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CONSTRUCTION OF FINE COMPARTIVE GENETIC MAPS FOR THE RAT AND IDENTIFICATION OF CAUSATIVE GENES IN NEUROLOGICAL MUTANT RATS

Research Project

Project/Area Number 12308044
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

SERIKAWA Tadao  KYOTO UNIVERSITY, GRADUATE SCHOOL OF MEDICINCE, PROFESSOR, 医学研究科, 教授 (30025655)

Co-Investigator(Kenkyū-buntansha) KITADA Kazuhiro  HOKKAIDO UNIVERSITY, CENTER FOR ADVANCED SCIENCE AND TECHNOLOGY, ASSOCIATE PROFESSOR, 先端科学技術共同センター, 助教授 (70263093)
MORI Masayuki  SHINSYU UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, ASSOCIATE PROFESSOR, 医学部, 助教授 (60273190)
KURAMOTO Takashi  KYOTO UNIVERSITY, GRADUATE SCHOOL OF MEDICINCE, ASSISTANT PROFESSOR, 医学研究科, 講師 (20311409)
KUWAMURA Mitsuru  OSAKA PREFECTURE UNIVERSITY, GRADUATE SHOOL OF AGRICULTURE AND BIOLOGICAL SCIENCE, ASSISTANT PROFESSOR, 農学生命科学研究科, 助手 (20244668)
YOKOI Norihide  KOBE UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, ASSOCIATE PROFESSOR, 医学系研究科, 客員助教授 (70311610)
Project Period (FY) 2000 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥43,800,000 (Direct Cost: ¥37,500,000、Indirect Cost: ¥6,300,000)
Fiscal Year 2003: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2002: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2001: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2000: ¥16,500,000 (Direct Cost: ¥16,500,000)
Keywordsrats / mutants / animal models for human diseases / linkage map / comparative genome / positional cloning / neurological disease / genetic analysis / 比較ゲノム地図
Research Abstract

Considering the rapid progress of the rat genome sequencing project in the US, we have put our efforts into the identification of causative genes in neurological mutant rats. For that reason, we constructed several fine comparative maps in genomic regions where the causative genes of the mutants are located. Twelve neurological mutant rat strains we studied in this project were as follows. Tremor rats, Zitter rats, mv rats, KZC rats, cvd rats, hob rats, SCR rats, qc rats, dmy rats, dfk rats, vf rats, and furue rats. By positional cloning for tremor rats, a genomic deletion was found within the critical region in which the aspartoacylase gene is located. We found a marked decrease in Attractin mRNA in the brain of the zi/zi rat and identified zi as an 8-bp deletion at a splice donor site of Atrn. A genomic deletion including exon 1 of the mv rats was detected by genomic and sequence analyses. As for the KDP rats, we identified a nucleotide insertion mutation, probably null allele, in the reelin gene. Rat neurological mutations cvd and hob were caused by mutations in the netrin-1 receptor gene Unc5h3. Abnormal vacuolation in the CNS of the vf rats was found to be controlled by a recessive gene on Chr8. As for the cataract phenotype in the SCR rats, a mutation of oxidosqualene cyclase gene that is located in the critical mapping region was found. Positional candidate genes for dmy and dfk rats were found and analyzed in detail. To clone the causative gene Cblb of Iddm/kdp 1 in KDP rats, a precise genetic and comparative map of rat Chr11 and mouse Chr16 in the vicinity of the locus was first constructed. Toward the identification of the dmy mutation, we determined the corresponding genomic region on mouse Chr13 and constructed its fine genetic and physical maps.

