| Project/Area Number |
12480011
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
体育学
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| Research Institution | JUNTENDO UNIVERSITY |
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Principal Investigator |
NAITO Hisashi Juntendo University, School of Health and Sports Science, Associate Professor, スポーツ健康科学部, 助教授 (70188861)
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| Project Period (FY) |
2000 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 2003: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2001: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2000: ¥3,700,000 (Direct Cost: ¥3,700,000)
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| Keywords | international information exchange / USA / heat shock protein / HSP72 / aging / exercise / muscle fiber type / ヒートショック蛋白質 / HSP70 / 加齢 / 筋 / トレーニング時間 / ラット / 骨格筋 / 温浴 / 心筋 / 走運動 / 持久的運動 |
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| Research Abstract |
The effects of regular exercise training on the expression of heat shock protein (HSP) in skeletal muscle of senescent animals are unknown. Therefore, the purpose of this study was to investigate the effects of chronic exercise training on skeletal muscle HSP expression in both young and old rats. Young adult (12 weeks old) and old (100 weeks old) female Fisher 344 rats were assigned to either a sedentary control or an endurance exercise trained group (n=6/group). Rats in both training groups completed a treadmill exercise program (75-80%Vo2max, 60min/day, 5days/wk) for 10 weeks. After 72 hours on completion of the training program, the soleus (SOL) and extensor digitorum longus (EDL) muscles were excised and the levels of HSP72 were determined by Western blot technique. No differences (p>0.05) existed in the basal levels of skeletal muscle HSP72 between young and old sedentary control animals. Compared to age-matched sedentary controls, exercise training resulted in increased (p<0.05) levels of HSP72 in skeletal muscles inn both young (SOL +22%, EDL +200%) and old animals (SOL +15%, EDL +115%). Endurance training increases the expression of HSP72 in skeletal muscle in young and old animals. However, the response to endurance training in fast skeletal muscle (EDL) is blunted with an aging.
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