| Project/Area Number |
12307046
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | Niigata University |
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Principal Investigator |
KOHNO Shoji NIIGATA UNIVERSITY Graduate School of Medical and Dental Science Professor, 大学院・医歯学総合研究科, 教授 (50014098)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Toyohiko Faculty of Engineering, Professor, 工学部, 教授 (40126446)
EJIRI Sadakazu Graduate School of Medical and Dental Science,Associate Professor, 大学院・医歯学総合研究科, 助教授 (40160361)
OZAWA Hidehiro Institute for Dental Science Matsumoto Dental University, Director, 総合歯科医学研究所, 所長 (60018413)
IKEDA Keisuke Graduate School of Medical and Dental Science,Assistant, 大学院・医歯学総合研究科, 助手 (30313521)
KOBAYASHI Hiroshi Graduate School of Medical and Dental Science, Associate Professor, 大学院・医歯学総合研究科, 助教授 (00225533)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥35,030,000 (Direct Cost: ¥33,500,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2002: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2001: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2000: ¥28,400,000 (Direct Cost: ¥28,400,000)
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| Keywords | Postmenopausal Osteoporosis / Jaw boue / Ovariectomized monkey / Estrogen Deficiency / Mechanical stress / Mastication |
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| Research Abstract |
1. Results of fundamental research on ovariectomized rat mandible
Estrogen deficiency caused osteoporotic changes of trabecular bone and thin alveolar bone proper in rat alveolar bone. Clinically, we must pay more attention to the state of periodontal disease and postmenopausal osteoporosis in elderly women.
The loss of occlusion caused by the extrusion of the antagonistic tooth resulted in an increase of its alveolar bone height. However, the bone volume of the internal alveolar area was significantly lower. In addition, it was demonstrated that estrogen deficiency caused severe internal bone loss and weakened trabecular bone structures on the alveolar bone that lost mechanical loading with the antagonistic tooth, although it did not affect alveolar bone height.
2. Results of fundamental research on ovariectomized monkey mandible
The ovariectomized monkey mandibles showed porotic changes in the cortical and trabecular bone. Mandibular cortex data in particular correlated closely with lumbar porosis. The subject whose lumbar bone mineral density was lowest showed the lowest mandibular BMD and had porous mandibular and radial cortices. Therefore, information on the mandibular cortical bone seems useful in screening severe osteoporosis patients.
3. Trials of measuring the BMD of human mandible
We succeeded to measure the BMD of human mandible, however, the BMD values were easily changed by only small gap of measuring surface. Further improvement is necessary to resolve the problems.
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