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The biological behavior and tumorigenesis of lymph node micro-metastasis (LMM)

Research Project

Project/Area Number 12470264
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKagoshima University

Principal Investigator

AIKOU Takashi  Kagoshima University Faculty of medicine, Professor, 医学部, 教授 (60117471)

Co-Investigator(Kenkyū-buntansha) HOKITA Syuichi  Kagoshima University Hospital, Faculty of medicine, Assistant Professor, 医学部附属病院, 講師 (60274833)
NATSUGOE Souji  Kagoshima University Hospital, Faculty of medicine, Assistant Professor, 医学部附属病院, 講師 (70237577)
TAKAO Sonsin  Kagoshima University, Faculty of medicine, Associate Professor, 医学部, 助教授 (80171411)
EIZURU Yoshihito  Kagoshima University Faculty of medicine, Professor, 医学部, 教授 (00041351)
YONEZAWA Suguru  Kagoshima University, Faculty of medicine, Professor, 医学部, 教授 (10175002)
馬場 政道  鹿児島大学, 医学部・付属病院, 講師 (60198950)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥14,200,000 (Direct Cost: ¥14,200,000)
Fiscal Year 2002: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2001: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2000: ¥9,000,000 (Direct Cost: ¥9,000,000)
Keywordstumorigenesis / micro-metastasis / tumor cell / lymph node / 微小転移 / Tumorgenesis / リンパ節微小転移 / Sentinel Node Concept / 消化器癌 / リンパ節転移 / センチネルノード / チミジンホスホリラーゼ
Research Abstract

