• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of the optimal therapies based on molecular genetics of multiple myeloma

Research Project

Project/Area Number 12470202
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionNagoya City University

Principal Investigator

UEDA Ryuzo  Nagoya City University, Graduate School of Medical Sciences, Professor, 大学院・医学研究科, 教授 (20142169)

Co-Investigator(Kenkyū-buntansha) IIDA Shinsuke  Nagoya City University, Graduate School of Medical Sciences, Assistant professor, 大学院・医学研究科, 講師 (50295614)
WAKITA Atsushi  Nagoya City University, Graduate School of Medical Sciences, Associate Professor, 大学院・医学研究科, 助教授 (20264715)
Project Period (FY) 2000 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥12,100,000 (Direct Cost: ¥12,100,000)
Fiscal Year 2003: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2002: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2001: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2000: ¥4,000,000 (Direct Cost: ¥4,000,000)
Keywordsmultiple myeloma / chromosomal translocation / t(14;20)(q32;q11) / MAFB / t(1;14)(q34;q32) / E3 / LAPTm5 / MGUS / developmental pathway / 定量PCR / 病型 / 進展 / Multiple Myeloma / Chromosomal Translocation / FISH / Real time PCR / MUM1 / IRF4 / LAPTM5 / Cyclin D1 / 二重色FISH法 / t(1;14)(p36;q32) / Ku80
Research Abstract

1.Identification of novel chromosomal translocations found in multiple myeloma :
1)t(1;14)(p34;q32) : 1p34 breakpoint of ODA cells was isolated by genomic cloning and found to have disrupted E3/LAPTm5 gene in terms of its expression. This phenomenon was caused by hypermethylation of the regulatory sequences of the gene.
2)t(1;14)(p34;q32) : 1p34 breakpoint of ODA cells was isolated by genomic cloning and found to have disrupted E3/LAPTm5 gene in the first intron. Interestingly, this gene was shut off in 60% of the myeloma cell lines in terms of its expression. This phenomenon was caused by hypermethylation of the regulatory sequences of the gene.
2.14q32 translocations in MGUS/smoldering multiple myeloma(SMM)
Purified plasma cells derived from 16 MGUS/SMM patients were examined concerning 14q32 chromosomal trans locations by means of double color-FISH analysis. 56% of the cases carried 14q32 translocations, in which two thirds were between 14q32(IgH) and 11q13(CCND1) loci with concomitant nuclear expression of CyclinD1.
3.Identification of the distinct developmental pathways of multiple myeloma :
Quantitative RT-PCR assay was established for CCND1, FGFR3, MUM1, c-MAF, MAFB and c-MYC genes, and applied for the study of 19 cell lines and 30 myeloma samples. It led to the identification of at least three distinct developmental pathways of multiple myeloma, which originated from altered expression of CCND1, FGFR3 and c-MAF/MAFB genes.

Report

(5 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (103 results)

All Other

All Publications (103 results)

  • [Publications] Tsuboi, K., Iida, S.Ueda, R.et al.: "MUM1/IRF4 expression as a frequent event in mature lymphoid malignancies."Leukemia. 14. 449-456 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Zhao, M., Uea, R., et al.: "In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor"Leukemia. 14. 374-378 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takeyama, K., Ueda, R.et al.: "Therapy-related leukemia and myelodysplastic syndrome : a large-scale Japanese study of clinical and cytogenetic features as well as prognostic factors"Int.J.Hematol.. 71. 144-152 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takeshita, A., Ueda, R.et al.: "Quantitative expression of erythropoietin receptor (EPO-R) on acute leukaemia cells : relationships between the amount of EPO-R and CD phenotypes, in vitro proliferative response, the amount of other cytokine receptors and clinical prognosis"Brit.J.Haematol.,. 108. 55-63 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanaka, Y., Iida, S.Ueda, R.et al.: "Lack of integrated TT virus (TTV) genomes into cellular DNA in infected human hematopoietic cells."Leukemia and Lymphoma. 38(3-4). 411-417 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Iida, S., Wakita, A., Ueda, R.et al.: "A nobel human multiple myeloma-derived cell line, NCU-MM-1, Carrying t(2;11)(p11;q23) and t(8;22)(q24;q11) chromasomal translocations with overexpression of c-Myc protein."Int.J.Hematol.,. 72. 85-91 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Naoe, T., Ueda, R., et al.: "Analysis of genetic polymoriphism in NQO1, GST-M1, GST-T1 and CYP3A4 in 469 Japanese patients with therapy-related leukemia/myelodysplastic syndrome and de novo acute myeloid leukemia."Clin.Cancer Res.,. 6. 4091-4095 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Murata, M., Ueda, R., et al.: "Apoptotic cytotoxic effects of a histone deacetylase inhibitor, FK228, on malignant lymphoid cells."Jpn.J.Cancer Res.. 91. 1154-1160 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohnishi, K., Ueda, R., et al.: "Multicenter prospective study of interferon-α and conventional chemotherapy versus bone marrow transplantation for newly diagnosed patients with chronic myelogenous leukemia"Int.J.Hematol.. 72. 229-236 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shimizu, S., Ueda, R., Takahashi, et al.: "High frequency of clonally related tumors in cases of multiple synchronous lung canceres as revealed by molecular diagnosis"Clin.Cancer Res.. 6. 3994-3999 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shinjo, K, Ueda, R. et al.: "Good prognosis of patients with acute promyelocytic leukemia who achieved second complete remission (CR) with a new retinoid, am80, after relapse from CR induced by all-trans-retinoic acid."Int.J.Hematology. 72. 470-473 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Inagaki, H., Ueda, R.et al.: "API2-MALT1 fusion transcripts involved in mucosa-associated lymphoid tissue lymphoma"Am.J.Pathology. 158(2). 699-709 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamamoto, Y, Ueda, R., et al.: "Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies."Blood. 97(8). 2434-2439 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hanamura, I., Iida, S., Wakita, A., Ueda, R.et al.: "Ectopic expression of MAFB gene in human myeloma cells carrying(14;20)(q32;q11) chromosomal translocations."Jpn.J.Cancer Res.. 92. 638-644 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Eguchi, M., Ueda, R.et al.: "GPHN, a novel partner gene fused to MLL in a leukemia with t(11;14)(q23;q24):"Genes, Chromosomes & Cancer. 32. 212-221 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Inagaki, H., Wakita, A., Ueda, R.: "Clonality assay of hematopoietic disorders : significance of the buccal epithelium as non-hematopoietic control and of 95% rejection limit as a novel criterion for monoclonality."Jpn.J.Cancer Res.. 92. 1305-1312 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tamura, A., Iida, S., Ueda, R.et al.: "Interphase detection of immunoglobulin heavy chain translocations with specific oncogene loci in 173 patients with B-cell lymphoma."Cancer Genetics and Cytogenetics. 129(1). 1-9 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamaguchi, M., Ueda, R., et al.: "De novo CD5^+ positive diffuse large B-cell lymphoma a clinicopathologic study of 109 patients."Blood. 99. 815-821 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kato, M., Iida, S., Ueda, R.et al.: "Lack of Ku80 alteration in multiple myeloma."Jpn.J.Cancer Res.. 93. 359-362 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ito, M., Iida, S.Ueda, R.et al.: "MUM1/IRF4 expression is an unfavorable prognostic factor in B-cell chronic lymphocytic leukemia (CLL)/small lymahocytic lymphoma (SLL)."Jpn.J.Cancer Res.,. 93. 685-694 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nomura, K., Ueda, R.et al.: "Detection of t(11;18)(q21;q21) in marginal zone lymphoma of mucosa-associated lymphocytic tissue type on paraffin-embedded tissue sections by using fluorescence in situ hybridization."Cancer Genetics and Cytogenetics. 140. 49-54 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Luo, J.M., Iida, S., Ueda, R.et al.: "Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia"Leukemia. 17. 2-8 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Okabe, M., Ueda, R.et al.: "API2-MALT1 fusion defines a distinctive clinicopathologic subtype in pulmonary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue."Am.J.Pathology,. 162(4). 1113-1122 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Iida, S., Ueda R.: "Multistep tumorigenesis of multiple myeloma : its molecular delineation."Int.J.Hematology. 77. 207-212 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Miura, K., Iida, S., Ueda, R.et al.: "Frequent occurrence of CCND1 deregulation in patients with early stages of plasma cell dyscrasia."Cancer Science. 94(4). 350-354 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ito, H., Ueda, R.et al.: "A limited association of OGG1 ser326Cys polymorphism for adenocarcinoma of the lung."J.Epidemiology. 12(3). 258-265 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kato, H., Ueda, R., et al.: "Frequent coinfection with hepatitis B virus srains of distinct genotypes detected by hybridization with type-specific probes immobilized on a solid-phase support."J.Virological Methods. 110. 29-35 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Miyazaki, M., Ueda, R., et al.: "Potential limitations in using minor histocompatibility antigen- specific cytotoxic T cells for targeting solid tumor cells."Clinical Immunology. 107. 198-201 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tsuboi, K., Iida, S., Ueda, R.et al.: "T-cell acute lymphoblastic leukemia as a secondary leukemia after a 3-year remission of acute myelocytic leukemia."Int.J.of Hematology. 77. 518-521 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishida, T., Iida, S., Wakita, A., Ueda, R.et al.: "Clinical significance of CCR4 expression in adult T-cell leukemia/lymphoma its close association with skin involvement and unfavorable outcome"Clinical Cancer Res.. 9. 3625-3634 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ozeki, K., Ueda, R., et al.: "Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia."Blood. 103(5). 1901-1908 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kikuchi, M., Ueda, R.et al.: "Histopathological investigation of salivary glands in the asymptomatic elderly"Arch.Gerontol.Geriatr.. 38. 131-138 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Niwa, R., Ueda, R.et al.: "Defucosylated anti-CCR4 IgG1 with enhanced antiboy-dependent cellular cytotoxicity shows potent therapeutic anctiviy to T cell leukemia and lymphoma"Cancer Res.. 64. 2127-2133 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tsuboi, K., Iida, S., Inagaki, H., Kato, M., Hayami, Y., Hanamura, I., Miura, K., Harada, S., Kikuchi, M., Komatsu, H., Banno, S., Wakita, A., Nakamura, S., Eimoto, T., Ueda, R.: "MUM1/IRF4 expression as a frequent event in mature lymphoid malignancies."Leukemia. 14. 449-456 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Zhao, M., Kiyoi, H., Yamamoto, Y., Ito, M., Towatari, M., Omura, S., Kitamura, T., Ueda, R., Saito, H., Naoe, T.: "In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor."Leukemia. 14. 374-378 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takeyama, K., Seto, M., Uike, N., Hamajima, N., Ino, T., Mikuni, C., Kobayashi, T., Maruta, A., Muto, Y., Naseki, N., Sakamaki, H., Saitoh, H., Shimoyama, M., Ueda, R.: "Therapy-related leukemia and myelodysplastic syndrome : a large-scale Japanese study of clinical and cytogenetic features as well as prognostic factors."Int.J.Hematol.. 71. 144-152 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takeshita, A., Shinjo, K., Higuchi, M., Miyawaki, S., Takemoto, Y., Kishimoto, Y., Saito, K., Takuchi, H., Kuriyama, K., Kimura, Y., Asou, N., Takahashi, M., Hotta, T., Kanamaru, A., Ueda, R., Ohno, R.for the Japan Adult Leukaemia Study Group: "Quantitative expression of erythropoietin receptor (EPO-R) on acute leukaemia cells : relationships between the amount of EPO-R and CD phenotypes, in vitro proliferative response, the amount of other cytokine receptors and clinical prognosis."Brit.J.Haematol.. 108. 55-63 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanaka, Y., Mizokami, M., Orito, E., Ohno, T., Nakano, T., Kato, T., Iida, S., Ueda, R.: "Lack of integrated TT virus (TTV) genomes into cellular DNA in infected human hematopoietic cells."Leukemia and Lymphoma. 38(3-4). 411-417 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Iida, S., Hanamura, I, Suzuki, T., Kamiya, T., Kato, M., Hayami, Y., Miura, K., Harada, S., Tsuboi, K., Wakita, A., Akano, Y., Taniwaki, M., Nitta, M., Ueda, R.: "A nobel human multiple myeloma-derived cell line, NCU-MIM-1, Carrying t(2;11)(p11;q23) and t(8;22)(q24;q11) chromasomal translocations with overexpression of c-Myc protein."Int.J.Hematol.. 72. 85-91 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Naoe, T., Takeyama, K., Yokozawa, T., Kiyoi, H., Seto, M., Uike, N, Ino, T., Utsunomiya, A., Maruta, A., Jin-nai, I., Kamada, N., Kubota, Y., Nakamura, H., Shimazaki, C., Horiike, S., Kodera, Y., Saito, H., Ueda, R., Wiemels, J., Ohno, R.: "Analysis of genetic polymoriphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/myelodysplastic syndrome and de novo acute myeloid leukemia."Clin.Cancer Res.. 6. 4091-4095 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Murata, M., Towatari, M., Kosugi, H., Tanimoto, M., Ueda, R., Saito, H., Naoe, T.: "Apoptotic cytotoxic effects of a histone deacetylase inhibitor, FK228, on malignant lymphoid cells."Jpn.J.Cancer Res.. 91. 1154-1160 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohnishi, K., Minami, S., Ueda, T., Nishimura, M., Tsubaki, K., Takemoto, Y., Takeshita, A., Sao, H., Kageyama, S., Ueda, R., Ohno, R., for the Kouseisho Leukemia Study Group: "Multicenter prospective study of interferon-α and conventional chemotherapy versus bone marrow transplantation for newly diagnosed patients with chronic myelogenous leukemia."Int.J.Hematol.. 72. 229-236 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shimizu, S., Yatabe, Y., Koshikawa, T., Haruki, N., Hatooka, S., Shinoda, M., Suyama, M., Oagawa, M., Hamajima, N., Ueda, R., Takahashi, T., Mitsudomi, T.: "High frequency of clonally related tumors in cases of multiple synchronous lung canceres as revealed by molecular diagnosis."Clin. Cancer Res.. 6. 3994-3999 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shinjo, K., Takeshita, A., Ohnishi, K., Sakura, T., Miyawaki, S., Hiraoka, A., Takeuchi, M., Tomoyasu, S., Wakita, H., Ata, K., Fukutani, H., Ueda, R., Ohno, R., for the Koseisho Leukemia Study Group: "Good prognosis of patients with acute promyelocytic leukemia who achieved second complete remission (CR) with a new retinoid, am80, after relapse from CR induced by all-trans-retinoic acid."Int.J.Hematology. 72. 470-473 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Inagaki, H., Okabe, M.Seto, M., Nakamura, S., Ueda, R., Eimoto, T.: "API2-MALT1 fusion transcripts involved in mucosa-associated lymphoid tissue lymphoma."Am.J.Pathology. 158(2). 699-709 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamamoto, Y., Kiyoi, H., Nakano, Y., Suzuki, R., Kodera, Y., Miyawaki, S., Asou, N., Kuriyama, K., Yagasaki, F., Shimazaki, C., Akiyama, H., Saito, K., Nishimura, M., Motoji, T., Shinagawa, K., Takeshita, A., Saito, H., Ueda, R., Ohno, R., Naoe, T.: "Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies."Blood. 97(8). 2434-2439 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hanamura, I., Iida, S., Akano, Y., Hayami, Y., Kato, M., Miura, K., Harada, S., Banno, S., Wakita, A., Kiyoi, H., Taniwaki, M., Ueda, R: "Ectopic Expression of MAFB gene in human myeloma cells carrying (14;20)(q32;q11) chromosomal translocations."Jpn.J.Cancer Res.. 92. 638-644 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Eguchi, M., Eguchi-I, M., Seto, M., Morishita, K., Suzuki, K., Ueda, R., Ueda, K., Kamada, N., Greaves, M: "GPHN, a novel partner gene fused to MLL in a leukemia with t(11;14)(q23;q24) :"Genes, Chromosomes & Cancer. 32. 212-221 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tamura, A., Miura, I., Iida, S., Yokota, S., Horiike, S., Nishida, K., Fujii, H., Nakamura, S., Seto, M., Ueda, R., Taniwaki, M.: "Interphase detection of immunoglobulin heavy chain translocations with specific oncogene loci in 173 patients with B-cell lymphoma."Cancer Genetics and Cytogenetics. 129(1). 1-9 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tamura, A., Miura, I., Iida, S., Yokota, S., Horiike, S., Nishida, K., Fujii, H., Nakamura, S., Seto, M., Ueda, R., Taniwaki, M.: "Interphase detection of immunoglobulin heavy chain translocations with specific oncogene loci in 173 patients with B-cell lymphoma."Cancer Genetics and Cytogenetics. 