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Analysis of the species specific pathogenicity of morbillivirus by reverse genetics.

Research Project

Project/Area Number 12306014
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionThe University of Tokyo

Principal Investigator

KAI Chieko  The University of Tokyo, Institute of Medical Science, Professor, 医科学研究所, 教授 (10167330)

Co-Investigator(Kenkyū-buntansha) TUJIMOTO Hajime  The University of Tokyo, Graduate School of Agriculture and Life Sciences, Professor, 大学院・農学生命科学研究科, 教授 (60163804)
NAKAYAMA Hiroyuki  The University of Tokyo, Graduate School of Agriculture and Life Sciences, Associate Professor, 大学院・農学生命科学研究科, 助教授 (40155891)
MIURA Ryuichi  The University of Tokyo, Institute of Medical Science, Research Associate, 医科学研究所, 助手 (00322074)
KOHARA Kyoko  The University of Tokyo, Institute of Medical Science, Lecturer, 医科学研究所, 講師 (20225478)
YAMANOUCHI Kazuya  Nippon Institute for Biological Science, Senior Researcher, 研究部, 主任研究員 (30072888)
遠藤 泰之  東京大学, 医科学研究所, 助手 (90332600)
Project Period (FY) 2000 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥47,770,000 (Direct Cost: ¥39,700,000、Indirect Cost: ¥8,070,000)
Fiscal Year 2003: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2002: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2001: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2000: ¥12,800,000 (Direct Cost: ¥12,800,000)
Keywordsmononega virus / new reverse genetics / rinderpest virus / canine distemper virus / 新リバースジェネティクス系 / CDV / リバースジェネティクス / RPV / 欠損ウイルス / レプリコン / 組み換えウイルス
Research Abstract

Emerging and reemerging virus infection by the mono-nega virus pose a social problem globally, and the elucidation of the infection mechanism exceeding the animal species considered to be the factor is a big proposition. Canine distemper virus (CDV) made 20,000 seals and 1000 lion numbers die in recent years. We have done abundant fundamental researches from epidemiology investigation with virus isolation, a gene analysis, antibody production, and the animal experiment to this problem. Moreover, although rinderpest virus shows critical pathogenicity, an infection experiment with a cow is not easy and the mechanism of pathogenicity is not solved. In order to solve this fundamental proposition, we established the extremely excellent animal model experiment system of a rabbit, and have performed detailed analysis of the pathogenicity. The group with these backgrounds does not have an example in the world, either. Although the reverse genetics system was established by the monochrome negat … More ive virus recently, this new technology has only very few teams also in the world. We succeeded in development of this new technology by CDV and Rinderpest virus (RPV). Furthermore, about the measles virus (Measles virus; MV), it was established using the original wild strain. With those basic researches, we started the study on the viral pathogenicity and species specificity. Specifically, the following research item performed.
(1) Analysis of viral species specificity (2) Identification of a CDV receptor (3) Analysis of viral pathogenicity (4) Analysis of a host cell factor which participates in virus multiplication
We could obtain the many results including not also expected, and they direction to a big proposition about species-specific pathogenicity of the morbillivirus. Especially, about (1) and (4), it suggested that P protein was greatly concerned with the pathogenicity which exceeded the seed using the RBOK stock of RPV, and L stocks. Moreover, as protein which governs the pathogenicity of L stocks of inside, the possibility of N protein became clear. Moreover, (2), About (3), the new molecule in connection with infection of CDV surfaced, and the neutralization epitope on H protein combined with this was also analyzed. Moreover, CDV with the reporter gene was produced and identification of an infection susceptibility cell and importance of intervention arrangement were clarified. Thus, by this research, the knowledge of many important also for fundamental research could be acquired, and it was thought that the contribution of this research was large. Less

Report

(5 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (145 results)

All Other

All Publications (145 results)

