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The roles of cytokines on the development of rheumatoid arthritis

Research Project

Project/Area Number 12470076
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionThe University of Tokyo

Principal Investigator

IWAKURA Yoichiro  Instittute of Medical Science, Professor, 医科学研究所, 教授 (10089120)

Co-Investigator(Kenkyū-buntansha) SUDO Katsuko  Institute of Medical Science, Research Associate, 医科学研究所, 助手 (50126091)
宝来 玲子  東京大学, 医科学研究所, 助手 (20313091)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥14,100,000 (Direct Cost: ¥14,100,000)
Fiscal Year 2002: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2001: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2000: ¥6,100,000 (Direct Cost: ¥6,100,000)
KeywordsRheumatoid Arthritis / Animal Models1 / IL-1 / HTLV-I / IL-6 / TNF-α / IL-17 / IL-1R antagonist / 自己免疫疾患 / トランスジェニックマウス / ノックアウトマウス / HTLV-1
Research Abstract

We have produced transgenic mice carrying tax gene of HTLV-I (HTLV-I Tg) and IL-1 receptor antagonist knockout (IL-1Ra KO) mice, and found these mice spontaneously develop autoimmune arthritis. Also, we have reported that T cell dependent cellular immunity is crucial for the development of the disease. In this project, we evaluated that the roles of cytokine on the development of the autoimmune arthritis using those 2 mouse models. We showed that IL-1 and IL-6 is crucial for the development of the disease of HTLV-I Tg and TNF-a is required in the disease of IL-1Ra KO mice. Unlike other cytokines, IL-17 is known to be produced by the activated CD4 T cells, and induces other cytokines and chemokines. Also, it is suggested to be involved in rheumatoid arthritis in humans, because this cytokine is detected in the joints of the patients. Then, we produced IL-17 knockout (IL-17 KO) mice, and found that IL-17 deficiency completely suppresses the disease in the IL-1Ra KO mice.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (117 results)

All Other

All Publications (117 results)