129(1). 1-9 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamaguchi, M., Seto, M., Okamoto, M., Ichinohasama, R., Nakamura, N., Yoshino, T., Suzumiya, J., Murase, T., Miura, I., Akasaka, T., Tamaru, J., Suzuki, R., Kagami, Y., Hirano, M., Morishima, Y., Ueda, R., Shiku, H., Nakamura, S.: "De novo CD5^+ positive diffuse large B-cell lymphoma : a clinicopathologic study of 109 patients."Blood. 99. 815-821 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kato, M., Iida, S., Sato, M., Hayami, Y., Hanamura, I., Miura, K., Ito, M., Harada, S., Komatsu, H., Wakita, A., Manabe, T., Ueda, R.: "Superior Mesenteric venous thrombosis associated with a familial missense mutation (pro626leu) in the SHBG-Like domain of the protein S molecule."Int.J.Hematology. 75. 100-103 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ito, M., Iida, S., Inagaki, H., Tsuboi, K., Komatsu, H., Yamaguchi, M., Nakamura, N., Suzuki, R., Seto, M., Nakamura, S., Morishima, Y., Ueda, R.: "MUM1/IRF4 expression is an unfavorable prognostic factor in B-cell chronic lymphocytic leukemia (CLL)/small lymahocytic lymphoma (SLL)."Jpn.J.Cancer Res.. 93. 685-694 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nomura, K., Yoshino, T., Nakamura, S., Akano, Y., Tagawa, H., Nishida, K., Seto, M., Nakamura, S., Ueda, R., Yamagishi, H., Taniwaki, M.: "Detection of t(11;18)(q21;q21) in marginal zone lymphoma of mucosa-associated lymphocytic tissue type on paraffin-embedded tissue sections by using fluorescence in situ hybridization."Cancer Genetics and Cytogenetics. 140. 49-54 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Luo, J.M., Yoshida, H., Komura, S., Ohishi, N., Shigeno, K., Hanamura, I., Miura, K., Iida, S., Ueda, R., Naoe, T., Akao, Y., Ohno, R., Ohnish, K.: "Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia."Leukemia. 17. 1-8 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Okabe, M., Inagaki, H., Ohshima, K., Yoshino, T., Tadaaki, C.L., Ueda, R., Nakamura, S.: "API2-MALT1 fusion defines a distinctive clinicopathologic subtype in pulmonary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue."Am.J.Pathology. 162(4). 1113-1122 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Iida, S., Ueda, R.: "Multistep tumorigenesis of multiple myeloma : its molecular delineation."Int.J.Hematology. 77. 207-212 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Miura, K., Iida, S., Hanamura, I., Kato, M., Banno, S., Ishida, T., Kusumoto, S., Takeuchi, G., Miwa, H., Nitta, M., Inagaki, H., Eimoto, T., Nomura, K., Taniwaki, M, Ueda, R.: "Frequent occurrence of CCND1 deregulation in patients with early stages of plasma cell dyscrasia."Cancer Science. 94(4). 350-354 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ito, H., Hamajima, N., Takezaki, T., Matsuo, K., Tajima, K., Hatooka, S, Mitsudomi, T., Suyama, M., Sato, S., Ueda, R.: "A limited association of OGG1 ser326Cys polymorphism for adenocarcinoma of the lung."J.Epidemiology. 12(3). 258-265 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kato, H., Orito, E., Sugauchi, F., Ueda, R., Koshizaka, T., Yanaka, S., Gish, R.G., Kurbanov, F., Ruzibakiev, R., Kramvis, A., Kew, M.C., Ahmad, N., khan, M., Usuda, S., Miyakawa, Y., Mizokami, M.: "Frequent coinfection with hepatitis B virus strains of distinct genotypes detected by hybridization with type-specific probes immobilized on a solid-phase support."J.Virological Methods. 110. 29-35 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Miyazaki, M., Akatsuka, Y., Nishihida, T., Fujii, N., Hiraki, A., Ikeda, K., Tsujimura, K., Kuzushima, K., Morishima, Y., Sato, S., Ueda, R., Takahashi, T.: "Potential limitations in using minor histocompatibility antigen-specific cytotoxic T cells for targeting solid tumor cells."Clinical Immunology. 107. 198-201 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tsuboi, K., Komatsu, H., Miwa, H., Iida, S., Banno, S., Wakita, A., Nitta, N., Ueda, R.: "T-cell acute lymphoblastic leukemia as a secondary leukemia after a 3-year remission of acute myelocytic leukemia."Int.J.of Hematology. 77. 518-521 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishida, T., Utsunomiya, A., Iida, S., Inagaki, H., Takatsuka, Y., Kusumoto, S., Takeuchi, G., Shimizu, S., Ito, M., Komatsu, H., Wakita, A., Eimoto, T., Matsushima, K., Ueda, R.: "Clinical significance of CCR4 expression in adult T-cell leukemia/lymphoma : its close association with skin involvement and unfavorable outcome."Clinical Cancer Res.. 9. 