  • [Publications] Wakasa., et al.: "Sequence analysis of the genes encoding the phophoprotein of recent isolates of canine distemper virus in Japan."J.Vet.Med Sci.. 62. 97-101 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Iwatsuki, K., et al.: "Antigenic differences in the H proteins of canine distemper viruses."Vet.Microbiol. 71. 281-286 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Miura, R., et al.: "Purification of recombinant canine granulocyte-macrophage colony stimulating factor produced by Sendai virus expression system."Proceedings of the International Veterinary Cytokine and Vaccine Conference. 230-233 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fujita, K., et al.: "Analysis of Canine interferon-gamma ecpressed by recombinant Sendai virus"Proceedings of the International Veterinary Cytokine and Vaccine Conference. 227-229 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohashi, K., et al.: "Properties of a new CDV isolate from a raccoon dog (Nyctereutes procyonoides viverrinus) in Japan."Vet.Record. 148. 148-150 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohashi, K., et al.: "Seroepidemiological survey of distemper virus infection in the Caspian Sea and in Lake Baikal."Vet.Micrbil. 82. 203-210 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shiotani, M., et al.: "Molecular properties of the matrixprotein(M) gene of the lapinized rinderpest virus."J.Vet.Med Sci. 63. 801-805 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yoneda, M., et al.: "Rinderpest virus H protein : role in determining host range in rabbits."J Gen Virol. 83(Pt6)2. 1457-1463 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirama, K.et al.: "Cytotoxic T-Lymphocyte Activity Specific for Hemagglutinin (H) Protein of Canine Distemper Virus in Dogs."J.Vet.Med.Sci.. 65. 109-112 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nishi, T., et al.: "Involvement of apoptosis in syncytial cell death induced by canine distemper virus."Comp.Immunol.Microbiol.Infect.Dis.. (in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nuntaprasert, A., et al.: "Expression and purification of recombinant swine interleukin-4"Comp.Immunol.Microbiol.Infect.Dis.. (in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nuntaprasert, A., et al.: "Characterization of specific antibodies and the establishment of sandwich ELISA and ELISPOT systems for swine IL-4"Comp.Immunol.Microbiol.Infect.Dis.. (in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yoneda, M., et al.: "Rinderpest virus phosphoprotein gene is major determinant of species-specific pathogenicity."Journal of Virology. (in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ikeda M., et al.: "Picryl chloride-induced allergic dermatitis in IQI/Jic female mice."Exp.Toxicol.Pathol.. 52. 235-240 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Jeong K.I., et al.: "Ultrastructural study on the follicle-associated lymphoid tissue in specific pathogen-free (SPF) and conventional environment-adapted (SPF-CV) rats."J.Anat.. 196. 443-451 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Katayama K., et al.: "Ethylnitrosourea (ENU)-induced apoptosis in the rat fetal tissues."Histol.Histopathol. 15. 707-711 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Albarenque S.M, et al.: "Kinetics of transforming growth factor (TGF)-E_1 mRNA in the dorsal skin of hypotrichotic WBN/ILA-Ht rats following topical application of T-2 toxin."Exp.Toxicol.Pathol.. 52. 297-301 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki J., et al.: "Autoimmune hemolytic anemia (AIHA) in an infant macaque (Macaca mulatta)"J.Med.Primatol.. 29. 88-94 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki K., et al.: "Renal tubulointerstitial lesions in mercuric chloride-treated F344 rats."J.Toxicol.Pathol.. 13. 213-218 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakayama H., et al.: "Fractal analysis of senile plaques observed in various animal spieces."Neurosci.Lett.. 297. 195-198 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kano R, et al.: "Isolation of Fusarium solani from a dog : identification by molecular."Med Mycol. 40(4). 435-437 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ueno M, et al.: "5-Azacytidine (5AzC)-induced histopathological changes in the central nervous system of rat fetuses."Exp Toxicol Pathol. 54(2). 91-96 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ueno M, et al.: "Expression of protein L4 (rpL4) during neurogenesis and 5-azacytidine (5AzC)-induced apoptotic process in the rat."Histol Histopathol. 17(3). 789-798 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Katayama K, et al.: "Expression of p53 and its transcriptional target genes mRNAs in the ethylnitrosourea-induced apoptosis and cell cycle arrest in the fetal central nervous system."Histol Histopathol. 17(3). 715-720 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Malcotti V, et al.: "Dorsal skin responses to subchronic ultraviolet B (UVB)-irradiation in Wistar-derived hypotrichotic WBN/ILA-Ht rats."Histol Histopathol. 