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Gene transfer-mediated molecular analysis of pathophysiology in injured arteries

Research Project

Project/Area Number 12470157
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionUniversity of Occupational and Environmental Health

Principal Investigator

UENO Hikaru  University of Occupational and Environmental Health, School of Medicine, Professor, 医学部, 教授 (50260378)

Co-Investigator(Kenkyū-buntansha) SASAGURI Yasuyuki  University of Occupational and Environmental Health, School of Medicine, Professor, 医学部, 教授 (60140646)
MATSUDA Takehisa  Kyushu University, Faculty of Medical Sciences, School of Medicine, Professor, 大学院・医学系研究科, 教授 (60142189)
HAMADA Hirofumi  Sapporo Medical University, School of Medicine, Professor, 医学部, 教授 (00189614)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥14,100,000 (Direct Cost: ¥14,100,000)
Fiscal Year 2002: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 2001: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 2000: ¥5,300,000 (Direct Cost: ¥5,300,000)
Keywordsthrombosis / inflammation / injured arteries / gene transfer / extracelluar matrix protein / TFPI / C-type natriuretic peptide / PAF-AH / 血栓症 / 再狭窄 / 傷害血管 / 糖尿病 / 不全心筋 / 抗血栓分子 / 遺伝子治療 / 人工血管 / TGF-β
Research Abstract

We tried to analyze the molecular pathophysiology of injured arteries using in vivo gene transfer technique. We focused on inflammation, thrombosis and fibroproliferative changes (remodeling or fibrosis).
1. Gene transfer of TFP1 (Tissue factor pathway inhibitor) into injured arteries showed an anti-thrombotic effect. A combination of irrigation with TFP1 protein and gene transfer exhibited additional benefits.
2. Over expression of CNP (C-type natriuretic peptide) enhances expression of inducible nitric oxide synthase leading to increased production of NO, thus eliminates thrombosis and suppresses inflammation.
3. PAF-AH (Platelet activating factor acetylhydrolase) inactivates PAF and PAF-like phospholipids. Overexpression of PAF-AH potent anti-inflammatory, anti-thrombotic and anti-proliferative effects. We found that oxidized LDL is accumulated in the walls in a short period of time following injury even in non-hyperlipidemic animals.
4. Local expression of angiopoietin-1 also showed anti-thrombotic and anti-inflammatory effects. Molecular basis underlying these effects are now investigated.
5. In the injured arteries of diabetic animals, extracellular matrix proteins are readily accumulated. When we introduced a soluble form of TGF-β receptor (which adsorbs TGF-β and may function as a dominant-negative receptor to inhibit function of the receptor), the activity of matrix metalloproteinase was reduced, and fibroproliferative changes were almost eliminated. The soluble TGF-β receptor may have a potent therapeutic effect.
6. We analyzed intracellular signaling in failed cardiomyocytes.
7. We investigated a thrombosis-resistant artificial artery which is a hybrid between biomaterials and fibroblasts in which TFPI, CNP and or VEGF gene was transfected.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (66 results)

All Other

All Publications (66 results)

  • [Publications] Hirotani S: "Involvement of NF-kB and ASK1 in G-Protein coupled receptor agonist-induced cardiomyocyte hypertrophy"Circulation. 105. 509-515 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Qian J.-Y: "Local expression of C-type natriuretic peptide suppresses inflammation and eliminates shear stress-induced thrombosis through enhanced nitric oxide production in rabbit injured carotid arteries"Circ.Res.. 91. 1063-1069 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Higuchi Y: "Involvement of reactive oxygen species-mediated NF-κB activation in TNF-ct-induced cardiomyocyte hypertrophy"J Mol.Cell, Cardiol.. 34. 233-240 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakayama Y: "Development of high-performance stent : gelatinous photogel-coated stent that permits drug delivery and gene transfer"J.Biomed.Mater.Res.. 57. 559-566 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masaki I: "Recombinant Sendai Virus-mediated Gene Transfer to Vasculature : a new class of efficient gene transfer vector to the vascular system"FASEB J.15:1294-1296,2001.. 15. 1294-1296 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Iwatate M: "Effects of in vivo gene transfer of FGF-2 on cardiac function and collateral vessel formation In microembolized rabbit heart"Jpn.Circ.J.65:226-231,2001. 65. 226-231 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirotani S, Otsu K, Higuchi Y, Morita T, Nakayama H, Yamaguchi O, Mano T, Matsumura Y, Ueno H, Tada M, Hori M.: "Involvement of NF-KB and ASK1 in V-Protein coupled receptor agonist-induced cardiomyocyte hypertrophy"Circulation. 105. 509-515 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Qian J.-Y, Haruno A, Asada Y, Nishida T, Nakamura T, Saito Y, Matsuda T, Ueno H.: "Local expression of C-type natriuretic peptide suppresses inflammation and eliminates shear stress-induced thrombosis through enhanced nitric oxide production in rabbit injured carotid arteries"Circ. Res.. 91. 1063-1069 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Higuchi Y, Otsu K, Nishida K, Hirotani S, Nakayama H, Yamaguchi O, Matsuyama Y, Ueno H, Tada M, Hori M.: "Involvement of reactive oxygen species-mediated NF-κB activation in TNF-α-induced cardiomyocyte hypertrophy"J Mol. Cell, Cardiol.. 34. 233-240 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakayama Y, Ji-Youn K, Nishi S, Ueno H, Matsuda T.: "Development of high-performance stent: gelatinous photogel-coated stent that permits drug delivery and gene transfer"J. Biomed. Mater. Res.. 57. 559-566 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masaki I, Yonemitsu Y, Komori K, Ueno H, Nakashima Y, Sugimachi K, Hasegawa M, Sueishi K.: "Recombinant Sendai Virus-mediated Gene Transfer to Vasculature: a new class of efficient gene transfer vector to the vascular system"FASEB J.. 15. 1294-1296 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Iwatate M, Miura T, Ikeda Y, Kawamura S, Dairaku Y, Okamura T, Kimura M, Yamaguchi K, Ueno H, Matsuzaki M.: "Effects of in vivo gene transfer of FGF-2 on cardiac function and collateral vessel formation in microembodied rabbit heart"Jpn. Circ. J.. 65. 226-231 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Iwasaki H, Eguchi S, Ueno H, Marumo F, Hirata Y.: "Mechanical stretch stimulates growth of vascular smooth muscle cells via epidermal growth factor receptor"Am. J. Physiol.. 278. H521-H529 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Morishige K, Shimokawa H, Yamawaki Y, Miyata K, Eto Y, Kandabashi T, Yogo K, Higo T, Egashira K, Ueno H, Takeshita A.: "Local adenovirus-mediated transfer of C-type natriuretic peptide suppresses vascular remodeling in porcine coronary arteries in vivo"J. Am. Coll. Cardiol.. 35. 1040-1047 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shinozaki M, Ueno H, Kashiwagi M, Ando T, Nishio S, Tamaki K, Hirakata H, Okuda S, Shimizu K, Oohashi H, Fujishima M: "In vivo gene transfer of soluble TGF-β recepter prevents renal fibrosis"J Am Soc of Nephrol. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mehrara BJ, Spector JA, Greenwald JA, Ueno H, Longaker MT.: "Adenovirus-mediated transmission of a dominant negative transforming growth factor-beta receptor inhibits in vitro mouse cranial suture fusion"Plast Reconstr Surg. 110. 506-514 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sakaue H, Konishi M, Ogawa W, Asaki T, Mori T, Yamasaki M, Takata M, Ueno H, Kato S, Kasuga M, Itoh N.: "Requirement of fibroblast growth factor 10 in development of white adipose tissue"Genes Dev.. 16. 908-912 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ogawa T, Takayama K, Takakura N, Kitano S, Ueno H.: "Anti-tumor angiogenesis therapy using soluble receptors: enhanced inhibition of tumor growth when soluble FGF receptor are used with soluble VEGF receptor"Cancer Gene Ther. 9. 633-402 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okamoto M, Ono M, Uchumi T, Ueno H, Kohno K, Sugimachi K, Kuwano M.: "Up-regulation of thrombospondin-1 gene by epidermal growth factor and transforming growth factor-β in human cancer cells: transcriptional activation and messenger RNA stabilization"Biochimica. Biophisica. Acta.. 1574. 24-34 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hisatomi T, Sakamoto T, Sassa Y, Kubota T, Ohnishi Y, Ishibashi T, Ueno H.: "Retinal gliosis was inhibited by systemically expressed soluble TGF-b II receptor in rats"Lab Invest. 82. 863-870 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Oshima Y, Sakamoto T, Hisatomi T, Ishibashi T, Ueno H.: "Gene transfer of soluble TGF-β receptor II inhibits the progression of experimental PVR"Gene Ther.. 9. 