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General investigation of malocclusion in the aspect of age-related expression mechanism

Research Project

Project/Area Number 12307050
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field 矯正・小児・社会系歯学
Research InstitutionTokyo Medical and Dental University

Principal Investigator

SOMA Kunimichi  Tokyo Medical and Dental University, Division of Oral Health Sciences, Graduate School, Professor, 大学院・医歯学総合研究科, 教授 (10014200)

Co-Investigator(Kenkyū-buntansha) FUJITA Yukihiro  Tokyo Medical and Dental University, Division of Oral Health Sciences, Graduate School, Lecturer, 大学院・医歯学総合研究科, 講師 (50192729)
TODA Kazuo  Faculty of Dentistry, Nagasaki University, Professor, 歯学部, 教授 (80134708)
YANAGISHITA Masaki  Tokyo Medical and Dental University, Division of Oral Health Sciences, Graduate School, Professor, 大学院・医歯学総合研究科, 教授 (70132793)
MATSUMOTO Yoshiro  Tokyo Medical and Dental University, Division of Oral Health Sciences, Graduate School, Research Associate, 大学院・医歯学総合研究科, 助手 (20292980)
WARITA Hiroyuki  Tokyo Medical and Dental University, Faculty of Dentistry, Dental Hospital, Lecturer, 歯学部・附属病院, 講師 (30262207)
石田 哲也  東京医科歯科大学, 大学院・医歯学総合研究科, 助教授 (80211043)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥36,200,000 (Direct Cost: ¥32,900,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2001: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2000: ¥21,900,000 (Direct Cost: ¥21,900,000)
Keywordsaging / malocclusion / periodontium / alveolar bone
Research Abstract

Extracellular matrix
Occlusal hypofunction of rat unilateral mandibular molars was induced by extraction of the opposing teeth, and immunohistochemical analyzes were performed to clarify the influence of occlusal hypofunction on the changes of proteoglycan content in the periodontal ligament.
proteoglycan decreased in the periodontal ligament due to loss of occlusal function, and these results suggest that proteoglycans are closely related to occlusal function and play important roles in tissue homeostasis or tissue remodeling.
Microvasculature
We examined the effect of occlusal stimuli on the microvasculature of the periodontal ligament using a model of occlusal hypofunction in rat molars. The occlusal hypofunction caused narrowing of the periodontal membrane and reduction in the vessel size with decrease in the number of blood vessles. In this study, a mechanism is revealed that hypofunction would result in increase of the expression of endothelin, a potent vasoconstrictive factor, furth … More ermore it also suggested the relation to expression of nitric oxide synthase(NOS), a vasodilator factor.
Periodontal mechanoreceptors
The neurophysiological properties of the periodontal mechanoreceptors were studied using an in vitro jaw-nerve preparation. Results of this study have demonstrated the effects of experimental occlusal hypofunction on the periodontal mechanical signaling. Moreover, changes related to growth and development have also been investigated
Activity of bone formation
In order to clarify the mechanism of bone remodeling under mechanical stress, cultured osteoblastic-cells were subjected to shear stress, in which we have revealed that the enhancement of intracellular Ca^<2+> depended on the property of stretch-activated channel and were modulated by the cytoskeleton such as actin filament.
We also elucidated the hypofunctional condition of the root, remodeling of the alveolar bone and the physiological tooth movement in rats. And, the experimental tooth movements under hypofunctional condition have made it more obvious that light orthodontic forces contribute to the conservation of sound periodontal tissue. Less

