• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The phenotypical difference between the Japanese males of the different Y chromosome lineage and their fitness to the modern society.

Research Project

Project/Area Number 12470517
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Human genetics
Research InstitutionThe University of Tokushima

Principal Investigator

NAKAHORI Yutaka  The University of Tokushima, Graduate School of Medicine, Professor, 医学研究科, 教授 (10172389)

Co-Investigator(Kenkyū-buntansha) TAMURA Takamichi  The University of Tokushima, Graduate School of Medicine, Lecturer, 医学研究科, 講師 (80155267)
SHINKA Toshikatsu  The University of Tokushima, Graduate School of Medicine, Associate Professor, 医学研究科, 助教授 (10311820)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥13,400,000 (Direct Cost: ¥13,400,000)
Fiscal Year 2002: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2001: ¥5,200,000 (Direct Cost: ¥5,200,000)
Fiscal Year 2000: ¥4,800,000 (Direct Cost: ¥4,800,000)
KeywordsY chromosome / Japanese / Jomon / Yayoi / phenotype / 家系図 / 栄養 / 日本人男性 / DHPLC / ゲノム / 精子数 / ハプロタイプ / 適応度
Research Abstract

The nowadays Japanese consists of two main groups. One group is original Japanese (≒ Jomon people) who resides in the Japanese Islands from 10,000 years or more before. The other group is the immigrant (≒ Yayoi people) who came across the sea mainly via the Korean Peninsula from 3000 years before to the Asuka period. The population of the Japanese Islands increased from 100,000 to 6 million in this period. The rate of population increase was marvelous thinking of natural increase rate in the other population. Therefore, a considerable number of immigrant reached Japan. In the present population, interests are on the ratio and the distribution of these two groups. In 2002, newly Y chromosome pedigrees around the world was introduced by the Y chromosome consortium. This offered us the new aspect to the classification of Japanese males.
My working hypothesis has been that at least a part of the genes on Y chromosome are working on sexual selection of a male. Under the cooperation of students, we investigated various characters of male students and statistically analyzed the data obtained from them. The first-stage impression suggests that the phenotypical difference exist in males of the different Y chromosome lineage. Since the data we collected were too wide in the range and too rough in the quality, the detailed and well organized experimental design is needed to elucidate the phenotypical differences between the different male lineages.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (36 results)

All Other

All Publications (36 results)

  • [Publications] Ewis, A.A.: "Two Y-chromosome-specific polymorphisms 12f2 and DFFRY in the Japanese population and heir relations to other Y-polymorphisms"J.Med.Invest. 49. 44-50 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ewis, A.A.: "Linkage between prostate cancer incidence and different alleles of the human Y-linked tetranucleotide polymorphism DYS192002"J.Med.Invest. 49. 56-60 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ewis, A.A.: "Microdeletions of a Y-specific marker, Yfm1, and implications for a role in spermatogenesis"J Hum.Genet. 47. 257-261 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Jabasini, M.: "Analysis of DNA polymorphisms on the human Y-chromosome by microchip electrophoresis"Electrophoresis. 23. 1537-1542 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Lettice LA: "Disruption of a long-range cis-acting regulator for Shh causes preaxialpolydactyly"Proc Natl Acad Sci U S A. 99. 7548-7553 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ewis A.A.: "Yfm1, a multi-copy marker, specific for the Y chromosome and beneficialforforensic population genetic and spermatogenesis-related studies"J Hum.Genet.. 47. 523-528 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tomomasa, H.: "Pericentric inversion of the Y chromosome of infertile male"Archives of Andrology. 45. 181-185 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Lee, J.W.: "Y-chromosome compound haplotypes with the microsatellite markers DXYS265, DXYS266, and DXYS241"J.Hum.Genet.. 46. 80-84 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shinka, T.: "A rapid and simple method for sex identification by heteroduplex analysis, using denaturing high-performance liquid chromatography (DHPLC)"J.Hum.Genet. 46. 263-266 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ewis, A.A.: "Occupational cancer genetics : Infrequent ras oncogenes point mutations in lung cancer samples from chromate workers"Amer.J.Indust.Med. 40. 92-97 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tomomasa, H., Adachi, Y., Iwabuchi, M., Oshio, S., Umeda, T., Iino, Y., Takano, T., Nakahori, Y.: "Pericentric inversion of the Y chromosome of infertile male."Archives of Andrology. 45. 181-185 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Lee, J. W., Kotliarova, S. E., Ewis, A. A., Hida, A., Shinka, T., Kuroki, Y., Tokunaga, K., Nakahori, Y.: "Y-chromosome compound haplotypes with the microsatellite markers"DXYS265, DXYS266, and DXYS241. J. Hum. Genet.. 46. 80-84 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shinka, T., Naroda, T., Tamura, T., Sasahara, K., Nakahori, Y.: "A rapid and simple method for sex identification by heteroduplex analysis, using denaturing high-performance liquid chromatography (DHPLC)."J. Hum. Genet.. 46. 263-266 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ewis, A. A., Kondo, K., Lee, J. W., Tsuyuguchi, M., Hashimoto, M., Yokose, T., Mukai, K., Kodama, T., Shinka, T., Monden, Y., Nakahori, Y.: "Occupational cancer genetics : Infrequent ras oncogenes point mutations in lung cancer samples from chromate workers."Amer. J. lndust. Med.. 40. 92-97 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ewis, A. A., Lee, J. W, Shinka, T., Nakahori,Y.: "Two Y-chromosome-specific polymorphisms 12f2 and DFFRY in the Japanese population and their relations to other Y- polymorphisms."J. Med. Invest.. 49. 44-45 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ewis, A. A., Lee, J. W., Naroda, T, Sasahara, K., Sano, T., Susumu Kagawa S., Iwamoto, T., Nakahori, Y.: "Linkage between prostate cancer incidence and different alleles of the human Y-linked tetranucleotide polymorphism DYS19."J. Med. Invest.. 49. 56-60 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ewis, A. A., Lee, J. W, Shinka, T, Nakahori, Y.: "Micro deletions of a Y-specific marker, Yfm1, and implications for a role in spermatogenesis."J Hum Genet.. 47. 257-261 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Jabasini, M., Zhang, L., Dang, F., Xu, F., Almofli, F. R., Ewis, A. A., Lee, L. W, Nakahori, Y., Baba, Y.: "Analysis of DNA polymorphisms on the human Y-chromosome by microchip electrophoresis."Electrophoresis. 23. 1537-1542 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Lettice LA, Horikoshi T, Heaney SJ, van Baren MJ, van der Linde HC, Breedveld GJ, Joosse M, Akarsu N, Oostra BA, Endo N, Shibata M, Suzuki M, Takahashi E, Shinka T, Nakahori Y, Ayusawa D, Nakabayashi K, Scherer SW, Heutink P, Hill, RE, Noji S.: "Disruption of a long-range cis-acting regulator for Shh causes preaxialpolydactyly."Proc Natl Acad Sci USA. 99. 7548-7553 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ewis A. A., Lee J. W, Kuroki Y., Shinka T., Nakahori Y.: "Yfm1, a multi-copy marker, specific for the Y chromosome and beneficial for forensic, population genetic and spermatogenesis-related studies."J. Hum. Genet.. 47. 523-528 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ewis, A.A.: "Two Y-chromosome-specific polymorphisms 12f2 and DFFRY in the Japanese population and heir relations to other Y-polymorphisms"J. Med. Invest. 49. 44-50 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ewis, A.A.: "Linkage between prostate cancer incidence and different alleles of the human Y-linked tetranucleotide polymorphism DYS192002"J. Med. Invest. 49. 56-60 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ewis, A.A.: "Microdeletions of a Y-specific marker, Yfm1, and implications for a role in spermatogenesis"J Hum. Genet. 47. 257-261 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Jabasini, M.: "Analysis of DNA polymorphisms on the human Y-chromosome by microchip electrophoresis"Electrophoresis. 23. 1537-1542 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Lettice LA: "Disruption of a long-range cis-acting regulator for Shh causes preaxialpolydactyly"Proc Natl Acad Sci U S A. 99. 7548-7453 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ewis A.A.: "Yfm1, a multi-copy marker, specific for the Y chromosome and beneficialforforensic population genetic and spermatogenesis-related studies"J Hum. Genet.. 47. 523-528 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Lee, J.W.: "Y-chromosome compound haplotypes with the microsatellite markers DXYS265, DXYS266 and DXYS241"J Hum Genet.. 46. 80-84 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Shinka, T.: "A rapid and simple method for sex identification by analysis of a heteroduplex using denaturing high performance liquid chromatography (DHPLC)"J Hum Genet.. 46. 263-266 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ewis, A.A.: "Occupational cancer genetics : Infrequent ras oncogenes point mutations in lung cancer samples from chromate workers. Amer"J. Indust. Med.. 40. 92-97 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ewis, A.A.: "Two Y-chromosome-specific polymorphisms 12f2 and DFFRY in the Japanese population and their relations to other Y polymorphisms"J. Med. Invest.. 49(in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ewis, A.A.: "Linkage between prostate cancer incidence and different alleles of the human Y-linked tetranucleotide polymorphism DYS19"J. Med. Invest.. 49(in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Jabasini, M.: "Fast Analysis of DNA Polymorphims on the Human Y Chromosome by Using Microchip Electrophoresis"Electrophoresis. 23(in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tomomasa,H.: "Pericentric inversion of the Y chromosome of infertile male. Archives of Andrology."Archives of Andrology. 45. 181-185 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Lee,J.W.: "Y-chromosome compound haplotypes with the microsatellite markers DXYS265, DXYS266 and DXYS241."J.Hum Gent.. 46. 80-84 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shinka,T.: "A rapid and simple method for sex identification by analysis of a heteroduplex using denaturing high performance liquid chromatography(DHPLC)."J Hum Genet..

    • Related Report
      2000 Annual Research Report
  • [Publications] Ewis,A.: "Occupational cancer genetics : Infrequent ras oncogenes point mutations in lung cancer samples of chromate workers."Amer.J.Industrial Med..

    • Related Report
      2000 Annual Research Report

URL: 

Published: 2000-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi