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Molecular Mechanism and Hemodynamic Function in the Outflow Tract of Heart

Research Project

Project/Area Number 12470172
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionTokyo Women's Medical University

Principal Investigator

NAKAZAWA Makoto  Tokyo Women's Med Univ., Medicine, Professor, 医学部, 教授 (10075567)

Co-Investigator(Kenkyū-buntansha) TAKEUCHI Takashi  Mitsubishi Kagaku Institute of Life Sciences, Developmental Regulation, Chief Research Scientist, 発生制御, 主任研究員
YAMAMURA Hideji  Tokyo Women's Med Univ., Medicine, Research Associate, 医学部, 助手 (90230531)
TOMITA Sachiko (MIYAGAWA Sachiko)  Tokyo Women's Med Univ., Research Associate, 医学部, 助手 (40231451)
SUGIMURA Hiroko  Tokyo University, Medicine, Research Associate, 医学部, 助手 (70291698)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥12,500,000 (Direct Cost: ¥12,500,000)
Fiscal Year 2002: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2001: ¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 2000: ¥6,500,000 (Direct Cost: ¥6,500,000)
Keywordsheart / the outflow tract / jumonji / mouse embryo / chick embryo / development / the cardiac neural crest / Jumonji遺伝子 / Jumonji
Research Abstract

The recessive mutant mouse Jumonji, obtained by a gene trap strategy, shows cardiac defects. Myocytes in the ventricular trabeculae show hyperproliferation suggesting that Jumonji gene downregulates cell growth of the cardiac myocytes. Jumonj - overexpressing mice shows repression of cyclin D1 expression in the heart. We found that Jumonj protein binds to a region in the cyclin D1 promoter and represses the promoter activity. Cyclin D1-overexpressing mice shows same abnormalities observed in the heart of Jumonj mutant mice. These results showed that Jumonj gene downregulates cell growth of the cardiac myocytes by repressing the expression of cyclin D1 directly. Furthermore, cyclin D1 is necessary for th e arrest of cardiac proliferation. Ablation of the premigrated cardiac neural crest from chick embryos induces trucus areteriosus in heart. Resulting from the ablation and transplantation experiments of the cardiac neural crest in chick embryos shows that the cardiac neural crest may regulate proliferation and cell death of myocardium.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report

Research Products

(170 results)

All Other

All Publications (170 results)

  • [Publications] Suzuki A, Miyagawa-Tomita S, Nakazawa M, Sakamura Y, et al.: "Active remodeling of the coronary arterial lesions in the late phase of Kawasaki disease : immunohistochemical study"Circulation. 101. 2941-2953 (2000)

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  • [Publications] Suzuki A, Miyagawa-Tomita S, Nakazawa M, Yutani C: "Remodeling of coronary artery lesions due to Kawasaki Disease"Jpn Heart J. 41(3). 245-256 (2000)

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  • [Publications] Saga Y, Kitajima S, Miyagawa-Tomita S: "Mesp1 expression is the earliest sign of cardiovascular development"Trend Cardiovasc Med. 10(8). 345-352 (2000)

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  • [Publications] Toyoda, M., Kojima, M., Takeuchi, T.: "Jumonji proteinis a nuclear protein that participates in the negative regulation of cell growth"Biochem. Biophys. Res. Commun. 274. 332-336 (2000)

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  • [Publications] Shen J, Nakanishi T, Gu H, Miyagawa-Tomita S, Wu GR, Momma K, Nakazawa M: "The role of endothelin in oxygen-induced contraction of the ductus arteriosus in rabbit and rat fetuses"Heart Vessels. 16. 181-188 (2002)

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  • [Publications] Naruse M, Ishihara Y, Miyagawa-Tomita, et al.: "3-Methyl-cholanthrene, which binds to the arylhydrocarbon receptor, inhibits proliferation and differentiation of osteoblasts in vitro and ossification in vivo"Endocrinology. 143(9). 3575-3581 (2002)

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  • [Publications] 鈴木淳子, 宮川-富田幸子, 中澤 誠, 小松敬子, 由谷親夫, 川瀬昌司, 大塚拓治, 川端健二: "川崎病血管炎の免疫組織化学的検討"Prog Med. 21(7). 1676-1678 (2001)

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  • [Publications] Kitajima, K., Kojima, M., Kondo, S., Takeuchi T.: "A role of jumonji gene in proliferation but not differentiation of megakaryocyte lineage cells"Exp. Hematol.. 29. 507-514 (2001)

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  • [Publications] Osada, T., Watanabe, G., Toyoda, M., Kondo, S., Sakaki, Y., Takeuchi, T.: "Male reproductive defects caused by puromycin-sensitive aminopeptidase deficiency in mice"Molecular Endocrinology. 15. 960-971 (2001)

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  • [Publications] Osada, T., Watanabe, G., Sasaki, Y., Takeuchi, T.: "Puromycin-sensitive aminopeptidase is essential for maternal recognition of pregnancy in mice"Molecular Endocrinology. 15. 882-893 (2001)

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  • [Publications] 鈴木淳子, 宮川-富田幸子, 小松敬子, 中澤 誠, 深谷 隆, 馬場國藏, 由谷親夫: "川崎病既往正常冠動脈の免疫組織化学的検討"Prog in Med. 22(7). 1624-1628 (2002)

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  • [Publications] Toyoda, M., Shirato, H., Nakajima, K., Kojima, M., Takahashi, M., Suzuki, R., Motegi, Y., Yokoyama, M., Takeuchi, T.: "jumonji downregulates cardiac cell proliferation by repressing cyclin D1 expression"Dev. Cell. (Submitted and revised). (2003)

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  • [Publications] 中澤 誠, 宮川-富田幸子: "先天性心疾患。心臓大血管奇形の原因の分子生物学的検討を中心に。"呼吸と循環. 48(2). 175-179 (2001)

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  • [Publications] 宮川-富田幸子, 小松敬子, 鈴木淳子, 中澤 誠: "冠動脈に発現する各種サイトカイン染色"Organ Biology. 8(1). 43-47 (2001)

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  • [Publications] 宮川-富田幸子, 中澤 誠, 北村邦夫: "心内膜床欠損に関与する遺伝子"遺伝子医学. 5(2). 234-239 (2001)

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  • [Publications] 門間和夫, 宮川-富田幸子: "神経堤細胞と先天性心疾患"小児科. 42(7). 1115-1123 (2001)

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  • [Publications] 竹内 隆, 長田 智治: "マウス遺伝子トラップ法により作製された生殖異常マウス"goku 最新医学. 57. 2651-2656 (2002)

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  • [Publications] 竹内 隆: "縁は異なもの"細胞工学. 21. 813 (2002)

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  • [Publications] 竹内 隆: "発生過程における細胞増殖とjumonji遺伝子"生化学. (印刷中). (2003)

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  • [Publications] 竹内 隆: "発生・再生過程における細胞増殖の制御機構"実験医学. (印刷中). (2003)

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  • [Publications] Miyagawa-Tomita S, Komatsu K, Morishima M, Nakazawa M: "Alterations in RAR and TGF-beta expression in developing hearts exposed to retinoic acid"Etiology and morphogenesis of congenital heart disease : Twenty years of progress in genetics and developing biology. EB Clark, et al. Eds., Furuta, New York. 223-225 (2000)

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  • [Publications] Nakazawa M, Yasui H, Morishiam M, Miyagawa-Tomita s, Kurihara Y, Kurihara H, Yamazaki N: "The similarity of ventricular function and morphology of embryonic heart of endothelin-1 knock-out and retinoic acid treated mice"Etiology and morphogenesis of congenital heart disease : Twenty years of progress in genetics and developing biology. EB Clark, et al. Eds., Futura, New York. 281-284 (2000)

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  • [Publications] Takeuchi, T.: "Control of mouse cardiac morphogenesis and myogenesis by jumonji"Etiology and morphogenesis of congenital heart disease : twenty years of progress in genetics and developmental biology. (eds. E.B.Clark, M.Nakazawa, A.Takao) Futura Publishing Company, Inc.. 127-129 (2000)

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  • [Publications] Takeuchi, T.: "Male reproductive defects in puromycin-densitive aminopeptidase deficient mice, goku"Neuroplasticity, Development and Steroid Hormone Action (ed. S.Hayashi and R.J.Handa) CRC Press. 131-140 (2001)

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  • [Publications] 宮川-富田幸子, 中澤 誠: "心臓の発生と成長を制御する分子経路"臨床発達心臓病学 高尾篤良ら編 中外医学社、東京. 8-17 (2001)

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  • [Publications] 宮川-富田幸子, 中澤 誠: "レチノイン酸受容体と発達心"臨床発達心臓病学 高尾篤良ら編 中外医学社、東京. 18-12 (2001)

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  • [Publications] 宮川-富田幸子, 相羽 純: "刺激伝導系の発達"臨床発達心臓病学 高尾篤良ら編 中外医学社、東京. 57-59 (2001)

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  • [Publications] 竹内 隆: "発生過程における細胞増殖とjumonji遺伝子"生化学. (印刷中). (2003)

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  • [Publications] 竹内 隆: "発生と細胞増殖"発生における細胞増殖制御(竹内 隆, 岸本律雄編集) シュプリンガー・フェアラーク東京. (準備中). (2003)

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  • [Publications] 竹内 隆: "心臓形態形成と増殖制御"発生における細胞増殖制御(竹内 隆, 岸本律雄編集) シュプリンガー・フェアラーク東京. (準備中). (2003)

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  • [Publications] Miyagawa-Tomita S: "Cardiogenesis, Neural crest in heart, and Cardiac anomalies in Pitx2 knockout mice"Dr.Kerby Oberg, Department of Anatomy, Loma LindaUniversity, Loma Linda, CA, USA. (2000)

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  • [Publications] Miyagawa-Tomita S: "Cardiogenesis, Neural crest in heart, and Cardiac anomalies in Pitx2 knockout mice"Dr.Isamu Kato, Insitute of Opto-Electromagnetic Biology, Waseda Univ. Tokyo. (2001)

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  • [Publications] Takeuchi, T.: "Male Reproductive defects in puromycin-sensitive aminopeptidase dificient mice, goku"International symposium : Neuroplasticity, Development and, Steroid Hormone Action, Honolulu, USA, Sept., 2000. (2000)

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  • [Publications] 竹内 隆: "遺伝子トラップ法によって作成されたgokuマウスの雌雄生殖異常および原因遺伝子の解析"下垂体研究集会シンポジウム、名古屋、8月. (2001)

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  • [Publications] 竹内 隆: "ピューロマイシン感受性アミノペプチダーゼ欠損マウスは行動異常と雌雄の生殖異常を示す"第74回日本生化学会シンポジウム、京都、10月. (2001)

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  • [Publications] 豊田 雅士, 竹内 隆: "Jumonji-cyclin D1カスケードによる発生過程の心筋細胞増殖制御"第74回日本性科学会シンポジウム、京都10月. (2001)

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  • [Publications] 宮川-富田幸子, 中澤 誠, 北村邦夫: "心内膜床欠損の形態形成機構"第74回日本生化学会シンポジウム、京都S8-4. (2001)

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  • [Publications] 竹内 隆: "jumonji遺伝子による発生過程の細胞増殖抑制機構"第35回日本発生生物学会、第55回日本細胞生物学会 合同大会 合同シンポジウム、横浜、5月. (2002)