  • [Publications] Nakae, S.: "IL-1-induced TNE elicits inflammatory cell infiltration in the skin by inducing interferon-g-inducible protein-10 in the elicitation phase of CHS"Int. Immunol.. 15. 251-260 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakae, S.: "Interleukin-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response"Int. Immunol.. 15. 483-490 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakae, S.: "Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, resulting in the suppression of allergic cellular and humoral responses"Immunity. 17. 375-387 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakae, S.: "IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist"Proc. Natl. Acad. USA. 100. 5986-5990 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Iwakura, Y.: "Roles of IL-1 in the development of rheumatoid arthritis : Consideration from mouse models"Cytokine Growth Factor Rev.. 13. 341-355 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saijo, S.: "Suppression of autoimmune arthritis in IL-1-deficient mice in which T cell activation is impaired due to low levels of CD40L and OX40 expression on T cell"Arth. Rheum.. 13. 533-544 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Iwakura, Y.: "Autoimmune chronic inflammatory arthropathy in mice transgenic for the HTLV-I tax gene"Gann Monograph. (in press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakae, S., Komiyama, Y., Narumi, S., Sudo, K., Horai, R., Tagawa, Y., Sekikawa, K., Matsushima, K., Asano, M., and Iwakura. Y.: "IL-1-induced TNFα elicits inflammatory cell infiltration in the skin by inducing interferon-γ-inducible protein-10 in the elicitation phase of contact hypersensitivity response"Int. Immunol.. 15. 251-260 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakae, S., Komiyama, K., Yokoyama, H., Nambu, A., Umeda, M., Iwase, M., Homma, I., Sudo, K., Horai, R., Asano, M. and Iwakura. Y.: "Interleukin-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response"Int. Immunol.. 15. 483-490 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakae, S., Komiyama, Y., Nambu, A., Sudo, K., Iwase, M., Homma, I., Sekikawa, K., Asano, M., and Iwakura, Y.: "Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, resulting in the suppression of allergic cellular and humoral responses"Immunity. 17. 375-387 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakae, S., Saijo, S., Horai, R., Sudo, K., Mori, S., and Iwakura, Y.: "IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist"Proc. Natl. Acad. Sci. USA. 100. 5986-5990 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Iwakura, Y.: "Roles of IL-1 in the development of rheumatoid arthritis : Consideration from mouse models"Cytokine Growth Factor Rev.. 13. 341-355 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saijo, S., Asano, M., Horai, R., Yamamoto, H., and Iwakura. Y.: "Suppression of autoimmune arthritis in IL-1-deficient mice in which T cell activation is impaired due to low levels of CD40L and OX40 expression on T cells"Arth. Rheum.. 46. 533-544 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Voronov, E.: "Interleukin 1 is required for tumor invasiveness and angiogenesis"Proc. Natl. Acad. Sci. USA. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nakae, S.: "Interleukin-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response"Int. Immunol.. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ohtaki, H.: "Suppression of oxidative neuronal damage after transient middle cerebral artery occlusion in mice lacking interleukin-1"Neuroscience Res.. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sashinami, H.: "Effective induction of acquired resistance to Listeria monocytogenes by immunizing mice with in vivo-infected dendritic cells"Infect. Immun.. 71. 117-125 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Li, H.: "Aberrant responses to acoustic stimuli in mice deficient for neural recognition molecule NB-2. Aberrant responses to acoustic stimuli in mice deficient for neural recognition molecule NB-2"Eur. J. Neurosci.. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tanaka, J.: "Latent HIV-1 reactivation in transgenic mice requires cell cycle-dependent demethylation of CREB/ATF sites in the LTR"AIDS. 17. 167-175 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Iwakura, Y.: "Autoimmune chronic inflammatory arthropathy in mice transgenic for the HTLV-1 tax gene"Gann Monograph. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nakae, S.: "IL-1-induced TNFα elicits inflammatory cell infiltration in the skin by inducing interferon-γ-inducible protein-10 in the elicitation phase of contact hypersensitivity response"Int. Immunol.. 15. 251-260 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ikegaya.Y.: "Interleukin-1βabrogates long-term depression of hippocampal CA1 synaptic transmission"Synapse. 47. 54-57 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kurisaki, T.: "Phenotypic analysis of Meltrin α (ADAM12)-deficient mice : involvement of Meltrin α in adipogenesis and myogenesis"Mol. Cell. Biol.. 23. 55-61 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yokoyama, H.: "Pathological changes of renal epithelial cells in mice transgenic for the TT virus ORF1 gene"J. Gen. Virol.. 83. 141-150 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yano, A.: "Roles of IFN-γ on stage conversion of an obligate intracellular protozoan parasite, Toxoplasma gondii"Int. Rev. Immunol.. 21. 405-421 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Desaki, M.: "Role of interferon-γ in the development of murine bronchus-associated lymphoid tissues induced by silica in vivo"Toxicol. Appl. Pharmacol.. 185. 1-7 (2002)

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      2002 Annual Research Report
  • [Publications] Yoshida, M.: "Differential localization of colitogenic Th1 and Th2 cells monospecific to a microflora-associated antigen in mice"Gastroenterology. 123. 1949-1961 (2002)

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      2002 Annual Research Report
  • [Publications] Oguri, S.: "Primary role of interleukin-1α and Interleukin-1β in lipopolysaccharide-induced hypoglycemia in mice"Clin. Diagn. Lab. Immunol.. 9. 1307-1312 (2002)

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      2002 Annual Research Report
  • [Publications] Kakuta, S.: "Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family"J. Interferon Cytokine Res.. 22. 981-993 (2002)