3625-3634 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ozeki, K., Kiyoi, H., Hirose, Y., Iwai, M., Ninomiya, M., Kodera, Y., Miyawaki, S., Kuriyama, K., Shimazaki, C., Akiyama, H., Nishimura, M., Motoji, T., Shinagawwa, K., Takeshita, A., Ueda, R., Ohno, R., Emi, N., Naoe, T.: "Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia."Blood. 103(5). 1901-1908 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kikuchi, M., Inagaki, T., Ogawa, K., Banno, S., Matsumoto, Y., Ueda, R., Hanaki, H.: "Histopathological investigation of salivary glands in the asymptomatic elederly."Arch.Gerontol.Geriatr.. 38. 131-138 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Niwa, R., Hosaka, S.E., Sakurada, M., Shinkawa, T., Uchida, K., Nakamura, K., Matsushima, K., Ueda, R., Hanai, N., Shitara, K.: "Defucosylated chimeric anti-CCR4IgG1 with enhanced antiboy-dependent cellular cytotoxicity shows potent therapeutic anctiviy to T cell leukemia and lymphoma."Cancer Res.. 64. 2127-2133 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Iida, S., Ueda, R.et al.: "Multistep tumorigenesis of multiple myeloma : its molecular delineation"Int.J.Hematology. 77. 207-212 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Miura, K., Ueda, R.et al.: "Frequent occurrence of CCND1 deregulation in patients with early stages of plasma cell dyscrasia"Cancer Science. 94(4). 350-354 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nomura, K., Ueda, R.et al.: "Detection of t(11;18)(q21;q21) in marginal zone lymphoma of mucosa-associated lymphocytic tissue type on paraffin-embedded tissue sections by using fluorescence in situ hybridization"Cancer Genetics and Cytogenetics. 140. 49-54 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Luo, J.M., Iida, S., Ueda, R.et al.: "Possible dominant-negative mutation of the SHIP gone in acute myeloid leukemia"Leukemia. 17. 1-8 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Okabe, M., Ueda, R.et al.: "API2-MALT1 fusion defines a distinctive clinicopathologic subtype in pulmonary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue"Am.J.Pathology. 162(4). 1113-1122 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ito, H., Ueda, R.et al.: "A limited association of OGG1 ser326Cys polymorphism for adenocarcinoma of the lung"J.Epidemiology. 12(3). 258-265 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kato, H., Ueda, R et al.: "Frequent coinfection with hepatitis B virus strains of distinct genotypes detected by hybridization with type-specific probes immobilized on a solid-phase support"J.Virological Methods. 12(3). 258-265 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Miyazaki, M., Ueda, R et al.: "Potential limitations in using minor histocompatibility antigen-specific cytotoxic T cells for targeting solid tumor cells"Clinical Immunology. 110. 29-35 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hayami, Y., Iida, S., Ueda, R.et al.: "Inactivation of the E3/LAPTm5 gene by chromosomal rearangement and DNA methylation in human multiple myeloma"Leukemia. 17. 1650-1657 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tsuboi, K., Ueda, R.et al.: "T-cell acute lymphoblastic leukemia as a secondary leukemia after a 3-year remission of acute myelocytic leukemia"Int.J.of Hematology. 77. 518-521 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ishida, T., Iida, S., Ueda, R.et al.: "Clinical significance of CCR4 expression in adult T-cell leukemia/lymphoma : its close association with skin involvement and unfavorable outcome"Clinical Cancer Res.. 9. 3625-3634 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ozeki, K., Ueda, R., et al.: "Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia"Blood. 103(5). 1901-1908 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kikuchi, M., Ueda, R.et al.: "Histopathological investigation of salivary glands in the asymptomatic elederly"Arch.Gerontol.Geriatr. 38. 131-138 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Niwa, R., Ueda, R.et al.: "Defucosylated chimeric anti-CCR4 IgG1 with enhanced antibody-dependent cellular cytotoxicity shows potent therapeutic activity to T cell leukemia and lymphoma"Cancer Res.. 64. 2127-2133 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Iida S, Ueda R: "Multistep tumorigenesis of mutlitple myeloma : Its molecular delineation"International Journal of Hematology. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Miura K, Ueda R, et al.: "Frequent Occurrence of CCND1 deregulation in patients with early stages of Plasma cell dyscrasia"Cancer Science. 