| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Takayuki Graduate school of medicine, KYOTO UNIVERSITY, instructor, 医学研究科, 講師 (50335270)
TSUJI Jun Graduate school medicine, KYOTO UNIVERSITY, Instructor, 医学研究科, 助手 (30252448)
ITO Juichi Graduate school of medicine, KYOTO UNIVERSITY, Professor, 医学研究科, 教授 (90176339)
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| Budget Amount *help |
¥7,000,000 (Direct Cost: ¥7,000,000)
Fiscal Year 2001: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2000: ¥4,200,000 (Direct Cost: ¥4,200,000)
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| Research Abstract |
We used positron emission tomography (PET) to investigate cortical and sub-cortical correlates of vestibulo-visual interaction. Caloric vestibular stimulation activated the bilateral inferior parietal lobules (Brodmann area (BA) 40), the left posterior insula, right post-central gyrus (BA 3/1/2), the right precuneus (BA 7), the right fusiform gyrus (BA 37/19), the left hippocampal gyrus (BA 30), the anterior cingulate gyrus (BA 24), and the left caudate nucleus. Fixation suppression of caloric nystagmus activated the bilateral visual areas (BA 17/18/19/37), the left fusiform gyrus (BA 20), the bilateral temporal tips (BA 38), the right middle temporal gyrus (BA22), and the area around the right frontal eye field (BA 6). In the cerebellum, activation of the uvula/nodulus and the bilateral flocculi was identified. The regions that were activated with vestibular habitation were the left post-central gyrus (BA 3/1/2), the right anterior temporal cortex (BA 38), the left lingual gyrus (BA 19), and the right anterior cingulate gyrus (BA 32), and the uvula/nodulus in the cerebellum. The regions that showed significant co-activation with habitation and fixation suppression of caloric nystagmus were the right anterior temporal cortex (BA 38), the left lingual gyrus (BA 19) and the uvula/nodulus of the cerebellum. Regions that showed significant codeactivation with habituation and fixation suppression of caloric nystagmus were the bilateral inferior parietal lobules (BA 40) and the bilateral superior temporal gyrus (BA 22/42). Our results are consistent with previous observations, and are in line with the expectation that vestibular information may be used incorporated with other sensory and sonsori-motor information. Fixation suppression and habituation of caloric nystagmus jointly activated several regions, suggesting that that these two mechanisms that modulate VOR are not completely independent but may share some cortical and sub-cortical regions in common.
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