17(3). 683-690 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Uchida, K., et al.: "Ganglioglioma in the thalamus of a puppy."J Vet.Sci. 65. 113-115 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takai, H.et al.: "Distribution of N-methyl-D-aspartate receptors (NMDARs) in the developing rat brain."Exp.Mole.Pathol.. 75. 89-94 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takai, H., et al.: "NMDA-induced apoptosis in the developing rat brain."Exp.Toxic Pathol.. 55. 33-37 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Uchida, K.et al.: "Age-related histological changes in the canine substantia nigra."J.Vet.Med.Sci.. 65. 179-185 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki, M., et al.: "A comparetive pathological study on canine necrotizing meningoencephalitis and granulomatous meningoencephomyelitis."J.Vet.Med.Sci.. 65. 1233-1239 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki, M., et al.: "A comparetive pathological study on granulomatous meningoencephalomyelitis and central malignant histiocytosis in dogs."J.Vet.Med.Sci.. 65. 1319-1324 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Su, W.P., et al.: "Susceptibility of primary culture neurons from rats of different ages to encephalomyocarditis (EMC) virus infection."Exp.Mol.Pathol.. 75. 160-164 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakayama, H., et al.: "A comparative study of age-related brain pathology -A neurodegenerative iseases present in nonhuman animals?"Med.Hypotheses. (in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Machida, K., et al.: "Inhibition of cytochrome c release in Fas-mediated signaling pathway in transgenic mice induced to express HCV proteins. Transgenic Mice Liver."J.Biol.Chem. 276. 12140-12146 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishida, S., et al.: "Icosahedral Hepatitis C Virus Core Particles Detected by Immunoelectron Microscopy and Rotation Technique."Hepatology Research.. 20. 335-347 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tsukiyama-Kohara, K, et al.: "Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1."Nature Medicine. 7. 1128-1132 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kashiwagi, T., et al.: "Kinetic analysis of C-terminally truncated RNA-dependent RNA polymerase of Hepatitis C virus."B.B.R.C. 290. 1188-1194 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirama, K., et al.: "Cytotoxic T-Lymphocyte Activity Specific for Hemagglutinin (H) Protein of Canine Distemper Virus in Dogs."JVMS. 65(1). 109-112 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanaka, T., et al.: "Virological significance of low level hepatitis B virus infection in patients with hepatitis C liver disease."J.Med.Virol.. 72. 223-229 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tsukiyama-Kohara, K., et al.: "Activation of the CKI-cdk-Rb-E2F Pathway in Full-Genome Hepatitis C Virus Expressing Cells."J.Biol.Chem.. 279(15). 14531-14541 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 甲斐 知恵子: "野生動物でのエマージングウイルス"SUT。東京理科大学出版会. 5 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 甲斐 知恵子: "ジステンバー"Info Vets. 4 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 井上貴文, 上間匡, 相原優子, 甲斐知恵子: "実験医学別冊「必ず上手くいく遺伝子導入と発現解析プロとコール」遺伝子銃による導入法"羊土社. 7 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 甲斐 知恵子: "「環境リスクマネージメントハンドブック」感染症流行による野生動物の減少"朝倉書店. 8 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 甲斐 知恵子: "2003年増刊「新世紀の感染症学」グローバル時代の感染症学、ニパウイルス感染症"日本臨床. 4 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Wakasa, C., Iwatsuki, K., Ohashi, K., Nakamura, K, Kai, C.: "Sequence analysis of the genes encoding the phophoprotein of recent isolates of canine distemper virus in Japan."J.Vet.Med.Sci.. 62. 97-101 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Iwatsuki, K., Tokiyoshi, S., Hirayama, N., Nakamura, K., Ohashi, K., Wakasa, C., Mikami, T, Kai, C.: "Antigenic differences in the H proteins of canine distemper viruses."Vet.Microbiol.. 71. 281-286 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Miura, R., Kato, A., Fujita, K., Sato, H., Shimizu, F., Ohashi, K., Yoneda, M., Nuntaprasert, A., Wakasa, C., Uema, M., Shiotani, M., Nishi, T., Takahashi, E., Kai C.: "Purification of recombinant canine granulocyte-macrophage colony stimulating factor produced by Sendai virus expression system"Proceedings of the International Veterinary Cytokine and Vaccine Conference. 1. 230-233 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fujita, K., Kato, A., Miura, R., Ohashi, K., Yoneda, M., Nuntaprasert, A., Wakasa, C., Uema, M., Shiotani, M., Nishi, T., Takahashi, E., Kai, C.: "Analysis of Canine interferon-gamma expressed by recombinant Sendai virus"Proceedings of the International Veterinary Cytokine and Vaccine Conference. 1. 227-229 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohashi, K., Iwatsuki, K., Murata, K., Miyashita, M., Hukumoto, Y., Nakamura, K., Wakasa, C., Takahashi, E., Kai C.: "Properties of a new CDV isolate from a raccoon dog (Nyctereutes procyonoides viverrinus) in Japan."Vet.Record. 