94・4(in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kato M, Ueda R, et al.: "Lack of Ku80 alteration in multiple myeloma"Japanese Journal of Cancer Research. 93・5. 359-362 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ito M, Ueda R, et al.: "MUM1/IRF4 expression is an unfavorable prognostic factor in B-CLL/SLL"Japanese Journal of Cancer Research. 93・6. 685-694 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Luo JM, Ueda R, et al.: "Possible dominat-negative mutation of the SHIP gene in acute myeloid leukemia"Leukemia. 17・1. 1-8 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hanamura I, et al.: "Ectopic expression of MAFB gene in human myeloma cells csrrying (14; 20)(832; 811)chromesomal translocations"Jpn. J. Cancer Res.. 92. 638-644 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tamura A, et al.: "Interphase detection of immunoglobulin heary chain translocation with specific oncogene loci in 173 patients with B-cell lymphoma"Cancer Genet. Cytogenet.. 129(1). 1-9 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hatzuvassilion G, et al.: "IRTA1 and IRTA2, novel immunoglobulin superfomily recaptors expressed in Bcells and involved in chromoseme lg21 abnormalities in Bcell maligneacy"Immunity. 14. 277-289 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamamoto, Y.: "Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies"Blood. 97・8. 2434-2439 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Inagaki, H.: "API2-MALTI fusion transciipts involved in mucosa-associated lymphoid tissue lymphoma"Am. J. Pathology. 158・2. 699-709 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Inagaki, H.: "Clonality assay of hematopoietic disorders: significance of the buccal epithelium as non-hematopoietic control and of 95% rejection limit as novel criterionn for monoclonality"Jpn. J. Cancer Res.. 92. 1305-1312 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Eguchi, M.: "GPHN, a novel partner gene fused to MLL in a leukemia with t(11;14)(q23;q24): Genes"Chromosomes & Cancer. 32. 212-221 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamaguchi, M.: "De novo CD5+ positive diffuse large B-cell lymphoma : a clinicopathologic study of 109 patients"Blood. 99. 815-821 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Naoe, T.: "Prognostic significance of the null genotype of glutathione S-transferase-T1 in patients with acute myeloid leukemia : increased early death after chemoltherapy"Leukemia. 16. 203-208 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Iida,S.: "A novel human multiple myeloma derived cell line, NCU-MM-1, carrying t(2;11)(p11;23) and t(8;22)(q24;q11) chromosomal tra nslocations with overexpression of c-Myc protein."International Journal of Hematology. 72・1. 85-97 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tsuboi,K.: "MUM1/IRF4 expression as a frequent event in mature lymphoid malignancies."Leukemia. 14. 449-456 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Zhao,M.: "In vivo treatment of mutant FLT3-transformed munne leukemia with A Tyrosine kinase inhibitor"Leukemia. 14. 374-378 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Takeyama,K.: "Therapy-related leukemia and myelodysplastic syndrome : a large-scale Japanese study of clinical and cytogenetic features as well as prognostic factors"Int.J.Hematol.. 71. 144-152 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Takeshita,A.: "Quantitative expression of erythropoietin receptor (EPO-R) on acute leukaemia cells : relationships between the amount of EPO-R and CD phenotypes, in vitro proliferative response, the amount of other cytokine receptors and clinical prognosis"Brit.J.Haematol.. 108. 55-63 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hayashi,K.: "Usefulness of uracil loading test for detecting 5-flurorouracil metabolic enzyme deficiencies in humans."Int.J.Clin.Oncol.. 5. 171-173 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ohnishi,K.: "Multicenter prospective study of interferon alpha and conventional chemotherapy versus bone marrow transplantation for newly diagnosed patients with chronic myelogenous leukemia."Int.J.Hematol.. 72. 229-236 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Murata,M.: "Apoptotic cytotoxic effects of a histone deacetylase inhibitor, FK228,on malignant lymphoid cells"Jpn.J.Cancer Res.. 91. 1154-1160 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hatzivassiliou G.: "IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy "Immunity. (in press) . (2001)

    • Related Report
      2000 Annual Research Report

URL: 

Published: 2000-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi