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STUDIES ON IMMUNOREGULATORY MECHANISM OF FOOD COMPONENTS

Research Project

Project/Area Number 12460060
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 食品科学・栄養科学
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

YAMADA Koji  KYUSHU UNIV., FAC. AGR., PROF., 大学院・農学研究院, 教授 (60158186)

Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥12,400,000 (Direct Cost: ¥12,400,000)
Fiscal Year 2001: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2000: ¥10,100,000 (Direct Cost: ¥10,100,000)
KeywordsTocoferol / Tocotrienol / γ-Linolenic acid / Dietary fiber / Dietary protein / Immunoglobulin / Leukotriene / Prostaglandin / サイトカイン / 共役リノール酸 / エイコサペンタエン酸 / ドコサヘキサエン酸
Research Abstract

We examined the effect of irradiation on immunoglobulin (Ig) production of lymphocytes and found that it strongly suppressed their Ig production. The suppressive effect was enhanced in the presence of Rose Bengal, but depressed in the presence of α-tocopherol. In addition, we found that dietary tocotrienols had serum lipid-decreasing and Ig production-enhancing activities stronger than α-tocopherol. We also examined the dietary effect of γ-linolenic acid and found that it did not enhance of 4-series leukotriene production even at high dose administrations. On the contrary, it induced accumulation of dihomo-γ-linolenic acid in immune tissues, but the level was not correlated with their prostaglandin E_1 productivity. On immunoregulatory activity of dietary fibers, we examined the effect of aging. In aged rats, the expression of serum lipid-decreasing and Ig production-enhancing activities of water-soluble dietary fibers were weaker than those observed in young rats. Enhancement of Ig productivity in mesenteric lymph node lymphocytes was observed in aged rats as well as young rats, but not in splenocytes. This suggests that the target tissue of water-soluble dietary fibers is gut immune system in aged rats. In addition, we examined the combinational effect of dietary proteins and fats, and found that soy protein exerted stronger LTB_4 production-inhibiting activity than casein without affecting the level of arachidonic acid in immune cells. These results suggest that various food components exert regulatory activities on lipid metabolism and immune functions, and interact each other on the expression of their biological effect.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] M.Yamasaki et al.: "Dietary conjugated linoleic acid increases immunoglobulin productivity of Sprague-Dawley rat spleen lymphocytes"Biosci. Biotechnol. Biochem.. 64・10. 2159-2164 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] P.Hung et al.: "Dietary effect of eicosapentaenoic and docosahexaenoic acid esters on lipid metabolism and immune parameters in Sprague-Dawley rats"Biosci. Biotechnol. Biochem.. 64・12. 2588-2593 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Takasugi et al.: "Development of assay system for immunoglobulin production regulatory factors using whole cell culture of mouse splenocytes"Biosci. Biotechnol. Biochem.. 65・1. 143-149 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S.Kaku et al.: "Interaction of dietary fats and proteins on fatty acid composition of immune cells and LTB4 production by peritoneal exudates cells of rats"Biosci. Biotechnol. Biochem.. 65・2. 315-321 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y.Miyazaki et al.: "Oxidative stress by visible light irradiation induces suppression of immunoglobulin production by mouse spleen lymphocytes"Biosci. Biotechnol. Biochem.. 65・3. 593-598 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y.Miyazaki et al.: "Effect of dietary cabbage fermentation extract and young barley leaf powder on immune function of Sprague-Dawley rats"J. Nutr. Sci. Vitaminol.. 47. 253-257 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y.Miyazaki et al.: "Polyunsaturated fatty acids are not essential for survival and proliferation of a human B cell line"In Vitro Cell. Develop. Biol.. 37. 275-282 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M. Yamasaki. K. Mansho, H. Mishima, M. Kasai, M. Sugano, H. Tachibana and K. Yamada: "Dietary conjugated linoleic acid increases immunoglobulin productivity of Sprague-Dawley rat spleen lymphocytes"Bioscience Biotechnology and Biochemistry. 64-10. 2159-2164 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] P. Hung, J-Y. Gu, S. Kaku, S. Yunoki, K. Ohkura, I. Ikeda, H, Tachibana, M. Sugano, K, Yazawa and K. Yamada: "Dietary effect of eicosapentaenoic and docosahexaenoic acid esters on lipid metabolism and immune parameters in Sprague-Dawley rats"Bioscience Biotechnology and Biochemistry. 64-12. 2588-2593 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M. Takasugi, Y. Tamura, H. Tachibana, M. Sugano and K. Yamada: "Development of assay system for immunoglobulin production regulatory factors using whole cell culture of mouse splenocytes"Bioscience Biotechnology and Biochemistry. 65-1. 143-149 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S. Kaku, S. Yunoki, K. Ohkura, M. Sugano, M. Nonaka, H. Tachibana and K. Yamada: "Interaction of dietary fats and proteins on fatty acid composition of immune cells and LTB_4 production by peritoneal exudates cells of rats"Bioscience Biotechnology and Biochemistry. 65-2. 315-321 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y. Miyazaki, M. Yamasaki, H. Mishima, K. Mansho, H. Tachibana and K. Yamada: "Oxidative stress by visible light irradiation induces suppression of immunoglobulin production by mouse spleen lymphocytes"Bioscience Biotechnology and Biochemistry. 65-3. 593-598 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y. Miyazaki, Y. Tokunaga, K. Takagaki, S. Tsusaki, H. Tachibana and K. Yamada: "Effect of dietary cabbage fermentation extract and young barley leaf powder on immune function of Sprague-Dawley rats"Journal of Nutrional Science and Vitaminology. 47. 253-257 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y. Miyazaki, M. Noguchi, H. Tachibana and K. Yamada.: "Polyunsaturated fatty acids are not essential for survival and proliferation of a human B cell line"In Vitro Cellular and Developmental Biology. 37. 275-282 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H.Yamasaki et al.: "Dietary conjugated linoleic acid increases immunoglobulin productivity of Sprague-Dawley rat spleen lymphocytes"Biosci.Biotechnol.Biochem.. 64・10. 2159-2164 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] P.Hung et al.: "Dietary effect of eicosapentaenoic and docosahexaenoic acid esters on lipid metabolism and immune parameters in Sprague-Dawley rats"Biosci.Biotechnol.Biochem.. 64・12. 2588-2593 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.Takasugi et al.: "Development of assay system for immunoglobulin production regulatory factors using whole cell culture of mouse splenocytes"Biosci.Biotechnol.Biochem.. 65・1. 143-149 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] S.Kaku et al.: "Interaction of dietary fats and proteins on fatty acid composition of immune cells and LTB4 production by peritoneal exudates cells of rats"Biosci.Biotechnol.Biochem.. 65・2. 315-321 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Y.Miyazaki et al.: "Oxidative stress by visible light irradiation in duces suppression of immunoglobulin production by mouse spleen lymphocytes"Biosci.Biotechnol.Biochem.. 65・3. 593-598 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Y.Miyazaki et al.: "Effect of dietary cabbage fermentation extract and yonng barley leaf powder on immune function of Sprague-Dawley rats"J.Nutr.Sci.Vitaminol.. 47. 253-257 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Y.Miyazaki et al.: "Polyunsaturated fatty acids are not essential for survival and proliferation of a human B cell line"In Vitro Cell.Develop.Biol.. 37. 275-282 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.Yamasaki et al.: "Dietary conjugated linoleic acid increases immunoglobulin productivity of Sprague-Dawley rat spleen lymphocytes."Biosci.Biotechnol.Biochem.. 64・10. 2159-2164 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] P.Hung et al.: "Dietary effect of eicosapentaenoic and docosahexaenoic acid esters on lipid metabolism and immune parameters in Sprague-Dawley rats."Biosci.Biotechnol.Biochem.. 64・12. 2588-2593 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] M.Takasugi et al.: "Development of assay system for immunoglobulin production regulatory factors using whole cell culture of mouse splenocytes."Biosci.Biotechnol.Biochem.. 65・1(印刷中). (2001)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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