148. 148-150 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohashi, K., Miyazaki, N., Tanabe, S., Nakata, H., Miura, R., Fujita, K., Wakasa, C., Uema, M., Shiotani, M., Takahashi, E., Kai, C.: "Seroepidemiological survey of distemper virus infection in the Caspian Sea and in Lake Baikal."Vet.Microbil.. 82. 203-210 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shiotani, M., Miura, R., Fujita, K., Wakasa, C., Uema, M., Kai, C.: "Molecular properties of the matrixprotein(M) gene of the lapinized rinderpest virus."J.Vet.Med.Sci.. 63. 801-805 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yoneda, M., Bandyopadhyay, S., Shiotani, M., Fujita, K., Nuntaprasert, A., Miura, R., Baron, M.D., Barrett, T., Kai.C.: "Rinderpest virus H protein: role in determining host range in rabbits."J Gen Virol.. 83(Pt 6). 1457-1463 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirama, K., Togashi, K., Wakasa, C., Yoneda, M., Nishi, T., Endo, Y., Miura, R., Tsukiyama-Kohara, K., Kai C.: "Cytotoxic T -Lymphocyte Activity Specific for Hemagglutinin (H) Protein of Canine Distemper Virus in Dogs."JVMS. 65(1). 109-112 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nishi, T., Tsukiyama-Kohara, K., Togashi, K., Kohriyama, N., Kai C.: "Involvement of apoptosis in syncytial cell death induce by canine distemper virus."Comp.Immunol.Microbiol.Infect.. (in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nuntaprasert, A., Mori, Y., Fujita, K., Yoneda, M., Miura, R., Tsukiyama-Kohara, K., Kai, C.: "Expression and purification of recombinant swine interleukin-4."Comp.Immunol.Micmbiol.Infect.Disk. (in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nuntaprasert, A., Mori, Y., Fujita, K., Yoneda, M., Miura, R., Tsukiyama-Kohara, K., Kai, C.: "Characterization of specific antibodies and the establishment of sandwich ELISA and ELISPOT systems for swine IL-4."Comp.immunol.Microbiol.Infect.. (in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yoneda, M., Miura, R., Barrett, T., Tsukiyama-Kohara, K., Kai, C.: "Rinderpest virus phosphoprotein gene is major determinant of species-specific pathogenicity."J.Virol.. (in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ikeda M., Kuroki K., Suzuki H., Nakayama H., Saegusa J., Doi K: "Picryl chloride-induced allergic dermatitis in IQI/lie female mice"Exp.Toxicol.Pathol. 52. 235-240 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Jeong K.I., Nakayama H., Doi K.: "Ultrastructural study on the follicle-associated lymphoid tissue in specific pathogen-free (SPF) and conventional environment-adapted (SPF-CV) rats."J.Anat.. 196. 443-451 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Katayama K., Ishigami N., Uetsuka K., Nakayama H., Doi K: "Ethylnitrosourea (ENU)-induced apoptosis in the rat fetal tissues."Histol.Histopathol.. 15. 707-711 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Albarenque S.M., Shinozuka J., Suzuki K., Nakayama H., Doi K.: "Kinetics of transforming growth factor (TGF)-E_1 mRNA in the dorsal skin of hypotrichotic WBN/ILA-Ht rats following topical application of T-2 toxin."Exp.Toxicol.Pathol.. 52. 297-301 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
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      2003 Final Research Report Summary
  • [Publications] Suzuki J., Gotoh S., Miwa N., Terao K, Nakayama H.: "Autoimmune hemolytic anemia (AIHA) in an infant macaque (Macaca mulatta)"J.Med.Primatol. 29. 88-94 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki K., Nakayama H., Doi K.: "Renal tubuiointer lesions in mercuric chloride-treated F344 rats"J.Toxicol.Pathol. 13. 213-218 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakayama H., Kiatipattanasakul W., Nakamura S., Miyawaki K., Kikuta F., Uchida K., Kuroki K., Makifuchi T., Yoshikawa Y., Doi K.: "Fractal analysis of senile plaques observed in various animal spieces."Neurosci.Lett.. 297. 195-198 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kano R, Okayama T, Hamamoto M, Nagata T, Ohno K, Tsujimoto H, Nakayama H, Doi K, Fujiwara K, Hasegawa A.: "Isolation of Fusarium solani from a dog : identification by molecular analysis."Med Mycol.. 40(4). 435-437 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ueno M, Katayama K, Yasoshima A, Nakayama H, Doi K.: "5-Azacytidine (5AzC)-induced histopathological changes in the central nervous system of rat fetuses."Exp Toxicol Pathol. 54(2). 91-96 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ueno M, Nakayama H, Kajikawa S, Katayama K, Suzuki K, Doi K.: "Expression of ribosomal protein L4 (rpL4) during neurogenesis and 5-azacytidine (5AzC)-induced apoptotic process in the rat."Histol Histopathol.. 17(3). 789-798 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Katayama K, Ohtsuka R, Takai H, Nakayama H, Doi K.: "Expression of p53 and its transcriptional target genes mRNAs in the ethylnitrosourea-induced apoptosis and cell cycle arrest in the fetal central nervous system."Histol Histopathol.. 