| Project/Area Number |
12470218
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
IIRI Taroh Tokyo Univ., Dept. of Medicine Assist. Prof., 医学部・附属病院, 助手 (90313022)
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| Co-Investigator(Kenkyū-buntansha) |
OHNISHI Hirohide Tokyo Univ., Dept. of Medicine Prof., 医学部・附属病院, 助手 (00313023)
MOTOKURA Tohru Tokyo Univ., Dept. of Medicine Prof., 医学部・附属病院, 講師 (00192823)
FUJITA Toshiro Tokyo Univ., Dept. of Medicine Prof., 医学部・附属病院, 教授 (10114125)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥11,500,000 (Direct Cost: ¥11,500,000)
Fiscal Year 2001: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 2000: ¥6,500,000 (Direct Cost: ¥6,500,000)
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| Keywords | G protein / Receptor / Molecular Medianism / G protein disease / Gene therapy |
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| Research Abstract |
G protein diseases have taught us a great deal about how G proteins work. By taking advantage of the notion and model we proposed (Nature, 394 : 35-39, 1998), we demonstrated the followings.
(1) Clarification of the mechanism of a new PHP-Ia mutant, αs-AVDT,
(2) We extended the model of receptor-dependent motivation of G proteins.
(3) Design of dominant positive/negative G protein α submits.
(4) We made simple method of tranfection using DEAE adenovirus.
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