| Project/Area Number |
12450271
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Inorganic materials/Physical properties
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| Research Institution | Tokyo Metropolitan University |
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Principal Investigator |
UMEGAKI Takao Tokyo Metropolitan University, Graduate School of Engineering, Prof., 工学研究科, 教授 (70087287)
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| Co-Investigator(Kenkyū-buntansha) |
HAMAGAMI Jun-ichi Tokyo Metropolitan University, Graduate School of Engineering, Research Associate, 工学研究科, 助手 (30285100)
KANAMURA Kiyoshi Tokyo Metropolitan University, Graduate School of Engineering, Associate Prof., 工学研究科, 助教授 (30169552)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥13,500,000 (Direct Cost: ¥13,500,000)
Fiscal Year 2001: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2000: ¥11,200,000 (Direct Cost: ¥11,200,000)
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| Keywords | Atomic Force Microscopy / Surface Potential Microscopy / Apatite Crystal Growth / Bioglass / In Situ Observation / Simulated Body Fluid / 表面電位電位顕微鏡 / 生体活性ガラス |
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| Research Abstract |
Artificial hydroxyapatite and Bioglass【○!R】 are well known as bioactive materials in a medical field. During an implantation of these materials in a human body, the materials are gradually bonded to a natural bone thorough a bonelike calcium phosphate apatite layer formed by chemical reactions of the bioactive materials in human body fluid around 37℃. However, the chemical reactions occurring on the material surfaces have not been understood, well. In order to obtain some new information on this problem, a direct observation technique has been used. In this study, an in situ atomic force microscope combined with surface potential measurement was used to observe the apatite formation on the Bioglass【○!R】 in simulated body fluid (SBF). From the observation, it can be seen that small islands with 5-10 nm size are formed on the Bioglass【○!R】 surface in the initial period (within 1 hour). These islands correspond to nuclei of apatite. These nuclei grew very slowly in SBF solution. This means that the growth of nuclei is a limiting process for the formation of the calcium phosphate apatite layer.
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