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Discovery of Novel Adipocyte-Derived Factors and Their Pathological and Physiological Roles in Humans; Adipocentric Hypothesis in Molecular Basis for the Development of Common Diseases

Research Project

Project/Area Number 12307022
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionOsaka University

Principal Investigator

MATSUZAWA Yuji  Osaka University Graduate School of Medicine, Professor, 医学系研究科, 教授 (70116101)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Tadashi  Osaka University Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (90252668)
YAMASHITA Shizuya  Osaka University Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (60243242)
FUNAHASHI Tohru  Osaka University Graduate School of Medicine, Associate Professor, 医学系研究科, 講師 (60243234)
SAKAI Naohiko  Osaka University Graduate School of Medicine. Assistant Professor, 医学系研究科, 助手 (80294073)
HIRAOKA Hisatoyo  Osaka University Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (00273681)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥40,190,000 (Direct Cost: ¥35,600,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2002: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2001: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2000: ¥20,300,000 (Direct Cost: ¥20,300,000)
KeywordsVISCERAL FAT / ADIPOCYTOKINE / ADIPONECTIN / AQUAPORIN ADIPOSE
Research Abstract

Ovemutrition and physical inactivity are the common basis for the development of common human diseases such as type 2 diabetes and atherosclerotic vascular diseases. Recent researches exploited that adipose tissue is not solely energy storage organ but also an endocrine organ to produce various bioactive substances named 'adipocytokines'. This project was designed to prove 'adipocentric hypothesis' that dysregulation of adipocytokines in visceral fat is responsible for the development of common diseases caused by overnutrition. Expression of Plasminogen activator inhibitor and heparin binding EGF-like growth factor were upregulated by accumulated visceral fat. Overproduction of these adipocytokines will lead thrombotic tendency and enhanced proliferation of vascular smooth muscle cells. In contrast, plasma concentration of adiponectin, which we discovered in human adipose cDNA project, was decreased in the subjects with visceral fat accumulation. Adiponectin exhibited anti-atherogenic and insulin sensitizing activities in vitro. Mice lacking adiponectin gene showed diet-induced insulin resistance and severe neointimal thickening against vascular injury. Humans carrying missense mutation in adiponectin gene showed markedly low plasma adiponectin levels and clinical phenotype of the metabolic syndrome. A series of these studies revealed that adipose tissue produces a self-defense molecule against diabetes and atherosclerotic diseases and hyposecretion of adiponectin in visceral fat accumulation plays a central role, at least in part, in the development of common diseases. This project provided evidences against 'adipocentric hypothesis'.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (148 results)

All Other

All Publications (148 results)