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  • [Publications] 宮川-富田幸子: "ニワトリ胚心臓流出路におけるプログラム細胞死への心臓神経堤の関与"第33回日本発生生物学会、高知. 30 (2000)

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  • [Publications] 杉村洋子, 富田幸子, 富田 斉, 中澤 誠, 門間和夫: "ニワトリ胚の心臓流出路におけるプログラム細胞死への心臓神経堤の関与"第36回日本小児循環器学会、鹿児島. 120 (2000)

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  • [Publications] 鈴木淳子, 富田幸子, 中澤 誠, 由谷親夫, 大塚拓治: "川崎病急性期から遠隔期までの冠動脈リモデリング;免疫組織化学的検討"第36回日本小児循環器学会、鹿児島. 133 (2000)

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  • [Publications] 富田幸子, 中澤 誠, 北村邦夫: "Pitx2ノックアウトマウスにおける心臓形態異常"第36回日本小児循環器学会、鹿児島. 283 (2000)

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  • [Publications] H Sugimura, S Miyagawa-Tomita, K Komatsu, H Tomita, Y Tomizawa, T Ohno, K Mommma, M Nakazawa: "Aortic stenosis induced by unilateral ablation of cranial neural crest in chick embryo"Weinstein Cardiovascular Development Conference, Washington Univ, St. Louis, MO, USA. 50 (2000)

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  • [Publications] S Miyagawa-Tomita, M Nakazawa, K Kitamura: "Cardiovascular anomalies in mouse Pitx2 deficiency"Weinstein Cardiovascular Development Conference, Washington University, St. Louis, MO, USA. 22 (2000)

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  • [Publications] 竹内 隆, 小島 瑞代, 中島 久仁子, 高橋 美穂, 工藤 佳久, 豊田 雅士, 鈴木 理可, 横山 峯介: "組織形成におけるJumonji遺伝子の機能-細胞増殖と分化の制御"第23回分子生物学学会大会、福岡. (2000)

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  • [Publications] Sugimura H, Ohno T, Nakazawa M, Miyagawa-Tomita S: "Relation between the cardiac neural crest and apotosis in the cardiac outflow tract of chick embryo"Weinstein Cardiovsacular Meeting, Texas, USA. D2-37 (2001)

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  • [Publications] 杉村洋子, 大野忠行, 中澤 誠, 宮川-富田幸子: "鶏胚心の流出路におけるアポトーシスと心臓神経堤細胞の関係"第37回日本小児循環器学会, 静岡. 112 (2001)

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  • [Publications] Sugimura H, Ohno T, Nakazawa M, Miyagawa-Tomita S: "Relation between the cardiac neural crest and apotosis in the cardiac outflow tract of chick embryo"14^<th> International Congress of Developmental Biology, Kyoto, Japan. 37 (2001)

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  • [Publications] 北嶋 聡, 高木篤也, 富田幸子, 井上 達, 相賀祐美子: "転写因子Mesp1の発現を指標とした心臓形成における細胞系譜の解析"第24回日本分子生物学会, 横浜. 4P-525 (2001)

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  • [Publications] Takashi Takeuchi, Masashi Toyoda, Mizuyo Kojima, Kuniko Nakajima, Miho Takahashi: "A novel pathway, jumonji-cyclin D1 regulates cell proliferation in various tissues during mouse development"Comparative Developmental Biology Meeting, Ischia, Italy, Apr., 2001. (2001)

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  • [Publications] Tomoharu Osada, Gen Watanabe, Shunzo Kondo, Masashi Toyoda, Yoshiyuki Sakaki, Takashi Takeuchi: "Puromycin-sensitive aminopeptidase deficient "goku" mice, lack male sexual behavior"14^<th> International Congress of Developmental Biology, Symposium, Kyoto, Japan, July., 2001. (2001)

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  • [Publications] Masashi Toyoda, Mizuyo Kojima, Kuniko Nakajima, Miho Takahashi, Takashi Takeuchi: "A novel pathway, jumonji-cyclin D1 regulates cardiomyocyte proliferation"14^<th> International Congress of Developmental Biology, Kyoto, Japan, July., 2001. (2001)

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  • [Publications] Miho Takahashi, Masashi Toyoda, Mizuyo Kojima, Kuniko, Nakajima, Rika Suzuki, Aya Jyuni, Minesuke Yokoyama, Yoshihisa Kudo, Takashi Takeuchi: "Functions of jumonji gene in cell proliferation : Analyses by conditional rescue of jmj mutant embryos using transgenesis"14^<th> International Congress of Developmental Biology, Kyoto, Japan July., 2001. (2001)

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  • [Publications] Hiroko Anzai, Akihide Kamiya, Takashi Takeuchi, Atsushi Miyajima: "Role of jumonji in fetal liver development"14^<th> International Congress of Developmental Biology, Kyoto, Japan, July., 2001. (2001)

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  • [Publications] Masashi Toyoda, Mizuyo Kojima, Kuniko Nakajima, Miho Takahashi, Takashi Takeuchi: "A novel pathway, jumonji-cyclin D1 regulates cardiomyocyte proliferation"Mouse Molecular Genetics Meeting, Heidelberg, Germany, August, 2001. (2001)

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  • [Publications] 竹内 隆: "Jumonji-サイクリンD1カスケードによる心筋細胞の増殖抑制機構"第24回日本分子生物学会ワークショップ、横浜. (2001)

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    • Related Report
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  • [Publications] 高橋 美穂, 小島 瑞代, 中島 久仁子, 豊田 雅士, 鈴木 理可, 従二 綾, 横山 峯介, 工藤 佳久, 竹内 隆: "jumonji変異体マウスの中枢神経細胞の増殖異常"第24回日本分子生物学会、横浜. (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 安西弘子, 紙谷聡英, 谷水直樹, 竹内隆, 宮島 篤: "胎仔肝細胞の増殖・成熟に及ぼすjumonjiの作用機構"第24回日本分子生物学会、横浜、12月.

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 金子 真也, 柘植 謙爾, 竹内 隆, 板谷 光泰: "遺伝子機能解析のツールとしての枯草菌ゲノムベクターの活用"第24回日本分子生物学会ワークショップ、横浜. (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 館山 誠司, 宮本 悦子, 竹内 隆, 高島 秀昭, 柳川 浩志: "In vitro virusを用いたjumonji(jmj)遺伝子のネットワーク解析"第24回日本分子生物学会、横浜. (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 今野結子, 富田幸子, 萩原啓実, 石原陽子: "マウス胎仔骨の発達に及ぼす各種内分泌撹乱物質の影響"第72回日本衛生学会、三重. 57(1). 137 (2002)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 今野結子, 富田幸子, 萩原啓実, 石原陽子: "ホ乳類の骨形成・分化に基づいた偽内分泌撹乱化学物質の健康影響評価"第75回日本産業衛生学会、神戸. 44. 470 (2002)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] Sugimura H, Miyagawa-Tomita S, Nakazawa M: "Effect of the cardiac neural crest for the coronary angiogenesis and/or vasculogenesis"Weinstein Cardiovasc Meeting, Salt Lake, Utah, USA. (2002)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 宮川-富田幸子, 柳澤昌子, 大道佳世, 中澤 誠, 北村邦夫: "心内膜床欠損における静脈洞の異常とPitx2の役割"第35回日本発生生物学会、神奈川. PD2-085 (2002)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 北嶋 聡, 宮川-富田幸子, 高木篤也, 井上 達, 相賀祐美子: "転写因子Mesp1の発現を指標とした心臓中胚葉の細胞系譜解析"第35回日本発生生物学会、神奈川. PD1-078 (2002)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] Kitajima S, Miyagawa-Tomita S, Takagi A, Inoue T, Saga Y: "Cell-lineage analysis of Mesp1-expressing mesodermal cells in the developing murine heart"67^<th> Cold Spring Harbor Symp. The Cardiovascular System. NY, USA. (2002)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 杉村洋子, 宮川-富田幸子, 中澤 誠: "心臓神経堤の冠動脈脈管形成への影響について"第38回日本小児循環器学会, 東京. P-VI-12 (2002)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 宮川-富田幸子, 中澤 誠, 北村邦夫: "心内膜床欠損における静脈洞の異常とPitx2の役割"第38回日本小児循環器学会, 東京. P-VI-13 (2002)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] 呉 桂栄, 中西敏雄, 宮川-富田幸子, 古谷喜幸, 沈 菁, 羽山恵美子, 中澤 誠: "発生早期胚の心筋における細胞膜と小胞体との連関"第38回日本小児循環器学会, 東京. D-V-1 (2002)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] 萩原啓実, 成瀬雅衣, 宮川-富田幸子, 今野結子, 小池由紀子, 石原陽子: "メチルコラントレンによる骨形成異常のメカニズムの解析"第75回日本生化学学会、京都. 3P-793 (2002)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Kokubo H, Miyagawa-Tomita S, Tomimatsu H, Saga Y, Johonson RL: "Function analysis of hesr genes in cardiovascular development"Symposium on phenotyping : Mouse Cardiovascular Function and Development, NHLBI, Bethesda, MD, USA. (2002)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] Miyagawa-Tomiya S, Nakazawa M, Kitamura: "Pitx2 gene function in cardiac Morphogenesis in mice"The 1^<st> International Symposium on Etiology and morphogenesis of Congenital Cardiovascular Disease in the Post-Genomic Era.. 138-139 (2002)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Kokubo H, Miyagawa-Tomita S, Tomimatsu H, Saga Y, Johonson RL: "Function analysis of hesr genes in cardiovascular development"The 1^<st> International Symposium on Etiology and Morphogenesis of Congenital Cardiovascular Disease in the Post-Genomic Era. 174-175 (2002)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 小久保博樹, 宮川-富田幸子, 富松宏文, 中澤 誠, Johonson RL, 相賀祐美子: "心臓形成におけるhesr遺伝子群の機能解析"第25回日本分子生物学会、横浜. W4aM-3 (2002)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 白土 治己, 豊田 雅士, 小島瑞代, 高橋 美穂, 鈴木 理可, 横山 峯介, 竹内 隆: "jumonji-サイクリンD1カスケードによる心筋細胞の増殖抑制機構"第35回日本発生生物学会、第55回日本細胞生物学会 合同大会 横浜. (2002)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 大野 忠行, 豊田 雅士, 小島 瑞代, 中島 久仁子, 竹内 隆: "jmj非依存性カスケードによる心筋細胞の増殖抑制機構"第35回日本発生生物学会、第55回日本細胞生物学会 合同大会 横浜. (2002)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 竹内 隆, 豊田 雅士: "マウスjmumonji遺伝子はサイクリンD遺伝子の発現を制御することにより発生過程の細胞増殖を制御する"第61回日本癌学会総会、東京. (2002)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 大野 忠行, 中島 久仁子, 小島 瑞代, 右島 理可, 横山 峯介, 竹内 隆: "時期特異的サイクリンD1発現誘導マウスを用いた心筋細胞増殖停止機構の解析"第25回日本分子生物学会、横浜. (2002)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 神保 雅, 白土 治己, 金子 真也, 板谷 光泰, 右島 理可, 横山 峯介, 竹内 隆: "マウスjumonji遺伝子の発現調節領域の解析"第25回日本分子生物学会、横浜. (2002)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 金子 真也, 柘植 謙爾, 竹内 隆, 板谷 光泰: "枯草菌ゲノム工学:枯草菌ゲノム(BGM)ベクターへの巨大DNAクローニングの効率化"第25回日本分子生物学会、横浜. (2002)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 館山 誠司, 宮本 悦子, 竹内 隆, 高島 秀昭, 馬場 知哉, 森 浩禎, 柳川 浩志: "In vitro virusを用いてのjumonji遺伝子のネットワーク解析"第25回日本分子生物学会、横浜. (2002)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 今野結子, 米田早織, 富田幸子, 星 桂芳, 植松 宏, 石原陽子: "マウス胎仔骨の発達を指標とした合成女性ホルモンの濃度反応曲線について"第回日本衛生学会、大分. (発表予定).

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] 杉村洋子, 富田 斉, 中澤 誠, 宮川-富田幸子: "心臓流出路における心臓神経堤細胞の役割"埼玉県立循環器・呼吸器病センター、平成11年度研究報告書. 4. 12-14 (2000)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 宮川-富田幸子, 杉村洋子, 大野忠行, 中澤 誠: "心臓に発現するシグナル分子の検討"東京女子医科大学総合研究所 2000年度報告書. 紀要21. 66-67 (2003)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 竹内 隆, 宮川-富田幸子, 中澤 誠: "jumonji遺伝子の心臓発生における機能と心筋再生への応用"〔財〕日本心臓血圧研究振興会 平成12年度研究業績集. 15. 13-16 (2000)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 北村邦夫, 宮川-富田幸子, 柳澤昌子, 中澤 誠: "心臓の房室心内膜床形成機構におけるpitx2の機能解析"〔財〕日本心臓血圧研究振興会 平成12年度研究業績集. 15. 23-25 (2000)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 杉村洋子, 富田 斉, 宮川-富田幸子, 中澤 誠: "心臓流出路における心臓神経堤細胞の役割"埼玉県立循環器・呼吸器病センター、平成11年度研究報告書. 4. 20-22 (2000)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 篠原徳子, 富田 斉, 中澤 誠, 宮川-富田幸子: "心臓流出路における心臓神経堤細胞の役割"埼玉県立循環器・呼吸器病センター、平成12年度研究報告書. 5. 22-24 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 今野結子, 小池昌子, 石原陽子, 西川俊郎, 萩原啓美, 宮川-富田幸子: "内分泌撹乱化学物質ダイオキシンのマウス胎仔および新生仔の骨形成・文化に及ぼす影響に関する研究-3-methylcholanthreneを用いたin vivo実験"東京女子医科大学総合研究所 2001年度報告書. 紀要22. 35-36 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 宮川-富田幸子, 柳澤昌子, 中澤 誠, 北村邦夫: "発達心におけるシグナル発現"東京女子医科大学総合研究所 2001年度報告書. 紀要22. 61-67 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 相賀祐美子, 北嶋 聡, 宮川-富田幸子, 中澤 誠: "Mesp転写因子による心臓前駆細胞の分化"〔財〕日本心臓血圧研究振興会 平成13年度研究業績集. 16. 7-9 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] 竹内 隆, 宮川-富田幸子, 中澤 誠: "心筋細胞の増殖制御機構の解明と心筋再生"〔財〕日本心臓血圧研究振興会 平成13年度研究業績集. 16. 11-14 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 北村邦夫, 宮川-富田幸子, 柳澤昌子, 中澤 誠: "心臓の房室心内膜床形成機構におけるPitx2の機能解析"〔財〕日本心臓血圧研究振興会 平成13年度研究業績集. 16. 15-18 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Suzuki A, Miyagawa-Tomita S, Nakazawa M, Sakomura Y, Horie T, Komatsu K: "Active remodeling of the coronary arterial lesions in the late phase of Kawasaki disease : immunohistochemical study."Circulation. 101. 2953-2941 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Suzuki A, Miyagawa-Tomita S, Nakazawa M, Yutani C: "Remodeling of coronary artery lesions due to Kawasaki disease."Jpn Heart J. 41(3). 245-256 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Saga Y, Kitajima S and Miyagawa-Tomita S: "Mesp1 expression is the earliest sign of cardiovascular development."Trend Cardiovasc Med. 10(8). 345-352 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Toyoda, M., Kojima, M., and Takeuchi, T.: "Jumonji proteinis a nuclear protein that participates in the negative regulation of cell growth."Biochem. Biophys. Res. Commun.. 274. 332-336 (2000)

    • Description
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  • [Publications] Suzuki A, Miyagawa-Tomita S, Nakazawa M, Komatsu K, Yutani C, Kawasa S, Ohtsuka T, Kawasaki K: "Immunohistochemical study in coronary artery lesions with Kawasaki disease (Japanese)."Prog Med. 21(7). 1676-1678 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Kitajima, K., Kojima, M., Kondo, S., and Takeuchi, T.: "A role of jumonji gene in proliferation but not differentiation of megakaryocyte lineage cells."Exp. Hematol.. 29. 507-514 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Osada, T., Watanabe, G., Sakaki, Y., and Takeuchi, T.: "Puromycin-sensitive aminopeptidase is essential for the maternal recognition of pregnancy in mice."Molecular Endocrinology. 15. 882-893 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Osada, T., Watanabe, G., Toyoda, M., Kondo, S., Sakaki, Y., and Takeuchi, T.: "Male reproductive defects caused by puromycin-sensitive aminopeptidase deficiency in mice."Molecular Endocrinology. 15. 960-971 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Naruse M, Ishihara Y, Miyagawa-Tomita S, Koyama A, and Hagiwara H: "3-Methyl- cholanthrene, which binds to the arylhydrocarbon receptor, inhibits proliferation and differentiation of osteoblasts in vitro aid ossification in vivo."Endocrinology. 143(9). 3575-3581 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Shen J, Nakanishi T, Gu H, Miyagawa-Tomita S, Wu GR, Momma K, Nakazawa M: "The role of endothelin in oxygen-induced contraction of the ductus arteriosus in rabbit and rat fetuses."Heart Vessels. 16. 181-188 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Suzuki A, Miyagawa-Tomita S, Komatsu K, Nakazawa M, Fukaya T, Baba K, Yutani C: "Immunohistochemical study in normal coronary artery with Kawasaki disease (Japanese)."Prog Med. 22(7). 1624-1628 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Toyoda, M., Shirato, H., Nakajima, K., Kojima, M., Takahashi, M., Suzuki, R., Motegi, Y., Yokoyama, M., and Takeuchi, T.: "jumonji downregulates cardiac cell proliferation by repressing cyclin D1 expression."Submitted and revised to Dev. Cell. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Nakazawa M and Miyagawa-Tomita S: "Cardiovascular Malformation : Clinico-molecular correlation (Japanese)."Respiration & Circulation. 48(2). 175-179 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Miyagawa-Tomita S, Komatsu K, Suzuki A, and Nakazawa M: "Staining of cytokines expressed in the human coronary artery (Japanese)."Organ Biology. 8(1). 43-47 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Miyagawa-Tomita S, Nakazawa M and Kitamura K: "Molecules in atrioventricular canal defects (Japanese)."Gene Med. 5(2). 234-239 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Momma K and Miyagawa-Tomita S: "Neural crest and congenital heart defect (Japanese)."Pediatrics Jpn. 42(7). 1115-1123 (2001)

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  • [Publications] Takeuchi T.: "Cell proliferation and jumonji gene during development."Seikagaku (Japanese). (in press). (2003)

    • Description
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  • [Publications] Takeuchi T.: "Role of regulation in cell proliferation during development and regeneration."Jikken-Igaku (Japanese). (in press). (2003)

    • Description
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  • [Publications] Takeuchi T, Osada T: "Male reproductive defects, goku, produced by mouse-gene trap method."Saishin-igaku (Japanese). 57. 2651-2656 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Miyagawa-Tomita S: "Cardiac neural crest mediated programmed cell death in the cardiac outflow tract in chick embryo."33rd Ann Meeting Jpn Soc Dev Biol, Kochi, Japan. 30. (2000)

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    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sugimura H, Miyagawa-Tomita S, Tomita H, Nakazawa M, Momma K: "Cardiac neural crest associated with apoptosis of the outflow tract in chick embryo."36th Ann Meeting Jpn Soc Ped Cardiol, Kagoshima, Japan. 120. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Suzuki A, Miyagawa-Tomita S and Nakazawa M: "The remodeling of coronary artery with Kawasaki disease from acute to late phase : Immunohistochemical study."36th Ann Meeting Jpn Soc Ped Cardiol, Kagoshima, Japan. 133. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Miyagawa-Tomita S, Nakazawa M and Kitamura K: "Cardiovascular anomalies in Pitx2 deficient mice."36th Ann Meeting Jpn Soc Ped Cardiol, Kagoshima, Japan. 283. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Sugimura H, Miyagawa-Tomita S, Tomita H, Nakazawa M, Momma K: "Aortic stensosis induced by unilateral ablation of cranial neural crest in chick embryo."Weinstein Cardiovasc Dev Conf, St Louis, MO, USA. 50 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Miyagawa-Tomita S, Nakazawa M and Kitamura K: "Cardiovascular anomalies in Pitx2 deficient mice."Weinstein Cardiovasc Dev Conf, St Louis, MO, USA. 22 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Sugimura Y, Ohno T, Nakazawa M and Miyagawa-Tomita S: "Relation between the cardiac neural crest and apoptosis in the cardiac outflow tract of chick embryo."Weinstein Cardiovasc Meeting, Dallas, TX, USA. D2-37. (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sugimura Y, Ohno T, Nakazawa M and Miyagawa-Tomita S: "Relation between the cardiac neural crest and apoptosis in the cardiac outflow tract of chick embryo."37th Ann Meeting Jpn Soc Ped Cardiol, Shizuoka, Japan. 112. (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sugimura Y, Ohno T, Nakazawa M and Miyagawa-Tomita S: "Relation between the cardiac neural crest and apoptosis in the cardiac outflow tract of chick embryo."14th Intentional Congress of Developmental Biology, Kyoto, Japan. 37 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kitajima S, Takagi A, Miyagawa-Tomita S, Inoue T, Saga Y: "Analysis of cell lineage in cardiogenesis indicated by expression of transcription factor Mesp1."24th Mol Biol Society Jpn, Yokohama, Japan. 4-52S (2001)

