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10nm-orderd 33D structures for bio-mechanical handling

Research Project

Project/Area Number 12305011
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field 機械工作・生産工学
Research InstitutionThe University of Tokyo

Principal Investigator

NAKAO Masayuki  The University of Tokyo, Graduate School of Engineering, Professor, 大学院・工学系研究科, 教授 (90242007)

Co-Investigator(Kenkyū-buntansha) TAKEUCHI Takatsugu  The University of Tokyo, Graduate School of Engineering, Research Associate, 大学院・工学系研究科, 助手 (10134470)
HATAMURA Yotaro  Kogakuin University, Department of Basic Engineering in Global Environment, Professor, 国際基礎工学科, 教授 (40010863)
MATSUMOTO Kiyoshi  The University of Tokyo, Graduate School of Information Science and Technology, Assoc. Professor, 大学院・情報理工学系研究科, 助教授 (10282675)
WASHIZU Masao  The University of Tokyo, Graduate School of Engineering, Professor, 大学院・工学系研究科, 教授 (10201162)
TANAKA Shinji  The University of Tokyo, Graduate School of Engineering, Lecturer, 大学院・工学系研究科, 講師 (00312611)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
Fiscal Year 2002: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2001: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Keywords3-dimensional fine structure / Biotechnology handling / Near-field optics / The electron beam depositing method / Focused ion beam machining method / DNA / 微小電極
Research Abstract

