| Co-Investigator(Kenkyū-buntansha) |
NOMURA Akihiko Kyushu University, Graduate School of Medical Sciences, Teaching staff, 大学院・医学研究院, 助手 (00325531)
KANEMITSU Satomi Kyushu University Hospital, Teaching staff, 医学部附属病院, 助手 (50315066)
IHARA Kenji Kyushu University Hospital, Teaching staff, 医学部附属病院, 助手 (80294932)
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| Budget Amount *help |
¥8,700,000 (Direct Cost: ¥8,700,000)
Fiscal Year 2002: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 2001: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 2000: ¥3,500,000 (Direct Cost: ¥3,500,000)
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| Research Abstract |
Mycobacterial infections
IFN-gamma-mediated immunity plays an important role in host defense against ituraceliuiar pathogens, especially mycobacteria. Japanese children with bacille Calmelte-Guerin (BCG) osteomyelitis or recurrent mycobacterial infections were evaluated for mutations of genes involved in IL-I2-dependent, IFN-gamma-mediated immunity. Heterozygous smalt deletions with frameshift (818del4 and 811del4) that are consistent with the diagnosis of partial dominant IFN-gamma receptor 1 deficiency were detected in 3 unrelated patients. This study demonstrated that IFN-gammaR1 gene analysis would be useful in the determination of individuals who are susceptible to mycobacterial infections (J Infect Dis 2002).
Asthma
We investigated the association of Th1/Th2-related molecules and atopic asthma in Japanese population. With regard to IFNG, IFNGR1, IFNGR2, IL-13 receptor, IL-13, FcεR, CD28, CTLA-4, SLAM, histamine receptor 1, 2, and histamine N-methyltransferase genes, no associations were observed. IL-4, IL-4 receptor, and IRF1 genes showed significant associations with atopic asthma. Thus, analysis of IL-4, IL-4 receptor, and IRF1 polymorphisms would be useful in the determination of individuals of atopic asthma (J Allergy Clin Immunol 2000).
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