  • [Publications] Kumada M et al.: "Association of hypoadiponectinemia with coronary artery disease in men"Arterioscler Thromb Vasc Biol.. 23. 85-89 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Adamczak M et al.: "Decreased plasma adiponectin concentration in patients with essential hypertension"Am J Hypertens. 16. 72-75 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nemet D et al.: "Adipocytokines, body composition, and fitness in children"Pediatr Res.. 53. 148-152 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mallamaci F et al.: "Adiponectin in essential hypertension"J Nephrol.. 15. 507-511 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okamoto Y et al.: "Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice"Circulation. 106. 2767-2770 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yang WS et al.: "Plasma adiponectin levels in overweight and obese Asians"Obes Res. 10. 1104-1110 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Stefan N et al.: "Plasma adiponectin levels are not associated with fat oxidation in humans"Obes Res. 10. 1016-1020 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Stefan N et al.: "Plasma adiponectin concentrations in children : relationships with obesity and insulinemia"J Clin Endocrinol Metab.. 67. 4652-4656 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Vozarova B et al.: "Low plasma adiponectin concentrations do not predict weight gain in humans"Diabetes.. 51. 2964-2967 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kuriyama H et al.: "Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9"Diabetes.. 51. 2915-2921 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishizawa H et al.: "Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein"Diabetes.. 51. 2734-2741 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Imagawa A et al.: "Elevated serum concentration of adipose-derived factor, adiponectin, in patients with type 1 diabetes"Diabetes Care.. 25. 1665-1666 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Delporte ML et al.: "Pre-and post-translational negative effect of beta-adrenoceptor agonists on adiponectin secretion : in vitro and in vivo studies"Biochem J.. 367. 677-685 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matsuda M et al.: "Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis"J Biol Chem.. 277. 37487-37491 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Lindsay RS et al.: "Adiponectin and development of type 2 diabetes in the Pima Indian population"Lancet.. 360. 57-58 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kondo H et al.: "Association of adiponectin mutation with type 2 diabetes : a candidate gene for the insulin resistance syndrome"Diabetes.. 51. 2325-2358 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Arita Y et al.: "Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell"Circulation. 105. 2893-2898 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Maeda N et al.: "Diet-induced insulin resistance in mice lacking adiponectin/ACRP30"Nat Med.. 8. 731-737 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Stefan N et al.: "Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans"Diabetes.. 51. 1884-1888 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yokota T et al.: "Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins"J Clin Invest.. 109. 1303-1310 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kondo H et al.: "Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation"Eur J Biochem.. 269. 1814-1826 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matsumoto S et al.: "Increased plasma HB-EGF associated with obesity and coronary artery disease"Biochem Biophys Res Commun.. 292. 781-786 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yang WS et al.: "Synthetic peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients"Diabetes Care.. 25. 376-380 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nagaretani H et al.: "Visceral fat is a major contributor for multiple risk factor clustering in Japanese men with impaired glucose tolerance"Diabetes Care.. 24. 2127-2133 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishizawa H: "Small heterodimer partner, an orphan nuclear receptor, augments PPARg transactivation"J Biol Chem. 277. 1586-1592 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Zoccali C et al.: "Adiponectin, the most abundant adipocyte-derived protein, is functionally related to metabolic risk factors and predicts cardiovascular outcomes in end stage renal disease"J Am Soc Nephrol.. 109. 134-141 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kishida K et al.: "Enhancement of the aquaporin adipose (AQPap) gene expression by a peroxisome proliferator-activated receptory"J Biol Chem.. 276. 48572-48579 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakamura T et al.: "Thiazolidinedione derivative improves fat distribution and multiple risk factors in subjects with visceral fat accumulation-double-blind placebo-controlled trial.."Diabetes Res Clin Pract.. 54. 181-190 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Halleux CM et al.: "Secretion of adiponectin and regulation of apM1 gene expression in human visceral adipose tissue"Biochem Biophys Res Commun.. 288. 1102-1107 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yang WS et al.: "Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin"J. Clin. Endocrinol. Metab. 86. 3815-3819 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Comuzzie AG et al.: "The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome"J. Clin. Endocrinol. Metab. 