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Development of Tele-Neuroendovascular Therapy Support System

Research Project

Project/Area Number 12470283
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionTohoku University

Principal Investigator

TAKAHASHI Akira  School of Medicine, Professor, 大学院・医学系研究科, 教授 (40301048)

Co-Investigator(Kenkyū-buntansha) TAKAYAMA Kazuyoshi  Institute of Fluid Science, Professor, 流体科学研究所, 教授 (40006193)
ESASHI Masayoshi  New Industry Creation Hatchery Center, Professor, 未来科学技術共同研究センター, 教授 (20108468)
NITTA Shinichi  Institute of Development, Aging and Cancer, Professor, 加齢医学研究所, 教授 (90101138)
大槻 昌夫  東北大学, 大学院・医学系研究科, 教授 (40108486)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥13,900,000 (Direct Cost: ¥13,900,000)
Fiscal Year 2002: ¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2001: ¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 2000: ¥4,400,000 (Direct Cost: ¥4,400,000)
KeywordsNeuroendovascular Therapy / Neurosurgery / Intervention / Embolization / Aneurysm / Computer simulation / Flow dynamics / Telesurgery / 脳血管 / 脳卒中 / 脳血管障害 / 脳動脈瘤 / 三次元画像 / 動脈硬化 / コンピューター / 脳動脈硬化 / 三次元画像処理 / シミュレーション / 血管内治療
Research Abstract

1.Three-dimensional reconstruction of brain vessels using super-computer: The method was developed using super-computer fluid dynamics analysis within few hours from data acquisition by high resolution 3D-DSA. Four dimensional analysis is now possible (3D with cardiac cycle into account).
2.Application into clinical case analysis: Brain aneurysm, atherosclerosis and arterio-venous fistulas were analyzed with useful contribution for the treatment. Special attention was paid to analyze the initiation, growth and rupture of brain aneurysm and some hemodynamically significant clue was brought in.
3.Development of virtual reality simulation of neuroendovascular therapy: Using PHANToM force-feed back device, it is now possible to simulate neuroendovascular therapy. Primitive guide wire mainipulation simulation software enabled us to use this virtual reality system for training, simulation beforehand the real treatment and so on.
4.Future directions: Tele-Neuroendovascular therapy will be a reality with the development of virtual reality system and its application into training. It is mandatory to develop various types of master-slave system utilizing micro-robotics technology. The results of this research will be widely applied to the scientific evidence based pathophysilogical meticulous analysis of cerebrovascular diseases.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (76 results)

All Other

All Publications (76 results)

  • [Publications] 江面正幸: "脳動脈瘤に対する瘤内塞栓療法"脳神経外科. 28. 489-498 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saito R: "Combined neuroendovascular stenting and coil embolization for cervical carotid artery dissection causing symptomatic mass effect"Surg Neurol. 53. 318-322 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 吉本高志: "脳血管外科におけるinterventional surgeryの現況と今後"綜合臨牀. 49. 185-186 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 吉本高志: "急性期脳梗塞に対する血管内治療"神経内科. 52. 192-199 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hosseini SHR: "Study on laser driven underwater shock waves for medical applications"Proceedings of Symposium on Shock Wave, Japan 2000. 613-616 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hosseini SHR: "Study of underwater shock wave propagation in non-uniform media for medical application"Proceedings of Symposium on Shock Wave, Japan 2000. 617-620 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 齋藤務: "衝撃波捕獲法による計算コードの開発と応用"Proceedings of Symposium on Shock Wave, Japan 2000. 679-682 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 小野洋也: "岐部動脈瘤内流れの数値解析"Proceedings of Symposium on Shock Wave, Japan 2000. 661-664 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ezura M: "Diffusion-weighted MRI and selection of patients for fibrinolytic therapy of acute cerebral ischemia"Neuroradiology. 42. 379-383 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ezura M: "Intraaneurysmal GDC embolization for ruptured aneurysm in the acute stage. Indication and results"Interventional Neuroradiology. 6(suppl.). 75-78 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sheikh BY: "Basilar artery percutaneous transluminal angioplasty. Technique and results"Interventional Neuroradiology. 6(suppl.). 155-158 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ezura M: "Endovascular treatment of aneurysm associated with cerebral arteriovanous malformations : Experience after the introduction of Guglielmi detachable coils"J Clin Neuroscience. 7(suppl.). 14-18 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 加藤徳之: "親動脈の近位閉塞が奏功せず瘤内塞栓を含めた親動脈遠位塞栓術を追加した部分血栓化巨大椎骨脳動脈瘤の1例"脳神経外科. 28. 817-822 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kagawa K: "Intraaneurysmal embolization of an unruptured basilar tip aneurysm associated with moyamoya disease"J Clin Neuroscience. 8(suppl.). 460-464 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sato K: "Fusiform aneurysm of the vertebral artery presenting hemifacial spasm treated by intravascular embolization. Case report"Surg Neurol. 56. 52-55 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ezura M: "Neuroendovascular Therapy -Current technical advancement"Kor J Cerebrovascular Disease. 3. 11-18 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirano T: "Enhancement of fibronilytics with a laser-induced liquid jet"Lasers in Surgery and Medicine. 29. 360-368 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirano T: "Formation of a liquid jet by interaction between a laser-induced bubble and shock wave"Interventional Neuroradiology. 7(suppl.). 35-40 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 江面正幸: "塞栓療法後に再増大、再治療を繰り返した破裂脳底動脈瘤の1例"脳卒中の外科. 30. 164-169 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirano T: "A novel method of drug delivery for fibrinolysis with Ho : YAG laser-induced liquid jet"Lasers Med Sci. 17. 165-172 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 冨永悌二: "Paraclinoid carotid aneurysmの外科的治療-血管内治療との分担と協働"The Mt. Fuji Workshop on CVD. 20. 69-72 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kinouchi H: "Combined embolization and microsurgery for cerebral arteriovenous malformation"Neurol Med Chir. 42. 372-379 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 江面正幸: "無症候性破裂脳動脈瘤に対する瘤内塞栓療法"The Mt. Fuji Workshop on CVD. 20. 17-20 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hassan T: "Numerical simulation of blood flow in cerebral vessels with aneurysms"Proceedings of the fifth international JSME-KSME Fluid Engineering Conference, Nagoya, Japan. 30. 164-169 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hassan T: "Hemodynamic analysis of an adult vein of Galen aneurysm malformation by use of 3D image-based computational fluid dynamics"AJNR. 24(In press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hassan T: "Computational simulation of therapeutic parernt artery occlusion featuring a complex geometry of giant vertebrobasilar aneurysm"AJNR. 24(In press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ezura M: "Intraaneurysmal embolization for cerebral aneurysms"No Shinkei Geka. 28. 489-498 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saito R: "Combined neuroendovascular stenting and coil embolization for cervical carotid artery dissection causing symptomatic mass effect"Surg Neurol. 53. 318-322 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshimoto T: "Interventional surgery for cerebro-vascular diseases-present status and future-"Sogo Rinsho. 49. 185-186 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshimoto T: "Neuroendovascular treatment for acute ischemic stroke"Neurol Med. 52. 192-199 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hosseini SHR: "Study on laser driven underwater shock waves for medical applications"Proceedings of Symposium on Shock Wave. Japan 2000. 613-616 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hosseini SHR: "Study on underwater shock wave propagation in non-uniform media for medical applications"Proceedings of Symposium on Shock Wave. Japan 2000. 617-620 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saito T: "Development and application of shock-capturing numerical code"Proceedings of Symposium on Shock Wave. Japan 2000. 679-682 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ono H: "Numerical simulation on flow in bifurcated aneurysm"Proceedings of Symposium on Shock Wave. Japan 2000. 661-664 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ezura M: "Diffusion-weighted MRI and selection of patients for fibrinolytic therapy of acute cerebral ischemia"Neuroradiology. 42. 379-383 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ezura M: "Intraaneurysmal GDC embolization for ruptured aneurysm in the acute stage. Indication and results"Interventional Neuroradiology. 6(suppl.). 75-78 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sheikh BY: "Basilar artery percutaneous transluminal angioplasty, Technique and results"Interventional Neuroradiology. 6(suppl.). 155-158 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ezura M: "Endovascular treatment of aneurysm associated with cerebral arteriovenous malformations: Experience after the introduction of Guglielmi detachable coils"J Chin Neuroscience. 7(suppl.). 14-18 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kato N: "Intraaneurysmal embolization and parent artery trapping to treat a giant partiall thrombosed vertebral artery aneurysm after surgical proximal clipping"No Shinkei Geka. 28. 817-822 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kagawa K: "Intraaneurysmal embolization of an unruptured basilar tip aneurysm associated with moyamoya disease"J Chin Neuroscience. 8(suppl.). 