Project/Area Number |
12470111
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
内科学一般
|
Research Institution | UNIVERSITY OF TSUKUBA |
Principal Investigator |
SHIBUYA Akira University of Tsukuba, Institute of Basic Medical Sciences, Department of Immunology, Professor, 基礎医学系, 助教授 (80216027)
|
Co-Investigator(Kenkyū-buntansha) |
IWAMA Atsushi University of Tsukuba, Institute of Basic Medical Sciences, Department of Immunology, Assistant Professor, 基礎医学系, 講師 (70244126)
SHIBUYA Kazuko Laboratory for Immune Receptor, RIKEN(RCAI), Research Scientist, 免疫アレルギー科学総合研究センター, 研究員 (00302406)
|
Project Period (FY) |
2000 – 2001
|
Project Status |
Completed (Fiscal Year 2001)
|
Budget Amount *help |
¥9,500,000 (Direct Cost: ¥9,500,000)
Fiscal Year 2001: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 2000: ¥5,100,000 (Direct Cost: ¥5,100,000)
|
Keywords | DNAM-1 / killer lymphocytes / viral infection / cancer / CD155 / CD1112 |
Research Abstract |
Cytotoxic lymphocytes play an important role for immune defense against virus-infected cells and cancer. Intercellular adhesion molecule is involved in binding between killer lymphocytes and target cells. We previously identified a novel adhesion molecule DNAM-1 (CD226). Here we have explored the regulatory mechanisms of intercellular binding and signaling mediated by DNAM-1, leading to fundamental understanding for immune defense against virus infection and cancer. Moreover, we have also identified CD155 and CD112 as the DNAM-1 ligands. DNAM-1 binding with its ligands mediates activation signal in cytotoxic Lymphocytes. In addition, we have demonstrated that DNAM-1 also plays an important role for regulation of immune system and thrombosis.
|