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STUDIES FOR ESTABLISHMENT OF PEDIATRIC HEART AND LUNG TRANSPLANTATION IN JAPAN

Research Project

Project/Area Number 12307027
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionOSAKA UNIVERSITY

Principal Investigator

MATSUDA Hikaru  Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (00028614)

Co-Investigator(Kenkyū-buntansha) ECHIGO Shigeyukli  National Cardiovascular Center, Director, 部長(研究職)
WADA Youji  Kyoto University, Graduate School of Medicine, Professor, 医学研究科, 教授 (90167205)
YASUI Hisataka  Kyushu University, Graduate School of Medicine, Professor, 医学研究院, 教授 (20089923)
MITSUDOME Akihisa  Fukuoka University, Graduate School of Medicine, Professor, 医学部, 教授 (30038749)
SANO Shunji  Okayama University, Graduate School of Medicine, Professor, 医歯学総合研究科, 教授 (50235438)
加藤 裕久  久留米大学, 医学部, 教授 (30080724)
門間 和夫  東京女子医科大学, 医学部, 教授 (80075233)
岡田 伸太郎  大阪大学, 医学系研究科, 教授 (30028609)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥43,030,000 (Direct Cost: ¥36,100,000、Indirect Cost: ¥6,930,000)
Fiscal Year 2002: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2001: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2000: ¥13,000,000 (Direct Cost: ¥13,000,000)
KeywordsHEART TRANSPLANTATION / LUNG TRANSPLANTATION / END-STAGE CARDIAC FAILURE / PULMONARY HYPERTENTION / ORGAN PRESERVATION / CHILDREN / XENOTRANSPLANTATION / CRAFT CORONARY ATHEROSCRELOSIS / 小児循環器疾患 / 心臓移植 / 肺移植 / 心肺移植 / 適応基準 / 実態調査 / 脳死判定基準 / 異種移植
Research Abstract

As Organ transplantation law prohibits for donation from brain dead children younger than 15 years old, small children had almost no chance to undergo heart or lung transplantation in Japan. In thisstudy, the criteria of indication for heart and lung transplantation in children, how many children required heart or lung transplantation in Japan and prognosis of these children were clarified. Although 30 to 50 children required heart or lung transplantation every year in Japan, only two children underwent heart transplantation and five children underwent living lung transplantation in Japan since the law was issued. Altough more than 40 children tried to undergo heart transplantation in USA, only 22 children underwent heart transplantation and 14 died during waiting since the law was issued. To manage pediatric heart and lung recipients, the immunosuppressive regimen and post-transplant care as well as immunization were also investigated. To expand donor pool for children, heart and lung transplantation from non-heart beating donor or animals and living lung transplantation have been also studied. Brain death criteria In children have been also investigated. In the final year, International symposium for pediatric heart and lung transplantation was held and how to establish for pediatric heart and lung transplantation in Japan was discussed with public. The book about for pediatric heart and lung transplantation was published

