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Morphologic and functional varieties of thymic epithelial tumors: clinicopathologic and molecular-pathologic analyses

Research Project

Project/Area Number 12470047
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionNagoya City University

Principal Investigator

EIMOTO Tadaaki  Nagoya City University, Graduate School of Medical Sciences, Professor and Chair, 医学研究科, 教授 (60140779)

Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥6,200,000 (Direct Cost: ¥6,200,000)
Fiscal Year 2002: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2001: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2000: ¥3,200,000 (Direct Cost: ¥3,200,000)
KeywordsThymoma / Thymic carcinoma / WHO classification / Clinical Pathology / Molecular pathology / Immunohistochemistry / Flow cytometry / In situ hybridization / 胸腺 / MALTリンパ腫 / シェーグレン症候群 / API2-MALT1遺伝子 / CT所見 / 胸線腫 / 腫瘍予後 / EBウイルス / 核型解析 / ステロイド / 細胞増殖能 / アポトーシス / 免疾組織化学
Research Abstract

(1) The changes in histology, proliferative activity, and apoptosis of thymoma due to steroid pretreatment were examined. In addition to lymphocyte depletion, the tumor cell morphology was also changed with increased apoptotic cells and decreased proliferative cells (Virchows Arch, 2001).
(2) Clinical usefulness of WHO classification of thymic epithelial tumors was ascertained. Immature T lymphocytes in each WHO subtype were quantified by flow cytometry to evaluate the functional aspect of tumors (Am J Surg Pathol, 2001).
(3) In a large series of patients with thymoma, each of Masaoka's staging and WHO classification was found to be an independent prognostic factor by multivariate analysis (Cancer, 2002).
(4) In micronodular thymic epithelial tumors with stromal lymphoid infiltration, a spectrum ranging from benign tumor to lymphoepithelioma-like carcinoma was found. Association with EB virus was not detected (Histopathology, 2001).
(5) Two rhabdomyosarcoma-like thymic tumors were proved to be carcinosarcoma by immunohistochemistry, electron microscopy, and karyotyping (Histopathology, 2002).
(6) MALT lymphoma of the thymus is rare and not well established. Fifteen cases were clinicopathologically and genetically analyzed (Am J Pathol, 2002).
(7) In collaborative work with radiologists, some correlation between WHO subtypes of thymic epithelial tumors and CT findings was detected (Am J Roentgenol, 2002)