1214-1220 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yan Y, Zeng Z-Z, Higashi S, Denda A, Konishi Y, Onishi S, Ueno H, Higashi K, Hirai H.: "Resistance of DRH strain rats to chemical carcinogenesis of liver: genetic analysis of later progression stage"Carcinogenesis. 23. 189-195 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Greenwald JA, Mehrara BJ, Spector JA, Warren SM, Fagenholz PJ, Smith LE, Bouletreau PJ, Crisera FE, Ueno H, Longaker MT.: "In vivo modulation of FGF biological activity alters cranial suture fate"Am J Pathol. 158. 441-452 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Atsuchi N, Nishida A, Ueno H.: "Combination of a brief irrigation with tissue factor pathway inhibitor (TFPI) and adenovirus-mediated local TFPI gene transfer additively reduces neointima formation in balloon-injured rabbit carotid arteries"Circulation. 103. 570-575 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yashima R, Abe M, Tanaka K, Ueno H, Shitara K, Takenoshita S, Sato Y.: "Heterogeneity of the signal transduction pathways for VEGF-induced MAPKs activation in human vascular endothelial cells"J. Cell. Physiol.. 188. 201-210 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Iida N, Namikawa K, Kiyama H, Ueno H, Nakamura S, Hattori S.: "Requirement of Ras for the activation of mitogen-activated protein kinase by calcium influx, cAMP, and neurotrophin in hippocampal neurons"J. Neurosci.. 21. 6459-6466 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takayama K, Ueno H, Nakanishi Y, Sakamoto T, Inoue K, Shimizu K, Oohashi H, Hara N.: "Suppression of tumor angiogenesis and growth by gene transfer of a soluble form of VEGF receptor into a remote organ"Cancer Res. 60. 2169-2177 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sato N, Mizumoto K, Nakamura M, Ueno H, Minamishima Y, Farber JL, Tanaka M.: "A possible role for centrosome overduplication in radiation-induced cell death"Oncogene. 19. 5281-5290 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Honda M, Sakamoto T, Ishibashi T, Inomata H, Ueno H.: "Adenovirus-mediated gene transfer of soluble flt-1 receptor inhibits the experimental subretinal neovascularization"Gene Ther. 7. 978-985 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shiose S, Sakamoto T, Yoshikawa H, Hata Y, Kawano Y, Ishibashi T, Inomata H, Takayama K, Ueno H.: "Adenovirus-mediated gene transfer of a soluble receptor of vascular endothelial growth factor inhibits the growth of experimental eyelid malignant melanoma"Invest. Ophthalmol. Vis. Sci.. 41. 2395-2403 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tokumitsu K, Nakano S, Ueno H, Niho Y.: "Suppression of malignant growth potentials of v-Src-transformed human gallbladder epithelial cells by adenovirus-mediated dominant negative Ras"J Cell. Physiol.. 183. 221-227 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tremain T, Marko M, Kinnimulki V, Ueno H, Bottinger E, Glick A.: "Defects in TGF-β signaling overcome senescence of mouse keratinocytes expressing v-Ha-ras"Oncogene. 19. 1698-1709 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ueoka Y, Kato K, Kuriaki Y, Horiuchi S, Terao Y, Nishida J, Ueno H, Wake N.: "Hepatocyte growth factor modulates motility and invasiveness of ovarian carcinomas via Ras-MAP kinase cascade"Br. J. Cancer. 82. 891-899 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saadeh PB, Mehrara BJ, Steinbrech DS, Spector JA, Greenwald JA, Chin GS, Ueno H, Gittes GK, Longaker MT.: "Mechanisms of FGF-2 modulation of VEGF expression by osteoblastic cells"Endocrinology. 141. 2075-2083 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Osaki S, Nakanishi Y, Takayama K, Pei X-H, Ueno H, Hara N.: "Alteration of drug chemosensitivity caused by the adenovirus-mediated transfer of the wild-type p53 gene in human lung cancer cells"Cancer Gene Ther.. 7. 300-307 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakamura T, Sakata R, Ueno T, Sata M, Ueno H.: "Inhibition of Transforming Growth Factor-β prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats"Hepatology. 32. 247-255 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sakamoto T, Ueno H, Sonoda KH, Hisatomi T, Shimizu K, Ohashi H, Inomata H.: "Blockade of TGF-β by in vivo gene transfer of a soluble TGF-β type II receptor in the muscle inhibits corneal opacification, edema and angiogenesis"Gene Ther.. 7. 1915-1924 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ueno H, Sakanoto T, Nakamura T, Atsuchi N, Takeshita A, Shimizu S, Ohashi H.: "A soluble TGF-βreceptor expressed in muscle prevents liver fibrogenesis and dysfunction in rats"Hum Gene Ther. 11. 33-42 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tanaka E, Ando K, Ueno H, Sugio Y, Mohammed MU, Voltchikhina SA, Mori H.: "Amelioration of microvascular myocardial ischemia by gene transfer of vascular endothelial growth factor in rabbits"J Thorac Cardiov Sur. 120. 720-728 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirashima Y, Ueno H, Karasawa K, Yokoyama K, Setaka N, Takaku A.: "Transfection of the plasma-type platelet-activating factor acethylhydrolase gene attenuates glutamate-induced apoptosis in cultured rat cortical neurons"Brain Res. 885. 128-132 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Qian J.-Y.: "Local expression of C-type natriuretic peptide suppresses inflammation and eliminates shear stress-induced thrombosis through enhanced nitric oxide production in rabbit injured carotid arteries"Circ. Res.. 91. 