17(3). 715-720 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Malcotti, V, Yasoshima, A, Imaoka, K, Nakayama H, Doi K.: "Dorsal skin responses to subchronic ultraviolet B (UVB)-irradiation in Wistar-derived hypotrichotic WBN/ILA-Ht rats."Histol Histopathol.. 17(3). 683-690 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Uchida K., Nakayama H., Endo Y., Kai C., Tatewaki S., Yamaguchi R., Doi K., Tateyama S.: "Ganglioglioma in the thalamus of a puppy."J.Vet.Med.Sci. 65. 113-115 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takai H., Katayama K., Uetsuka K., Nakayama H., Doi K.: "Distribution of N-methyl-D-aspartate receptors (NMDARs) in the developing rat brain."Exp.Mole.Pathol.. 75. 89-94 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takai H., Katayama K., Yasoshima A., Uetsuka K., Nakayama H., Doi K.: "NMDA-induced apoptosis in the developing rat brain."Exp.Toxic Pathol.. 55. 33-37 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Uchida K., Kihara N., Hashimoto K., Nakayama H., Yamaguchi R., Tateyama S.: "Age-related histological changes in the canine substantia nigra."J.Vet.Med.Sci.. 65. 179-185 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki M., Uchida K., Morozumi M., Hasegawa T., Yanai T., Nakayama H., Tateyama S.: "A comparative pathological study on canine necrotizing meningoencephalitis and granulomatous meningoencephalomyelitis."J.Vet.Med.Sci.. 65. 1233-1239 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Su, W.P., Ikegami, H., Nakayama, Y., Suzuki, K., Kate K., Nakayama, H., Doi, K.: "A comparative pathological study on granulomatous meningoencephalomyelitis and central malignant histiocytosis in dogs."J.Vet.Med.Sci.. 65. 1319-1324 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Su W.P., Ikegami H, Nakayama Y, Suzuki K, Katayama K, Nakayama H, Doi K.: "Susceptibility of primary culture neurons from rats of different ages to encephalomyocarditis (EMC) virus infection."Exp.Mol.Pathol.. 75. 160-164 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakayama, H., Uchida, K, Doi, K.: "A comparative study of age-related brain pathology -A neurodegenerative diseases present in nonhuman animals?"Med.Hypothese. (in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Machida, K., Tsukiyama-Kohara, K., Seike, E., Tone, S., Shibasaki, F., Shimizu, M., Takahashi, H., Hayashi, Y., Funada, N., Taya, C., Yonekawa, H., Kohara, M.: "Inhibition of Cytochrome C Release in Fas-mediated Signaling Pathway in Transgenic Mice Induced to Express Hepatitis C Viral Proteins."J.Biol.Chem. 276. 12140-12146 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishida, S., Kaito, M., Kohara, M., Tsukiyama-Kohora, K., Fujita, N., Ikoma, J., Adachi, Y., Watanabe, S.: "Icosahedral Hepatitis C Virus Core Particles Detected by Immunoelectron Microscopy and Rotation Technique."Hepatology Research. 20. 335-347 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tsukiyama-Kohara, K., Poulin, F., Kohara, M., DeMaria, C.T., Cheng, A., Wu, Z., Gingras, A.-C., Katsume, A., Elchebly, M., Spiegelman, B.M., Harper, M.-E., Tremblay, M.L., Sonenberg, N.: "Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1."Nature Medicine. 7. 1128-1132 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kashiwagi, T., Hara, K., Kohara, M., Kohara, K., Iwahashi, J., Hamada, N., Yoshino, H., Toyoda, T.: "Kinetic analysis of C-terminally truncated RNA-dependent RNA polymerase of Hepatitis C virus."B.B.R.C.. 290. 1188-1194 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanaka, T., Inoue, K., Hayashi, Y., Abe, A., Tsukiyama-Kohara, K., Nuriya, H., Aoki, Y., Kawaguchi, R., Kubota, K., Yoshiba, M., Koike, M., Tanaka, S., Kohara.M.: "Virological significance of low level hepatitis B virus infection in patients with hepatitis C liver disease."J.Med.Virol. 72. 223-229 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Tsukiyama-Kohara, S.Tone, I.Maruyama, K.Inoue, A.Katsume, H.Nuriya, H.Ohmori, J.Ohkawa, K.Taira, Hoshikawa, F.Shibasaki, M.Reth, Y.Minatogawa, M.Kohara: "Activation of the CKI-cdk-Rb-E2F Pathway in Full-Genome Hepatitis C Virus Expressing Cells."J.Biol.Chem. 279 (15). 14531-14541 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] "Emerging virus in wild animals."SUT. 5 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] "Distemper"Info.Vets.. 4 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] "Powerful protocol of gene transfer and characterization"Experimental Medicine. 7 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
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      2003 Final Research Report Summary
  • [Publications] "Decrease of wild animal by infectious diseases"Hand Book of Environmental Risk Management. 8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] "Nippon virus infection"Nippon Rinshyo. 4 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirama, K. et al.: "Lymphocyte Activity Specific for Hemagglutinin (H) Protein of Canine Distemper Virus in Dogs."J.Vet.Med.Sci.. 65. 109-112 (2003)