106. 4321-4325 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kishida K et al.: "Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel"J Biol Chem.. 276. 36251-36260 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takahashi M et al.: "The expression of sparc in adipose tissue and its increased plasma concentration in patients with coronary artery disease"Obes Res.. 9. 388-393 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Maeda N et al.: "PPAR_ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein"Diabetes.. 50. 2094-2099 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hotta K et al.: "Galectin-12, an adipose-expressed galectin-like molecule possessing apoptosis-inducing activity"J Biol Chem.. 276. 34089-34097 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kobayashi H et al.: "Visceral fat accumulation contributes to insulin resistance, small-sized low-density lipoprotein, and progression of coronary artery disease in middle-aged non-obese Japanese men"Circ. J. 65. 193-199 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Weyer C et al.: "Hypoadiponectinemia in obesity and type 2 diabetes : Evidence for a role of insulin resistance and/or hyperinsulinemia"J. Clin. Endocrinol. Metab. 86. 1930-1935 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hotta K et al.: "Circulating concentrations of the adipocyte protein, adiponectin, are decreased in parallel with reduced insulin sensitivity during the progression to type-2 diabetes in rhesus monkeys"Diabetes. 50. 1126-1133 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takahashi M et al.: "Genomic structure and mutations in adipose-specific gene, adiponectin"Int. J. Obes.. 24. 861-868 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hotta K et al.: "Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients"Arterioscler Thromb Vasc Biol.. 20. 1595-1599 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kishida K et al.: "Aquaporin adipose, a putative glycerol channel in adipocytes"J Biol Chem.. 275. 20896-20902 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okamoto Y et al.: "An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls"Horm Metab Res.. 32. 47-50 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hotta K et al.: "Mutation in bombesin receptor subtype-3 gene is not a major cause of obesity in the Japanese"Horm Metab Res.. 32. 33-34 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kumada M et al: "Association of hypoadiponectinemia with coronary artery disease in men"Arterloscier Thromb Vasc Biol.. 23. 85-89 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Adamczak M et al: "Decreased plasma adiponectin concentration in patients with essential hypertension"Am J Hypertens. 53. 148-152 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nemet D et al: "Adipocytokines, body composition, and fitness in children"Pediatr Res.. 16. 72-75 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mallamaci F et al: "Adiponectin in essential hypertension"J Nephrol.. 15. 507-511 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okamoto Y et al: "Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice"Circulation. 106. 2767-2770 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yang WS et al: "Plasma adiponectin levels in overweight and obese Asians"Obes Res. 10. 1104-1110 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Stefan N et al: "Plasma adiponectin levels are not associated with fat oxidation in"Obes Res. 10. 1016-1020 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Stefan N et al: "Plasma adiponectin concentrations in children: relationships with obesity and insulinemia"J Clin Endocrinol Metab.. 87. 4652-4656 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Vozarova B et al: "Low plasma adiponectin concentrations do not predict weight"Diabetes.. 51. 2964-2967 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kuriyama H et al: "Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9"Diabetes.. 51. 2915-2921 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishizawa H et al: "Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein"Diabetes.. 51. 2734-2741 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Imagawa A et al: "Elevated serum concentration of adipose-derived factor, adiponectin, in patients with type 1 diabetes"Diabetes Care.. 25. 1665-1666 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Delporte ML et al: "Pre- and post-translational negative effect of beta-adrenoceptor agonists on adiponectin secretion; in vitro and in vivo studies"Biochem J.. 367. 677-685 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matsuda M et al: "Role of adiponectin in preventing vascular stenosis The missing link of adioo-vascular axis"J Biol Chem.. 277. 37487-37491 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Lindsay RS et al: "Adiponectin and development of type 2 diabetes in the Pima Indian"Lancet. 360. 57-58 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kondo H et al: "Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome"Diabetes.. 51. 2325-2358 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Arita Y et al: "Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell"Circulation. 105. 2893-2898 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Maeda N et al: "Diet-induced insulin resistance in mice lacking adiponectin/ACRP30"Nat Med.. 8. 