Report

(5 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (141 results)

All Other

All Publications (141 results)

  • [Publications] Akimitsu, T. et al.: "Epileptic seizures induced by N-acetyl-L-aspartate (NAA) in rats : in vivo and in vitro studies."Brain Res. 861. 143-150 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kitada, K. et al.: "Accumulation of N-acetyl-L-aspartate in the brain of the tremor rat, a mutant exhibiting absence-like seizure and spongiform degeneration in the central nervous system."J.Neurochem. 74. 2512-2519 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kitada, K. et al.: "An integrated rat genome map based on genetic and cytogenetic data."Exp Anim. 49. 119-126 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kitada, K. et al.: "Determination of the mouse homologous region for the rat dmy locus."J Exp Anim Sci. 41. 40-43 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 庫本高志, 牛島俊和: "ゲノム機能解析の実験 モデル生物による研究 ラット(Rattus norvegicus)"実験医学別冊 ゲノム機能研究プロトコール 辻本豪三、田中利男/編. 228-242 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Maihara, T. et al.: "Chromosomal mapping of genes for epilepsy in NER : a rat strain with to nic-clonic seizures."Epilepsia. 41(8). 941-949 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mashimo T. et al.: "Mapping of four simple sequence repeat (SSR) markers on rat chromosome 4."Hypertens Res. 23(1). 47-50 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 中根良文, 芹川忠夫: "ラットの染色体地図と比較ゲノム地図"遺伝子医学. 4(2). 131-137 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sasa, M. et al.: "Effects of clobazam on epileptic seizures in spontaneously epileptic rats (SER)."Jpn Pharmacol Ther. 28(4). 259-265 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Voigt, B. et al.: "Genetic comparison between laboratory rats and Japanese and German wild rats."Mamm Genome. 11(9). 789-790 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yokoi, N. et al.: "Genetic mapping of the rat mutation creeping and evaluation of its positional candidate gene reelin."Mamm Genome. 11. 111-114 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Amano, H. et al.: "Enhanced calcium influx in hippocampal CA3 neurons of spontaneously epileptic rats."Epilepsia. 42(3). 345-350 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Gunn, T.M.et al.: "Molecular and phenotypic analysis of attraction mutant mice."Genetics. 158. 1683-1695 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hamada, S. et al.: "Evaluation of the general suitability of the rat for the micronucleus assay : the effect of cyclophosphamide in 14 strains."Mutation Res. 495. 127-134 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 北田一博, 芹川忠夫: "ポジショナルクローニング法を用いたtremorラットにおける原因遺伝子の同定研究"日本疾患モデル学会記録. 17. 6-10 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kuramoto, T. et al.: "Attractin/Mahogany/Zitter plays a critical role in myelination of the central nervous system."Proc Natl Acad Sci USA. 98(2). 559-564 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kuramoto, T. et al.: "Cloning of the rat agouti gene and identification of the rat nonagouti mutation."Mamm Genome. 12. 469-471 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kuramoto, T. et al.: "Linkage mapping of the rat interleukin 1 receptor antagonist gene on chromosome 3."Exp Anim. 50(4). 355-357 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 芹川忠夫: "疾患モデル動物"ヒューマンサイエンス. 12(1). 24-27 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Okamoto, M. et al.: "Linkage mapping of the mouse nephrosis (nep) gene to chromosome 15."J Vet Med Med Sci. 63(12). 1347-1350 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Soury E. et al.: "Chromosomal assignments of mammalian genes with an acute inflammation regulated expression in liver."Immunogenetics. 53(8). 634-642 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yokoyama, M. et al.: "Genetic analysis of cataract in Ihara epileptic rat."Mamm Genome. 12(3). 207-211 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Amano, T. et al.: "Aberrant reduction of an inhibitory protein factor in a rat epileptic model."Epilepsy Res. 51(1-2). 81-91 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Baslow, M.H. et al.: "The effects of lithium chloride and other substances on levels of brain N-acetyl-L-aspartic acid in Canavan disease-like rats."Neurochem Res. 27(5). 403-406 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kuramoto, T. et al.: "Insertional mutation of the Attractin gene in the black tremor hamster."Mamm Genome. 13. 36-40 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hanaya, R. et al.: "Epileptiform burst discharges in hippocampal CA3 neurons of young but not mature Noda epileptic rats (NER)."Brain Res. 950(1-2). 317-320 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hanaya, R. et al.: "Effects of vigabatrin on epileptiform abnormal discharges in hippocampal CA3 neurons of spontaneously epileptic rats (SER)."Epilepsy Res. 50(3). 223-231 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 庫本高志, 芹川忠夫: "自然発症ミュータントの原因遺伝子同定におけるトランスジェニックラットの利用"アニテックス. 14(4). 182-188 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 庫本高志, 牛島俊和: "癌研究におけるラットゲノム解析"Molecular Medicine 増刊号『癌ゲノム学』. 39. 236-245 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kuwamura, M. et al.: "The myelin vacuolation (mv) rat with a null mutation in the attractin gene."Lab Invest. 82(10). 1279-1286 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakane, Y. et al.: "Comparative mapping of 31 rat genes."Exp Anim. 51(1). 109-111 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakane, Y. et al.: "A novel mutation vf causing abnormal vacuoles in the central nervous system maps on rat chromosome 8."Exp Anim. 51(2). 149-155 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Seki, T. et al.: "Adenoviral gene transfer of aspartoacylase into the tremor rat, a genetic model of epilepsy, as a trial of gene therapy for inherited epileptic disorder."Neuroscience Lett. 328(3). 249-252 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 芹川忠夫: "実験用ラットの価値"関西実験動物研究会会報. 23. 27-34 (2002)

