| Project/Area Number |
12470052
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KANNAGI Mari Tokyo Medical and Dental University Graduate School, Immunotherpeutics, Professor, その他の独立研究科, 教授 (80202034)
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| Project Period (FY) |
2000 – 2001
|
| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥10,800,000 (Direct Cost: ¥10,800,000)
Fiscal Year 2001: ¥4,700,000 (Direct Cost: ¥4,700,000)
Fiscal Year 2000: ¥6,100,000 (Direct Cost: ¥6,100,000)
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| Keywords | Immune torelance / Vertical infection / Virus / Infection immunity / Tumor immunity / HTLV-I / HTLV-1 |
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| Research Abstract |
The level of host immune responses against HTLV-I varies among HTLV-I-infected individuals. In the present study, we examined the effect of the routes of HTLV-I-transmission on the host anti-HTLV-I immune responses. When immune competent adult rats were inoculated with HTLV-I-infected cells, the orally infected rats were persistently infected with HTLV-I without humoral and cellular immune responses against HTLV-I, whereas all intravenously or intraperitoneally inoculated rats showed significant levels of immune responses. Similar defects of humoral and cellular immunity specific for HTLV-I were observed in offsprings from HTLV-I infected rats. These observations indicated that host anti-HTLV-I immunity can be affected by the conditions of the primary infection, especially in. This study provides an experimental evidence that vertical transmission can be a reason for low cell-mediated immunity against HTLV-I, which is considered to be one of the risk factors for adult T cell leukemia.
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