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DEVELOPMENT OF SYNTHETIC LIPOSOMES WITH CERAMIC SURFACE AND THEIR NOVEL FUNCTIONS

Research Project

Project/Area Number 12450364
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Synthetic chemistry
Research InstitutionNARA INSTITUTE OF SCIENCE AND TECHNOLOGY

Principal Investigator

KIKUCHI Jun-ichi  NARA INSTITUTE OF SCIENCE AND TECHNOLOGY, GRADUATE SCHOOL OF MATERIALS SCIENCE, PROFESSOR, 物質創成科学研究科, 教授 (90153056)

Co-Investigator(Kenkyū-buntansha) SASAKI Yoshihiro  NARA INSTITUTE OF SCIENCE AND TECHNOLOGY, GRADUATE SCHOOL OF MATERIALS SCIENCE, ASSISTANT PROFESSOR, 物質創成科学研究科, 助手 (90314541)
HASHIZUME Mineo  NARA INSTITUTE OF SCIENCE AND TECHNOLOGY, GRADUATE SCHOOL OF MATERIALS SCIENCE, ASSISTANT PROFESSOR, 物質創成科学研究科, 助手 (40333330)
ARIGA Katsuhiko  NARA INSTITUTE OF SCIENCE AND TECHNOLOGY, GRADUATE SCHOOL OF MATERIALS SCIENCE, ASSOCIATE PROFESSOR, 物質創成科学研究科, 助教授 (50193082)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥14,500,000 (Direct Cost: ¥14,500,000)
Fiscal Year 2002: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2001: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2000: ¥8,700,000 (Direct Cost: ¥8,700,000)
KeywordsORGANIC-INORGANIC HYBRID / CERASOME / NANO-PARTICLE / CERAMICS / LIPOSOME / BILAYER MEMBRANE / ARTIFICIAL MULTICELLULAR SYSTEM / ARTIFICIAL ORGAN / 光触媒 / 分子デバイス / 交互積層 / 多細胞モデル / 光触媒機能 / ゾル-ゲル法 / 脂質リポソーム / 膜物性
Research Abstract

The aim of this research project is to develop liposomal vesicies having ceramic surfaces as novel organic-inorganic hybrid nanomaterials. Liposomes, organic bilayer vesicles formed with lipids such as biomembrane-forming phospholipids, have been employed as biomembrane models and drug carriers. On the other hand, in recent years, much attention has been focused on unique functions of organic-inorganic hybrids which were derived from fusion of characteristics of organic materials with those of inorganic ones. On these grounds, we designed and prepared a novel organic-inorganic hybrid vesicle, which is a liposome coated with silica ceramics, and investigated in their novel functions. Topics in this research are as follows.
(1) Development of organic-inorganic hybrid vesicles "Cerasomes"
Liposome-forming double-chain lipids each having a trialkoxysilyl head moiety were designed and synthesized. In aqueous media, liposomes with inorganic frameworks like a silica ceramic on the surface were … More successfully prepared through hydrolysis of the head moiety and followed condensation of the silanol head, and self-assembling under appropriate conditions. We named the hybrid vesicle "Cerasome".
(2) Physical properties, surface modification, and functionalization of Carecomes
Morphological stability of the Cearsomes was drastically increased as compared with the conventional liposomes, while the Cerasomes possessed basic physical properties characteristic to the liposomes, such as compartmentation ability and gel-to-liquid-crystallibne phase transition behavior. Functionalization of the Cerasomes was achieved by surface modification of the nanohybrids.
(3) Three-dimensional organization of Cerasomes
Remarkable morphological stability of the Cerasomes led us to construct hierarchical and three-dimensional architectures of the liposomal vesicles on substrate by employing layer-by-layer assembling technique. Thus, the results of the present study would provide us a new promising research field of the liposome chemistry for aiming to develop artificial multicellular systems and artificial organs. Less

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (55 results)

All Other

All Publications (55 results)