    • Description
      「研究成果報告書概要(和文)」より
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      2003 Final Research Report Summary
  • [Publications] 花谷亮典 その他: "N-Acetyl-L-Aspartate (NAA)による神経興奮作用メカニズムの解明"てんかん治療振興財団研究年報. 14. 29-34 (2002)

    • Description
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    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yokoi, N. et al.: "Cblb is a major susceptibility gene for rat type 1 diabetes mellitus."Nature Genet. 31(4). 391-394 (2002)

    • Description
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    • Related Report
      2003 Final Research Report Summary
  • [Publications] 横井伯英, 清野 進: "ラットで同定された1型糖尿病感受性遺伝子Cblb"実験医学. 20(18). 2654-2657 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 横井伯英, 清野 進: "1型糖尿病に関わる主要遺伝子Cblb"遺伝子医学. 6(4). 669-671 (2002)

    • Description
      「研究成果報告書概要(和文)」より
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      2003 Final Research Report Summary
  • [Publications] 横井伯英: "1型糖尿病ラット"別冊・医学のあゆみ(免疫疾患-state of arts ver.2). 347-350 (2002)

    • Description
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      2003 Final Research Report Summary
  • [Publications] 横井伯英, 米田嘉重郎, 清野 進: "モデルラットで同定された新規1型糖尿病遺伝子"分子糖尿病学の進歩2003. 60-65 (2003)

    • Description
      「研究成果報告書概要(和文)」より
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      2003 Final Research Report Summary
  • [Publications] 横井伯英, 清野 進: "Cblb遺伝子変異と1型糖尿病:Komeda diabetes-prone rat."糖尿病学2003 診断と治療社. 68-77 (2003)

    • Description
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      2003 Final Research Report Summary
  • [Publications] Hamada, S. et al.: "Sex. differences in the chemical induction of micronuclei in the rat."Environ Mutagen Res. 25(1). 33-37 (2003)

    • Description
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    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hamada, S. et al.: "The effect of aging on the results of the rat micronucleus assay."Mutagenesis. 18(3). 273-275 (2003)

    • Description
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      2003 Final Research Report Summary
  • [Publications] Kiura, Y. et al.: "Involvement of Ca^<2+> Channels in abnormal excitability of hippocampal CA3 pyramidal cells in Noda epileptic rats."J Pharmacol Sci. 91. 137-144 (2003)

    • Description
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      2003 Final Research Report Summary
  • [Publications] Klugmann, M. et al.: "Identification and distribution of aspartoacylase in the postnatal rat brain."Neuroreport. 14(14). 1837-1840 (2003)

    • Description
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      2003 Final Research Report Summary
  • [Publications] 庫本高志, 芹川忠夫: "動き出した米国と日本のラットリソースセンター"疾患モデル通信. 15. (2003)

    • Description
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    • Related Report
      2003 Final Research Report Summary
  • [Publications] 芹川忠夫: "「珍翫鼠育草」に登場する鼠への想い"疾患モデル通信. 16. (2003)

