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Construction of safety gude system for Operation by magnetic particles

Research Project

Project/Area Number 12480262
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionToyohashi University of Technology

Principal Investigator

TANAKA Saburo  Toyohashi University of Technology, Dep.of Engineering Professor, 工学部, 教授 (10271602)

Co-Investigator(Kenkyū-buntansha) TAMAKI Yasuhiro  Osaka University Assoc.Professor, 医学部, 助手 (10273690)
MATSUZAWA Yukiko  Toyohashi University of Technology, Dep.of Engineering Research Assoc., 工学部, 助手 (10273335)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥9,200,000 (Direct Cost: ¥9,200,000)
Fiscal Year 2002: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2001: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 2000: ¥4,100,000 (Direct Cost: ¥4,100,000)
KeywordsSQUID / Lymph Node / Particles / ELISA / Immunoassay / 磁気センサ / DNA / 抗原抗体反応 / 磁性微粒子 / センチネルリンパ節 / がん / ラジオガイド / 乳がん
Research Abstract

The performance of a lymph node detection system used with an ultra-small superparamagnetic iron oxide and a high-Tc SQUID was investigated. This system is applicable for sentinel lymph node biopsy which is a newly developed surgical technology. The sentinel node biopsy is a kind of examination to investigate whether the sentinel node, which initially receives malignant cells from a breast carcinoma is disease-free or not. If the sentinel node is free of disease, you can leave the rest of the lymph-nodes because of no concern for progression. Conventionally, a radio isotope was used to identify the sentinel lymph node. We propose the use of radio exposure-safe ultra small ion oxide particles such as a magnetic resonance imagine (MRI) contrast agent.
After giving a shot of a MRI contrast agent to an arm of an anesthetic rat, a sentinel lymph node was extracted from the rat. Then the lymph node was measured by the SQUID system. We could successfully measure the magnetic signal from the lymph node. Although the real detection of the location of the lymph node in vivo was not performed yet, this result was good enough to apply the technology for the real detection.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] S.Tanaka他: "Application of High Tc SQUID Magnetometer for Sentinel-Lymph Node Biopsy"IEEE Transactions on Applied Superconductivity. 11. 665-668 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Tanaka他: "Lymph-Node detection system using a high Tc SQUID and ultra-small particles"IEICE Transactions Electron.. E85-C No.3. 687-690 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saburo Tanaka他: "Position Determine System for Lymph Node relating Breast Cancer using a High Tc SQUID"Physica C. 368. 32-36 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saburo他: "Sentinel Lymph Node Biopsy by a High Tc SQUID"Singapore Journal of Physics. 18. 17-22 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Tanaka他: "Lymph-Node detection system using a high-Tc SQUID and ultra-small particles"Proceedings of the 2^<nd> Japan-Korea Joint Workshop on Clean Technology and Science,. 28-30 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Tanaka他: "Lymph-Node detection system using a high Tc SQUID and ultra-small particles"Extended Abstracts of International Superconductive Electronics Conference. 345-346 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Tanaka and A.Hirata, Y.Saito. T.Mizoguchi, Y.Tamaki, I.Sakita and M.Monden: "Application of High Tc SQUID Magnetometer for Sentinel-Lymph Node Biopsy"IEEE Transactions on Applied Superconductivity. 11. 665-668 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Tanaka. T.Mizoguchi, H.Ota and Y.Kondo: "Lymph-Node detection system using a high Tc SQUID and ultra-small particles"IEICE Transactions Electron. E85-C No.3. 687-690 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saburo Tanaka, Hajime Ota, Yoichi Kondo, Yasuhiro Tamaki, Shinzaburo Noguchi and Masakatsu Hasegawa: "Position Determine System for Lymph Node relating Breast Cancer using a High Tc SQUID"Physica C. 368. 32-36 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saburo Tanaka, Hajime Ota Yoichi Kondo, Yukiko Matsuzawa, Yasuhiro Tamaki, and Shinzaburo Noguchi: "Sentinel Lymph Node Biopsy by a High Tc SQUID"Singapore Journal of Physics. 18. 17-22 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Tanaka, T.Mizoguchi, H.Ota and Y.Kondo: "Lymph-Node detection system using high-Tc SQUID and ultra-small particles"Proceedings of the 2^<nd> Japan-Korea Joint Workshop on Clean Technology and Science. 13-14 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Tanaka, T.Mizoguchi, H.Ota and Y.Kondo: "Lymph-Node detection system using a high Tc SQUID and ultra-small particles"Extended Abstracts of International Superconductive Electronics Conference (ISEC'01). 345-346 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Tanaka, T.Mizoguchi, H.Ota, Y.Kondo: "Lymph Node detection system using a high Tc SQUID on ultra small particles"IEICE Transactions Electron. E85-C No.3. 687-690 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Saburo Tanaka 他: "Position Determine System for Lymph Node relating Breast Cancer using a High Tc SQUID"Physica C. 368. 32-36 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Saburo Tanaka 他: "Sentinel Lymph Node Biopsy by a high Tc SQUID"Singapole Journal of Physics. 18. 17-22 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Tanaka, T.Mizoguchi, Y.Kondo, H.Ota: "Lymph-Node detection systemusing a high Tc SQUID and Ultra small particles"IEICE Trans.Electron.. E85-C. 687-690 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] S.Tanaka, H.Ota, Y.Kondo, Y.Tamaki, S.Noguchi, M.Hasegawa: "Position Determine System for Lymph Node relating Breast Cancer usigh High Tc SQUID"Physica C. 368. 32-36 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] S.Tanaka,A.Hirata,Y.Saito,T.Mizoguchi,Y.Tamaki,I.Sakiza and M.Mohden: "Application of High Tc SQUID Magnetometer for sentinel Node Biopsy"IEEE Trans. Appl.Supercond.. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 田中三郎: "SQUIDを用いた磁気ガイドシステムの医療への応用"応用物理. Vol.70 No.01. 55-56 (2001)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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