| Project/Area Number |
12307013
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
MIZUSAWA Hidehiro TOKYO MEDICAL AND DENTAL UNIVERSITY, DEPARTMENT OF NEUROLOGY AND NEUROLOGICAL SCIENCE, PROFESSOR, 大学院・医歯学総合研究科, 教授 (30144091)
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| Co-Investigator(Kenkyū-buntansha) |
KANOUCHI Tadashi TOKYO MEDICAL AND DENTAL UNIVERSITY, DEPARTMENT OF NEUROLOGY AND NEUROLOGICAL SCIENCE, ASSISTANT LECTURER, 医学部附属病院, 助手 (50345287)
ISHIKAWA Kinya TOKYO MEDICAL AND DENTAL UNIVERSITY, DEPARTMENT OF NEUROLOGY AND NEUROLOGICAL SCIENCE, ASSISTANT LECTURER, 医学部附属病院, 助手 (30313240)
YOKOTA Takanori TOKYO MEDICAL AND DENTAL UNIVERSITY, DEPARTMENT OF NEUROLOGY AND NEUROLOGICAL SCIENCE, ASSISTANT PROFESSOR, 医学部附属病院, 講師 (90231688)
大和田 潔 東京医科歯科大学, 医学部・附属病院, 助手 (40313241)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥43,280,000 (Direct Cost: ¥37,400,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2002: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2001: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2000: ¥17,800,000 (Direct Cost: ¥17,800,000)
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| Keywords | SPINOCEREBELLAR DEGENERATION / CAG REPEAT / SCA6 / CA CHANNEL / PURKINJE CELL / ANIMAL MODEL / CACNA1A / αTTP / CAGピート / ノックインマウス / CACN1A / 脊髄小脳変形症 / ES細胞 / CACNAIA |
|---|
| Research Abstract |
In the research on pathogenesis of spinocerebellar ataxia type 6 (SCA6), we found Purkinje cell specific inclusions and SCA6 gene resulted in Ca channel abnormality in cultured cells. A new gene locus for pure cerebellar ataxia was disclosed and the candidate area was narrowed. Regarding glial cytoplasmic inclusions in multiple system atrophy, we identified the 7 KD core fragment of α-synuclein molecule.
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