    • Description
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      2003 Final Research Report Summary
  • [Publications] Masui, N. et al.: "The rat lysozomal trafficking regulator (Lyst) gene is mapped on the telomeric region of chromosome 17."Exp Anim. 52(1). 89-91 (2003)

    • Description
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      2003 Final Research Report Summary
  • [Publications] Mori, M. et al.: "A new beige mutant rat ACI/N-Lyst^<bg-Kyo>"Exp Anim. 52(1). 31-36 (2003)

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      2003 Final Research Report Summary
  • [Publications] 森 政之: "多因子遺伝性疾患モデルとしての白内障ラットの解析"信州医学雑誌. 51(2). 105-106 (2003)

    • Description
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      2003 Final Research Report Summary
  • [Publications] 森 政之, 芹川忠夫: "遺伝学的解析のモデル生物、マウス"遺伝子医学別冊 メディカルドウ. 154-158 (2003)

    • Description
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      2003 Final Research Report Summary
  • [Publications] Nakatsukasa, E. et al.: "Cryopreservation of spermatozoa from closed colonies, and inbred, spontaneous mutant, and transgenic strains of rats."Comp Med. 53(6). 639-641 (2003)

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      2003 Final Research Report Summary
  • [Publications] 芹川忠夫: "「珍翫鼠育草」の鼠はマウスからラットかネズミか"関西実験動物研究会会報. 24. 14-18 (2003)

    • Description
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      2003 Final Research Report Summary
  • [Publications] Yan, H-D. et al.: "Activation by N-acetyl-L-aspartate of acutely dissociated hippocampal neurons in rats via metabotropic gluamate receptors."Epilepsia. 44(9). 1153-1159 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yokoi, N. et al.: "Rat neurological disease creeping is caused by a mutation in the reelin gene."Brain Res Mol Brain Res. 112(1-2). 1-7 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yokoi, N.: "Establishment and characterization of the Komeda diabetes-prone rat as a segregating inbred strain."Exp.Anim.. 52(4). 295-301 (2003)