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      2002 Annual Research Report
  • [Publications] Sakamaki, K.: "Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart"Cell Death and Differentiation. 11. 1196-1206 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nakae, S.: "Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, resulting in the suppression of allergic cellular and humoral responses"Immunity. 17. 375-387 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yan, X.: "Antibacterial effect of Kampo herbal formulation Hochu-ekki-to (Bu-Zhong-Yi-Qi-Tang) on Helicobacter pylori infection in mice"Microbiol. Immunol.. 46. 475-482 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Iwakura, Y.: "Roles of IL-1 in the development of rheumatoid arthritis : Consideration from mouse models"Cytokine Growth Factor Rev.. 13. 341-355 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Mizuki, M.: "Comparison of host resistance to primary and secondary Listeriamonocytogenes infections in mice by intranasal and intravenous routes"Infect. Immun.. 70. 4805-4811 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shiraishi, K.: "Roles of RecJ, RecO, and RecR in RecET-mediated illegitimate recombination in Escherichia coli"J. Bacteriol.. 184. 4715-4721 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Minami, M.: "Role of IFN-γ and tumor necrosis facto r-α in herpes simplex virus type I infection"J. Interferon Cytokine Res.. 22. 671-676 (2002)

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      2002 Annual Research Report
  • [Publications] Ishida, Y.: "A pivotal involvement of IFN-γ in the pathogenesis of acetaminophen-induced acute liver injury"FASEB J.. 16. 1227-1236 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Konishi, H.: "IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IqE/stat6 under specific pathogen-free conditions"Proc. Natl. Acad. Sci. USA. 99. 11340-11345 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sasaki, S.: "Roles of gamma interferon and tumor necrosis factor-alpha in shiga toxin lethality"Microb. Pathog.. 33. 43-47 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nagai, Y.: "Essential role of MD-2 in LPS responsiveness and TLR4 distribution"Nat. Immunol.. 3. 667-672 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yamamoto, S.: "Mice deficient in nervous system-specific carbohydrate epitope HNK-1 exhibit impaired synaptic plasticity and spatial learning"J. Biol. Chem.. 277. 27227-27231 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Mizushima, H.: "Reduced postischemic apoptosis in the hippocampus of mice deficient in interleukin-1"J. comparative Neurol.. 448. 203-216 (2002)

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      2002 Annual Research Report
  • [Publications] Asada, H.: "Significant antitumor effects obtained by autologous tumor cell vaccine engineered to secrete interleukin (IL)-12 and IL-18 by means of the EBV/lipoplex"Molec. Therapy. 5. 609-616 (2002)

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      2002 Annual Research Report
  • [Publications] Oguro, T.: "Involvement of tumor necrosis factorα、rather than interleukin-1 or nitric oxides in the HEME Oxygenase-1 gene expression by lipopolysaccharide in the mouse liver"FEBS Letters. 516. 63-66 (2002)

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      2002 Annual Research Report
  • [Publications] Battsetseg, B.: "Immune responses of interferon γ (IFN-γ) knock out mice to repeated Haemaphysalis longicornis (Acari : Ixodidae) nymph infestations"J. Med. Entomol.. 39. 173-176 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Asahi, Y.: "Protection against influenza virus infection in polymeric Ig receptor knockout mice immunized intranasally with adjuvant-combined vaccines"J. Immunol.. 168. 2930-2938 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Furuzawa, M.: "Diurnal variation of heart rate, locomotor activity, and body temperature in interleukin-1 α/β doubly deficient mice"Exp. Anim.. 51. 49-56 (2002)

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      2002 Annual Research Report
  • [Publications] Shinozawa, Y.: "Role of interferon-gamma in inflammatory responses in murine respiratory infection with Legionella pneumophila"J. Med. Microbiol.. 51. 225-230 (2002)

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      2002 Annual Research Report
  • [Publications] Kyuwa, S.: "Acute hepatic failure in IFN-γ-deficient BALB/c mice after murine coronavirus infection"Virus Research. 83. 169-177 (2002)

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      2002 Annual Research Report
  • [Publications] Nagai, Y.: "Requirement for MD-1 in cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide"Blood. 99. 1699-1705 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Brough, D.: "Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism"Mol. Cell. Neurosci.. 19. 272-280 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kakuta, S.: "Inhibition of B16 melanoma experimental metastasis by interferon-γ through direct inhibition of cell proliferation and activation of antitumour host mechanisms"Immunology. 105. 92-100 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Saijo, S.: "Suppression of autoimmune arthritis in IL-1-deficient mice in which T cell activation is impaired due to low levels of CD40L and OX40 expression on T cells"Arth. Rheum.. 46. 533-544 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Le Feuvre, R.A.: "Priming of macrophages with LPS potentiates P2X7 mediated cell death via a caspase-1 dependent mechanism, independently of cytokine production"J. Biol. Chem.. 277. 3210-3218 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 岩倉洋一郎: "関節リウマチモデルマウス"医学のあゆみ. (印刷中). (2003)

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  • [Publications] 岩倉洋一郎: "関節リウマチモデルマウスと創薬への応用"日本薬理学雑誌. 120. 303-313 (2002)

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  • [Publications] 中江進: "接触型過敏症に於けるサイトカインの役割"臨床免疫. 38. 171-178 (2002)

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  • [Publications] 岩倉洋一郎: "IL-1の過剰シグナルによる自己免疫の誘導"蛋白質・核酸・酵素(増刊). 47. 2349-2354 (2002)

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  • [Publications] 岩倉洋一郎: "関節炎発症に於けるIL-1の役割"最新医学. 57. 840-818 (2002)

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  • [Publications] 岩倉洋一郎: "ヒトレトロウイルス感染症モデル:エイズおよび関節リウマチモデル"病理と臨床. 20. 291-299 (2002)

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  • [Publications] 宝来玲子: "IL-1Raノックアウトマウスの関節炎"炎症と免疫. 10. 85-89 (2002)

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  • [Publications] 岩倉洋一郎: "動物発生工学"朝倉書店. 254 (2002)

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  • [Publications] 浅島誠: "バイオサイエンスの新世紀 15「生命工学・新しい生命へのアプローチ」"共立出版社. 291 (2002)

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  • [Publications] 井上達: "ヒト型モデル動物"シュプリンガー・フェアラーク東京. 221 (2002)

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  • [Publications] Takeda, K: "Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells"Nature Medicine. 7. 94-100 (2001)

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  • [Publications] Fukamauchi, F: "TAG-1-deficient mice have marked elevation of adenosine A1 receptors in the hippocampus"Biochem.Biphys.Res.Commun. 281. 220-226 (2001)

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  • [Publications] Seino, K: "Requirement for NKT cells in the induction of allograft tolerance"Proc.Natl.Acad.U.S.. 98. 2577-2581 (2001)

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  • [Publications] Ishii, T: "Projection of three subsets of olfactory neurons expressing the odorant receptor transgene and the two cognate endogenous alleles"Genes to Cell. 6. 71-78 (2001)

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  • [Publications] Naruse-Nakajima, C: "Involvement of EphA2 in the formation of the tail notochord via interaction with ephrinA1"Mecha. Develop. 102. 95-105 (2001)

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  • [Publications] Ozaki, H: "Six-4, a putative myogenin gene regulator, is not essential for mouse embryonal development"Mol.Cell.Biol. 21. 3343-3350 (2001)

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  • [Publications] Kotani, N: "Knockout of mouse β1, 4-galactosyltransferase-1 gene results in a dramatic shift of outer chain moieties of N-glycans from type 2 to type 1 chains in hepatic membrane and plasma glycoproteins"Biochem J.. 357. 827-834 (2001)

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  • [Publications] Boutin, H.: "Role of IL-1α and IL-1β in ischaemic brain damage"J.Neuroscience. 21. 5528-5534 (2001)

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  • [Publications] Morita, Y: "Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function"Cell Death Differ. 8. 614-620 (2001)

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  • [Publications] Sato, M: "Th1 cytokine-conditioned bone marrow-derived dendritic cells can bypass the requirement for Th functions during the generation of CD8(+ CTL"J.Immunol.. 167. 3687-3691 (2001)

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  • [Publications] Imaizumi, Y: "Increased expression of interleukin-1β in mouse hippocampus after global cerebral ischemia"Acta Histochem. Cytochem.. 34. 357-362 (2001)

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  • [Publications] Dal, J.H.: "Glycyrrhizin enhances interleukin-12 production in peritoneal macrophage"Immunology. 103. 235-243 (2001)

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  • [Publications] Norose, K: "Organ infectivity of Toxoplasma gondii in interferon-γ knockout mice"J. Parasitol. 87. 447-452 (2001)

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  • [Publications] Yoneto, T: "A critical role of Fc receptor-mediated antibody-dependent phagocytosis in the host resistance to blood-stage Plasmodium berghei XAT infection"J.Immunol.. 166. 6236-6241 (2001)

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  • [Publications] Hayakawa, Y: "Critical contribution of INF-gamma and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of alpha-galactosylceramide"Eur J Immunol.. 31. 1720-1727 (2001)

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  • [Publications] Shibata, S: "Cloning of a novel 2', 5'-oligoadenylate synthetase-like molecule, Oasl5 in mice"Gene. 271. 261-271 (2001)

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  • [Publications] Nakae, S: "IL-1 enhances T cell-dependent antibody production through induction of CD40L and OX40 on T cells"J.Immunol.. 167. 90-97 (2001)

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  • [Publications] Yasuda, J: "T cell apoptosis causes peripheral T cell depletion in mice transgenic for the HIV-1 vpr"Virology. 285. 181-192 (2001)

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  • [Publications] Miura, T.: "Effect of 6-Hydroxydopamine on host resistance against Listeria monocytogenes infection. Infect"Infect Immun.. 69. 7234-7241 (2001)

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  • [Publications] Le Feuvre, R.A: "Priming of macrophages with LPS potentiates P2X7 mediated cell death via a caspase-1 dependent mechanism, independently of cytokine production"J.Biol.Chem. (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nakae, S: "IL-1α, but not IL-1β, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivity"Int.Immunol.. 13. 1471-1478 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kyuwa, S.: "The severity of hepatic lesion after intraperitoneal JHMV infection in IFN-gamma deficient mice is parallel to viral replication in hepatocytes in vitro"Adv Exp Med Biol.. 494. 95-99 (2001)

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      2001 Annual Research Report
  • [Publications] Moshkin, M.P.: "Social behavior in male mice deficient in genes for interleukin-1"Med.Immunolo.. 3. 449-457 (2001)

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      2001 Annual Research Report
  • [Publications] Yokoyama, H.: "Pathological changes of renal epithelial cells in mice transgenic for the TT virus ORF1 gene"J.Gen.Virol.. 83. 141-150 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Saijo, S.: "Suppression of autoimmune arthritis in IL-1-deficient mice in which T cell activation is impaired due to low levels of CD40L and OX40 expression on T cells"Arth.Rheum.. 46. 533-544 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hayakawa,Y.: "Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells."Nat Med.. 7. 94-100 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Fukamauchi,F.: "TAG-1-deficient mice have marked elevation of adenosine A1 receptors in the hippocampus."Biochem.Biphys.Res.Commun.,. 281. 220-226 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Horai,R.: "Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in IL-1 receptor antagonist-deficient mice."J.Exp.Med.. 191. 313-320 (2000)

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  • [Publications] Serizawa,S.: "Mutually exclusive expression of odorant receptor transgenes."Nat.Neurosci.. 3. 687-693 (2000)

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  • [Publications] Uetani,N.: "Impaired learning with enhanced hippocampal long-term potentiation in PTPδ-deficient mice."EMBO J.. 19. 2775-2785 (2000)

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  • [Publications] Tanaka,J.: "Lipopolysaccharide-induced HIV-1 expression in transgenic mice is mediated by tumor necrosis factor-alpha and interleukin-1, but not by interferon-gamma nor interleukin-6."AIDS. 14. 1299-1307 (2000)

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  • [Publications] Hayashi,K.: "Diminution of the AML1 transcription factor function causes differential effects on the fates of CD4 and CD8 single-positive T cells."J.Immunol.. 165. 6816-6824 (2000)

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  • [Publications] Tagawa,Y.: "Bimodal role of endogenous interleukin-6 in concanavalin A-induced hepatitis in mice."J.Leukoc.Biol.. 67. 90-96 (2000)

