| Project/Area Number |
12470190
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Grant-in-Aid for Scientific Research (B) (2) |
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Principal Investigator |
SHIMADA Morio Toho University the 1st Department of Radiology Lecturer, 医学部, 講師 (20196489)
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| Co-Investigator(Kenkyū-buntansha) |
TERAMOTO Ryusei Toho University the 1st Department of Radiology Professor, 医学部, 教授 (00146713)
FUNAHASHI Kimihiko Toho University the 1st Department of Radiology Lecturer, 医学部, 講師 (90297698)
HAYASHI Sanshin Toho University the 1st Department of Radiology Professor, 医学部, 教授 (50010252)
INOUE Yusuke The Institute of Medical Science The university of Tokyo the Department of Radiology Lecturer, 医科研部, 講師 (40232566)
YOSHIKAWA Kohki The institute of Medical Science The university of Tokyo the Department of Radiology Assistant professor, 医科研, 助教授 (10272494)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥7,500,000 (Direct Cost: ¥7,500,000)
Fiscal Year 2002: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2001: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2000: ¥3,200,000 (Direct Cost: ¥3,200,000)
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| Keywords | MR / Contrast Agent / Lymph nocle / Undofluorise 8 / Metastases / Lymph nocle / SPIO / Metastasses / MRI / gadofluorine 8 / Gd-DTPA / Rat study / Gd-EOB-DTPA / Gd-BOPTA / animal study / VX2 tumor |
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| Research Abstract |
We evaluated the usefulness of Gadofluorine 8(G8) and Gd-DTPA for interstitial MR Lymphography (MRL)
Materials: Phantom imaging studies were conducted with G8 and Gd-DTPA corresponding to 0.1-0.005 μmolGd/ml and SI (signal intensity) was measured. Popliteal lymph mode (PLN) accumulation was investigated in the rabbits. Imaging performed before and after administration of G8 (50μmolGd/ml) and Gd-DTAP (50μmolGd/ml) subcutaneously. CER measurements of PLN were determined both prior to and following the administration
Results: SI of phantom for G8 are higher than those for Gd-DTAP from 0.1 to 0.002 μmol/Gd/ml (p<0.0001). Imaging after 5 min can clearly detect PLN accumulation on two contrast agents. Nevertheless, PLN accumulation of Gd-DTAP disappeared after about 30min. A statistically significant difference between G8 and Gd-DTPA can be seen from 5 to 90 min in CER (p<0.0001)
PLN became visible clearly at 5 min after the injection of G8 and Gd-DTAP, Nevertheless, PLN accumulation of Gd-DTAP disappeared at 30 min. Otherwise, PLN accumulation of G8 continued up to 90 min
Conclusion: These studies indicated that G8 was more suitable than Gd-DTAP as a contrast agent for interstitial MRL up to 90min
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