  • [Publications] 有賀 克彦: "有機・無機ハイブリッドベシクル"Cerasome"の作製条件"高分子論文集. 57(4). 251-253 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 有賀 克彦: "膜の上で機能を組合わせる-人工脂質のハイブリッド化と新機能・新素材の開発-"現代化学. (349). 16-22 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 有賀 克彦: "ベシクルナノ粒子のデザインとデバイス機能の発現"表面. 38(5). 203-213 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kiyofumi Katagiri: "Novel Class of Organic-Inorganic Hybrid Vesicle "Cerasome" Derived from Various Amphiphiles with Alkoxysilyl Head"Stud.Surface Sci.Catal.. 132. 599-602 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Katsuhiko Ariga: "Langmuir Monolayer of Organoalkoxysilane for Vitamin B_<12>-Modified Electrode"Phys.Chem.Chem.Phys.. 3(16). 3442-3446 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 片桐 清文: "自己組織性を利用した有機-無機複合材料の開発"BIO INDUSTRY. 18(4). 19-25 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 菊池 純一: "人工細胞膜で創る超分子ナノデバイス"マテリアルインテグレーション. 14(5). 49-53 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kiyofumi Katagiri: "Layered Paving of Vesicular Nanoparticles Formed with Cerasome as a Bioinspired Organic-Inorganic Hybrid"J.Am.Chem.Soc.. 124(27). 7892-7893 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kiyofumi Katagiri: "Layer-by-Layer Self-Assembling of Liposomal Nanohybrid "Cerasome" on Substrates"Langmuir. 18(17). 6709-6711 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 橋詰 峰雄: "ベシクル構造を有する有機-無機ナノハイブリッド「セラソーム」の作製と三次元集積化"高分子加工. 51(9). 413-419 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kiyofumi Katagiri: "Preparation and Surface Modification of Novel Vesicular Nanoparticle "Cerasome" with Liposomal Bilayer and Silicate Surface"J.Sol-Gel Sci.Tech.. 26(1-3). 393-396 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mineo Hashizume: "Stable Vesicular Nanoparticle "Cerasome" as an Organic-Inorganic Hybrid Formed with Organoalkoxysilane Lipids Having a Hydrogen-Bonding Unit"Thin Solid Films. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 片桐 清文: "図解ナノテクノロジーのすべて"工業調査会. 4 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Jun-ichi Kikuchi: "Advances in Supramolecular Chemistry (Vol.8)"Cerberus Press. 43 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Ariga, et al.: "Preparation Condition of a Novel Organic-Inorganic Hybrid Vesicle "Cerasome""Kobunshi Ronbunshu. 57 (4). 251-253 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Ariga, et al.: "Functional Connection on Lipid Membranes-Hybridization of Artificial Lipids and Development of New Functional Materials"Chemistry Today. (349). 16-22 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Ariga, et at.: "Design of Vesicular Nanoparticles and Their Functions as Molecular Devices"Hyomen (Surface). 38 (5). 203-213 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Katagiri, et al.: "Novel Class of Organic-Inorganic Hybrid Vesicle "Cerasome" Derived from Various Amphiphiles with Alkoxysilyl Head"Stud.Surface Sci.Catat.. 132. 599-602 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Ariga, et al.: "Langmuir Monolayer of Organoalkoxysilane for Vitamin B_<12>-Modified Electrode"Phys.Chem.Chem.Phys.. 3 (16). 3442-3446 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Katagiri, et al.: "Development of Organic-Inorganic Hybrid Materials vis Self-Assembled Process"BIO INDUSTRY. 18(4). 19-25 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] J.Kikuchi: "Supramolecular Nanodevices Constructed with Artificial Cell Membranes"Materials Integration. 14 (5). 49-53 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Katagiri, et al.: "Layered Paving of Vesicular Nanoparticles Formed with Cerasome as a Bioinspired Organic-Inorganic Hybrid"J.Am.Chem.Soc.. 124 (27). 7892-7893 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Katagiri, et al.: "Layer-by-Layer Self-Assembling of Liposomal Nanohybrid "Cerasome" on Substrates"Langmuir. 18 (17). 6709-6711 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Hashizume, et al.: "Preparation of Organic-Inorganic Nanohybrids Having Vesicular Structures "Cerasome" and Their Three-Dimensional Integration"Polymer Applications. 51 (9). 413-419 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Katagiri, et al.: "Preparation and Surface Modification of Novel Vesicular Nanoparticle "Cerasome" with Liposomal Bilayer and Silicate Surface"J.Sol-Gel Sci.Tech.. 26 (1-3). 393-396 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Hashizume, at el.: "Stable Vesicular Nanoparticle "Cerasome" as an Organic-Inorganic Hybrid Formed with Organoalkoxysilane Lipids Having a Hydrogen-Bonding Unit"Thin Solid Films. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Katagiri, et al., (T.Kawai, ed.): "Ceramic-Coated Artificial Cell Membranes, In Nanotechnology"Kogyo Chosakai Publishing. 192-195 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] J.Kikuchi, et al., (G.W.Gokel, ed.): "Molecular Recognition and Functional Connection in Lipid Membranes, In Advances in Supramolecular Chemistry, 8"Cerberus Press. 131-173 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 有賀克彦: "有機・無機ハイブリッドベシクル"Cerasome"の作製条件"高分子論文集. 57・4. 251-253 (2000)

    • Related Report
      2002 Annual Research Report
  • [Publications] 有賀克彦: "膜の上で機能を組合わせる-人工脂質のハイブリッド化と新機能・新素材の開発-"現代化学. 349. 16-22 (2000)

    • Related Report
      2002 Annual Research Report
  • [Publications] 有賀克彦: "ベシクルナノ粒子のデザインとデバイス機能の発現"表面. 38・5. 203-213 (2000)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Katagiri: "Novel Class of Organic-Inorganic Hybrid Vesicle "Cerasome" Derived from Various Amphiphiles with Alkoxysilyl Head"Stud. Surface Sci. Catal.. 132. 500-602 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Ariga: "Langmuir Monolayer of Organoalkoxysilane for Vitamin B_<12>-Modified Electrode"Phys. Chem. Chem. Phys.. 3・16. 3442-3446 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 片桐清文: "自己組織性を利用した有機-無機複合材料の開発"BIO INDUSTRY. 18・4. 19-25 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 菊池純一: "人工細胞膜で創る超分子ナノデバイス"マテリアルインテグレーション. 14・5. 49-53 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Katagiri: "Layered Paving of Vesicular Nanoparticles Formed with Cerasome as a Bioinspired Organic-Inorganic Hybrid"J. Am. Chem. Soc.. 124・27. 7892-7893 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Katagiri: "Layer-by-Layer Self-Assembling of Liposomal Nanohybrid "Cerasome" on Substrates"Langmuir. 18・17. 6709-6711 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Katagiri: "Preparation and Surface Modification of Novel Vesicular Nano-Particle "Cerasome" with Liposomal Bilayer and Silicate Surface"J. Sol-Gel Sci. Tech.. 26・1-3. 393-396 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 橋詰峰雄: "ベシクル構造を有する有機-無機ナノハイブリッド「セラソーム」の作製と三次 元集積化"高分子加工. 51・9. 413-419 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Hashizume: "Stable Vesicular Nanoparticle "Cerasome" as an Organic-Inorganic Hybrid Formed with Organoalkoxysilane Lipids having a Hydrogen-Bonding Unit"Thin Solid Films. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] 片桐清文: "図解ナノテクノロジーのすべて"表面をセラミックコーティングした人工細胞膜. 4 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] J.Kikuchi: "Advances in Supramolecular Chemistry, Vol.8"Cerberus Press. 43 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 片桐 清文: "自己組織性を利用した有機-無機複合材料の開発"BIO ONDUSTRY. 18・4. 19-25 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 菊地 純一: "人工細胞膜で創る超分子ナノデバイス"マテリアルインテグレーション. 14・5. 49-53 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 菊地 純一: "生体機能を模した超分子デバイスの構築"応用物理. 70・12. 1414-1418 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kiyofumi Katagiri: "Preparation and Surface Modification of Novel Vesicular Nano-Particle "Cerasome" with Liposomal Bilayer and Silicate Surface"J. Sol-Gel Sci. Technol.. (印刷中). (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 片桐 清文: "図解ナノテクノロジーのすべて"工業調査会. 4 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Jun-ichi Kikuchi: "Advances in Supramolecular Chemistry(Volume 8)"Sun Coast Press. 43 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 有賀克彦: "有機・無機ハイブリッドベシクル"セラソーム"の作製条件"高分子論文集. 57・4. 251-253 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 有賀克彦: "膜の上で機能を組合わせる-人工脂質膜のハイブリッド化と新機能・新素材の開発-"現代化学. ・349. 16-22 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Katsuhiko Ariga: "Novel Class of Oganic-Inorganic Hybrid Vesicle"Cerasome" Derived from Various Amphiphiles with Alkoxysilyl Head"Stud.Surface Sci.Catal.. 132・. 599-602 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 片桐清文: "自己組織性を利用した有機-無機複合材料の開発"BIO INDUSTRY. (印刷中). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 菊池純一: "人工細胞膜で創る超分子ナノデバイス"マテリアルインテグレーション. (印刷中). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 佐々木善浩: "生体の情報伝達を規範とする超分子デバイスの開発"オレオサイエンス. (印刷中). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Jun-ichi Kikuchi: "Advances in Supramolecular Chemistry(Volume8)"JAI Press (印刷中). (2001)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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