In this research, fabrication technology of the 3-dimensional nano structure was developed for the purpose of making detailed the tool which is used for fixing, operating and analyzing a minute living body substance to 10nm order We classified the 3-dimensional nano structure into shape of needlelike, tubular and granular structure.
To febrieate needlelihe structures, we developed the electron beam depositing (EBD) method which make carbon deposit using the beam of the scanning electron microscope. It was shown that using the φ20nm key-like probe forme at the tip of a glass needle by the EBD method, a part of single lambda-DNA molecule elongated on the hydrophobic substrate is reroverable. Moreover, by the EBD method, the needle of nano meter size was formed at the tip of a cantilever of an atomic foroe microscope, and this was applied to the scattering probe of a scanning near-field optical microscop. As a result of observing the sample in which the φ20nm bead and the φ200nm bead were intermingled, the scattening probe, which was φ10nm needle of amorphous carbon with a length of 1 micrometer, could obtain the optical image of the φ20nm bead near the φ200nm bead that was not obtained by the conventional scattering probe.
To fabricate tubular structures, we used detailed glass pipe and focused ion beam. Tubular structure of about 500nm of bores can be produced. Moreover, the system which generates the granular fine structure, using this tubular structure further was developed. The above-mentioned tubular structure (detailed pipet) was driven up and down using the piezo-electric element, and the system which form and gelates about φ1 micrometer droplets on a glass substrate was developed. Moreover, it was shown that a gnen is enclosed which this droplets and it can apply to the capsule for the transformations of a plant cell.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] 竹中良, 大井健, 中尾政之, 福井希一: "遺伝子封入用マイクロカプセルの開発"第6回化学とマイクロ・ナノシステム研究会講演予稿集. 51 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 竹中良, 大井健, 中尾政之, 長森英二, 福井希一: "遺伝子封入用マイクロカプセルの開発"医用電子と生体工学. 第40巻特別号. 81 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeshi OOI, Yusuke OKABE, Masayuki NAKAO, Keisuke IWATA: "Laminated electrodes chip for pulse-immunoassay"Micro Total Analysis Systems 2002. 121-123 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masaaki FUJISAKI, et al.: "ON-CHIP CULTURE FOR MONITORING SINGLE CELLS"EMBEC '02. 302-303 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kensuke Tsuchiya, Takeshi Ooi, Yuki Sakamaki, Masayuki Nakao: "High aspect ratio SNOM probe fabricated using Electron Beam Deposition and Focused Ion Beam"Proceedings from ASPE 2002 Annual Meeting. Vol.27. 20-23 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 中尾政之, 大井健, 土屋健介: "マイクロチップにナノチャネルを作る"BME(Bio Medical Engineering). 15・10. 57-62 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 中尾政之, 大井健: "ナノチャネルとナノツール"化学工業. 52・1. 18-22 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 藤岡聡太, 大井健, 中尾政之, 畑村洋太郎: "ナノメータサイズのプローブを用いた単一DNAの切断と断片の単離"医用電子と生体工学. 第39巻. 280 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 坂巻勇紀, 大井健, 中尾政之, 畑村洋太郎: "高アスペクト比散乱プローブを用いた近接場光学顕微鏡の開発"医用電子と生体工学. 第39巻. 278 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Ooi, et al.: "3D-nano Wire-frame for Handling and Observing a single DNA Probe"Proc. of MEMS.'00. 580-583 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 坂巻勇紀, 中尾政之: "高分解能で蛍光観察するための近接場光学顕微鏡の開発"1-73 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ryo Takenaka, Takashi Ooi, Masayuki Nakao, Kiichi Fukui: "Development of the microcapsule for gene enclosure"The 6th conference of chemistry and micro nano system. 51 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ryo Takenaka, Takashi Ooi, Masayuki Nakao, Eiji Nagamori, Kiichi Fukui: "Developemt of the microcapsule for gene enclosure"BME. 40. 81 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takashi OOI, Yusuke OKABE, Masayuki NAKAO, Keisuke IWATA: "Kaminated electrodes chip for pulse-immunoassay"Micro Total Analysis System. 121-123 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masayuki FUJISAKI, et.al: "ON-CHIP CULTURE FOR MONITORING SINGLE CELLS"EMBEC '02. 302-303 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kensuke Tsuchiya, Takeshi Ooi, Yuki Sakamaki, Masayuki Nakao: "High aspect ratio SMOM probe fabricated using Electron Beam Deposition and Focused Ion Beam"Proceedings from ASPE 2002 Annual Meeting. 27. 20-23 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masayuki Nakao, Takeshi Ooi, Kensuke Tsuchiya: "A nano channel is made to a microchip"BME(Bio Medical Engineering). 15 No.10. 57-62 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masayuki Nakao, Takeshi Ooi: "A nano channel and a nano tool"Chemical industry. 52 No.1. 18-22 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sota Fujioka, Takeshi Ooi, Masayuki Nakao, Yotaro Hatamura: "Cutting of single DNA and isolation of a firagment using the people of nano meter size"BME. 39. 280 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yuki Sakamaki, Takeshi Ooi, Masayuki Nakao, Yotaro Hatamura: "Development of the near-field optical microscope using a high aspect ratio scattening probe"BME. 39. 278 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Ooi, et.al: "3D-nano Wire-frame for Handling and Observing a single DNA Probe"Proc. Of MEMES '00. 580-583 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yuki Sakamaki, Masayuki Nakao: "Scanning Near-Field Optical Microscope to observe luminscent micro-parts with nanometer resolution"1-73 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 竹中良, 大井健, 中尾政之, 福井希一: "遺伝子封入用マイクロカプセルの開発"第6回化学とマイクロ・ナノシステム研究会講演予稿集. 51 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 竹中良, 大井健, 中尾政之, 長森英二福井希一: "遺伝子封入用マイクロカプセルの開発"医用電子と生体工学. 第40巻特別号. 81 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takeshi OOI, Yusuke OKABE, Masayuki NAKAO, Keisuke IWATA: "Laminated electrodes chip for pulse-immunoassay"Micro Total Analysis Systems 2002. 121-123 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Masaaki FUJISAKI, et al.: "ON-CHIP CULTURE FORM MOINITORING SINGLE CELLS"EMBEC '02. 302-303 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kensuke Tsuchiya, Takeshi Ooi, Yuki Sakamaki, Masayuki Nakao: "High aspect ratio SNOM probe fabricated using Electron Beam Deposition and Focused Ion Beam"Prcceedings from ASPE 2002 Annual Meeting. Vol.27. 20-23 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 坂巻勇紀, 大井健, 中尾政之, 畑村洋太郎: "高アスペクト比散乱プローブを用いた近接場光学顕微鏡の開発"医用電子と生体工学. 39巻特別号. 278 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 藤岡聡太, 大井健, 中尾政之, 畑村洋太郎: "ナノメータサイズのプローブを用いた単一DNAの切断と断片の単離"医用電子と生体工学. 39巻特別号. 280 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 中尾政之, 大井健: "ナノチャンネルとナノツール"化学工業. Vol.52 No.1. 18-22 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 中尾政之, 大井健, 土屋健介: "マイクロチップにナノチャンネルを作る"BME(Bio Medical Engineering). Vol.15 No.10. 57-62 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Ooi, et.al.: "3D-nano Wire-frame for Handling and Observing a single DNA Probe"Proc.of MEMS.'00. 580-583 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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