    • Description
      「研究成果報告書概要(和文)」より
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      2003 Final Research Report Summary
  • [Publications] Kuramoto, T. et al.: "Rat neurological mutations cerebellar vermis defect and hobble are caused by mutations in the netrin-1 receptor gene Unc5h3."Brain Res Mol Brain Res. 122(2). 103-108 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kuwamura, M., T. et al.: "Rat mutations cvd and hob with cerebellar malformations map to Chromosome 2."Exp Anim. 53(1). 21-26 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masui, N. et al.: "An allele-specific genotyping method for rat Lyst (lysosomal trafficking regulator) gene."Exp Anim. 53(1). 77-80 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tokuda, S. et al.: "PCR-based genotyping of the rat Atrn^<mv> mutation."Exp Anim. 53(1). 73-76 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Akimitsu, T. et al.: "Epileptic seizures induced by N-acetyl-L-aspartate (NAA) in rats: in vivo and in vitro studies"Brain Res. 861. 143-150 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kitada, K. et al.: "Accumulation of N-acetyl-L-aspartate in the brain of the tremor rat, a mutant exhibiting absence-like seizure and spongiform degeneration in the central nervous system"J.Neurochem. 74. 2512-2519 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kitada, K. et al.: "An integrated rat genome map based on genetic and cytogenetic data"Exp Anim. 40. 119-126 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kitada, K. et al.: "Determination of the mouse homologous region for the rat dmy locus"J Exp Anim Sci. 41. 40-43 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Maihara, T. et al.: "Chromosomal mapping of genes for epilepsy in NER: a rat strain with tonic-clonic seizure"Epilepsia. 41(8). 941-949 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mashimo T. et al.: "Mapping of four simple sequence repeat (SSR) markers on rat chromosome 4"Hypertens Res. 23(1). 47-50 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sasa, M. et al.: "Effects of clobazam on epileptic seizures in spontaneously epileptic rats (SER"Jpn Pharmacol Ther. 28. 259-265 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Voigt, B. et al.: "Genetic comparison between laboratory rats and Japanese and German wild rats"Mamm Genome. 11(9). 789-790 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yokoi, N. et al.: "Genetic mapping of the rat mutation creeping and evaluation of its positional candidate gene reelin"Mamm Genome. 11. 111-114 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Amano, H. et al.: "Enhanced calcium influx in hippocampal CA3 neurons of spontaneously epileptic rats"Epilepsia. 42(3). 345-350 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Gunn, T.M.et al.: "Molecular and phenotypic analysis of attractin mutant mice"Epilepsia. 158. 1683-1695 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hamada, S. et al.: "Evaluation of the general suitability of the rat for the micronucleus assay: the effect of cyclophosphamide in 14 strains"Mutation Res. 495. 127-134 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kuramoto, T. et al.: "Attractin/Mahogany/Zitter plays a critical role in myelination of the central nervous system"Proc Natl Acad Sci USA. 98(2). 559-564 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kuramoto, T et al.: "Cloning of the rat agouti gene and identification of the rat nonagouti mutation"Mamm Genome. 12. 469-471 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kuramoto, T et al.: "Linkage mapping of the rat interleukin 1 receptor antagonist gene on chromosome 3"Exp Anim. 50(4). 355-357 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Okamoto, M. et al.: "Linkage mapping of the mouse nephrosis (nep) gene to chromosome 15"J Vet Med Med Sci. 63(12). 347-1350 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Soury E. et al.: "Chromosomal assignments of mammalian genes with an acute inflammation regulated expression in liver"Immunogenetics. 53(8). 634-642 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yokoyama, M. et al.: "Genetic analysis of cataract in Ihara epileptic rat"Mamm Genome. 12(3). 207-211 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Amano, T. et al.: "Aberrant reduction of an inhibitory protein factor in a rat epileptic model"Epilepsy Res. 51(1-2). 81-91 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Baslow, M.H. et al.: "The effects of lithium chloride and other substances on levels of brain N-acetyl-L-aspartic acid in Canavan disease-like rats"Neurochem Res. 27(5). 403-406 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kuramoto, T. et al.: "Insertional mutation of the Attractin gene in the black tremor hamster"Mamm Genome. 13. 36-40 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hanaya, R. et al.: "Epileptiform burst discharges in hippocampal CA3 neurons of young but not mature Noda epileptic rats (NER)"Brain Res. 950(1-2). 317-320 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hanaya, R. et al.: "Effects of vigabatrin on epileptiform abnormal discharges in hippocampal CA3 neurons of spontaneously epileptic rats (SER)"Epilepsy Res. 50(3). 223-231 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kuwamura, M. et al.: "The myelin vacuolation (mv) rat with a null mutation in the attractin gene"Lab Invest. 82(10). 1279-1286 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakane, Y. et al.: "Comparative mapping of 31 rat genes"Exp Anim. 51(1). 109-111 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakane, Y. et al.: "A novel mutation vf causing abnormal vacuoles in the central nervous system maps on rat chromosome 8"Exp Anim. 51(2). 149-155 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Seki, T. et al.: "Adenoviral gene transfer of aspartoacylase into the tremor rat, a genetic model of epilepsy, as a trial of gene therapy for inherited epileptic disorder"Neuroscience Lett. 328(3). 249-252 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yokoi, N. et al.: "Cblb is a major susceptibility gene for rat type 1 diabetes mellitus"Nature Genet. 31(4). 391-394 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hamada, S. et al.: "Sex. differences in the chemical induction of micronuclei in the rat"Environ Mutagen Res. 25(1). 33-37 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hamada, S. et al.: "The effect of aging on the results of the rat micronucleus assay"Mutagenesis. 18(3). 273-275 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kiura, Y. et al.: "Involvement of Ca2+ Channels in abnormal excitability of hippocampal CA3 pyramidal cells in Noda epileptic rats"J Pharmacol Sci. 91. 137-144 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Klugmann, M. et al.: "Identification and distribution of aspartoacylase in the postnatal rat brain"Neuroreport. 14(14). 1837-1840 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masui, N. et al.: "The rat lysozomal trafficking regulator (Lyst) gene is mapped on the telomeric region of chromosome 17"Exp Anim. 52(1). 89-91 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mori, M. et al.: "A new beige mutant rat ACI/N-Lystbg-Kyo"Exp Anim. 52(1). 31-36 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakatsukasa, E. et al.: "Cryopreservation of spermatozoa from closed colonies, and inbred, spontaneous mutant, and transgenic strains of rats"Comp Med. 53(6). 639-641 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yan, H-D.et al.: "Activation by N-acetyl-L-aspartate of acutely dissociated hippocampal neurons in rats via metabotropic gluamate receptors"Epilepsia. 44(9). 1153-1159 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yokoi, N. et al.: "Rat neurological disease creeping is caused by a mutation in the reelin gene"Brain Res Mol Brain Res. 112(1-2). 1-7 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yokoi, N: "Establishment and characterization of the Komeda diabetes-prone rat as a segregating inbred strain"Exp. Anim. 52(4). 295-301 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kuramoto, T. et al.: "Rat neurological mutations cerebellar vermis defect and hobble are caused by mutations in the netrin-1 receptor gene Unc5h3"Brain Res Mol Brain Res. 122(2). 103-108 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] uwamura, M., T.et al.: "Rat mutations cvd and hob with cerebellar malformations map to Chromosome 2"Exp Anim. 53(1). 21-26 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masui, N. et al.: "An allele-specific genotyping method for rat Lyst (lysosomal trafficking regulator) gene"Exp Anim. 53(1). 77-80 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tokuda, S. et al.: "PCR-based genotyping of the rat Atrnmv mutation"Exp Anim. 53(1). 73-76 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kiura, Y., et al.: "Involvement of Ca^<2+> Channels in abnormal excitability of hippocampal CA3 pyramidal cells in Noda epileptic rats"J Pharmacol Sci. 91(2). 137-144 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Klugmann, M., et al.: "Identification and distribution of aspartoacylase in the postnatal rat brain"Neuroreport. 14(14). 1837-1840 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kuramoto, T., et al.: "Rat neurological mutations cerebellar vermis defect and hobble are caused by mutations in the netrin-1 receptor gene Unc5h3"Brain Res Mol Brain Res. 122(2). 103-108 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kuwamura, M., et al.: "Rat mutations cvd and hob with cerebellar malformations map to Chromosome 2"Exp Anim. 53(1). 21-26 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Masui, N., et al.: "The rat lysozomal trafficking regulator(Lyst)gene is mapped on the telomeric region of chromosome 15"Exp Anim. 52(1). 89-91 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Masui, N., et al.: "An allele-specific genotyping method for rat Lyst(lysosomal trafficking regulator)gene"Exp Anim. 53(1). 77-80 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kuwamura, M., et al.: "Rat mutations cvd and hob with cerebellar malformations maps to Chromosome 2"Experimental Animals(Tokyo). 53(1). 21-26 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Mori, M., et al.: "A new beige mutant rat ACI/N-Lyst^<bg-Kyo>"Exp Anim. 52(1). 31-36 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tokuda, S., et al.: "PCR-based genotyping of the rat Atrn<mv>mutation"Exp Anim. 53(1). 73-76 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yan, H-D., et al.: "Activation by N-acetyl-L-aspartate of acutely dissociated hippocampal neurons in rats via metabotropic gluamate receptors"Epilepsia. 44(9). 1153-1159 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yokoi, N., et al.: "Rat neurological disease creeping is caused by a mutation in the reelin gene"Mol. Brain Res.. 112(1-2). 1-7 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 庫本高志, 芹川忠夫: "自然発症ミュータントの原因遺伝子同定におけるトランスジェニックラットの利用"アニテックス. 14(4). 182-188 (2002)

