| Project/Area Number |
12470361
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Nagoya University |
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Principal Investigator |
TERASAKI Hiroko Graduate School of Medicine,Nagoya University Professor, 大学院・医学研究科, 教授 (40207478)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Satoshi University Hospital, Nagoya University Research Associates, 医学部・附属病院, 助手 (90314012)
MIYAKE Yozo Graduate School of Medicine, Nagoya University Professor, 大学院・医学研究科, 教授 (30166136)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥12,200,000 (Direct Cost: ¥12,200,000)
Fiscal Year 2001: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2000: ¥9,200,000 (Direct Cost: ¥9,200,000)
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| Keywords | Virgpretinal surgery / focal macularERG / full-field ERG / internal limiting membrane / diabetic maculopathy / age-related macular degeneration / macular translocation / polypoidal choroidal vasculopathy / 黄斑円孔 / 黄斑浮腫 / 加齢黄斑変性 / 網膜電図 / インドシアニングリーン |
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| Research Abstract |
We studied the effects of vitreoretinal surgery on retinal function and morphology. Vitrectomy is one of the effective treatments for improvements of retinal pathological conditions by removing the diseased vitreous and proliferative tissues. Conversely, however, the procedure itself may give adverse effects on the retinal function and/or retinal circulation. We evaluated the effects of removal of internal limiting membrane on macular retinal function in idiopathic macular hole surgery by focal macular ERG (FMERG) and concluded that this procedure had no adverse effect on visual acuity. However, the selective delay of recovery of the FMERG b-wave after surgery suggests an alteration of retinal physiology in the macular region(IOVS200 1). We further evaluated the macular morphology using optical coherent tomography in diabetic macular edema with visible vitreous traction and concluded that the structure recovered well after surgery, although the recovery of visual acuity was limited because of their preoperative retinal pahological conditions(AJO2001). We further studied the local macular and full-field retinal functions of age related macular degeneration (AMD) after removal of choroidal neovascularization and macular translocation surgery, respectively(IOVS2002) (IOVS2002). These study demonstrated the recovery of macular function was contributed by the decreased retinal thickness. Macular translocation surgery may be well feasible technique, however, the total function of the retina was decreased after surgery. In our additional study, the histopathology of polypoidal choroidal vasculopathy obtained during macular translocation surgery demonstrated the similarity to those of the AMD(BJO2002).
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