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] 松田 暉, 福嶌教偉: "心臓移植"小児内科. 34・1. 63-68 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 福嶌教偉, 他: "高度肺高血圧合併心疾患の肺移植適応評価法の検討"Therapeutic Research. 23・11. 52-54 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 北 知子, 松下 享: "成人ドナーより行った国内小児心臓移植の1症例"日本小児循環器学会雑誌. 18・5. 586-590 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 佐地 勉, 海津慶子: "小児期の肺移植・心肺移植のシンポ"小児科. 43・8. 1044-1054 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawauchi M, et al.: "Gene therapy for attenuating cardiac allograft arteriopathy using ex vivo E2F decoy transfection by HVJ-AVE-liposome method in mice and nonhuman primates"Circulation Research. 87・11. 1063-1068 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 松石 豊次郎, 他: "小児の脳死"小児科. 44・5. 880-887 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 松田 暉, 他: "小児の心臓移植・肺移植"日本医学館. 122 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H Matsuda, N Fukushima: "Heart transplantation"Pediatric Medicine. 34. 63-68 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] N Fukushima, H Matsuda, et al.: "The studies of evaluation methods for indication of lung transplantation in patients' with secondary pulmonary hypertension associated with cardiac disease"Therapeutic Research. 23. 52-54 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T Kita, T Matsushita, et al.: "Heart transplantation for child from brain-dead adult,donor in Japan : One-year follow-up after transplantation"Pediatric cardiology and cardiac surgery. 18. 586-590 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T Saji, et al.: "Development of heart and lung transplantation in children"Pediatrics. 43. 1044-1054 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M Kawauchi, et al.: "Gene therapy for attenuating cardiac allograft arteriopathy using ex vivo E2F decoy transfection by HVJ-AVE-liposome method in mice and non-human primate"Circulation Research. 87. 1063-1068 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Matsuishi, et al.: "Brain death in children"Pediatrics. 44. 880-887 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H Matsuda, et al.: "Pediatric heart and lung transplantation"Nihon Igakukan. 122

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 松田 暉, 福嶌教偉: "心臓移植"小児内科. 34・1. 63-68 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 福嶌教偉他: "高度肺高血圧合併心疾患の肺移植適応評価法の検討"Therapeutic Research. 23・11. 52-54 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 北 知子, 松下 享: "成人ドナーより行った国内小児心臓移植の1症例"日本小児循環器学会雑誌. 18・5. 586-590 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 佐地 勉, 海津慶子: "小児期の肺移植・心肺移植のシンポ"小児科. 43・8. 1044-1054 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 松石 豊次郎, 他: "小児の脳死"小児科. 44・5. 880-887 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kawauchi M, et al.: "Gene therapy for attenuating cardiac allograft arteriopathy using ex vivo E2F decoy transfection by HVJ-AVE-liposome method in mice and nonhuman primate"Circulation Research. 87・11. 1063-1068 (2000)

    • Related Report
      2002 Annual Research Report
  • [Publications] 松田 暉他: "小児の心臓移植・肺移植"日本医学館. 122 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 松田 暉, 福嶌教偉: "心臓移植"小児内科. 34・1. 63-68 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 福嶌教偉: "心筋症 小児期心臓移植"Cardiovascular Med-Surg. 3・1. 100-105 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 小野安生, 越後茂之: "小児の心臓移植"先端医療シリーズ・心臓病の最新医療. 12. 186-191 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hhirata T, Wada Y, et al.: "Mitochondrial respiration as an early marker of viability in cardiacarrested rat lungs"Journal of Surgical Research. 96. 268-276 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 松石 豊次郎, 他: "小児の脳死"小児科. 44・5. 880-887 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Matsuda H.: "Thoracic organ transplantation in Japan : Still in the beginning stages."Ann Thorac Cardiovasc Surg. 6(6). 353-355 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hirata T,Fukuse T, et al.: "Reperfusion lung injury after cold preservation correlates with decreased level of intrapulmonary high-energy phosphates."Transplantation. 69(9). 1793-1801 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kawauchi M,Nakajama J, et al.: "Ontogeny of antipig xenoantibody and hyperacute rejection."Transplanattion. 70(4). 686-694 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kawauchi M,Suzuki K, et al.: "Gene therapy for attenuating cardiac allograft arteriopathy using ex vivo E2F decoy transfection by HVJ-AVE-liposome method in mice and nonhuman primates"Circulation Research. 87. 1063-1068 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 田村恵子,橋口玲子,佐地勉 他: "肺高血圧症例におけるトロンポキサン合成酵素阻害剤(OKY-046:オザグレル)の血中プロスタノイドに及ぼす影響及び臨床効果"呼吸と循環. 48(8). 849-853 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 大府正治,満留昭久: "小児の脳死における電気生理"臨床脳波. 42. 487-92 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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