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] Tateyama H, et al.: "Histopathologic changes of thymoma preoperatively treated with corticosteroids"Virchows Archly. 438. 238-247 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okumura M, et al.: "Clinical and functional significance of WHO classification on human thymic epithelial neoplasms. A study of 146 consecutive tumors"American Journal of Surgical Pathology. 25. 103-110 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tateyama H, et al.: "The spectrum of micronodular thymic epithelial tumours with lymphoid B-cell hyperplasia"Histopathology. 38. 519-527 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Eimoto T, et al.: "Thymic sarcomatoid carcinoma with skeletal muscle differentiation. Report of two cases, one with cytogenetic analysis"Histopathology. 40. 46-57 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Inagaki H, et al.: "Primary thymic extranodal marginal-zone B-cell lymphoma of mucosa-associated lymphoid tissue type exhibits distinctive clinicopathological and molecular features"American Journal of Pathology. 160. 1435-1443 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tomiyama N, et al.: "Using the World Health Organization classification of thymic epithelial neoplasms to describe CT findings"American Journal of Roentgenology. 179. 881-886 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tateyama,H., Takahashi,E., Saito,Y., Fukai,I., Fujii,Y., Niwa,H., Eimoto,T.: "Histopathologic changes of thymoma preoperatively treated with corticosteroids"Virchows Arch. 438(3). 238-247 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okumura,M., Miyoshi,S., Fujii,Y., Takeuchi,Y., Shiono,H., Inoue,M., Fukuhara,K., Kadota,Y., Tateyama,H., Eimoto,T., Matsuda,H.: "Clinical and functional significance of WHO classification on human thymic epithelial neoplasms. A study of 146 consecutive tumors"Am J Surg Pathol. 25(1). 103-110 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okumura,M., Ohta,M., Tateyama,H., Nakagawa,K., Matsumura,A., Maeda,H. Tada,H., Eimoto,T., Matsuda,H., Masaoka,A.: "The Wo Health Organization histologic classification system ref the oncologic behavior of thymoma. A clinical study of 273 patients"Caner. 94(3). 624-632 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tateyama,H., Saito,Y., Fujii,Y., Okumura,M., Nakayama,K., Tada,H., Yasumitsu,T., Eimoto,T.: "The spectrum of micronodu thymic epithelial tumours with lymphoid B-cell hyperplasia"Histopathology. 38(6). 519-527 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Eimoto,T., Kitaoka,M., Ogawa,H., Niwa,H., Murase,T., Tateyama,H., Inagaki,H.,Soji,T., Hong Jian Wang.: "Thymic sarcomatoid carcinoma with skeletal muscle differentiation: report of two cases, one with cytogenet analysis"Histopathology. 40(1). 46-57 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Inagaki,H., Chan JK., Josephine W.M.Ng., Okabe,M., Yoshino,T., Okamoto,M., Ogawa,H., Matsushita,H., Yokose,T., Matsuno,Y., Nakamura,N., Nagasaka,T., Ueda,R., Eimoto,T., Nakamura,S.: "Primary thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type exhibits distinctive clinicopathological and molecular features"Am J Pathol. 160(4). 1435-1443 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tomiyama N., Johkoh T., Mihara N., Honda O., Kozuka T., Koyama M., Hamada S., Okumura M., Ohta M., Eimoto T., Miyagawa M., Muller NL., Ikezoe J., Nakamura H.: "Using the World Health Organization classification of thymic epithelia neoplasms to describe CT findings"AJR Am J Roentgenol. 179(4). 881-886 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okumura M, et al.: "Clinical and functional significance of WHO classification on human thymic epithelial neoplasms. A study of 146 consecutive tumors"American Journal of Surgical Pathology. 25・1. 103-110 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tateyama H, et al.: "Histopathologic changes of thymoma preoperatively treated with corticosteroids"Virchows Archiv. 438・3. 238-247 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tateyama H, et al.: "The spectrum of micronodular thymic epithelial tumours with lymphoid B-cell hyperplasia"Histopathology. 38・6. 519-527 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Eimoto T, et al.: "Thymic sarcomatoid carcinoma with skeletal muscle differentiation. Report of two cases, one with cytogenetic analysis"Histopathology. 40・1. 46-57 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Inagaki H, et al.: "Primary thymic extranodal marginal-zone B-cell lymphoma of mucosa-associated lymphoid tissue type exhibits distinctive clinicopathological end molecular features"American Journal of Pathology. 160・4. 1435-1443 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tomiyama N, et al.: "Using the World Health Organization classification of thymic epithelial neoplasms to describe CT findings"American Journal of Roentgenology. 179・4. 881-886 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Okumura M, et al.: "Clinicall and functional significance of WHO classification on human thymic epithelial neoplasms. A study of 146 consecutive tumors"American Journal of Surgical Pathology. 25・1. 103-110 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tateyama H, et al.: "Histopathologic changes of thymoma preoperatively treated with corticosteroids"Virchows Archiv. 438・3. 238-247 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tateyama H, et al.: "The spectrum of micronodular thymic epithelial tumours with lymphoid B-cell hyperplasia"Histopathology. 38・6. 519-527 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Okumura M, et al.: "The World Health Organization histologic classification system reflects the oncologic behavior of thymoma"Cancer. 94・3. 624-632 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Eimoto T, et al.: "Thymic sarcomatoid carcinoma with skeletal muscle differentiation. Report of two cases, one with cytogenetic analysis"Histopathology. 40・1. 46-57 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Okumura M, et al.: "Clinical and functional significance of WHO classification on human thymic epithelial neoplasms. A study of 146 consecutive tumors"American Journal of Surgical Pathology. 25・1. 103-110 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tateyama H, et al.: "Histopathologic changes of thymoma preoperatively treated with corticosteroids"Virchows Archiv. (In press). (2001)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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