731-737 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Stefan N et al: "Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphoryiation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans"Diabetes.. 51. 1884-1888 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yokota T et al: "Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins"J Clin Invest.. 109. 1303-1310 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kondo H et al: "Human aquaporin adipose (AQPap) gene Genomic structure, promoter analysis and functional mutation"Eur J Biochem.. 269. 1814-1826 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matsumoto S et al: "Increased plasma HB-EGF associated with obesity and coronary artery disease"Blochem Biophys Res Commun.. 292. 781-786 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yang WS et al: "Synthetic peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients"Diabetes Care.. 25. 376-380 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nagaretani H et al: "Visceral fat is a major contributor for multiple risk factor clustering in Japanese men with impaired glucose tolerance"Diabetes Care.. 24. 2127-2133 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kishida K et al: "Enhancement of the aquaporin adipose (AQPap) gene expression by a peroxisome proliferator-activated receptory"J BiolChem.. 276. 48572-48579 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakamura T et al: "Thiazolidinedione derivative improves fat distribution and multiple risk factors in subjects with visceral fat accumulation-double-blind placebo-controlled trial"Diabetes Res Clin Pract.. 54. 181-190 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Haileux CM et al: "Secretion of adiponectin and regulation of apM1 gene expression in human visceral adipose tissue"Biochem Biophys Res Commun.. 288. 1102-1107 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yang WS et al: "Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin"J. Clin. Endocrinol. Metab. 86. 3815-3819 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Comuzzie AG et al: "The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the"J. Clin. Endocrinol. Metab.. 86. 4321-4325 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kishida K et al: "Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel"J Biol Chem.. 276. 36251-36260 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takahashi et al: "The expression of spare in adipose tissue and its increased plasma concentration in patients with coronary artery disease"Obes Res.. 9. 388-393 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Maeda N et al: "PPARg ligands increase expressipn and plasma concentrations of adiponectin, an adipose-derived protein"Diabetes.. 50. 2094-2099 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hotta K et al: "Galectin-12, an adipose-expressed galectin-like molecule possessing apoptosis-inducing activity"J Biol Chem.. 276. 34089-34097 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kobayashi H et al: "Visceral fat accumulation contributes to insulin resistance, small-sized low-density lipoprotein, and progression of coronary artery disease in middle-aged non-obese Japanese men"Circ. J. 65. 193-199 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Weyer C etal: "Hypoadiponectinemia in obesity and type 2 diabetes: Evidence for a role of insulin resistance and/or"J. Clin. Endocrinol. Metab. 86. 1930-1935 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hotta K et al: "Circulating concentrations of the adipocyte protein, adiponectin, are decreased in parallel with reduced insulin sensitivity during the progression to type-2 diabetes in rhesus monkeys"Diabetes. 50. 1126-1133 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakamura T et al: "Magnitude of sustained multiple risk factors for ischemic heart disease in Japanese employees: a case-control study"Circ J.. 65. 11-17 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ouchi N et al: "Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages"Circulation. 103. 1057-1063 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ouchi N et al: "Adiponectin, adipocyte-derived plasma protein, inhibits endothelial NF-kB signaling through cAMP-dependent pathway"Circulation. 102. 1296-301 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yokota T et al: "Adiponectin, a novel member of soluble defense collagens, negatively regulates the growth of myelo-monocytic progenitors and the functions of macrophages"Blood. 96. 1723-1732 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takahashi M et al: "Genomic structure and mutations in adipose-specific gene, adiponectin"lnt. J. Obes.. 24. 861-868 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hotta K et al: "Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients"Arterloscler Thromb Vase Biol.. 20. 1595-1599 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kishida K et al: "Aquaporin adipose, a putative glycerol channel in adipocytes"J Biol Chem.. 275. 20896-20902 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okamoto Y et al: "An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls"Horm Metab Res.. 32. 47-50 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hotta K et al: "Mutation in bombesin receptor subtype-3 gene is not a major cause of obesity in the Japanese"Horm Metab Res.. 32. 33-34 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kumada M et al.: "Association of hypoadiponectinemia with coronary artery disease in men"Arterioscler Thromb Vase Biol.. 23. 85-89 (2003)

