| Project/Area Number |
12470371
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | National Institute of Radiological Sciences (2001-2002)
University of Tsukuba (2000) |
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Principal Investigator |
IWAKAWA Mayumi National Institute of Radiological Sciences, Frontier Research Center, Group Leader, フロンティア研究センター, グループリーダー (30231723)
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| Co-Investigator(Kenkyū-buntansha) |
OHASHI Yasuo Tokyo University, 医学系研究科・生物統計学教室, 教授 (00134461)
KANEKO Yasuhiko Saitama provisional Cancer Center, 化学療法部, 部長
HATA Jun-ichi Keio University, 医学部, 教授 (90051614)
TSUCHIDA Yoshiaki Gunmms provisional Cancer Center, 院長 (80010164)
山田 正夫 国立小児病院, 研究センター・先天異常研究部, 部長
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥5,100,000 (Direct Cost: ¥5,100,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2001: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2000: ¥2,900,000 (Direct Cost: ¥2,900,000)
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| Keywords | Wilms' tumor / WT1 / Wilms種瘍 / LOH / LOI / WT1gene / RTK / CCSK |
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| Research Abstract |
*To investigate the carcinogenesis mechanism of Wilms tumor, LOH and LOI analysis in genes related with Wilms tumor, such as WT1 was performed. The nation-wide registration system and central review system of pathological diagnosis was established. More than 200 new cases were registered into our group study supported by this grant. Sixty cases with stage I, 42 cases with stage II, 23 cases with stage III, and 19 cases with stage IV among 191 cases until the end of 2002 showed a good prognosis without any disease-caused death. Malignant rhabdoid tumor of the kidney, however, had the poorest prognosis resulted in no survival. Central review system was run precisely to diagnose each case registered by the each institution with its local pathological diagnosis which was in some cases incorrect. Molecularbiological analysis for gene WT1 revealed 6 mutations and 1 hemi-deletion. Further
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