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Action Mechanism of Stress in the Higher Brain Mechanisms and Modulation of Sedation

Research Project

Project/Area Number 12470446
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionKyushu Dental College

Principal Investigator

KAWAHARA Hiroshi  Faculty of Dentistry, Assistant Professor, 歯学部, 講師 (10186124)

Co-Investigator(Kenkyū-buntansha) SHIIBA Shunji  Faculty of Dentistry, Instructor, 歯学部, 助手 (20285472)
TANAKA Masatoshi  Kurume University School, Professor of Medicine, Faculty of Medicine, 医学部, 教授 (10080954)
NAKANISHI Osamu  Faculty of Dentistry, Professor, 歯学部, 教授 (50137345)
SAKAMOTO Eiji  Faculty of Dentistry, Instructor, 歯学部, 助手 (00295859)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥11,100,000 (Direct Cost: ¥11,100,000)
Fiscal Year 2002: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2001: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2000: ¥5,100,000 (Direct Cost: ¥5,100,000)
KeywordsStress / Microdialysis / Neuronal Network / Monoamine Neurons / Locus Ceruleus / Prefrontal Cortex / Benzodiazepine / Anxiolytics
Research Abstract

The stress cognition and the emotional appearance are the higher brain functions formed with complex brain neural network mechanisms. The influence of selective anxiolytics, selective sedatives, and benzogeazepins to these higher brain functions, were examined used with microdiaiysis. The load time of the stress, and these drugs, laboratory animal in no anesthetizing, unrestraint, and the state of the freely moving were examined from the movement of the neurotransmitters in the brain when administering them.
As a result, it was shown that selective anxiolytics, selective sedatives, and benzogeazepins had different actions for the locus coeruleus (LC) - prefrontal cortex (PFC) norepinephrine nerve activity and ventral tegmental area (VTA) - nucleus accumbens (N.Acc.) dopamine nerve activity. Both of the norepinephrine nerve activity in the state of stress and VTA- N.Acc. dopamine nerve activity controlled by benzodiazepines. Selective anxiolytics controlled only the LC-PFC norepinephrine nerve activity. Selective sedatives controlled only the VTA-N. Acc. dopamine nerve activity. Differed the action on the neural network in the brain taking part in the selection of an anxyolytic action and sedative action
Selective anxiolytics and the selective sedatives showed the muscle relax action which differed from benzogeazepin system medicine, and originated in LC and it was shown not to appear. As for selective anxiolytics and selective sedatives have a few effect of the upper airway obstruction and depress breathing . It was thought that there was no muscle relax action which originated in LC as the reason.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] 河原 博: "選択的抗不安薬と選択的鎮静薬の中枢神経系作用"日本歯科麻酔学会雑誌. 30. 547-556 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawahara, Y., Kawahara, H., Westerink, BHC: "Hypotension-induced dopamine release in prefrontal cortex is mediated by local glutamatergic projections at the level of nerve terminals"Journal of Neurochemistry. 81. 285-291 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Westerink, BHC., Kawahara Y., De Boer, P.et al.: "Antiphyshotic drugs classified by the effects on the release of dopamine and noradrenaline in the prefrontal cortex and striatum"European Journal of Pharmacology. 412. 127-138 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Pudovkina, OL., Kawahara, Y., De Vries, J., Westerink, BHC.: "The release of noradrenalin in the locus coeruleus and prefrontal cortex studied with dual-probe microdialysis"Brain Research. 906. 38-45 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawahara, H., Kawahara, Y., Westerink, BHC: "Noradrenalin-dopamine interaction in the medial prefrontal cortex studied by multi-probe micordialysis"European Journal of Pharmacology. 418. 177-186 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawahara, H., Kawahara, Y., Westerink, BHC: "The role of afferents to the locus coeruleus in the handling stress-induced increase in the release of noradrenaline in the medial prefrontal cortex : a dual-probe microdialysis study in the rat brain"European Journal of Pharmacology. 387. 279-286 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 河原 博, 仲西 修: "歯科麻酔学 第6版"医歯薬出版(印刷中). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawahara H: "Action mechanisms of selective anxiolytics and Selective sedatives in central nervous system"Journal of Japanese Dental Society of Anesthesia. 30. 547-556 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawahara Y, Kawahara H, Westerink BHC: "Hypotension-induced dopamine release in prefrontal cortex is mediated by local glutamatergic projections at the level of nerve terminals"Journal of Neurochemistry. 81. 285-291 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Westerink, BHC, Kawahara Y, de Boer P, Geels C, de Vries JB, Wikstrom HV, Van Kalkeren A, Van Vliet, B, Kruse CG, Long, SK: "Antipsychotic drugs classified by their effects on the release of dopamine and noradrenaline in the prefrontal cortex and striatum"European Journal of Pharmacology. 412. 127-138 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Pudovkina OL, Kawahara Y, de Vries J, Westerink, BHC: "The release of noradrenaline in the locus coeruleus and prefrontal cortex studied with dual-probe Microdialysis"Brain Research. 906. 38-45 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawahara H, Kawahara Y. Westerink BHC: "The noradrenaline-dopamine interaction in the rat medial prefrontal cortex studied by multi-probe Microdialysis"European Journal of Pharmacology. 418. 177-186 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kawahara H, Kawahara Y. Westerink BHC: "The role of afferents to the locus coeruleus in the handling stress-induced increase in the release of noradrenaline in the medial prefrontal cortex : a dual-probe microdialysis study in the rat brain"European Journal of Pharmacology. 387. 279-286 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 河原 博: "選択的抗不安薬と選択的鎮静薬の中枢神経系作用"日本歯科麻酔学会雑誌. 30. 547-556 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kawahara, Y., Kawahara, H., Westerink, BHC: "Hypotension-induced dopamine release in prefrontal cortex is mediated by local glutamatergic projections at the level of nerve terminals"Journal of Neurochemistry. 81. 285-291 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Westerin, BHC., Kawahara, Y., De Boer, P., et al.: "Antipsychotic drugs classified by their effects on the release of dopamine and noradrenaline in the prefrontal cortex and striatum"European Journal of Pharmacology. 412. 127-138 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Pudovkina, OL., Kawahara, Y., De Vries, J., Wester ink, BHC.: "The release of noradrenaline in the locus coeruleus and prefrontal cortex studied with dual-probe microdialysis"Brain Research. 906. 38-45 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kawahara, H., Kawahara, Y., Westerink, BHC.: "Noradrenaline-dopamine interaction in the medial prefrontal cortex studied by multi-probe micordialysis"European Journal of Pharmacology. 418. 177-186 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kawahara, H., Kawahara, Y., Westerink, BHC.: "The role of afferents to the locus coeruleus in the handling stress-induced increase in the release of noradrenaline in the medial prefrontal cortex : a dual-probe microdialysis study in the rat brain"European Journal of Pharmacology. 387. 279-286 (2000)