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      2002 Annual Research Report
  • [Publications] Adamczak M et al.: "Decreased plasma adiponectin concentration in patients with essential hypertension"Am J Hypertens. 16. 72-75 (2003)

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      2002 Annual Research Report
  • [Publications] Nemet D et al.: "Adipocytokines, body composition, and fitness in children"Pediatr Res.. 53. 148-152 (2003)

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  • [Publications] Mallamaci F et al.: "Adiponectin in essential hypertension"J Nephrol.. 15. 507-511 (2002)

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  • [Publications] Okamoto Y et al.: "Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice"Circulation. 106. 2767-2770 (2002)

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  • [Publications] Yang WS et al.: "Plasma adiponectin levels in overweight and obese Asians"Obes Res. 10. 1104-1110 (2002)

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  • [Publications] Stefan N et al.: "Plasma adiponectin levels are not associated with fat oxidation in humans"Obes Res. 10. 1016-1020 (2002)

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  • [Publications] Stefan N et al.: "Plasma adiponectin concentrations in children : relationships with obesity and insulinemia"J Clin Endocrinol Metab.. 67. 4652-4656 (2002)

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  • [Publications] Vozarova B et al.: "Low plasma adiponectin concentrations do not predict weight gain in humans"Diabetes.. 51. 2964-2967 (2002)

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  • [Publications] Kuriyama H et al.: "Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9"Diabetes.. 51. 2915-2921 (2002)

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  • [Publications] Nishizawa H et al.: "Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein"Diabetes.. 51. 2734-2741 (2002)

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      2002 Annual Research Report
  • [Publications] Imagawa A et al.: "Elevated serum concentration of adipose-derived factor, adiponectin, in patients with type 1 diabetes"Diabetes Care.. 25. 1665-1666 (2002)

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  • [Publications] Delporte ML et al.: "Pre-and post-translational negative effect of beta-adrenoceptor agonists on adiponectin secretion : in vitro and in vivo studies"Biochem J.. 367. 677-685 (2002)

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  • [Publications] Matsuda M et al.: "Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis"J Biol Chem.. 277. 37487-37491 (2002)

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  • [Publications] Lindsay RS et al.: "Adiponectin and development of type 2 diabetes in the Pima Indian population"Lancet.. 360. 57-58 (2002)

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  • [Publications] Kondo H et al.: "Association of adiponectin mutation with type 2 diabetes : a candidate gene for the insulin resistance syndrome"Diabetes.. 51. 2325-2358 (2002)

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  • [Publications] Arita Y et al.: "Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell"Circulation. 105. 2893-2898 (2002)

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  • [Publications] Maeda N et al.: "Diet-induced insulin resistance in mice lacking adiponectin/ACRP30"Nat Med.. 8. 731-737 (2002)

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  • [Publications] Stefan N et al.: "Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans"Diabetes.. 51. 1884-1888 (2002)

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  • [Publications] Yokota T et al.: "Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins"J Clin Invest.. 109. 1303-1310 (2002)

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  • [Publications] Kondo H et al.: "Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation"Eur J Biochem.. 269. 1814-1826 (2002)

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  • [Publications] Matsumoto S et al.: "Increased plasma HB-EGF associated with obesity and coronary artery disease"Biochem Biophys Res Commun.. 292. 781-786 (2002)

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  • [Publications] Yang WS et al.: "Synthetic peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients"Diabetes Care.. 25. 376-380 (2002)

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  • [Publications] Nagaretani H et al.: "Visceral fat is a major contributor for multiple risk factor clustering in Japanese men with impaired glucose tolerance"Diabetes Care.. 24. 2127-2133 (2002)

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  • [Publications] Nishizawa H.: "Small heterodimer partner, an orphan nuclear receptor, augments PPARg transactivation"J Biol Chem. 277. 1586-1592 (2002)

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  • [Publications] Zoccali C et al.: "Adiponectin, the most abundant adipocyte-derived protein, is tunctionally related to metabolic risk factors and predicts cardiovascular outcomes in end stage renal disease"J Am Soc Nephrol.. 109. 134-141 (2002)

