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Modulation of Inflammatory Process in COPD Airways

Research Project

Project/Area Number 12470132
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionTohoku University

Principal Investigator

ICHINOSE Masakazu  Tohoku University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (80223105)

Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 2002: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2001: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsCOPD / nitric oxide / inducible nitric oxide aynthase / peroxynitrite / chronic bronchitis / emphysema / reactive nitrogen / airway inflammation / ニトロチロシン / スーパーオキサイド / ザンチンオキシデース / 誘発痰 / パーオキシナイトライト / 肺気腫 / ステロイド / キサンチンオキシデース / 酸化ストレス / 一酸化窒素合成酵素欠損マウス
Research Abstract

Reactive nitrogen species (RNS) including peroxynitrite and nitrogen dioxide, which are formed in the reaction of nitrogen oxide (NO) with superoxide anion and peroxidase-dependent mechanisms, have a potent inflammatory action. Therefore, these molecules may increase and have a role in inflammatory airway diseases. In the present study, we quantified the RNS using immunostaining of nitrotyrosine and inducible NO synthase (iNOS) in airway inflammatory cells obtained by the induced sputum technique as well as the exhaled NO concentration in chronic obstructive pulmonary disease (COPD), asthma and healthy subjets (HS). iNOS immunoreactivity observed in the airway inflammatory cells was significantly and similarly higher in COPD and asthma compared with HS, although the exhaled NO levels were elevated in asthma but not in COPD and HS. The nitrotyrosine immunoreactivity in the inflammatory cells was obvious in COPD and to a lesser extent in asthma but not in HS. There was a significant negative correlation between the percent predicted values of forced expiratory volume in one second and the amount of nitrotyrosine formation in COPD but not in asthma and HS. These results suggest that 1)RNS may be involved in the pathobiology of the airway inflammatory and obstructive process in COPD, 2)NO produced in the airways, presumably via iNOS, seems to be consumed by its reaction with superoxide anion and/or peroxidase-dependent mechanisms.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] 小荒井晃他: "INOS depletion completely diminishes reactive nitrogen-species formation after allergic response"European Respiratory Journal. 20. 609-616 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 戸蒔雅文他: "Comparison of effects of anti-IL3,Il-5 and GM-CSF treatments on Eosinophilopoiesis and airway eosinophilia induced by allergen"Pulmonary Pharmacology & Therapeutics. 15. 161-168 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 大類孝他: "Relationship between asthma severity and progression of Alzheimer's disease"Thorax. 57. 561-561 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Ohrui, H.Arai, M.Ichinose, T.Matsui, M.Yamaya, H.Sasaki: "Relationship between asthma severity and progression of Alzheimer's disease"Thorax 2002. 57. 561 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Tomaki, L.-L.Zhao, M.Sjostrand, A.Linden, M.Ichinose, J.L.Lotvall: "Comparison of effects of anti-IL-3, IL-5 and GM-CSF treatments on eosinophilopoiesis and airway eosinophilia induced by allergen"Pulm Pharm Ther 2002. 15. 161-168 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] A.Koarai, M.Ichinose, H.Sugiura, M.Tomaki, M.Watanabe, S.Yamagata, Y.Komaki, K.Shirato, T.Hattori: "iNOS depletion completely diminishes reactive nitrogen species formation after allergic response"Eur respir J2002. 20. 609-616 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 小荒井晃他: "INOS depletion completely diminishes reactive nitrogen-species formation After an allergic response"European Respiratory Journal. 20. 609-616 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 戸蒔雅文他: "Comparison of effects of anti-IL3, IL5 and GM-CSF treatments on Eosinophilopoiesis and airway eosinophilia induced by allergen"Pulmonary Pharmacology & Therapeutics. 15. 161-168 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 大類孝他: "Relationship between asthma severity and progression of Alzheimer's disease"Thorax. 57. 561-561 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 戸蒔雅文他: "新しい気道炎症の評価法"呼吸器科. 1. 392-397 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 駒木裕一他: "慢性閉塞性肺疾患の新しい診断的アプローチ"現代医療. 34. 109-113 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 一ノ瀬正和: "安定期COPDの薬物療法"治療. 84. 95-100 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 一ノ瀬正和: "Antiallergic drugs (Drugs for the treatment of respiratory diseases)"Cambridge University Press. 5 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 戸蒔雅文, 一ノ瀬雅一 他: "Comparison of effects of anti-IL-3,IL-5 and GM-C SF treatments on eosinophilopoiesis and airway eosinophilia induced by allergen"Pulmonary Pharmacology & Therapeutics. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 小荒井晃, 一ノ瀬正和 他: "iNOS depletion completely diminishes reactive nitrogen species formation after allerqic response"European Respiratory Journal. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 杉浦久敏, 一ノ瀬正和 他: "Correlation between pulmonary function change and supression in reactive nitrogen species production in COPD following steroid treatment"Thorax. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 山縣俊介, 一ノ瀬正和: "呼気ガス分析による気道炎症の評価"医学の歩み. 198. 483-487 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 一ノ瀬正和: "COPD薬物治療の進歩"日本医師会雑誌. 126. M22-M24 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 杉浦久敏, 一ノ瀬正和: "CDPDと新治療薬"治療学. 35. 53-56 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 小荒井晃 他: "Histamine Research in the New Millennium"Endogenous histamine and allergic eosinophil infiltration into the airways. 6 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 山縣俊介 他: "Effect of a calcium sensitization modulator, Y-27632, on isolated human bronchus and pulmonary artery"Pulmonary Pharmacology & Therapeutics. 13. 25-29 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 一ノ瀬正和 他: "Baseline airway hyperresponsiveness and its reversible component : role of inflammation and airway calibre"European Respiratory Journal. 15. 248-253 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 一ノ瀬正和 他: "Increased in reactive nitrogen species production in chronic obstructive pulmonary disease airways"American Journal of Respiratory & Critical Care Medicine. 162. 701-706 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 小荒井晃 他: "Allergic airway hyperresponsiveness and eosinophil infiltration is reduced by a selective iNOS inhibitor, 1400W, in mice"Pulmonary Pharmacology & Therapeutics. 13. 267-275 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 杉浦久敏 他: "インフルエンザウイルス感染と気道過敏性"呼吸と循環. 48. 1119-1125 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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