460-464 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sato K: "Fusiform aneurysm of the vertebral artery presenting hemifacial spasm treated by in travascular embolization. Case report"Surg Neurol. 56. 52-55 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ezura M: "Neuroendovascular Therapy-Current technical advancement"Kor J Cerebrovascular Disease. 3. 11-18 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirano T: "Enhancement of fibrinolytics with a laser-induced liquid jet"Lasers in Surgery and Medicine. 29. 360-368 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirano T: "Formation of a liquid jet by interaction between a laser-induced bubble and shock wave"Interventional Neuroradiology. 7(suppl.). 35-40 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ezura M: "A ruptured basilar tip aneurysm that experienced repeated regrowth and re-embolization after initial embolization"Surgery for Cerebral Stroke. 30. 164-169 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirano T: "A novel method of drug delivery for fibrinolysis with Ho:YAG laser-induced liquid jet"Lasers Med Sci. 17. 165-172 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tominaga T: "Surgical treatment of paraclinoid carotid aneurysm-collaboration and selection with endovascular therapy-"The Mt.Fuji Workshop on CVD. 20. 69-72 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kinouchi H: "Combined embolization and microsurgery for cerebral arteriovenous malformation"Neurol Med Chir. 42. 372-379 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ezura M: "Intraaneurysmal embolization for unruptured non-symptomatic aneurysms"The Mt.Fuji Workshop on CVD. 20. 17-20 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hassan T: "Numerical simulation of blood flow in cerebral vessels with aneurysms"Proceedings of the fifth international JSME-KSME Fluid Engineering Conference, Nagoya, Japan. 30. 164-169 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hassan T: "Hemodynamic analysis of an adult vein of Galen aneurysm malformation by use of 3D image-based computational fluid dynamics"AJNR. 24(in press). (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hassan T: "computational simulation of therapeutic parent artery occlusion featuring a complex geometry of giant vertebrobasilar aneurysm"AJNR. 24(in press). (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tamer Hassan, Eugene V.Timofeev, Masayuki Ezura, Tsutomu Saito, Akira Takahashi, Kazuyoshi Takayama, Takashi Yoshimoto: "Hemodynamic analysis of an adult vein of Galen aneurysmal malformation using 3D image based computational. fluid dynamics"AJNR Am J Neuroradiol. (in Press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tamer Hassan, Masayuki Ezura, Eugene V.Timofeev, Teiji Tominaga, Tsutomu Saito, Akira Takahashi, Kazuyoshi Takayama, Takashi Yoshimoto: "Computational simulation of therapeutic parent artery occlusion to treat giant vertebrobasilar aneurysm"AJNR Am J Neuroradiol. (in Press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tamer Hassan, Eugene V.Timofeev, Tsutomu Saito, Masayuki Ezura, Hiroaki Shimizu, Teiji Tominaga, Akira Takahashi, Kazuyoshi Takayama, Takashi Yoshimoto: "Computational replicas-Anatomical reconstructions of cerebral vessels as volume numerical grids using three-dimensional angiography"Annals of biomedical engineering (ABME). (in Press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hirano T 他: "Enhancement of fibrinolytics with a laser-induced liquid jet"Lasers in Surgery and Medicine. Vol.29. 360-368 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kim TS 他: "Guide wire induced carotid cavernous fistula"Interventional Neuroradiology. Vol.7. 161-165 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kagawa K 他: "Intraaneurysmal embolization of an unruptured basilar tip aneurysm associated with moyamoya disease"J Clinical Neuroscience. Vol.8. 462-464 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sato K 他: "Fusiform aneurysm of the vertebral artery presenting hemifacial spasm treated by intravascular embolization-Case Report-"Surg Neurol. Vol.56. 52-55 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ezura M 他: "Intraaneurysmal GDC embolization for ruptured aneurysm in the acute stageindication and results"Interventional Neuroraiology. Vol.6. 75-78 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kato N 他: "Intraaneurysmal embolization and parent artery trapping to treat a giant partial thrombosed vertebral artery aneurysm after surgical proximal clipping"Neurological Surgery. Vol.28. 817-822 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ezura M 他: "Endovascular treatment of aneurysms associated with cerebral arteriovenous malformations : experiences after the introduction of Guglielmi detachable coils"J Clinical Neuroscience. Vol.7. 14-18 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] 江面正幸: "脳動脈瘤に対する瘤内塞栓療法"脳神経外科(Neurological Surgery). 28巻. 489-498 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ryuta Saito ほか: "Combined Neuroendovascular Stenting and Coils Embolization for Cervical Carotid Artery Dissection Causing Symptomatic Mass Effect"Surgical Neurology. Vol.53. 318-322 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 吉本高志: "脳血管外科におけるInterventional surgeryの現況と今後"総合臨床. 49巻. 185-186 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 吉本高志 ほか: "急性期脳梗塞に対する血管内治療"神経内科. 52巻. 192-199 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] S.H.R.Hosseini: "Study on laser driven underwater shock waves for medical applications."平成11年度衝撃波シンポジウム講演論文集. 613-616 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 齋藤務: "衝撃波捕獲法による計算コードの開発と応用"平成11年度衝撃波シンポジウム講演論文集. 679-682 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 高山和喜: "衝撃波医療のこれから"日本ME学会BME別冊. Vol.14. 40-42 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 高橋明: "Ho : YAGレーザー脳塞栓破砕術に関する基礎研究"日本ME学会BME秋期特別号. 38巻. 127 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ezura M ほか: "Diffusion-weighted MRI and selection of patients for fibrinolytic therapy of acute cerebral ischaemia."Neuroradiology. Vol.42. 379-383 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ezura M ほか: "Intraaneurysmal GDC embolization for ruptured aneurysm in the acute stage."Interventional Neuroradiology. 6(suppl). 75-78 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sheikh BY ほか: "Basilar artery percutaneous transluminal angioplasty."Interventional Neuroradiology. 6(suppl). 155-158 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ezura M ほか: "Endovascular treatment of aneurysms associated with cerebral arteriovenous malformations : experiences after the introduction of Guglielmi detachable coils."Journal of Clinical Neuroscience. 7(suppl). 14-18 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Saito R ほか: "Combined neuroendovascular stenting and coil embolization for cerevical carotid artery dissection causing symptomatic mass effect."Surgcal Neurology. Vol.53. 318-322 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Suzuki K ほか: "Dissociation of letter and picture naming resulting from callosal disconnection."Neurology. Vol.51. 1390-1394 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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