1063-1069 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ogawa T.: "Anti-tumor angiogenesis therapy using soluble receptors : enhanced inhibition of tumor growth when soluble FGF receptor are used with soluble VEGF receptor"Cancer Gene Ther.. 9. 633-640 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sakaue H.: "Requirement of fibroblast growth factor 10 in development of white adipose tissue"Genes Dev.. 16. 908-912 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hisatomi T.: "Retinal gliosis was inhibited by systemically expressed soluble TGF-b II receptor in rats"Lab Invest. 82. 863-870 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hirotani S.: "Involvement of NF-kB and ASK1 in G-Protein coupled receptor agonist-induced cardiomyocyte hypertrophy"Circulation. 105. 509-515 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Higuchi Y.: "Involvement of reactive oxygen species-mediated NF-kB activation in TNF-a-induced cardiomyocyte hypertrophy"J Mol. Cell, Cardiol.. 34. 233-240 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Atsuchi N.: "Combination of a brief irrigation with tissue factor pathway inhibitor (TFPI) and adenovirus-mediated local TFPI gene transfer additively reduces neointima formation in balloon-injured rabbit carotid arteries"Circulation. 103. 570-575 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nakayama T.: "Development of high-performance stent : gelatinous photogel-coated stent that permits drug delivery and gene transfer"J. Biomed. Mater. Res. 57. 559-566 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Masaki I.: "Recombinant Sendai Virus-mediated Gene Transfer to Vasculature : a new class of efficient gene transfer vector to the vascular system"FASEB J.. 15. 1294-1926 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yashima R.: "Heterogeneity of the signal transduction pathways for VEGF-induced MAPKs activation in human vascular endothelial cells"J. Cell. Physiol.. 188. 201-210 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Iida N.: "Requirement of Ras for theactivation of mitogen-activated protein kinase by calcium influx, cAMP, and neurotrophin in hippocampal neurons"J. Neurosci.. 21. 6459-64466 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Okamoto M.: "Up-regulation of thrombospondi-1 gene by epidermal growth factor and transforming growth factor-b in human cancer cells : transcriptional activation and messenger RNA stabilization"Biochimica. Biophysica. Acta.. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Atsuchi N.: "Combination of a brief irrigation with tissue factor pathway inhibitor (TFPI) and adenovirus-mediated local TFPI gene transfer additively reduces neointima formation in balloon-injured rabbit carotid arteries."Circulation. 103. 570-575 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Morishige K.: "Local adnovirus-mediated transfer of C-type natriuretic peptide suppresses vascular remodeling in porcine coronary arteries in vivo."J.Am.Coll.Cardiol.. 35. 1040-1047 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tanaka E.: "Amelioration of microvascular myocardial ischemia by gene transfer of vascular endothelial growth factor in rabbits."J Thorac Cardiov Sur. 120. 720-728 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hirashima Y.: "Transfection of the plasma-type platelet-activating factor acethylhydrolase gene attenuates glutamate-induced apoptosis in cultured rat cortical neurons."Brain Res.. 885. 128-132 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Iwatate M.: "Effects of in vivo gene transfer of FGF-2 on cardiac function and collateral vessel formation in microembolized rabbit heart."Jap.Circ.J.. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Iwasaki H.: "Mechanical stretch stimulates growth of vascular smooth muscle cells via epidermal growth factor receptor."Am.J.Physiol.. 278. H521-H529 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Masaki I.: "Recombinant Sendai Virus-mediated Gene Transfer to Vasculature : a new class of efficient gene transfer vector to the vascular system."FASEB J.. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nakamura T.: "Inhibition of Transforming Growth Factor-β prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats."Hepatology. 32. 247-255 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sakamoto T.: "Blockade of TGF-β by in vivo gene transfer of a soluble TGF-β type II receptor in the muscle inhibits corneal opacification, edema and angiogenesis."Gene Ther.. 7. 1915-1924 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ueno H.: "A soluble TGF-β receptor expressed in muscle prevents liver fibrogenesis and dysfunction in rats."Hum Gene Ther.. 11. 33-42 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Takayama K.: "Suppression of tumor angiogenesis and growth by gene transfer of a soluble form of VEGF receptor into a remote organ."Cancer Res.. 60. 2169-2177

    • Related Report
      2000 Annual Research Report
  • [Publications] Sato N.: "A possible role for centrosome overduplication in radiation-induced cell death."Oncogene. 19. 5281-5290

    • Related Report
      2000 Annual Research Report
  • [Publications] Honda M.: "Adenovirus-mediated gene transfer of soluble flt-1 receptor inhibits the experimental subretinal neovasucularization."Gene Ther.. 7. 978-985 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shiose S.: "Gene transfer of a soluble receptor of VEGF inhibits the growth of experimental eyelid malignant melanoma."Invest.Ophthalmol.Vis.Sci.. 41. 2395-2403 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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