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      2003 Annual Research Report
  • [Publications] Nishi, T., et al.: "Involvement of apoptosis in syncytial cell death induced by canine distemper virus."Comp.Immunol.Microbiol.Infect.Dis.. (in press). (2004)

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      2003 Annual Research Report
  • [Publications] Nuntaprasert, A., et al.: "Expression and purification of recombinant swine interleukin-4."Comp.Immunol.Microbiol.Infect.Dis.. (in press). (2004)

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      2003 Annual Research Report
  • [Publications] Nuntaprasert, A., et al.: "Characterization of specific antibodies and the establishment of sandwich ELISA and ELISPOT systems for swine IL-4."Comp.Immunol.Microbiol.Infect.Dis.. (in press). (2004)

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      2003 Annual Research Report
  • [Publications] Yoneda, M. et al.: "Rinderpest virus phosphoprotein gene is major determinant of species-specific pathogenicity."Journal of Virology. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Uchida, K. et al.: "Ganglioglioma in the thalamus of a puppy."J.Vet.Med.Sci.. 65. 113-115 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takai, H. et al.: "Distribution of N-methyl-D-aspartate receptors (NMDARs) in the developing rat brain."Exp.Mole.Pathol.. 75. 89-94 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takai, H., et al.: "NMDA-induced apoptosis in the developing rat brain."Exp.Toxic Pathol.. 55. 33-37 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Uchida, K. et al.: "Age-related histological changes in the canine substantia nigra."J.Vet.Med.Sci.. 65. 179-185 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Suzuki, M., et al.: "A comparetive pathological study on canine necrotizing meningoencephalitis and granulomatous meningoencephomyelitis."J.Vet.Med.Sci.. 65. 1233-1239 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Suzuki, M., et al.: "A comparetive pathological study on granulomatous meningoencephalomyelitis and central malignant histiocytosis in dogs."J.Vet.Med.Sci.. 65. 1319-1324 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Su, W, P., et al.: "Susceptibility of primary culture neurons from rats of different ages to encephalomyocarditis (EMC) virus infection."Exp.Mol.Pathol.. 75. 160-164 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nakayama, H., et al.: "A comparative study of age-related brain pathology -A neurodegenerative iseases present in nonhuman animals?"Med.Hypotheses. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tanaka, T., et al.: "Virological significance of low level hepatitis B virus infection in patients with hepatitis C liver disease."J.Med.Virol.. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tsukiyama-Kohara, K., et al.: "Activation of the CKI-cdk-Rb-E2F Pathway in Full-Genome Hepatitis C Virus Expressing Cells."J.Biol.Chem.. (in press). (2004)