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Kaneko S.: "Occlusal hypofunction causes changes of proteoglycan content in the rat periodontal ligament"Journal of Periodontal Research. 36(1). 1-9 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Muramoto T.: "Time-related changes in periodontal mechanoreceptors in rat molars after loss of occlusal stimuli in"Archives of Histology and Cytology. 63(3). 369-380 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hayashi Y.: "Effect of Occlusal Hypofunction on the Microvasculature and Presence of Endothelin in the Periodontal Ligaments of Rat Molars"Orthodontic Waves. 60(6). 373-380 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Domon S.: "Temporal and Spatial mRNA Expression of Bone Sialoprotein and Type I Collagen During Rodent Tooth Movement"European Journal of Orthodontics. 23. 339-348 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Santiwong P.: "GAP-43 Immunohistochemical and Ultrastructural Changes in Jaw Muscle Spindles of the Rat Following Loss of Occlusion"Archives of Oral Biology. 47. 227-237 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Seki Y.: "Influence of occlusal hypofunction induced by opposed tooth loss on periodontal mechanoreceptors in rat"Japanese Journal of Oral Biology. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kohno T.: "The Aspects of Tooth Movement in Rats Under Light Orthodontic Forces"Journal of Orthodontics. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kaneko S.: "occlusal hypofunction causes changes of proteoglycan content in the rat periodontal ligament"Journal of Periodontal Research. 36(1). 1-9 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Muramoto T.: "Time-related changes in periodontal mechanoreceptors in rat molars after loss of occlusal stimuli in"Archives of Histology and Cytology. 63(4). 369-380 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hayashi Y.: "Effect of Occlusal Hypofunction on the Microvasculature and Presence of Endothelin in the Periodontal Ligaments of Rat Molars"Orthodontic Waves. 60(6). 373-380 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Domon S.: "Temporal and Spatial mRNA Expression of Bone Sialoprotein and Type I Collagen During Rodent Tooth Movement"European Journal of Orthodontics. 23. 339-348 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Santiwong P.: "GAP-43 Immunohistochemical and Ultrastructural Changes in Jaw Muscle Spindles of the Rat Following Loss of Occlusion"Archives of Oral Biology. 47. 227-237 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Seki Y.: "Influence of occlusal hypofunction induced by opposed tooth loss on periodontal mechanoreceptors in rat"Japanese Journal of Oral Biology. 44. 66-74 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kohno T.: "The Aspects of Tooth Movement in Rats Under Light Orthodontic Forces"Journal of Orthodontics. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kaneko S.: "Occlusal hypofunction causes changes of proteoglycan content in the rat periodontal ligament"Journal of Periodontal Research. 36(1). 1-9 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Muramoto T.: "Time-related changes in periodontal mechanoreceptors in rat molars after loss of occlusal stimuli in"Archives of Histology and Cytology. 63(4). 369-380 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hayashi Y.: "Effect of Occlusal Hypofunction on the Microvasculature and Presence of Endothelin in the Periodontal Ligaments of Rat Molars"Orthodontic Waves. 60(6). 373-380 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Domon. S: "Temporal and Spatial mRNA Expression of Bone Sialoprotein and Type I Collagen During Rodent Tooth Movement"European Journal of Orthodontics. 23. 339-348 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Santiwong P.: "GAP-43 Immunohistochemical and Ultrastructural Changes in Jaw Muscle Spindles of the Rat Following Loss of Occlusion"Archives of Oral Biology. 47. 227-237 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Seki Y.: "Influence of occlusal hypofunction induced by opposed tooth loss on periodontal mechanoreceptors in rat"Japanese Journal of Oral Biology. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Kohno T.: "The Aspects of Tooth Movement in Rats Under Light Orthodontic Forces"Journal of Orthodontics. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Amemiya K.: "Relationship between flow of bolus and occlusal condition during mastication-Computer simulation based on the measurement of characteristics of bolus-."Journal of Oral Rehabilitation.. 28(in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kaneko S.: "Occlusal hypofunction causes changes of proteoglycan content in the rat periodontal ligament."Journal of Periodontal Research.. 36. 9-17 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Muramoto K.: "Time-related changes in periodontal mechanoreceptors in rat molars after loss of occlusal stimuli in."Archives of Histology and Cytology.. 63(4). 369-380 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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