| Project/Area Number |
12470479
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
KIMURA Eiichi Hiroshima University, Faculty of Medicine, Professor, 医学部, 教授 (30034010)
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| Co-Investigator(Kenkyū-buntansha) |
AOKI Shin Hiroshima University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (00222472)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥16,300,000 (Direct Cost: ¥16,300,000)
Fiscal Year 2001: ¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 2000: ¥9,500,000 (Direct Cost: ¥9,500,000)
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| Keywords | Macrocyclic Compound / Supermolecule / Self-assembly / Multinuclear Zn Complex / double-stranded DNA / double-stranded RNA / anti-HIV agent / Gene expression / 大環状化合物 / DNA人工フォトリアーゼ |
|---|
| Research Abstract |
1) Synthesis of Bioactive or Catalytic Macrocyclic Compounds :
We have discovered new antiHIV agents and revealed their antiHIV mechanism. On the basis of our accumulated knowledge, new types of macrocyclic structures have been developed.
2) Creation of Self-assembling Supermolecules with Multinuclear Macrocyclic Complexes :
We have discovered that a trinuclear Zn^<2+> complex and cyanuric acid bind pH-dependently to yield 2 : 3 and 4 : 4 cubic supermolecules. In the central hollow, adamantane and other lipophilic molecules are enclosed.
3) Evolution of Macrocyclic Chemistry to Genetic Sciences :
We have developed macrocyclic complexes that control gene expression by exclusively binding to double-stranded DNA and RNA.
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