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      2003 Annual Research Report
  • [Publications] 井上貴文, 上間匡, 相原優子, 甲斐知恵子: "実験医学別冊「必ず上手くいく遺伝子導入と発現解析プロトコール」遺伝子銃による導入法"羊土社. 7 (2003)

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  • [Publications] 甲斐 知恵子: "「環境リスクマネージメントハンドブック」感染症流行による野生動物の減少"朝倉書店. 8 (2003)

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  • [Publications] 甲斐知恵子: "2003年増刊「新世紀の感染症学」グローバル時代の感染症学、ニパウイルス感染症"日本臨床. 4 (2003)

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  • [Publications] Yoneda M.et al.: "Rinderpest virus H protein : role in determining host range in rabbits"J. Gen. Virol.. 83(Pt6). 1457-1463 (2002)

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  • [Publications] Hirama K.et al.: "Lymphocyte Activity Specific for Hemagglutinin (H) protein of Canine Distemper Virus in Dogs"J.V.M.S.. 65. 109-112 (2003)

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      2002 Annual Research Report
  • [Publications] Nishigaki K.et al.: "Analysis of the disease potential of a recombinant retrovirus containing Friend murine leukemia virus"J. Virol.. 76(3). 1527-1532 (2002)

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  • [Publications] Masuda K.et al.: "Seasonal atopic dermatitis in dogs sensitive to a major allergen of Japanese cedar(Cryptomeria japonica)"Vet. Dermatol.. 13(1). 53-59 (2002)

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  • [Publications] Koga et al.: "Nucleotide sequence and expression of the feline vascular endothelial growth factor"J. Vet. Med. Sci. 64(5). 453-456 (2002)

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  • [Publications] Maeda et al.: "Lesional expression of thymus and activation-regulated chemokine in canine atopic dermatitis"Vet. lmmunol. lmmunopathol.. 6,88(1-2). 79-87 (2002)

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  • [Publications] Goto Y.et al.: "Association of plasma viral RNA load with prognosis in cats naturally infected with feline immunodeficiency virus"J. virol.. 76(19). 10079-10083 (2002)

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  • [Publications] Kubota et al.: "Parathyrod hormone-related protein(PTHrP)produced by dog lymphoma cells"J.V.M.S.. 64(9). 835-837 (2002)

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  • [Publications] Maeda S.et al.: "Expressin of CC chemokine receptor 4(CCR4)mRNA in canine atopic skin lesion"Vet. lmmunol. lmmunopathol.. 90(3-4). 145-154 (2002)

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  • [Publications] 小原 恭子: "代謝および脂肪分化制御における4E-BP1の新たな役割"実験医学. 4 (2002)

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  • [Publications] 甲斐 知恵子: "二パウイルス感染症"日本臨床 61巻 新世紀の感染症学(上). 4 (2003)

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  • [Publications] Shiotani, M., et al.: "Molecular properties of the matrixprotein(M) gene of the lapinized rinderpest virus"J Vet Med Sci.. 63(7). 801-805 (2001)

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  • [Publications] Ohashi, K. et al.: "Seroepidemiological survey of distemper virus infection in the Caspian Sea and in Lake Baikal"Vet Microbiol.. 28:82(3). 203-210 (2001)

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  • [Publications] Ikeda, Y., et al.: "Seroprevalence of canine distemper virus in cats"Clin Diagn Lab Immunol. 8(3). 641-644 (2001)

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  • [Publications] Ohashi K, et al.: "Properties of a new CDV isolate from a raccoon dog (Nyctereutes procyonoides viverrinus) in Japan"Vet Rec.. 3:148(5). 148-150 (2001)

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  • [Publications] Yoneda, M. et al.: "Rinderpest virus H protein : role in determining host range in rabbits"J. Gen. Virol.. (in press). (2002)

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  • [Publications] Jung, J.-Y., et al.: "Picryl chloride-induced contact dermatitis in IQI/Jic male mice"J. Toxicl. Pathol. 14. 231-236 (2001)

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  • [Publications] Nagata, T., et al.: "Development of apoptosis and changes in lymphocyte subsets in thymus, mesenteric lymph nodes and Peyers patches of mice orally inoculated with T-2 toxin"Exp. Toxic Pathol. 53. 309-315 (2001)

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  • [Publications] Suzuki, K., et al.: "Kinetics of matrix metalloproteinases and their regulatory factors in mercuric chrolide-induced tubulointerstitial fibrosis in Brown Norway rats"Exp. Toxic Pathol. 53. 337-343 (2001)

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  • [Publications] Ueno, M., et al.: "Expression of ribosomal protein L4 (rpL4) during neurogenesis and 5-azacytidine (5AzC)-induced apoptotic process in the rat"Histol. Histopathol. (in press). (2001)

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  • [Publications] Masuda, K., et al.: "Seasonal rhinitis in a cat sensitized to Japanese cedar (Cryptomeria japonica) pollen"J. Vet. Med. Sci.. 63. 79-81 (2001)

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  • [Publications] Maeda, S., et al.: "Molecular cloning of canine thymus and activation-regulated chemokine (TARC) gene and its expression in various tissues"J. Vet. Med. Sci.. 63. 1035-1038 (2001)

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  • [Publications] Masuda, K., et al.: "Seasonal atopic dermatitis in dogs sensitive to a major allergen of Japanese cedar (Cryptomeria japonica) pollen"Vet. Dermatol. (in press). (2001)

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  • [Publications] Ishizaka, K., et al.: "Molecular cloning of feline interferon-gamma-inducing factor (interleukin-18) and its expression in various tissues"Vet. Immunol. Immunopathol. 79. 208-218 (2001)

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  • [Publications] Kobayashi, Y, et al.: "Molecular cloning of feline hepatocyte growth factor (HGF) cDNA"J. Vet. Med. Sci.. 63. 211-214 (2001)

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  • [Publications] Mizuno, T., et al.: "TNF-alpha-induced cell death in feline immunodeficiency virus-infected cells is mediated by the caspase cascade"Virology. 287. 446-455 (2001)

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  • [Publications] Fujino, Y. et al.: "Assignment of the feline Fas ligand gene (TNFSF6) to chromosome F1q12-q13 by fluorescence in situ hybridization"Cytogenet. Cell Genet. 94. 92-93 (2001)

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  • [Publications] Yamamoto, A. et al.: "Molecular cloning and expression of the cDNA encoding feline granulocyte colony-stimulating factor"Gene. 63. 1035-1038 (2001)

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  • [Publications] Mizuno, T., et al.: "Molecular cloning of feline tumor necrosis factor receptor type I (TNFR I) and expression of TNFR I and TNFR II in lymphoid cells in cats"Eur. J. Immunogenetics. (in press). (2001)

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  • [Publications] Koga, L., et al.: "Nucleotide sequence and expression of the feline vascular endothelial growth factor"J. Vet. Med. Sci.. 64(in press). (2001)

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      2001 Annual Research Report
  • [Publications] Iwatsuki,K., et al.,: "Antigenic differences in the H proteins of canine distemper viruses."Vet.Microbiol.. 71. 281-286 (2000)

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  • [Publications] Ohashi,K., et al.,: "Properties of a new CDV isolated from a raccoon dog (Nyctereutes procyonoides viverrinus) in Japan."Vet.Record. 148. 148-150 (2001)

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  • [Publications] Wakasa,C., et al.,: "Sequence analysis of the genes encoding the phosphoprotein of recent isolates of canine distemper virus in Japan."J.Vet.Med.Sci.,. 62. 97-101 (2000)

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  • [Publications] Endo Y., et al.,: "Inhibitory effect of stromal cell derived factor-1 on the replication of divergent strains of feline immunodeficiency virus in a feline T-lymphoid cell line."Veterinary Immunology & Immunopathology.. 74. 303-14 (2000)

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  • [Publications] Masuda K., et al.,: "IgE-reactivity to major Japanese cedar (Cryptomeria japonica) pollen allergens (Cry j 1 and Cry j 2) by ELISA in dogs with atopic dermatitis."Veterinary Immunology & Immunopathology.. 74. 263-70 (2000)

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  • [Publications] Masuda K., et al.,: "Positive reactions to common allergens in 42 atopic dogs in Japan."Veterinary Immunology & Immunopathology.. 73. 193-204 (2000)

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      2000 Annual Research Report
  • [Publications] Kano R. et al.,: "Characterization of the cyclophilin of Trichophyton mentagrophytes."Microbiology & Immunology.. 44. 51-6 (2000)

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  • [Publications] Funakoshi Y. et al.,: "Cellular proliferative and telomerase activity in canine mammary gland tumors."Veterinary Pathology.. 37. 177-83 (2000)

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Published: 2000-04-01   Modified: 2016-04-21  

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