    • Related Report
      2002 Annual Research Report
  • [Publications] 河原 博, 仲西 修: "歯科麻酔学 第6版"医歯薬出版(印刷中). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 河原 博: "選択的抗不安薬と選択的鎮静薬の中枢神経系作用発現機構"日本歯科麻酔学会雑誌. (発表予定). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kawahara, Y.Kawahara, H., Westerink, B.H.C: "Hypotension-induced dopamine release in prefrontal cortex is mediated by local glutamatergic projections at the level of nerve terminals"Journal of Neurochemistry. (accepted). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kawahara, H.Kawahara, Y., Westeiink, B.H.C: "Noradrenaline-dopamine interaction in the medial prefrontal cortex studied by multi-probe micordialysis"European Journal of Pharmacolology. 418. 177-186 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kawahara, H.Kawahara, Y., Westerink, B.H.C: "The role of afferents to the locus coeruleus in the handling stress-induced increase in the release of noradrenaline in the medial prefrontal cortex : a dual-probe microdialysis study in the rat brain"European Journal of Pharmacolology. 387. 279-286 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kawahara,H.Kawahara,Y.and Westerink,B.H.C: "The role of afferents to the locus coeruleus in the handling stress-induced increase in the release of noradrenaline in the medial prefrontal cortex : a dual-probe microdialysis study in the rat brain"European Journal of Pharmacolology. 387. 279-286 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kawahara,H.Kawahara,Y.and Westerink,B.H.C: "Noradrenaline-dopamine interaction in the medial prefrontal cortex studied by multi-probe micordialysis"European Journal of Pharmacolology. (accepted). (2001)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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