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Activation of Olefins with Polarity Inversion and Its Synthetic Application

Research Project

Project/Area Number 12450355
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 有機工業化学
Research InstitutionOsaka University

Principal Investigator

KAMBE Nobuaki  OSaka University, Graduate School of Engineering, Professor, 大学院・工学研究科, 教授 (60144432)

Co-Investigator(Kenkyū-buntansha) TERAO Jun  OSaka University, Graduate School of Engineering, Assistant Professor, 大学院・工学研究科, 助手 (00322173)
KUNIYASU Hitoshi  OSaka University, Graduate School of Engineering, Associate Professor, 大学院・工学研究科, 講師 (00252594)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥14,400,000 (Direct Cost: ¥14,400,000)
Fiscal Year 2001: ¥5,300,000 (Direct Cost: ¥5,300,000)
Fiscal Year 2000: ¥9,100,000 (Direct Cost: ¥9,100,000)
Keywordsolefin / alkylation / silylation / Grignard reagent / zirconium / titanium / chlorosilane / alkyl halide / ニッケル / クロスカップリング反応 / ジエン / 亜鉛試薬 / 二量化
Research Abstract

The reactions which introduce functionalities to carbon-carbon unsaturated bonds have been widely used for organic syntheses as useful methods for the construction of organic molecules. As one methodology for such transformations, there have been developed a number of reactions using a transition metal catalyst, but in many cases the late transition metal catalysts have been employed. The main object of the present studies is to develop new catalytic reactions using the characteristics of early transition metal ate complexes. Terminal alkenes undergo silylation by the reaction with chlorosilanes in the presence of a Grignard reagent employing a catalytic amount of zirconocene dichloride to give alkenyl and/or allylsilanes as the products. The reaction also proceeds under mild conditions when silyl sulfides, silyl selenides, and silyl tellurides are used in place of chlorosilanes. As an extension of this reaction, a new transformation of aryl alkenes via regioselective alkylation using alkyl tosylates, sulfates and bromides having a β-hydrogen has been developed using a zirconocene complex as the catalyst. When the reaction was carried out using tianocene catalyst, double alkylation of aryl alkenes proceeds in THF to give 1,2-vic-dialkylated products. On the other hand, Heck type transformation of aryl alkenes with alkyl bromides proceeds in ether under similar conditions. Carbosilylation and double silylation of 1,3-butadienes with chlorosilanes and/or alkyl bromides were also developed. This reaction proceeds under mild conditions by the use of titanocene catalyst in the presence of ^<11>BuMgCl giving rise to 1,4-carbosilylated or 1,4-double silylated 2-butenes. Aryl substituted alkenes also afford 1,2-carbosilylated or 1,2-double silylated products under similar conditions.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] Kambe, N., Fujiwara, S. et al.: "Imidoylation of Acidic Hydrocarbons with Selenium and Isocyanides"The Jonrual of Organic Chemistry. 65(16). 5022-5025 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kambe, N., Terao, J. et al.: "Titanocene-Catalyzed Carbosilylation of Alkenes and Dienes Using Alkyl Halides and Chlorosilanes"The Jonrual of Organic Chemistry. 65(17). 5291-5297 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kambe, N., Terao, J. et al.: "Formation of 1,4-Disilyl-2-butenes from Vinyl Grignard Reagent and Chlorosilanes Catalyzed by a Titanocene Complex"Organic Letters. 3(11). 1733-1735 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kambe, N., Kuniyasu, H. et al.: "A Prototype of Transition-Metal-Catalyzed Carbothiolation of Alkynes"Journal of the American Chemical Society. 123(21). 5108-5109 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kambe, N., Terao, J.: "Titanocene-Catalyzed Reaction of Alkenes and Dienes with Alkyl Halides and Chlorosilanes"Journal of Synthetic Organic Chemistry of Japan. 59(11). 1044-1051 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kanbe, N., Fujiwara, S. et al.: "Imidoylation of Acidic Hydrocarbons with Selenium and Isocyanides"The Journal of Organic Chemistry. 65-16. 5022-5025 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kanbe, N., Terao, J. et al.: "Titanocene-Catalyzed Carbosilylation of Alkenes and Dienes Using Alkyl Halides and Chlorosilanes"The Journal of Organic Chemistry. 65-17. 5291-5297 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kanbe, N., Terao, J. et al.: "Formation of 1,4-Disilyl-2-butenes from Vinyl Grignard Reagent and Chlorosilanes Catalyzed by a Titanocene Complex"Organic Letters. 3-11. 1733-1735 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kanbe, N., Kuniyasu, H. et al.: "A Prototype of Transition-Metal-Catalyzed Carbothiolation of Alkynes"Journal of American Chemical Society. 123-21. 5108-5109 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kanbe, N., Terao, J.: "Titanocene-Catalyzed Reaction of Alkenes and Dienes with Alkyl Halides and Chlorosilanes"Journal of Synthetic Organic Chemistry of Japan. 59-11. 1044-1051 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kambe, N., Fujiwara, S., et al.: "Imidoylation of Acidic Hydrocarbons with Selenium and Isocyanides"The Journal of Organic Chemistry. 65(16). 5022-5025 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kambe, N., Terao, J.et al.: "Titanocene-Catalyzed Carbosilylation of Alkenes and Dienes Using Alkyl Halides and Chlorosilanes"The Journal of Organic Chemistry. 65(17). 5291-5297 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kambe, N., Terao, J.et al.: "Formation of 1, 4-Disilyl-2-butenes from Vinyl Grignard Reagent and Chlorosilanes Catalyzed by a Titanocene Complex"Organic Letters. 3(11). 1733-1735 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kambe, N., Kuniyasu, H.et al.: "A Prototype of Transition-Metal-Catalyzed Carbothiolation of Alkynes"Journal of the American Chemical Society. 123(21). 5108-5109 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kambe, N., Terao, J.: "Titanocene-Catalyzed Reaction of Alkenes and Dienes with Alkyl Halides and Chlorosilanes"Journal of Synthetic Organic Chemistry of Japan. 59(11). 1044-1051 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Shinsuke Nii,Jun Terao Nobuaki Kambe: "Titanocene-Catalyzed Carbosilylation of Alkenes and Dienes Using Allcyl Halides and Chlorosilanes"Journal of Organic Chemistry. 65・17. 5291-5297 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shin-ichi Fujiwara Nobuaki Kambe, et al.: "Imidoylation of Acidic Hydrocarbons with Selenium and Isocyanides"Journal of Organic Chemistry.. 65・16. 5022-5025 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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