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  • [Publications] Hino,A.: "Interferon γ priming is not critical for IL-12 production of murine spleen cells."Cytokine. 12. 12-20 (2000)

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  • [Publications] Miyazato,A.: "Chemokine synthesis and cellular inflammatory changes in lungs of mice bearing p40tax of human T-lymphotropic virus type 1."Clin.Exp.Immunol.. 120. 113-124 (2000)

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  • [Publications] Takikawa,O.: "Interferon-γ-dependent/independent expression of indoleamine 2,3-dioxygenase. Studies with interferon-γ-knockout mice."Adv.Exp.Med.Biol.. 467. 553-557 (2000)

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  • [Publications] Nishihori,H.: "Participation of endogenously produced IFN-γ in interleukin 4-mediated tumor rejection."Human Gene Therapy. 11. 659-668 (2000)

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  • [Publications] Yamaguchi,K.: "Involvement of interleukin-1 in the inflammatory actions of aminobisphosphonates in mice."Br.J.Pharmacol.. 130. 1646-1654 (2000)

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  • [Publications] Ohta,A.: "Indispensable role for TNF-α and IFN-γ at the effector phase of liver injury mediated by Th1 cells specific to hepatitis B virus surface antigen."J.Immunol.. 165. 956-961 (2000)

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  • [Publications] Kawakami,K.: "IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-γ production by NK cells."J.Immunol.. 165. 941-947 (2000)

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  • [Publications] Yamada,H.: "Protective role of interleukin-1 in mycobacterial infection in IL-1 α/β double-knockout mice."Lab.Invest.. 80. 759-767 (2000)

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  • [Publications] Ohkusu,K.: "Potentiality of interleukin-18 as a useful reagent for treatment and prevention of Leishmania major infection."Infect.Immun.. 68. 2449-2456 (2000)

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  • [Publications] Sasaki,S.: "Interleukin-4 and interleukin-10 are involved in host resistance to Staphylococcus aureus infection through regulation of gamma interferon."Infect.Immun.. 68. 2424-2430 (2000)

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  • [Publications] Kido,M.: "Presence of a higher molecular weight β-1,4-galactosyltransferase in mouse liver."Acta Histochem.Cytochem.. 33. 215-221 (2000)

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  • [Publications] Igarashi,I.: "Immunization with recombinant surface antigens p26 with Freund's adjuvants against Babesia rodhaini infection"J.Vet.Med.Sci.. 62. 717-723 (2000)

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  • [Publications] Miura,T.: "Roles of endogenous cytokines in liver apoptosis of mice in lethal Listeria monocytogenes infection."FEMS Immunol.Med.Microbiol.. 28. 335-341 (2000)

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  • [Publications] Mun,H.-S.: "Toxoplasma gondii Hsp70 as a danger signal in Toxoplasma gondii-infected mice."Cell Stress & Chaperones. 5. 328-335 (2000)

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  • [Publications] Sugawara,I.: "IL-4 is required for defense against Mycobacterial infection."Microbiol.Immunol.. 44. 971-979 (2000)

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  • [Publications] Morita,Y.: "Caspase-2 deficiency rescues female germ cells from death due to cytokine insufficiency but not meiotic defects caused by Ataxia Telangiectasia-mutated (Atm) gene inactivation."Endocrinology. (in press).

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  • [Publications] Ishii,T.: "Projection of three subsets of olfactory neurons expressing the odorant receptor transgene and the two cognate endogenous alleles."Genes to Cells.. (in press).

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  • [Publications] Seino,K.: "Requirement for NKT cells in the induction of allograft tolerance."Proc.Natl.Acad.U.S.A.. (in press).

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  • [Publications] Naruse-Nakajima,C.: "Involvement of EphA2 in the formation of the tail notochord via interaction with ephrinA1."Mechanisms of Development.. (in press).

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  • [Publications] Yoneto,T.: "A critical role of Fc receptor-mediated antibody-dependent phagocytosis in the host resistance to blood-stage plasmodium berghei XAT infecion."J.Immunol.. (in press).

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Published: 2000-04-01   Modified: 2016-04-21  

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