• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Chemokine signaling in myasthenia gravis and multiple sclerosis

Research Project

Project/Area Number 12470139
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionTohoku University

Principal Investigator

ONODERA Hiroshi  Graduate school, of medicine, associate professor, 大学院・医学系研究科, 助教授 (20214207)

Co-Investigator(Kenkyū-buntansha) FUJIHARA Kazuo  Graduate school of medicine, associate professor, 医学部附属病院, 助教授 (70280873)
ITOYAMA Yasuto  Graduate school of medicine, professor, 大学院・医学系研究科, 教授 (30136428)
YOSHIE Osamu  Kinki University, School of medicine, Professor, 医学部, 教授 (10166910)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2002: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2001: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsmyasthenia gravis / thymus / chemokine / multiple sclerosis / homing / 神経免疫疾患 / エオタキシン
Research Abstract

We studied chemokine signaling in lymphocytes of patients with myasthenia gravis and multiple sclerosis. Th1-type chemokine signaling in peripheral blood CD4+ T cells was significantly altered in myasthenia gravis patients with thymoma, while both Th1-and Th2-type chemokine signaling were altered in patients with hyperplasic thymus. The mRNA level for chemokine CCL21 was selectively increased in the hyperplasic thymuses, and cellular migration by CCL21 was markedly enhanced in thymocytes obtained from hyperplasic thymuses but not from normal thymuses or thymomas. The expression of another CCR7 ligand named CCL19 was similar among normal thymuses, hyperplasic thymuses, and thymomas. Since CCL21 plays a critical role in the homing of lymphocytes and dendritic cells to lymphoid organs and B cells activation, the elevated CCL21 expression in hyperplasic thymuses is causatively associated with the immune abnormalities of myasthenia gravis patients with thymic hyperplasia. Th1-type chemokine receptor expression on cerebrospinal fluid (CSF) T cells were significantly elevated in multiple sclerosis patients. The number of CD4+ T cells with CCR5 in CSF was transiently increased at relapse stage. In contrast, the number of CD4+ T cells with another Th1-type receptor CXCR3 remained high in the CSF obtained both at relapse stage and remission stage. These data suggest that modulation of chemokine signaling is a promising method to treat patients with myasthenia gravis and multiple sclerosis.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Misu T, Oncdera H, et al.: "Chemokine receptor expression on T cells in blood and cerebrospinal fluid at relapse and remission of multiple sclerosis"J. Neuroimmunology. 114. 207-212 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nagata T, Onodera H, et al.: "Decreased expression of c-myc genes in thymuses from myasthenia gravis patients"J. Neuroimmunology. 115. 199-202 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsuda T, Onodera H, et al.: "Impaired chemosensitivity of hypoxia is a marker of multiple system atrophy"Annals of Neurology. 52. 367-371 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Onodera H. et al.: "Effect of 10-T static magnetic field on human peripheral blood immune cells"Radiation Research. (in press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mitu T, Onodera H, Fujihara K, Matsushima K, Yoshie O, Okita N, Takase S, Itoyama Y: "Chemokine receptor expression on T cells in blood and cerebrospinal fluid at relapse and remission of multiple sclerosis: imbalance of Th1/Th2-associated chemokine signaling"J Neuroimmunol. 114. 207-12 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nagata T, Onodera H, Ohuchi M, Suzuki Y, Tago H, Fujihara K, Ishii N, Sugamura K, Shoji Y, Handa M, Tabayashi K, Itoyama Y: "Decreased expression of c-myc family genes in thymuses from myasthenia gravis patients"J Neuroimmunol. 115. 199-202 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsuda T, Onodera H, Okabe S, Kikuchi Y, Itoyama Y: "Impaired chemosensitivity to hypoxia is a marker of multiple system atrophy"Ann Neurol. 52. 367-71 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Onodera H, Jin Z, Chida S, Suzuki Y, Tago H, Itoyama Y: "Effects of 10-Tesia static magnetic field on human peripheral blood immune cells"Radiation Research. (in press). (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Onodera H. et al.: "Effect of 10-T static magnetic field on human peripheral blood immune cells"Radiation Research. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tsuda T, Onodera H. et al.: "Impaired chemosensitivity to hypoxia is a marker of multiple system atrophy"Annals of Neurology. 52. 367-371 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 小野寺 宏: "ケモカイン"医学のあゆみ(21世紀の神経免疫学). 36-39 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 田郷英昭, 小野寺 宏他: "重症筋無力症患者胸腺におけるCCRクリガンドの発現の検討"神経免疫学. 100 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 小野寺宏: "ケモカイン"医学のあゆみ(別冊 21世紀の神経免疫学). 36-39 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 小野寺宏: "重症筋無力症の分子免疫学"Molecular Medicine. 37. 122-130 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nagata T, Onodera H. 他: "Decreased expression of c-myc genes in thymuses from myasthenia gravis patients"J. Neuroimmunol. 115. 199-202 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Misu T, Onodera H. 他: "Chemokine receptor expression on Tcells in blood and cerebrospinal fluid at relapse and remission of multiple Sclerosis"J. Neuroimmunal. 114. 207-212 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 小野寺 宏: "多発性硬化症 EBM"臨床医. 27. 1580-1583 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 小野寺 宏: "重症筋無力症におけるケモカイン"Neuroimmunology. 9. 229-232 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Onodera H,Okabe S,Kikuchi Y,Tsuda T.Itoyama Y.: "Impaired chemosensitivity and perception of dyspnoea in Parkinson's disease"Lancet. 356. 739-740 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Onodera H,Okabe S,Kikuchi Y Tsuda T,Itoyama Y.: "Parkinson's disease and impaired chemosensitivity to hypoxia."Lancet. 356. 2099-2099 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Misu T,Onodera H 他: "Chemokine receptor expression on T-cells in blood and cerebrospinal fluid at relapse and emission of multiple sclerosis"Journal of Neuroimmunology. 114. 207-212 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Natagat T,Onodera H 他: "Decreased expression of c-myc family genes in thymuses from myasthenia gravis patients"Journal of Neuroimmunology. (印刷中). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 小野寺宏,鈴木靖士 他: "重症筋無力症胸腺細胞におけるケモカイン受容体発現細胞の変化"Neuroimmunology. 9. 84-85 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 鈴木靖士,小野寺宏 他: "重症筋無力症における胸腺摘出術前後でのケモカイン受容体発現細胞の変化Th1/Th2バランスの検討"Neuroimmunology. 9. 86-87 (2001)

    • Related Report
      2000 Annual Research Report

URL: 

Published: 2001-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi