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Search for dynamic neuronal assemblies underlying memory processes for order information

Research Project

Project/Area Number 12410028
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 実験系心理学
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

SAKURAI Yoshio  Kyoto University, Graduate School of Letters, Professor, 大学院・文学研究科, 教授 (60153962)

Project Period (FY) 2000 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥14,400,000 (Direct Cost: ¥14,400,000)
Fiscal Year 2003: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2002: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2001: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2000: ¥5,700,000 (Direct Cost: ¥5,700,000)
Keywordsneuron / cell-assembly / temporal information / multi-neurnnal activity / hippocampus / rat / テトロード / マイクロドライブ / ICA / 順序 / 記憶 / 神経回路 / マウス
Research Abstract

(1) For rats, we developed behavioral tasks to see memory for duration or order of presented tone stimuli and trained rats to perform both tasks. The rats acquired both tasks in three weeks. We recorded multi-neuronal activity. from their hippocampal formation during the performance of the tasks.
(2) For mice, we developed a behavioral task to see memory for order of presented light stimuli and trained mice to perform the task. Some mice could not fully acquire the task in a long training period and we needed to change parameters of the task to more adequate ones.
(3) We developed new techniques, i.e., electrode, head-amp, microdrive, and spike-sorting system, to record and analyze multi-neuronal activity in behaving animals.
(4) The most remarkable one of the newly developed techniques is a new method to detect precise sub-millisecond interactions among neurons in freely behaving animals. That is an in vivo electrophysiological technique capable of real-time and automatic sorting of extracellular activity of closely neighboring single-neurons to detect their sub-millisecond interactions. The technique uses a combination of independent component analysis (ICA) and newly developed multi-electrodes, dozentrodes.
(5) Up to 10 interacting single-neurons were simultaneously recorded with two dozentrodes implanted in the hippocampal CA1 and CA3 regions and the somatosensory cortex in.the rats.
(6) The technique also could detect dendritic backpropagation of action potentials and electrically coupled cells via gap junctions. These results demonstrate that our method can be employed to investigate extremely precise neuronal interactions, as well as the functions of dendritic compartments that underlie learning and motor control in freely behaving animals.

Report

(5 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (37 results)

All Other

All Publications (37 results)

  • [Publications] 櫻井芳雄: "マルチニューロン活動の記録-なぜ・どのようにして"電子情報通信学会誌. 87. 279-284 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 櫻井芳雄: "セル・アセンブリによる神経情報の表現-実験的検証に向けて"蛋白質・核酸・酵素. 49. 463-470 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takahashi, S. et al.: "A new approach to spike sorting for multi-neuronal activities recorded with a tetrode-how ICA can be practical"Neuroscience Research. 46. 265-272 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takahashi, S. et al.: "Automatic sorting for multi-neuronal activity recorded with tetrodes in the presence of overlapping spikes"Journal of Neurophysiology. 89. 2245-2258 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 櫻井芳雄: "マルチニューロン活動を記録するために"脳の科学. 25. 19-26 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakurai, Y.: "Coding of temporal and pitch information by hippocampal"Neuroscience. 115. 1153-1163 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 櫻井芳雄: "考える細胞ニューロン"講談社. 232 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakurai, Y: "Multi-neuronal recordings why and how."J. of the Institute of Electronics, Information and Communication Engineers. 87. 279-284 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakurai, Y: "Neuronal coding by cell assemblies."Protein, Nucleic Acid and Enzyme. 49. 463-470 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takahashi, S. et al.: "A new approach to spike sorting..."Neuroscience Research. 46. 265-272 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takahashi, S. et al.: "Automatic sorting for multi-neuronal.."J.of Neurophysiology. 89. 2245-2258 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakurai, Y: "To record multi-neuronal activity."Brain Science. 25. 19-26 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakurai, Y: "Coding of temporal and pitch information by..."Neuroscience. 115. 1153-1163 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 櫻井芳雄: "マルチニューロン活動の記録-なぜ・どのようにして"電子情報通信学会誌. 87. 279-284 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 櫻井芳雄: "セル・アセンブリによる神経情報の表現-実験的検証に向けて"蛋白質・核酸・酵素. 49. 463-470 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takahashi et al.: "A new approach to spike sorting for multi-neuronal...."Neuroscience Research. 46. 265-272 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takahashi et al.: "Automatic sorting for multi-neuronal activity..."Journal of Neurophysiology. 89. 2245-2258 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 櫻井芳雄: "マルチニューロン活動を記録するために"脳の科学. 25. 19-26 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 高橋晋, 安西祐一郎, 櫻井芳雄: "独立成分分析を応用したマルチニューロン活動の解析"脳の科学. 25. 53-60 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sakurai, Y.: "Coding of temporal and pitch information by hippocampal・・・"Neuroscience. 115. 1153-1163 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takahashi et al.: "Automatic sorting for multi-neuronal activity recorded with・・・"Journal of Neurophysiology. 89. 2245-2258 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 櫻井芳雄: "マルチニューロン活動を記録するために"脳の科学. 25. 19-26 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 高橋晋, 他: "独立成分分析を用いたマルチニューロン活動の解析"脳の科学. 25. 53-60 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takahashi et al.: "A new approach to spike sorting for multi-neuronal activities・・・"Neuroscience Research. (印刷中). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sakurai, Y.: "Working memory fo temporal and nontemporal events in monkeys"Learning & Memory. 8. 309-316 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sakata et al.: "Task-dependentand cell-type specific Fos enhancement in rat neocortex during audio-visual discrimination"European Journal of Neuroscience. 15. 735-743 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takahashi et al.: "Classification of neuronal activities from tetrode recordings using independent component analysis"Neurocomputing. (印刷中). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 櫻井芳雄: "脳の情報表現(共著)"朝倉書店(印刷中). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 櫻井芳雄: "考える細胞ニューロン-脳と心をつくる柔らかい回路網"講談社(印刷中). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 櫻井芳雄: "ライブラリ脳の世紀-記憶と脳(共著)"サイエンス社. (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 櫻井芳雄: "セル・アセンブリ仮説"脳の科学. 23. 81-86 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 櫻井芳雄: "記憶情報をコードする動的神経回路を探る"学術月報. 53. 382-386 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 櫻井芳雄: "多細胞同時記録実験の必要性と方法"神経回路学会誌. 7. 3-7 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 櫻井芳雄: "記憶情報をコードする動的な神経回路"脳の科学. 22. 288-232 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 櫻井芳雄: "ニューロンから心へ"Computer Today. 95. 9-17 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 櫻井芳雄: "脳の情報表現"朝倉書店(印刷中).

    • Related Report
      2000 Annual Research Report
  • [Publications] 櫻井芳雄: "脳とワーキングメモリー"京都大学出版会. 20 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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