| Project/Area Number |
12470349
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | NIPPON MEDICAL SCHOOL |
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Principal Investigator |
ARAKI Tsutomu NIPPON MEDICAL SCHOOL, OBSTETRICS AND GYNECOLOGY, PROFESSOR, 医学部, 教授 (40089751)
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| Co-Investigator(Kenkyū-buntansha) |
SAWA Rintaro NIPPON MEDICAL SCHOOL, OBSTETRICS AND GYNECOLOGY, ASSISTANT PROFESSOR, 医学部, 講師 (30267174)
YONEYAMA Yoshio NIPPON MEDICAL SCHOOL, OBSTETRICS AND GYNECOLOGY, ASSISTANT PROFESSOR, 医学部, 講師 (00201096)
鈴木 俊治 日本医科大学, 医学部, 助教授 (80291722)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥12,800,000 (Direct Cost: ¥12,800,000)
Fiscal Year 2002: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2001: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 2000: ¥5,500,000 (Direct Cost: ¥5,500,000)
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| Keywords | brain ischemia / brain hypoxia / fetus / ischemic preconditioning / adenosine / theophylline / ischemic tolerance / 5'-nucleotidase / Brain / Adenosine / 5'-nucleotidase |
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| Research Abstract |
[PURPOSE] The purpose of this study is to examine the relationship between ischemic preconditioning and ischemic tolerance in fetal brain, and evaluated the mechanism of the expression of the tolerance for ischemia by ischemic preconditioning.
[METHOD] We performed ischemic preconditioning by repeated umbilical cord occlusion, and then inducted fetal brain ischemia and hypoxia by repeated umbilical cord occlusion in ten chronically instrumented fetal sheep with and without adenosine agonists and antagonists.
[RESULTS] Fetal brain tolerance for ischemia was enhanced by ischemic preconditioning, which was partially augmented by adenosine agonists and diminished by adenosine antagonists.
[CONCLUSION] Ischemic preconditioning elicits fetal brain tolerance for ischemia, which was at least in part regulated by adenosine.
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