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ORIGINS AND PHYLOGENY OF MODERN HUMAN POPULATIONS INFERRED FROM DNA POLYMORPHISMS

Research Project

Project/Area Number 12440211
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 遺伝
Research InstitutionTHE GRADUATE UNIVERSITY FOR ADVANCED STUDIES

Principal Investigator

HORAI Satoshi  THE GRADUATE UNVERSITY FOR ADVANCED STUDIES, DEAPRTMENT OF BIOSYSTEMS SCIENCE, PROFESSOR, 先導科学研究科, 教授 (40126157)

Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥15,100,000 (Direct Cost: ¥15,100,000)
Fiscal Year 2002: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2001: ¥5,300,000 (Direct Cost: ¥5,300,000)
Fiscal Year 2000: ¥6,200,000 (Direct Cost: ¥6,200,000)
KeywordsMITOCHONDRIAL DNA / Y CHROMOSOME HAPLOTYPE / GENE PHYLOGENY / POPULATION TREE / CONERVAT1ON HUMAN SAMPLES / POLY MORPHISMS / ORIGIN OF JOMON / FORMATION OF MODERN JAPANESE / Y染色体ハプロタイプ / ミトコンドリアDNA多型 / Y染色体DNA多型 / 血清タンパク質多型 / 先住民集団 / 塩基置換数 / 塩基多様度 / 人類集団の拡散 / PCR法
Research Abstract

DNA variation on the non-recombining portion of the Y chromosome was examined in 610 male samples from 14 global populations in north, east, and southeast Asia, and other regions of the world. Eight haplotypes were observed by analyzes of seven biallelic polymorphic markers (DYS257_108, DYS287, SRY_4064, SRY_10831, RPS4Y_711, M9, and M15) and were unevenly distributed among the populations. Maximum parsimony tree for the eight haplotypes showed that these haplotypes could be classified into four distinct lineages characterized by three key mutations : an insertion of the Y Alu polymorphic (YAP) element at DYS287, a C-to-G transversion at M9, and a C-to-T transition at RPS4Y_711 of the four lineages, three major lineages (defined by the allele of YAP, M9-G, and RPS4Y_711-T, respectively) accounted for 98.6% of the Asian populations studied, indicating that these three paternal lineages have contributed to the formation of modem Asian populations. Moreover, phylogenetic analysis revealed three monophyletic Asian clusters, which consisted of north Asian, Japanese, and Han Chinese/southeast Asian populations, respectively. Coalescence analysis in the haplotype tree showed that the estimated ages for three key mutations ranged from 53,000 to 95,000 years, suggesting that the three lineages were separated from one another during early stages of human evolutionary history. The distribution patterns of the Y-haplotypes and mutational ages for the key markers suggest that three major groups with different paternal ancestries separately migrated to prehistoric east and southeast Asia

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] Tajima A., Horai S., et al.: "Three major lineages of Asian Y chromosomes : implication for the peopling of east and southeast Asia"Hum Genet. 110. 80-88 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tajima A., Horai S., et al.: "Miitochondrial DNA polymorphisms in nine aboriginal groups of Taiwan : Implications for the population history of aboriginal Taiwanese"Hum Genet. (In press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 宝来 聰: "ミトコンドリアDNAからみた日本人の起源"学術月報. 55(12). 49-52 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 宝来 聰: "ミトコンドリアDNAで探る現代人の起源と進化"武田薬報. 431号. 17-24 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Makino M., Horai S., Goto Y., Nonaka I.: "Mitochondrial DNA mutations in Leigh syndrome and their phylogenetic implications"J Hum Genet. 45(2). 69-75 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fucharoen G., Fucharoen S. and Horai S.: "Mitochondrial DNA polymorphisms in Thailand"J Hum Genet. 46. 115-125 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Qian YP, Chu Z-T, Dai Q, Wei C-D, Chu JY, Tajima A and Horai S.: "Mitochondrial DNA polymorphisms in Yunnan nationalities in China"J Hum Genet. 46. 211-220 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yuasa I., Umetsu k., Ago K., Sun C-S., Pan I-H., Ishida T., Saitou N. and Horai S.: "Population genetic studies onNine aboriginal ethnic groups of Taiwan II. Serum protein systems"Anthropological Science. 109(4). 257-273 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tajima A., Pan I-H., Fucharoen G., Fucharoen S., Matsuo M., Tokunaga K., Juji T., Hayami M., Omoto K. and Horai S.: "Three major lineages of Asian Y chromosome : implication for the peopling of east and southeast Asia"Hum Genet. 110. 80-88 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tajima A., Sun C-T., Pan I-H., Ishida T., Saitou N. and Horao S.: "Mitochondrial DNA polymorphisms in nene aboriginal groups of Taiwan : implications for the population history of aboriginal Taiwanese"Hum Genet. 113. 24-33 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Horai S.: "Mitochondrial DNA promoter region polymorphisms among Asian populations"The 2^(nd) International Symposium on "Free Radical and Vascular Biology of Diabetes." Seoul, Korea. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Horai S.: "Mitochondrial DNA polymorphism and evolution of Asian populations"International Symposium on "Human Genomic Diversity in Southeast Asia." Kunming, China. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tajima A., Horai S., et al.: "Three major lineages of Asian Y chromosomes : implication for the peopling of east and southeast Asia"Hum Genet. 110. 80-88 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tajima A., Horai S., et al.: "Miitochondrial DNA polymorphisms in nine aboriginal groups of Taiwan : Implications for the population history of aboriginal Taiwanese"Hum Genet. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 宝来 聰: "ミトコンドリアDNAからみた日本人の起源"学術月報. 55(12). 49-52 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 宝来 聰: "ミトコンドリアDNAで探る現代人の起源と進化"武田薬報. 431号. 17-24 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yuasa.I: "Population genetic studies on nine aboriginal ethnic groups of Taiwan II. Serum protein systems."Authropological Science. 109. 257-273 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tajima A: "Three major lineages of Asian Y chromosome : implications for the peopling of east and southeast Asia."Human Genetics. 110. 80-88 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 宝来 聰: "ミトコンドリアの遺伝子構造とその特徴「新ミトコンドリア学」(内海耕造・井上正康編)"共立出版. 81-87 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 宝来 聰: "ミトコンドリアからみた日本人の起原「新ミトコンドリア学」(内海耕造・井上正康編)"共立出版. 114-120 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Makino M.: "Mitochondrial DNA mutations in Leigh syndrome and their phylogenetic implications."Journal of Human Genetics. 45. 69-75 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Fucharoen G.: "Mitochondrial DNA polymorphisms in Thailand."Journal of Human Genetics. 46. 115-125 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Qian Y.P.: "Mitochondrial DNA polymorphisms in Yunnan nationalities in China."Journal of Human Genetics. 46(In press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 宝来聰: "ミトコンドリアゲノムからみた日本人"「現代医療」特集:ゲノム医学の現在と未来. 32(1). 285-289 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 宝来聰: "DNAから読む縄文-遺伝子から探る縄文人の系譜"白い国の詩. 523. 18-21 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 宝来聰: "ミトコンドリアDNAからみた人類の起原と拡散"「蛋白質核酸酵素」特集:人類の起原と進化をDNAレベルで探る. 45(16). 2579-2587 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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