In this study (No.12470264), our group has conducted several studies regarding with the biological behavior and tumorigenesis of lymph node micro-metastasis (LMM). Lymph node metastasis is one of the most important prognostic factors in patients with gastro-intestinal carcinoma. With recently developed biologic techniques, LMM has been detected in histologically negative nodes. There have been several reports regarding the clinical significance of LMM. Tumor cell spread to regional lymph node has been questioned whether the LMM represent truly metastases or whether they are an "epiphenomen" which has very little, if any, impact on the prognosis. According to our clinical analysis, a concept that may help to resolve the controversy is the idea that deposits of tumor cells might be classified as micro-metastasis as tumor cells with a stromal reaction and tumor cell micro-involvement without a stromal reaction. Former is impact on prognosis in our data.
Next our interest is whether micro-metastasis will develop as clinical metastasis. To resolve this puzzle, we established new animal model for micro-metastasis. In experimental study using this model, we investigated morphological formation of LMM and immunological reaction against tumor deposit as time passes as shown in paper list. In the future, tumor characteristics of micro-metastasis should be investigated. From the clinical viewpoint, the biological behavior of LMM in the sentinel lymph nodes also should be clarified.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Matsumoto M.: "Rapid immunohistochemical detection of lymph node micrometastasis during operation for upper gastrointestinal carcinoma]"Br J Surg. May;90(5). 563-566 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Higashi H.: "distribution of lymph node metastasis including micrometastasis in gastric cancer with submucosal invasion"World J Surg.. 27(4). 455-459 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakashima S.: "clinical significance of circulating tumor cells in blood by molecular detection and tumor markers in esophageal cancer"Surgery. 133(2). 162-169 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakashima S.: "Biological properties of biopsy specimens are useful for predicting lymph node micrometastasis in esophageal carcinoma"Anticancer Res.. 22(5). 2951-2956 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tokuda K.: "Clinical significance of CEA-mRNA expression in peritoneal lavage fluid from patients with gastric cancer"Int J Mol Med.. 11(1). 79-84 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ishigami S.: "Clinical and pathological features in T-cell gastric lymphoma associated with human T-cell leukemia virus type 1 (HTLV-1) in comparison with B-cell gastric lymphoma"Hepatogastroenterology. 49(48). 1737-1741 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matsumoto M, Natsugoe S, Ishigami S, Uenosono Y, Takao S, Aikou T: "Rapid immunohistochemical detection of lymph node micrometastasis during operation for upper gastrointestinal carcinoma."Br J Surg.. 90(5). 563-566 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Higashi H, Natsugoe S, Ishigami S, Uenosono Y, Matsumoto M, Nakajo A, Miyazono F, Hokita S, Takao S, Aikou T: "Distribution of lymph node metastasis including micrometastasis in gastric cancer with submucosal invasion."World J Surg.. 27(4). 455-459 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakashima S, Natsugoe S, Matsumoto M, Miyazono F, Nakajo A, Uchikura K, Tokuda K, Ishigami S, Baba M, Takao S, Aikou T: "Clinical significance of circulating tumor cells in blood by molecular detection and tumor markers in esophageal cancer."Surgery. 133(2). 162-169 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakashima S, Natsugoe S, Matsumoto M, Kijima F, Miyazono F, Ishigami S, Baba M, Takao S, Aikou T: "Biological properties of biopsy specimens are useful for predicting lymph node micrometastasis in esophageal carcinoma."Anticancer Res.. 22(5). 2951-2956 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tokuda K, Natsugoe S, Nakajo A, Miyazono F, Ishigami S, Hokita S, Takao S, Eizuru Y, Aikou T: "Clinical significance of CEA-mRNA expression in peritoneal lavage fluid from patients with gastric cancer."Int J Mol Med.. 11(1). 79-84 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ishigami S, Natsugoe S, Tokuda K, Nakajo A, Che X, Iwashige H, Aridome K, Hokita S, Aikou T: "Clinical and pathological features in T-cell gastric lymphoma associated with human T-cell leukemia virus type 1 (HTLV-1) in comparison with B-cell gastric lymphoma."Hepatogastroenterology. 49(48). 1737-1741 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 愛甲 孝: "胃癌治療の最近の進歩と今後の問題点"日本外科学会雑誌(0301-4894). 102巻10号. 764-769 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 愛甲 孝: "【胃癌治療のupdate 標準治療と研究段階治療の選択】胃癌治療の動向(解説/特集)"外科治療(0433-2644). 84巻5号. 511-517 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Koki Tokuda: "Clinical significance of CEA-mRNA expression in peritoneal lavage fluid from patients with gastric cancer"Int J Mol Med.. Jan;11(1). 79-84 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shouji Natsugoe: "Biologic and imaging diagnosis of lymph node metastasis in esophagesl carcinoma"J Surg Oncol.. Sep;81(1). 25-32 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hidehiko Matsumoto: "Lymph node micrometastasis and lymphatic mapping determined by in reverse transcriptase-polymerase chain reaction pNO gastric carcinoma"Surgery. Jun;131(6). 630-635 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Keiichirou Uchikura: "Intraoperative molecular detection of circulating tumor cells by reverse transcription-polymerase chain reaction in patients with biliary-pancreatic cancer is associated with hematogenous metastasis"Annals of Surgical Oncology. May;9(4). 364-370 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takashi Aikou et al.: "Can Sentinel Node Navigation Surgery Reduce the Extent of Lymph Node Dissection in Gastric Cancer ?"Annals of Surgical Oncology. 8(9S). 90-93 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] S.W.Qubain, Takashi Aikou et al.: "Micrometastases in the cervical lymph nodes in esophageal squamous cell carcinoma"Disease of the Esophagus. 14. 143-148 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yuko Kijima, Takashi Aikou et al.: "Amplification and Overexpression of c-met Gene in Epstein-Barr Virus-Associated Gastric Carcinoma"Onocology. 62. 60-65 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Che Xiangming 他: "The cooperative role of p27 with cyclin E in the prognosis of advance gastric cancer."Cancer. 89. 1214-1219 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Che Xiangming,Takashi Aikou 他: "p21 expression is a prognostic factor in patients with p53-negative gastric cancer."Cancer Letters. 148. 181-188 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Takashi Aikou: "Can the Extent of Lymph Node Disection be Reduced by Sentinel Node Biopsy in Gastric Cancer Surgery?"John Wayne Cancer Institute Sentinel Node 2000. (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sonshin Takao,Takashi Aikou: "Suppression of metastasis by thymidinephosphorylase inhibitor."Cancer Research. 60. 5345-5348 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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