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  • [Publications] 0uchi N, et al.: "Adipocyte-derived plasma protein, adiponectin, supppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages"Circulation. 103. 1057-1063 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hotta K, et al.: "Circulating concentrations of the adipocyte protein, adiponenctin, are decreascd in parallel with reduced insulin sensitivity during the progression to type-2 diabetes in rhesus monkeys"Diabetes. 50. 1126-1133 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Weycr C, et al.: "Hypoadiponcctinemia in obesity and type 2 diabetes: Evidence for a role of insulin resistance and/or hyperinsulinemia"J. Clin. Endocriml. Metab.. 86. 1930-1935 (2001)

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  • [Publications] Maeda N, et al.: "PPARγ ligands increase expression and plasma concentrations of adiponecitir an adipose-derived protein"Diabetes. 50. 2094-2099 (2001)

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  • [Publications] Comuzzie AG, et a.: "The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome"J. Clin. Endocrinol. Metab.. 86. 4321-4325 (2001)

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  • [Publications] Yamg WS, et al.: "Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin"J. Clin. Endocrinol. Metab.. 86. 3815-3819 (2001)

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  • [Publications] Halleux CM, et al.: "Secretion of Adiponectin and Regulation of apM1 Gene Expression in Human Visceral Adipose Tissue"Biochem Biophys Res Commun.. 288. 1102-1107 (2001)

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  • [Publications] Nakamura T, et al.: "Thiazolidinedione derivatives improves fat distribution and multiple risk factors in subjects with visceral fat accumulation-blind placebo-controlled trial"Diabetes Res Clin Pract.. 54. 181-190 (2001)

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  • [Publications] Nagaretani H, et al.: "Visceral fat is a major contributor for multiple risk factor clustering in Japanese men with impaired glucose tolerance"Diabetes Care.. 24. 2127-2133 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Zoccali C, et al.: "Adiponectin, the most adipocyte-derived protein, is functionally related to metabolic risk factors and predicts cardiovascular outcomes in end stage renal disease"J Am Soc Nephrol.. 13. 134-141 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamg WS, et al.: "Synthetic peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients"Diabetes Care.. 25. 376-380 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kishida K et al.: "Genomic structre and insulin-mediated repression of the aquaporin adipose(AQPap), adipose-specific glycerol channel"J Biol Chem.. 276. 36251-36260 (2001)

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  • [Publications] Kishida K et al.: "Enhancement of the aquaporin adipose (AQPap) gene expression by a peroxisome proliferator-activated receptorγ"J Biol Chem.. 276. 48572-48579 (2001)

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  • [Publications] Nakamura T et al.: "Magnitude of sustained risk for ischemic heart disease in Japanese employees: a case-control study"Jpn. Circ. J.. 65. 11-17 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kobayashi H, et al.: "Visceral fat accumulation to insulin resistance, small-sized low-density lipoprotein, and progression of coronary artery disease in middle-aged non-obese Japanese men"Jpn. Circ. J.. 65. 193-199 (2001)

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  • [Publications] Hotta K, et al.: "Galectin-12 an adipose-expressed galectin-like molecule possessing apoptosis-inducing activity"J Bio1 Chem.. 276. 34089-34097 (2001)

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  • [Publications] Takahashi M et al.: "The expression of sparc in adipose tissue and its increased plasma concentration in patients with coronary artery disease"Obcs Res.. 9. 388-393 (2001)

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  • [Publications] Nishizawa H et al.: "Small heterodimer partner, an orphan nuclear receptor, augments PPARg transactivation"J Biol Chcm. 277. 1586-1592 (2002)

    • Related Report
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  • [Publications] Hotta K,Funahashi T,Bodkin NL,Ortmeyer HK,Arita Y,Hansen BC,and Matsuzawa Y: "Circulating concentrations of the adipocyte protein, adiponectin, are decreased in parallel with reduced insulin sensitivity during the progression to type-2 diabetes in rhesus monkeys."Diabetes. (in press). (2001)

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  • [Publications] Weyer C,Funahashi T,Tanaka S,Hotta K,Matsuzawa Y,Pratley RE,Tataranni PA: "Hypoadiponectinemia in obesity and type 2 diabetes : Evidence for a role of insulin resistance and/or hyperinsulinemia."J.Clin.Endocrinol.Metab. (in press). (2001)

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  • [Publications] Nakamura T,Tsubono Y,Takemura K,Funahashi T,Matsuzawa y et al.: "Magnitude of sustained multiple risk factors for ischemic heart disease in Japanese employees"Jpn.Circ.J.. (in press). (2001)

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  • [Publications] Kobayashi H,Nakamura T,Miyaoka K,Nishida M,Funahashi T,Matsuzawa Y et al: "Visceral fat accumulation contributes to insulin resistance, small-sized low-density lipoprotein, and progression of coronary artery disease in middle-aged non-obese Japanese men"Jpn.Circ.J.. (in press). (2001)

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  • [Publications] Ouchi N,Kihara S,Arita Y,Nishida M,Funahashi T,Matsuzawa Y et al.: "Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages."Circulation. 103. 1057-1063 (2001)

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  • [Publications] Nishigori H,Tomura H,Tonooka N,Yamagata K,Matsuzawa Y,Takeda J. et al: "Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects."Proc Natl Acad Sci USA.. 98. 575-580 (2001)

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  • [Publications] Imagawa A,Hanafusa T,Miyagawa J,Matsuzawa Y.: "A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies."N Engl J Med.. 342. 301-307 (2000)

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  • [Publications] Ouchi N,Kihara S,Arita Y,Okamoto Y,Funahashi T,and Matsuzawa Y et al.: "Adiponectin, adipocyte-derived plasma protein, inhibits endothelial NF-kB signaling through cAMP-dependent pathway."Circulation. 102. 1296-1301 (2000)

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  • [Publications] Yamamoto K,Miyagawa J,Waguri M,Hanafuse T,Matsuzawa Y. et al: "Recombinant human betacellulin promotes the neogenesis of beta-cells and ameliorates glucose intolerance in mice with diabetes induced by selective by selective alloxan perfusion."Diabetes. 49. 2021-2027 (2000)

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  • [Publications] Hirano K,Matsuura F,Tsukamoto K,Matsuzawa Y et al: "Decreased expression of a member of the Rho GTPase family, Cdc42Hs, in cells from Tangier disease-the small G protein may play a role in cholesterol efflux."FEBS Lett.. 484. 275-279 (2000)

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  • [Publications] Zhu Q,Yamagata K,Yu L,Tomura H,Hanafusa T,Matsuzawa Y. et al: "Identification of missense mutations in the hepatocyte nuclear factor-3beta gene in Japanese subjects with late-onset Type II diabetes mellitus."Diabetologia.. 43. 1197-1200 (2000)

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  • [Publications] Matsuyama A,Yamashita S,Sakai N,Hirano K,Kihara S,Matsuzawa Y et al: "Identification of a GPI-anchored type HDL-binding protein on human macrophages."Biochem Biophys Res Commun.. 272. 864-871 (2000)

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  • [Publications] Yokota T,Oritani K,Funahashi T,Tenner AJ,Tomiyama Y,Matsuzawa Y et al.: "Adiponectin, a novel member of soluble defense collagens, negatively regulates the growth of myelo-monocytic progenitors and the functions of macrophages."Blood. 96. 1723-1732 (2000)

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  • [Publications] Takahashi1 M,Arita Y,Yamagata K,Funahashi T,and Matsuzawa Y et al.: "Genomic structure and mutations in adipose-specific gene, adiponectin."Int.J.Obes.. 24. 861-868 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hotta K,Funahashi T,Arita Y,Takahashi M,Matsuzawa Y et al.: "Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients."Arterioscler Thromb Vasc Biol.. 20. 1595-1599 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Okamoto Y,Arita Y,Nishida M,Funahashi T,Matsuzawa Y et al.: "An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls."Horm Metab Res.. 32. 47-50 (2000)

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      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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