| Project/Area Number |
12470315
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Chiba University |
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Principal Investigator |
YAMAMOTO Tatsuo Chiba University, Graduate School of Medicine, Lecturer, 大学院・医学研究院, 講師 (20200818)
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| Co-Investigator(Kenkyū-buntansha) |
AOE Tomohiko Chiba University, Graduate School of Medicine, Associate Professor, 大学院・医学研究院, 助教授 (90311612)
田口 奈津子 千葉大学, 医学部・附属病院, 助手 (80282474)
坂下 美彦 千葉大学, 医学部・附属病院, 助手 (30312937)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥16,900,000)
Fiscal Year 2002: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2001: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2000: ¥14,400,000 (Direct Cost: ¥14,400,000)
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| Keywords | orexin-A / orexin-1 receptor / NAALADase / neuropathic pain / mechanical allodynia / spinal cord / dorsal root ganglion / orexin-A / orexin-1受容体 / mechanical allodynia / 2-PMPA / ZJ11 / ZJ17 / partial sciatic nerve injury / nociceptin / pre-emptive analgesia / Fos蛋白 / 摘出脊髄 |
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| Research Abstract |
To search the new therapeutic approach to treating neuropathic pain, we investigated the role of nociceptin, pituitary adenylate cyclase activating polypeptide (PACAP), N-acetyl-aspartic-glutamate (NAAG) and orexin-A in spinal nociceptive transmission in the rats. Intrathecal administration of nociceptin, PACAP and orexin-A produced significant analgesic effect in the inflammatory pain models and intrathecal administration of either nociceptin or orexin-A attenuate the level of mechanical allodynia induced by partial sciatic nerve ligation. NAAG was catalyzed by NAALADase and inhibition of spinal NAALADase produced significant analgesic effect in both inflammatory pain models and neuropathic pain models. These data strongly suggested that nociceptin, inhibition of spinal NAALADase and orexin-A are new candidates for treating neuropathic pain in clinical situation.
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