| Project/Area Number |
12470451
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Matsumoto Dental University School of Dentistry |
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Principal Investigator |
FURUSAWA Kiyofumi Matsumoto Dental University, School of Dentistry, Professor, 歯学部, 教授 (90165481)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Yoko Matsumoto Dental University, School of Dentistry, Staff Member, 歯学部, 助手 (30308647)
TANAKA Mikiko Matsumoto Dental University, School of Dentistry, Lecturer, 歯学部, 講師 (40247531)
YASUDA Kouichi Matsumoto Dental University, School of Dentistry, Associate Professor, 歯学部, 助教授 (30230220)
小松 史 松本歯科大学, 歯学部, 講師 (90247528)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥5,700,000 (Direct Cost: ¥5,700,000)
Fiscal Year 2002: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2001: ¥4,000,000 (Direct Cost: ¥4,000,000)
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| Keywords | autonomic nerve / ganglia / upper airway / sympathetic nerve / parasympathetic nerve / 頸神経ワナ / 舌下神経 / オトガイ舌骨 / 嚥下 / 節後ニューロン / シナプス / ラット / 頚神経ワナ / オトガイ舌骨筋 |
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| Research Abstract |
Previous studies have indicated that the geniohyoid (GH) muscle is innervated by efferent axons in the hypoglossal (XII) nerve and the ansa cervicalis. To clarify the physiological significance of this dual innervation of the GH muscle, we examined the properties of the efferent innervation of the rat GH muscle using eleotrophysiologioal and immunohistochenical methods. Recordings from the branch of the XII nerve that innervates the GH muscle (GH.Br) showed that bursts of impulses during fictitious swallowing were conducted via the XII nerve trunk. In contrast, tonic discharges in the GH. Br were conducted via the ansa cervicalis. Tonic activity was abolished in vitro by mecamylamine, an antagonist of the nicotinic acetylcholine receptor (nAChR), and by pirenzepine, an antagonist of the muscarinic M1 receptor. Incubation of isolated XII nerve segments with antisera to vasoactive intestinal peptide, nAChR, and the muscarinic M1 receptor yielded a small number of labeled neurons with each antiserum. All of the labeled neurons had similar diameters and were located approximately 1.5 mm proximal to the bifurcation of the XII nerve into its medial and lateral branches. Our findings indicate that the GH muscle in the rat is innervated by both the somatic and the parasympathetic nervous systems.
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