| Project/Area Number |
12470142
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
KIRA Jun-ichi Dep. of Neurology, Kyushu University, Prof., 大学院・医学(系)研究科(研究院), 教授 (40183305)
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| Co-Investigator(Kenkyū-buntansha) |
MURAI Hiroyuki Dep. of Neurology, Kyushu University, Res. Ass., 大学院・医学(系)研究科(研究院), 助手 (80325464)
MATSUSHITA Sho Kumamoto Univ., Ass. Prof., 大学院・医学研究科, 助教授 (50167649)
FURUE Masutaka Dep. of Dermatology, Kyushu University, Prof., 大学院・医学(系)研究科(研究院), 教授 (70134583)
OSOEGAWA Manabu Dep. of Neurology, Kyushu University, 大学院・医学(系)研究科(研究院), 非常勤研究員
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥16,000,000 (Direct Cost: ¥16,000,000)
Fiscal Year 2001: ¥5,300,000 (Direct Cost: ¥5,300,000)
Fiscal Year 2000: ¥10,700,000 (Direct Cost: ¥10,700,000)
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| Keywords | atopic myelitis / atopic dermatitis / airway allergy / eosinophils / eosinophil cationic protein / CD8 T cells / optico-spinal form of multiple sclerosis / DPB1^*0501 / 運動ニューロン / Th2 / eotaxin / RANTES / EDN / ECP |
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| Research Abstract |
1) Clinicolaboratory findings of atopic myelitis with regard to the coexistence of atopic disorders
We conducted a nation-wide survey of atopic myelitis in Japan and then collected 85 cases of this myelitis. Comparison of clinicolaboratory findings between atopic myelitis with and without atopic dermatitis revealed the characteristics of this myelitis as follows ; myelitic patients with atopic dermatitis showed (1)female predominance, (2)younger age of onset, (3)preferential involvement of the cervical cord and (4)less frequent occurrences of sphincter disturbance as comopared to those without atopic dermatitis.
2) Immunopathological findings of eosinophilic myelitis
Five biopsid cases of eosinophilic myelitis with atopy was collected from all over the country. Immunohistological staining of all biopsied specimens revealed the perivascular lymphocyte cuffings mainly consisted of T cells. In three cases further examined for T cell subsets, CD8 T cells were predominant in the perivascular a
… More
reas. Moreover, large amounts of eosinophilic cationic protein was found to be deposited in the spinal cord tissues in all cases examined.
3) Class II MHC genotypes in atopic myelitis
The associations with DPB1*0501 and DRB1*1501 have been demonstrated in optico-spinal and conventional form of multiple sclerosis, respectively. However, we could not demonstrate either DPB1*0501 or DRB1*1501 association with topic myelitis.
4) Treatment of atopic myelitis
Although a treatment with corticosterods was shown to shorten the duration of acute events due to multiple sclerosis, this treatment was not effective in about two thirds of patients with atopic myelitis. About eighty percentages of patients with this myelitis were successfully treated with plasma exchange. Intravenous immunoglobulin therapy combined with plasma exchange was also useful.
The results of this study revealed the presence of atopy-related myeltis in Japanese, in which eosinophils were considered to play a critical role for tissue destruction like other atopic disorders, yet the precise mechanism including the spinal cord inflammation remains to be elucidated. Less
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