trend of colon cancer incidence and mortality in relation to fat and meat intake in Japan."Eur J Cancer Prev. 13(2)(印刷中). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Iwashita M, Kono S 他: "Relation of serum total cholesterol and other risk factors to risk of coronary events in middle-aged and elderly Japanese men with hypercholesterolemia."Circ J. 68(5)(印刷中). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sasaki J, Kono S 他: "Reduction in serum total cholesterol and risks of coronary events and cerebral infarction in Japanese men."Circ J. 67(6). 473-478 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Teramukai S, et al.: "Anthropometric and behavioral correlates of insulin-like growth factor I and insulin-like growth factor binding protein 3 in middle-aged Japanese men"American Journal of Epidemiology. 156(4). 344-348 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Teramukai S, et al.: "Insulin-like growth factor (IGF)-I, IGF-binding protein-3 and colorectal adenomas in Japanese men"Japanese Journal of Cancer Research. 93(11). 1187-1194 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Marugame T, et al.: "Relation of impaired glucose tolerance and diabetes mellitus to colorectal adenomas"Cancer Causes and Control. 13(10). 917-921 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Miyake Y, et al.: "Glucose intolerance and serum aminotransferase activities in Japanese men"Journal of Hepatology. 38(1). 18-23 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Lee KY, et al.: "Validity of a self-administered food frequency questionnaire against 7-day dietary records in four seasons"J Nutr Sci Vitaminol. 48(6)(印刷中). (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Marugame T, et al.: "Relation of plasma folate and methylenetetrahydrofolate reductase C677T polymorphism to colorectal adenomas"International Journal of Epidemiology. (印刷中).

    • Related Report
      2002 Annual Research Report
  • [Publications] Nishii T, et al.: "Glucose intolerance, plasma insulin levels, and colon adenomas in Japanese men"Japanese Journal of Cancer Research. 92(8). 836-840 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nagano J, et al.: "A prospective study of green tea and cancer incidence, Hiroshima and Nagasaki (Japan)"Cancer Causes and Control. 12(6). 501-508 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nagano J, et al.: "Lung cancer, myocardial infarction, and the Grossarth-Maticek personality types : a case-control study in Fukuoka, Japan"Journal of Epidemiology. 11(6). 281-287 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kono S.: "All epidemiological evidence is important in colorectal cancer [letter]"British Medical Journal. 322(7286). 611 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kono S.: "Green tea and gastric cancer in Japan [letter]"New England Journal of Medicine. 344(24). 1867 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kono S, et al.: "Cigarette smoking, alcohol use and gallstone risk in Japanese men"Digestion. (発表予定). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kono S, et al.: "Vegetables, Cereals and colon cancer mortality : long-term trend in Japan."European Journal of Cancer Prevention. 9. 363-365 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hoshiyama Y, et al.: "Relation of cigarette smoking, alcohol use, and dietary habits to colon adenomas : a case-control study in Saitama, Japan."Asian Pacific Journal of Cancer Prevention. 1. 139-146 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Takeshita T, et al.: "Relationships between cigarette smoking, alcohol drinking, the ALDH2 genotypc and adenomatous types of colorectal polyps in male self-defense force officials."Journal of Epidemiology. 10. 366-371 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Marugame T. et al.: "Methylenetetrahydrofolate reductase polymorphism and risk of colorectal adenomas."Cancer Letters. 151. 181-186 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Inoue H, et al.: "Cigarette smoking, CTP1A1 MspI and GSTM1 genotypes, and colorectal adenomas."Cancer Research. 60. 3749-3752 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Inoue H, et al.: "Glutathione S-transferase polymorphisms and risk of colorectal adenomas."Cancer Letters. (発表予定). (2001)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2018-03-28  

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