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      2003 Annual Research Report
  • [Publications] 森 政之: "多因子遺伝性疾患モデルとしての白内障ラットの解析"信州医学雑誌. 51(2). 105-106 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Baslow, M.H.: "The effects of lithium chloride and other substances on levels of brain N-acetyl-L-aspartic acid in canavan disease-like rats"Neurochem Res. 27(5). 403-406 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kuwamura, M.: "The myelin vacuolation (mv) rat with a null mutation in the Attract gene"Lab Invest. 82. 1279-1286 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nakane, Y.: "A novel mutation vf causing abnormal vacuoles in the central nervous system maps on rat chromosome 8"Exp. Anim.. 52(1). 149-155 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Seki, T.: "Adenoviral gene transfer of aspartoacylase into the tremor rat, a genetic model of epilepsy, as a trial of gene therapy for inherited epileptic disorder"Neuroscience Lett. 328(3). 249-252 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yokoi, N.: "Cblb is a major susceptibility gene for rat type 1 diabetes mellitus"Nature Genet. 31(4). 391-394 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Masui N.: "The rat lysosomal trafficking regulator (Lyst) gene is mapped on the telomeric region of chromosome 17"Exp. Anim.. 52(1). 89-91 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Mori M.: "A new beige mutant rat ACI/N-Lystbg-Kyo"Exp. Anim.. 52(1). 31-36 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yokoi, N.: "Rat neurological disease creeping is caused by a mutation in the reelin gene"Mol. Brain Res.. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Baslow, M.H.: "The effect of lithium chloride and other substances on levels of brain N-acethyl-L-asparatic acid in Canavan disease-like rats"Neurochem.Res. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Nakane, Y.: "A Novel Mutation vf Causing Abnormal Vacuoles in the Central Nervous System Maps on Rat Chromosome 8"Exp.Anim. 51・2. 149-155 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kuramoto, T.: "Insertional mutation of the Attractin gene in the black tremor hamster"Mamm.Genome. 13. 36-40 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nakane, Y.: "Comparative mapping of 31 rat genes"Exp.Anim. 51・1. 109-111 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Gunn, T.M.: "Molecular and phenotypic analysis of attractin mutant mice"Genetics. 158・4. 1683-1695 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kuramoto, T.: "Attractin/Mahogany/Zitter plays a critical role in myelination of the central nervous system"Proc Natl Acad Sci USA. 98・2. 559-564 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kuramoto,T.: "Linkage mapping of the rat interleukin 1 receptor antagonist gene on chromosome 3."Exp Anim. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Kuramoto,T.: "Cloning of the rat agouti gene and identification of the rat nonagouti mutation."Mamm Genome. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Yokoyama,M.: "Genetic analysis of cataract in Ihara epileptic rat."Mamm Genome. 12・3. 207-211 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kuramoto,T.: "Attractin/Mahogany/Zitter plays a critical role in myelination of the central nervous system."Proc Natl Acad Sci USA. 98・2. 559-564 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Voigt,B.: "Genetic comparison between laboratory rats and Japanese and German wild rats."Mamm Genome. 11・9. 789-790 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Maihara,T.: "Chromosomal mapping of genes for epilepsy in NER : a rat strain with tonic-clonic seizures."Epilepsia. 74. 2512-2519 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kitada,K: "Determination of the mouse homologous region for the rat dmy locus."J Exp Anim Sci. 41. 40-43 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kitada,K.: "An integrated rat genome map based on genetic and cytogenetic data."Exp Anim. 49. 119-126 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Akimitsu,T.: "Epileptic seizures induced by N-acetyl-L-aspartate (NAA) in rats : in vivo and in vitro studies."Brain Res. 861. 143-150 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kitada,K.: "Accumulation of N-acetyl-L-aspatate in the brain of the tremor rat, a mutant exhibiting absence-like seizure and spongiform degeneration in the central nervous system."J Neurochem. 74. 2512-2519 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yokoi,N.: "Genetic mapping of the rat mutation creeping and evaluation of its positional candidate gene reelin."Mamm Genome. 11. 111-114 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Mashimo T.: "Mapping of four simple sequence repeat (SSR) markers on rats chromosome 4."Hypertens Res. 23・1. 47-50 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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