| Project/Area Number |
12470109
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | The Jikei University School of Medicine |
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Principal Investigator |
TAKATSU Akihiro Jikei univ.School of Medicine, Med.Professor, 医学部, 教授 (60010089)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUNAGA Tatsushige Mie Univ.School of Medicine, Legal Med.Professor, 医学部, 教授 (70156800)
NAKASONO Ichiro Nagasaki Univ.School of Medicine, Legal Med.Professor, 医学部, 教授 (30108287)
YOSHIOKA Naofumi Univ.of Akita, Legal Med.Professor, 医学部, 教授 (80108935)
NISHI Katsuji Nishi Shiga Univ.of Medical Science, Legal Med.Professor, 医学部, 教授 (60073681)
MAEDA Hiroshi Osaka City Univ.Medical School, Legal Med.Professor., 医学部, 教授 (20135049)
三澤 章吾 筑波大学, 医学群社会医学系, 教授 (50086534)
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| Project Period (FY) |
2000 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥13,400,000 (Direct Cost: ¥13,400,000)
Fiscal Year 2003: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2002: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2001: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2000: ¥6,300,000 (Direct Cost: ¥6,300,000)
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| Keywords | sudden infant death syndrome / sudden infant death / SIDS / organ weight / petechial bleeding / asphyxation / KL-6 / pulmonary infection / 乳幼児突然死 / 肺サーファクタント |
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| Research Abstract |
There are many sudden unexpected infant death cases which are easily diagnosed as sudden infant death syndrome (SIDS) both with or without autopsy in Japan and a easy SIDS diagnosis may provide a cover for accidental or criminal death. Therefore we proposed criteria for a forensic pathological SIDS diagnosis, that is, SIDS should be diagnosed only on the basis of thorough autopsy, death scene investigation and complete rule out of suspicion of accidental or criminal death. The purpose of present study was to verify our criteria in the autopsy cases of sudden infant death, retrospectively and prospectively. Retrospective investigation revealed that only 14 cases of 307 forensic autopsy cases of sudden infant death, in which 122 cases were diagnosed SIDS as the cause of death, should be SIDS as the cause of death according to the criteria.. Our proposal of the criteria may contribute to the recent decrease of SIDS diagnosis in Japan with or without autopsy. As special communications we studied on analysis of autopsy findings, such as organ weight, the existence of petechial bleedings, immunohistochemical analysis of 1 50-kDa oxygen regulated protein, KL-6, pulmonary surfactant-associated protein A in the lung from sudden infant death cases and on the biochemical analysis of postmortem biochemical markers for differential diagnosis between asphyxation death and pulmonary infection death.
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