    • Description
      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Imano Y, Miyagawa-Tomita S, Hagiwara H, Ishihara Y: "Affects of endocrine-disrupting chemicals on mouse bone development."72nd Jpn Hygiene Asso, Mie, Japan. 57(1). 137 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Imano Y, Miyagawa-Tomita S, Hagiwara H, Ishihara Y: "Health effects of endocrine-disrupting chemicals based on mammalian bone morphogenesis and differentiation."75th Jpn Hygiene Asso, Kobe, Japan. 44. 470 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sugimura H, Miyagawa-Tomita S, Nakazawa M: "Effect of the cardiac neural crest for the coronary angiogenesis and/or vasculogenesis."Weinstein Cardiovasc Meeting, Salt Lake, Utah, USA. 80 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyagawa-Tomita S, Yanazawa M, Ohmichi K, Nakazawa M, Kitamura K: "Role of pitx2 and anomaly of sinus vesnosus in cardiac atrio-ventricular canal defect."35th Ann Meeting Jpn Soc Dev Biol, Yokohama, Japan. PD2-085. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kitajima S, Miyagawa-Tomita S, Takagi A, Inoue T, Saga Y: "Cell lineage analysis of Mesp1-expressing cardiac mesoderm."35th Ann Meeting Jpn Soc Dev Biol, Yokohama, Japan. PD2-087. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kitajima S, Miyagawa-Tomita S, Takagi A, Inoue T, Saga Y: "Cell-lineage analysis of Mesp1-expressing mesodermal cells in the developing murine heart."67th Cold Spring Harbor Sympo. The Cardiovascular System. NY, USA. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sugimura H, Miyagawa-Tomita S, Nakazawa M: "Effect of the cardiac neural crest to angiogenesis of the coronary artery."38th Ann Meeting Jpn Soc Ped Cardiol, Tokyo, Japan. P-VI-12. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyagawa-Tomita S, Nakazawa M, Kitamura K: "pitx2 and the sinus venosus in the atrioventricular canal defect."38th Ann Meeting Jpn Soc Ped Cardiol, Tokyo, Japan. P-VI-13. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hong Gu, Nakanishi T, Miyagawa-Tomita S, Furutani Y, Jing Shen, Haneyama E, Nakazawa M: "Relation between cell-membrane and sarcoplasmic reticulum in cardiomyocyte at the early developmental stage."38th Ann Meeting Jpn Soc Ped Cardiol, Tokyo, Japan. D-V-1. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Hagiwara H, Naruse M, Miyagawa-Tomita S, Imano Y, Koike Y, Ishihara Y: "Analysis of mechanism of methylcholanthrene induced abnormalities of bone."75th Aim Meeting Jpn Biochemical Society, Kyoto, Japan. 3P-793. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kokubo H, Miyagawa-Tomita S, Saga Y, Johnson RL: "Function analysis of hesr genes in cardiovascular development."Symposium on phenotyping : Mouse Cardiovascular Function and Development, NHLBI, Bethesda, MD, USA. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyagawa-Tomita S, Yanazawa M, Ohmichi K, Nakazawa M, Kitamura K: "pitx2 gene function in cardiac morphogenesis in mice."Etiology and morphogenesis of congenital cardiovascular disease in the post-genomic era, Tokyo, Japan. 138-139 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kokubo H, Miyagawa-Tomita S, Saga Y, Johnson RL: "Function analysis of hesr genes in cardiovascular development."Etiology and morphogenesis of congenital cardiovascular disease in the post-genomic era, Tokyo, Japan. 174-175 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kokubo H, Miyagawa-Tomita S, Tomimatsu H, Nakazawa M, Johnson RL, Saga Y: "hesr genes in cardiogenesis."25th Mol Biol Society Jpn, Yokohama, Japan. W4aM. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Imano Y, Yoneda S, Miyagawa-Tomita S, Hoshi Y, Uematsu H, Ishihara Y: "Affects of DES on mouse bone development."73rd Jpn Hygiene Asso, Oita, Japan. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sugimura H, Tomita H, Nakazawa M, Miyagawa-Tomita S: "Role of the cardiac neural crest in the outflow tract of heart."Reports of the Research Institute, Saitama Cardiovascular and Respiratory Center. 4. 12-14 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyagawa-Tomita S, Sugimura H, Ohno T, Nakazawa M: "Research of signal expression in heart."Bulletin of Medical Research Institute, Tokyo Women's Medical University. 21. 66-67 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Takeuchi T, Miyagawa-Tomita S, Nakazawa M: "The role of jumonji gene in the cardiac development and regeneration."Japan Research Promotion Society for Cardiovascular Diseases. 15. 13-16 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Kitamura K, Miyagawa-Tomita S, Yanazawa M, Nakazawa M: "pitx2 function in morphogenesis of atrioventricular septal defect."Japan Research Promotion Society for Cardiovascular Diseases. 15. 23-25 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shinohara T, Tomita H, Nakazawa M, Miyagawa-Tomita S: "Role of the cardiac neural crest in the outflow tract of the developing heart."Reports of the Research Institute, Saitama Cardiovascular and Respiratory Center. 5. 22-24 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Imano Y, Koike Y, Ishihara Y, Nishikawa T, Hagiwara H, Miyagawa-Tomita S: "Effects of dioxins as environmental hormone on formation and differentiation of bone in fetuses and porstnatal/newborn - Effect of 3-methylcholanthrene in vivo -."Bulletin of Medical Research Institute, Tokyo Women's Medical University. 22. 35-36 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyagawa-Tomita S, Yanazawa M, Nakazawa M, Kitamura K: "Signal expression in developing heart."Bulletin of Medical Research Institute, Tokyo Women's Medical University. 22. 66-67 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saga Y, Kitajima S, Miyagawa-Tomita S, Nakazawa M: Japan Research Promotion Society for Cardiovascular Diseases. 16. 7-9 (2001)

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      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Takeuchi T, Miyagawa-Tomita S, Nakazawa M: "The mechanisms of cell proliferation during cardiac development and regeneration."Japan Research Promotion Society for Cardiovascular Diseases. 16. 11-14 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kitanrura K, Miyagawa-Tomita S, Yanazawa M, Nakazawa M: "pitx2 function in morphogenesis of the atrioventricular septal defect."Japan Research Promotion Society for Cardiovascular Diseases. 16. 15-18 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyagawa-Tomita S, Komatsu K, Morishima M, Nakazawa M, Ed. E.B. Clark, M. Nakazawa and A. Takao: "Alterations in RAR and TGF-beta expression in developing hearts exposed to retinoic acid. In : Etiology and morphogenesis of congenital heart disease : Twenty years of progress in genetics and developmental biology."Futura. 223-225 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakazawa M, Yasui H, Morishima M, Miyagawa-Tomita S, Kurihara Y, Kurihara H, and Yamazaki N, Ed. E.B. Clark, M. Nakazawa and A. Takao: "The similarity of ventricular function and morphology of embryonic heart of endothelin-1 knock-out and retinoic acid treated mice. In : Etiology and morphogenesis of congenital heart disease : Twenty years of progress in genetics and developmental biology."Futura. 281-284 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeuchi, T., Ed. E.B. Clark, M. Nakazawa, A. Takao: "Control of mouse cardiac morphogeneis and myogenesis by jumonji. In Etiology and morphogenesis of congenital heart disease : twenty years of progress in genetics and developmental biology."Futura Publishing Company, Inc.. 127-129 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Takeuchi, T., Ed. S. Hayashi and R.J. Handa: "Male reproductive defects in puromycin-sensitive aminopeptidase deficient mice, goku. In Neuroplasticity, Development and Steroid Hormone Action."CRC Press. 131-140 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Miyagawa-Tomita S and Nakazawa M., Ed. A. Takao, K. Momma, M. Nakazawa, and T. Nakanishi: "Molecular pathways controlling cardiac development and growth (Japanese). In : Clinical developmental cardiology (3rd ed)."Chugai-igakusha. 8-17 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Miyagawa-Tomita S and Nakazawa M, Ed. A. Takao, K. Momma, M. Nakazawa, and T. Nakanishi: "Retinoic acid receptors and developing heart (Japanese). In : Clinical developmental cardiology (3rd ed)."Chugai-igakusha. 18-20 (2001)

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      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Miyagawa-Tomita S and Aiba S, Ed. A. Takao, K. Momma, M. Nakazawa, and T. Nakanishi: "Developmental conduction system (Japanese). In : Clinical developmental cardiology (3rd ed)."Chugai-igakusha. 57-59 (2001)

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      2002 Final Research Report Summary
  • [Publications] Toyada M, Shirato H, Nakajima K, et al.: "Jumonji dowunregulates cardiac cell proliferation by repressing cyclin Di expression"Developmental Cell. (in press). (2003)

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  • [Publications] 竹内 隆: "発生過程における細胞増殖とjumonji遺伝子"生化学. (印刷中). (2003)

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      2002 Annual Research Report
  • [Publications] 竹内 隆: "発生・再生過程における細胞増殖の制御機構"実験医学. 21(5). 580-586 (2003)

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  • [Publications] 竹内 隆, 長田智治: "マウス遺伝子トラップ法により作成された生殖異常マウス、goku"最新医学. 57(12). 2651-2656 (2002)

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      2002 Annual Research Report
  • [Publications] Shen J, Nakanishi T, Gu H, Miyagawa-Tomita S, Wu GR, Momma K, Nakazawa M: "The role of endothelin in oxygen-induced contraction of the ductus arteriosus in rabbit and rat fetuses"Heart Vessels. 16. 181-188 (2002)

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      2002 Annual Research Report
  • [Publications] Naruse M, Ishihara Y, Miyagawa-Tomita, et al.: "3-Methyl-cholanthrene, which binds to the arylhydrocarbon receptor, inhibits proliferation and differentiation of osteoblasts in vitro and ossification in vivo"Endocrinology. 143(9). 3575-3581 (2002)

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      2002 Annual Research Report
  • [Publications] 太田真弓, 中澤 誠, 門間和夫: "先天性心疾患の心不全に対するピモベンダン投与の初期経験"心臓. 33(5). 393-398 (2001)

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      2001 Annual Research Report
  • [Publications] Minamisawa S, Nakazawa M, Mommma K, Imai Y, Satomi G: "Effect of aerobic training on exercise performance in patients after the Fontan operation"Am J Cardiol. 88. 695-698 (2001)

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      2001 Annual Research Report
  • [Publications] 中澤 誠: "循環器の発生 編集:循環器の画像診断ガイド"総合臨床. 50. 1160-1165 (2001)

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      2001 Annual Research Report
  • [Publications] 中澤 誠: "Fallot四徴症。循環器疾患State of Arts. Ver.2"医学のあゆみ. 13. 762-764 (2001)

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      2001 Annual Research Report
  • [Publications] 宮川-富田幸子, 中澤 誠, 北村邦夫: "心内膜床欠損に関与する遺伝子"遺伝子医学. 5(2). 234-239 (2001)

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      2001 Annual Research Report
  • [Publications] Hazama K, Nakazawa M, Momma K: "Effective dose and cardiovascular effects of Celazapril in children with heart failure"Am H Cardiol. 88. 801-805 (2001)

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      2001 Annual Research Report
  • [Publications] Nakazawa M. et al.: "The similarity of ventricular function and morphology of embryonic heart of endothelin-1 knock-out and retinoic acid treated mice."Etiology and morphogenesis of congenital heart disease : Twenty years of progress in genetics and developmental biology.. 281-284 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Miyagawa-Tomita S. et al.: "Alterations in RAR and TGF-beta expression in developing hearts exposed to retinoic acid."Etiology and morphogenesis of congenital heart disease : Twenty years of progress in genetics and developmental biology.. 223-225 (2000)

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      2000 Annual Research Report
  • [Publications] 宮川,富田幸子 ら: "心臓の発達と成長を制御する分子経路"発達心臓病学(第3版). 8-17 (2001)

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      2000 Annual Research Report
  • [Publications] 宮川,富田幸子 ら: "冠動脈に発現する各種サイトカイン染色"Organ Biology. (2001)

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      2000 Annual Research Report

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Published: 2000-03-31   Modified: 2021-11-26  

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