| Project/Area Number |
12470353
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kanazawa University |
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Principal Investigator |
ISHIMARU Tadashi KANAZAWA UNIVERSITY, HOSPITAL, ASSISTANT PROFESSOR, 医学部・附属病院, 助手 (10272965)
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| Co-Investigator(Kenkyū-buntansha) |
MIWA Takaki KANAZAWA UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, ASSOCIATE PROFESSOR, 大学院・医学系研究科, 助教授 (20229909)
FURUKAWA Mitsuru KANAZAWA UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, PROFESSOR, 大学院・医学系研究科, 教授 (40092803)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥11,100,000 (Direct Cost: ¥11,100,000)
Fiscal Year 2001: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2000: ¥7,600,000 (Direct Cost: ¥7,600,000)
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| Keywords | Near infrared spectroscopy / Olfaction / Human / Orbit frontal cortex / Olfactmetry / Oxy hemoglobin / 還元ヘモグロビン / 脳血流 / 環元ヘモグロビン |
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| Research Abstract |
Near infrared spectroscopy (NIRS) is a non-invasive measuring method for brain activity using the difference of absorption between oxy-hemoglobin and de-oxy-hemoglobin in the cortex. We tried NIRS for measuring the human olfactory response from the orbitofrontal cortex and investigated the possibility of NIRS for objective olfaction test. Near infrared emitters and detectors were set on the both sides of a frontal scalp near orbitofrontal cortex and recorded the response elicited by olfactory stimulation. Two odorants, β-Phenyl ethyl alcohol (A) and Isovaleric acid c were chosen from 5 odorants of T＆T olfactometer for stimulants. Healthy subjects were examined and odorant elicited NIRS responses were detectable from 50% subjects. Increasings of the concentration of oxy-hemoglobin were observed after 10 seconds stimulation of odorant A or C. Placebo stimulation did not elicit oxy-hemoglobin concentration changing. Difference of oxy-hemoglobin concentration increasing between odorous and placebo stimulation was significant. NIRS technique was thought of the new powerful method to investigate human olfaction.
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